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All Journal Jurnal Ilmiah Farmasi Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Biotechnology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JURNAL FARMASI DAN KESEHATAN INDONESIA

Agung Endro Nugroho

Unknown Affiliation

Author-ID : 221218

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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PENGHAMBATAN PELEPASAN ENZIM -HEXOAMINIDASE DARI SEL MAST OLEH ZEORIN, SENYAWA DARI AEGLA MARMELOS CORREA Agung Endro Nugroho; Sugeng Riyanto; Mohd. Aspollah Hj. Sukari; Kazutaka Maeyama
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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ABSTRACTZeorin or 6,22-Dihydroxyhopane is a compound isolated from Aegle marmelos Correacollected in Yogyakarta Indonesia. The molecular structure was confirmed in Universiti PutraMalaysia. This compound was obtained from petroleum ether extract of the leaves of Aeglemarmelos Correa. In present study, we investigated the effects of zeorin on the -hexoaminidaseenzyme release from mast cell culture. The experiment was performed by using rat basophilicleukemia (RBL-2H3) cell line, a tumor analog of mast cells. DNP24-BSA and thapsigargin were usedas immunologic and non-immunologic inducers for -hexoaminidase enzyme release from mastcells, respectively. The release of -hexoaminidase enzyme was determined by using colorimetricmethods with an enzyme substrate, p-nitrofenil-2-Acetamido-2-deoksi--D-gluko-piranosida, and amicroplate reader at 405 nm. In this study, treatment of 20 ng/mL DNP24-BSA and 0.5 Mthapsigargin could stimulate the release of -hexoaminidase enzyme from RBL-2H3 cells by25.421.62 % and 33.163.72 %, respectively. Zeorin showed potent inhibitory effects on the -hexoaminidase enzyme release, when the release induced by DNP24-BSA. In contrast, zeorin showweak inhibitory effects, when the -hexoaminidase enzyme release from RBL-2H3 cells induced bya Ca2+stimulant, thapsigargin. The IC50 values of zeorin’s effects on DNP24-BSA and thapsigarginexperiments were 33,71 M and >100 M, respectively. Based on the results, the inhibitory effect ofzeorin on the -hexoaminidase enzyme release from RBL-2H3 cells involving mechanisms relatedto the interaction of IgE on the mast cell surface or intracellular signal transductions involved inmast cell degranulation.Key words : Aegle marmelos Correa, zeorin, sel mast, -hexoaminidase enzyme

EFEK FRAKSI LARUT AIR EKSTRAK ETANOL 50% KEMUNING (Murraya paniculata (L.) Jack) TERHADAP BERAT BADAN TIKUS BETINA DIET LEMAK TINGGI Suwijiyo Pramono; Agung Endro Nugroho; Crisna Wardhani
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTObesity is considered as a health problem that can promote the risks of getting disease, beingnot active and death. In some developing countries, many traditional therapies are applied for somediseases, including obesity. Kemuning (Murraya paniculata (L.) Jack) has been commonly knownas slimming potion. In present, kemuning leaf is used as ingredient of traditional medicine formula,indicated as slimming potion. Former researcher mentioned that 30% ethanol-bemusing extract hadbeen able to reduce trigliserid content in the blood reduce cholesterol content in blood serum ofmale Wistar furrow white rat (Rattus norvegicus). This research is proposed to examine the effect ofwater soluble fraction of 50% ethanol-kemuning extract to female Wistar furrow white rat bodyweight which given high fat diet and to compare the effect with anorextica (mazindol). Testedanimal are divided into 6 groups, each group contain 5 rats. Group I as negative control is given0,5% CMC Na solution. Group II as positive control is given 0,27 mg/kgBody Weight mazindolsuspension. Group III is given 50% ethanol-kemuning extract suspension with 475 mg/kg BWdosage. Group IV is given watersoluble fraction suspension of kemuning extract dosage I that is145 mg/kgBW. Group V is given watersoluble fraction suspension of kemuning extract dosage IIthat is 295 mg/kgBW. Group VI is given dose III that is 585 mg/kgBW. The suspension is givenorally with repeated dosage. Data collected are the increase of body weight, woof consumption anddrinking consumption. Body weight and woof consumption increases are analyzed by one-wayAnava with 90% significancy level. Research result shows that water soluble fraction of 50%ethanol-kemuning extract with 585 mg/kgBW dosage and positive control (mazindol) are able toobstruct rat body weight increase significancy (p < 0,10) compared to negative control group.Keys word : Murraya paniculata (L.) Jack, obesity, antiobesity

