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All Journal Folia Medica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JURNAL PENELITIAN KEBIDANAN & KESPRO Indian Journal of Forensic Medicine & Toxicology
Gadis Meinar Sari
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Health Professions Medicine & Pharmacology Public Health Other

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Calorie Restriction and Moderate-Intensity Continuous Exercise Decrease Free Fatty Acid Levels and Visceral Fat Weight on High Calorie Diet Female Mice Ahmad Rukhani Lutfi; Lilik Herawati; Widjiati; Gadis Meinar Sari
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14944

Abstract

Objective: This study aimed to analyze the effect of a combination of calorie restriction and moderateintensity continuous exercise on FFA levels and visceral fat weight in female mice exposed to a high-caloriediet.Material and Method: This research was randomized posttest used only control group design with femalemice as the sampl Balb/c mice (Mus musculus), 8 weeks old, 20-30 grams. It was randomly divided into fourgroups, namely C (control group), G1 (moderate-intensity continuous exercise group), G2 (calorie restrictiongroup), and G3 (combination group calorie restriction and moderate-intensity continuous exercise) wherein every group consisted six female mice. Providing a high-calorie diet using ad libitum plus D40 as muchas 3-5% of calories (0.0325 mL/gBB) for 4 weeks. The provision of a high-calorie diet was done usingthe sonde technique. Calorie restriction was done 3x/week in 4 weeks by limiting calorie intake to 50% ofstandard foods. The moderate-intensity continuous exercise was carried out by swimming for 15 minutesplus 6% gBB loading, it was done 3 times/week for 4 weeks. The measurement of cholesterol, visceral fatweight, and FFA level was done at the end of treatments.Results: The results found that the mean of cholesterol of C C (171.00±47.74 mg/dL), G1 (126.00±15.92 mg/dL), G2 (131.50±22.37 mg/dL), G3 (121.17±21.23 mg/dL) dan (p=0.032). The mean weight of visceral fatat C (0.68±0.23 grams), G1 (0.25±0.08 grams), G2 (0.28±0.06 grams), G3 (0.20±0.03 grams) and (p=0.000).The mean FFA levels were at C (1511.34±6.19 µmol/L), G1 (1419.31±53.61 µmol/L), G2 (1458.20±28.89µmol/L), G3 (1451.55±43.77 µmol/L) and (p=0.004).Conclusion: Based on the results of the study, it could be concluded that the provision of calorie restrictionand moderate-intensity continuous exercise significantly reduced cholesterol levels, visceral fat weight, FFAlevels and in female mice exposed to a high-calorie diet
THE EFFECT OF LONG TERM ADMINISTRATION OF GLUCOCORTICOID TO BONE LINING CELLS APOPTOSIS Gadis Meinar Sari
Folia Medica Indonesiana Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.393 KB) | DOI: 10.20473/fmi.v52i4.5471

Abstract

Glucocorticoid is widely used in medical treatment as an immune system or an inflammation therapy. However its long term administration can cause life-threatening side effects. One of them is bone mass loss which increases the risk of bone fractures in the long-term use. Bone lining cells derived from mesenchymal stem cells, which serve as a backup cell bone-forming osteoblasts. Glucocorticoids acting directly on osteoblasts, bone lining cells when reduced due to increased apoptosis, the reserve cells to bone formation will be decreased. The aim of this study was to count the amount of apoptotic bone lining cells after long term glucocorticoid administration. This study used Rattus norvegicus females aged 3 months that were divided into 3 groups, each group consisted of 7 rats. The groups are: (1) control group; (2) treatment group 1 were given glucocorticoid 0.01 mg/day; (3) treatment group 2 were given glucocorticoid 0.2mg/day. The treatment carried out for 4 weeks and at the end of treatment, rats were sacrified and continued with preparation, and the number of bone lining cells that undergoing apoptosis was calculated through examination of the femur bone tissue metaphysis section using immunohistochemical technique. All data were analyzed with statistical analysis Anova. The result showed that the number of apoptotic bone lining cells increased in group with glucocorticoid administration 0.01 mg/day and 0.2 mg/day compared to control group with p = 0.000 (p <0.05). The number of apoptotic bone lining cells on the group of glucocorticoid dose 0.2 mg/day higher than the group of glucocorticoid dose 0.01 mg/day with p = 0.000 (p <0.05). In conclusion, long term glucocorticoid administration increase apoptosis of bone lining cells.
Overview of Lifestyle and Anthropometry of Students of the Faculty of Medicine Airlangga University During COVID-19 Pandemic Jihadna Prima Santika Ruslan Musanip; Hermina Novida; Gadis Meinar Sari; Reny I’tishom
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18283