ASPEK FARMAKOLOGI TETRAHIDROKURKUMIN: METABOLIT UTAMA KURKUMIN Agung Endro Nugroho
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTTetrahydrocurcumin is a main metabolite product from biotransformation process of curcuminin the body. Biotransformation of curcumin is fast and occurred during absorption process ingastrointestinal tract. The biotransformation of curcumin to tetrahydrocurcumin and the stability oftetrahydrocurcumin play important roles in the biological effects of curcumin in the body. Thepresent article discussed about the pharmacological aspects of tetrahydrocurcumin.Tetrahydrocurcumin was reported possessing several pharmacological activities such as:antioxidant, anti-inflammatory, hepatoprotector, anti-allergy, protective for atherosclerosis and renaldamage, and also anticarcinogenesis. It’s main pharmacological activity is antioxidant, which isunderlying and responsible for the other activities. The antioxidant activity of tetrahydrocurcuminwas reported better than this of curcumin. The main factors for the antioxidant or free radicalscavenger effects of tetrahydrocurcumin are it’s aromatic/phenolic hydroxy and -diketon moieties.Key words : tetrahydrokurcumin, curcumin, pharmacology, antioxidant

Comparison of Cytotoxic and Antiproliferative Effects of Benzylidenecyclopentanone Analogues of Curcumin on RBL-2H3 Cells Agung Endro Nugroho; S. Sardjiman; Kazutaka Maeyama
Indonesian Journal of Biotechnology Vol 15, No 2 (2010)
Publisher : Universitas Gadjah Mada

Curcumin is a natural yellow pigment isolated from the rhizomes of Curcuma longa L. (turmeric), and has several pharmacological effects and no toxicity in both in animal and human clinical study. However, the problem of curcumin is its stability because of its active methylene moiety. Modification of this moiety to cyclopentanone is expected to increase the stability. Previous study reported that benzylidenecyclopentanone analogues of curcumin showed inhibitory effect on histamine release from RBL-2H3 (rat basophilic leukemia) cells, a tumor analog of mast cells. One of them, the hydroxy-methoxy analog (PGV-0), showed more potent effect than that of curcumin. In the present study, some benzylidenecyclopentanone analogues of curcumin were evaluated for their effects on the viability and proliferation of RBL-2H3 cells. Viable cells were counted under a light microscope with a cells-counting chamber or using the cell viability reagent WST-1. The results showed that mast cell viability and histamine content were not affected by curcumin and benzylidene cyclopentanone for 30 min incubation, however, impaired for overnight incubation. The hydroxy-dimethyl benzylidene analog (PGV-1) strongly decreased the mast cells viability for overnight incubation, and its effect was highest among the other analogues. In the proliferation study, this compound also strongly inhibited the proliferation of mast cells, whereas curcumin and hydroxy-methoxy benzylidene analog inhibited the proliferation slightly. There were no inhibitory effects on mast cells proliferation treated by dibenzylidene; dihydroxybenzylidene; and hydroxy-diethylbenzylidene cyclopentanone.Keywords : viability, proliferation, curcumin, benzylidene cyclopentanone, RBL-2H3 cells