Abstract

Background: The COVID-19 pandemic has spread worldwide, forcing governments to implement quarantines asa preventive measure against the spread of the virus. Quarantine causes changes in lifestyle and anthropometrystatus among communities.Objective: To describe the lifestyle and anthropometric status of medical students batch 2018 FM UA during thepandemic. Methods: This was a descriptive study using online questionnaires from September 2020 to February2021.Results: There were variations in students’ anthropometry. Students’ average height is 161.110 cm, the averageweight is 60.308 cm, the average body mass index is 23.193 cm, the average upper arm circumference is 27.846 cm,and the average abdominal circumference is 79.621 cm. Furthermore, 145 respondents (81.9%) stated that theyexperienced changes in their lifestyle during the pandemic. A total of 89 respondents (50.3%) continued to exerciseand the other 88 respondents (49.7%) did not. Regarding the sleep pattern, 108 respondents (61%) had quitegood sleep quality and 50 respondents (28.2%) had quite poor sleep quality. For the food consumption pattern,46 respondents (26%) ate more sweet foods. Furthermore, 156 respondents (88.1%) did sedentary activities, with77 respondents (43.5%) doing sedentary behavior for more than 6 hours a day.Conclusion: During the COVID-19 pandemic, the anthropometric status of medical students batch 2018 FMUAvaried; and tend to maintain their physical activity, have quite good sleep quality, prefer eating sweet foods, anddo a sedentary behavior for a longer duration
HUBUNGAN PENGETAHUAN, SIKAP DAN MOTIVASI TERHADAP PERILAKU MENJAGA HIGIENE VAGINA SAAT MENSTRUASI PADA REMAJA PUTRI Alfiyah Zahra Ulya; Gadis Meinar Sari; Wahyul Anis
JURNAL ILMIAH DHDT - KEBIDANAN Vol 5 No 1 (2022): JURNAL PENELITIAN KEBIDANAN & KESPRO
Publisher : Fakultas Kebidanan Institut Kesehatan Deli Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpk2r.v5i1.944

Abstract

Background: Lack of behavior to maintain vaginal hygiene during menstruation in adolescent girls, often causes harm to the reproductive organs, such as pruritus vulvae, and even reproductive tract infections (ISR). The purpose of this study was to describe and analyze the relationship of knowledge, attitude and motivation to the behavior of maintaining vaginal hygiene during menstruation in adolescent girls. Methods: The study was conducted at SMP Negeri 45 Surabaya using a quantitative design with a cross-sectional approach. The number of research samples was 114 respondents who met the inclusion criteria. Collecting data using a questionnaire and analyzed by Chi-square test. Results: The results of the Chi-Square analysis showed that there was a relationship between knowledge and behavior (p = 0.001) with an OR value of 4.916, which means that knowledge has a four times greater chance of influencing vaginal hygiene behavior during menstruation. There is a relationship between attitudes towards behavior (p < 0.001) with an OR value of 12.632, which means that attitudes have a 12 times greater influence in influencing vaginal hygiene behavior during menstruation in adolescent girls. While the relationship between motivation and behavior (p = 0.492) vaginal hygiene during menstruation in adolescent girls did not have a significant relationship. Conclusion: Vaginal hygiene behavior during menstruation in adolescent girls is influenced by knowledge and attitudes. The behavior of maintaining bad vaginal hygiene during menstruation can cause germs to easily enter and cause reproductive infections that have a bad impact in the future. Keywords: knowledge, attitude, motivation, behavior in adolescence menstruation
The effect of walking physical exercise on blood pressure of the pedestrian community in Penjaringan Sari Surabaya Akmal Zidan Alaudin; Gadis Meinar Sari; Yudi Her Octaviono
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 2 (2023): Journal Qanun Medika Vol 07 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i2.18710

Abstract

Hypertension is a non-communicable disease that is one of the main causes of premature death in the world. Pharmacologically by administering anti-hypertensive drugs. In non-pharmacological management of hypertension can be done with a healthy lifestyle. A study states that the most appropriate non-pharmacological treatment for people with hypertension is exercise. This research is quantitative research with a quasi-experimental design. The dependent variable in this study was walking physical exercise, while the independent variables in this study consisted of heart rate, systolic blood pressure, and diastolic blood pressure. The subjects of this study were 30 members of the pedestrian community, who were divided by purposive sampling into the treatment group and the control group. The tools used to obtain primary data in this study were the results of measuring blood pressure before and after walking. The results of the study: 1) there is a difference in the average pulse rate between the pretest and post-test in both the treatment and control groups; 2) there is an effect of walking physical exercise on pulse rate; 3) there is a difference in the mean systolic blood pressure and diastolic blood pressure between pretest and post-test; 4) there is a difference in the average blood pressure between the pretest and post-test of the control group; 5) there is no effect of physical exercise walking on blood pressure; 6) There was no difference in blood pressure and pulse between the treatment and control groups. In conclusion, the physical exercise of walking for 1 week could reduce pulse rate but could not reduce systolic blood pressure and diastolic blood pressure.
Co-Authors Ahmad Rukhani Lutfi Akmal Zidan Alaudin Alfiyah Zahra Ulya HERAWATI, LILIK Hermina Novida I'tishom, Reny Jihadna Prima Santika Ruslan Musanip Wahyul Anis Widjiati Yudi Her Octaviono