FORMULASI GRANUL KOMBINASI EKSTRAK TERPURIFIKASI HERBA PEGAGAN (Centella asiatica) (L.) Urban) dan HERBA SAMBILOTO (Andrographis paniculata) (Burm.f.) Nees) Lina Widiyastuti; Suwidjiyo Pramono; Agung Endro Nugroho
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Herba pegagan (Centella asiatica (L.) Urban dan herba sambiloto (Andrographis paniculata (Burm.f.) Ness) merupakan tanaman yang potensial untuk dikembangkan menjadi bahan obat. Diperlukan suatu formulasi yang baik agar kedua herba dapat dengan mudah digunakan dengan tetap memperhatikan standart parameter kualitasnya. Penelitian ini bertujuan untuk mendapatkan formula granul kombinasi ekstrak terpurifikasi herba pegagan dan sambiloto menggunakan Avicel PH 101 (pengisi-penghancur) dan PVP K-30 (bahan pengikat) dengan menggunakan factorial design 22. Granul dibuat dengan perbandingan ekstrak terpurifikasi 30:70. Hasil penelitian menunjukkan bahwa kombinasi Avicel PH 101 dan PVP K-30 serta interaksinya dapat menghasilkan granul dengan kecepatan alir 11,50 ± 0,41 g/detik, daya serap 26,58 ± 1,21 mg/menit, kandungan lembab 4,6% ± 0,21, indeks pengetapan 16,33% ± 0,58. Diperoleh formula optimum dengan bobot kombinasi ekstrak terpurifikasiherba pegagan dan herba sambiloto 360 mg, Avicel PH 101 360 mg dan PVP K-30 18 mg menghasilkan granul dengan sifat fisik yang memenuhi persyaratan.

AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL UMBI TAWAS UT (Ampelocissus rubiginosa Lauterb.) PADA MENCIT SECARA TOPIKAL Deka Rotama; Noor Cahaya; Sudarsono Sudarsono; Agung Endro Nugroho; Khoerul Anwar
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 1 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Tawas ut tuber (Ampelocissus rubiginosa Lauterb.) contains of flavonoid, tanin, compound and saponin which is potentially anti-inflammatory. This objective of this research is to prove by effect giving extrak ethanol tawas ut tuber about effect anti-inflammatory topical based on consideration the fold of the skin and amount of cell neutrofil to mice which induced by carageenan. Thirty mice ware divided into 6 groups. They were normal control group (palacebo gel), positive control (VoltarenÃƒâ€šÃ‚Â®), negative control (karagenin), and testing groups with gel extract concentrations of 0,5%, 1%, and 2%. Ethanol extract of Tawas ut tuber leaf applied, after back of test animals was induced by 0,2 ml of 3% carageenan, then every hour was measured for middosal skin fold thickness during 6 hours observation. The animalÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s skin was cut off to perform test at 24 hours after treatment. The neutrophils migration was observed using hematoxylin and eosin (HE) stining method. The percentage result of inhibition (%PI) ethanol extrak of tawas ut tuber with concentration 0,5%, 1%, and 2% were 20,00%; 23,51%; and 24,92% respetively. The average result of netrofil total from ethanol extrak of tawas ut tuber with concentration 0,5%, 1% and 2% were 28,28; 20,88; and 16,24 respecively. Gel 2% posesses the most effective topical anti-inflammatory. Based on the result, it can be concluded that ethanol extrak of tawas ut tuber posesses anti-inflammatory in skin oedema of back of mice induced by carageenan.

Uji Aktivitas Diuretik Ekstrak n-Heksana Daun Ceplukan (Physalis angulata L.) pada Tikus (Rattus norvegicus) Jantan Wistar INDRAWATI FITRIANA; AGUNG ENDRO NUGROHO; GUNAWAN PAMUDJI WIDODO
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Ceplukan (Physalis angulata L.) empirically have diuretic effect. This study aimed to determined the diuretic effect of n-hexane extract of ceplukan leaves on Wistar male rats. Ceplukan leaves powder were extracted by maceration with n-hexane solvent. Test animal was used 25 Wistar male rats were divided into 5 groups: group I were given CMCNa 0.5% (negative control), group II (positive control) were given furosemide dose 4.32 mg/200 g BW, group III, IV, V were given n-hexane extract suspension dose of 375, 187.5, 93.75 mg/200 g BW respectivelly. The urine volume were measured in hours-6, 12, 18 and 24. Diuretic effect is obtained by calculating the cumulative urine volume and AUC (Area Under the Curve). The data obtained were analyzed by one way ANOVA with a level of 95% significant, then test by LSD (Least Significant Difference).The results showed that n-hexane extract of ceplukan leaves had diuretic effect. The effective dose of n-hexane extract of ceplukan leaves for diuretic effect was dose 375 mg / 200 g BW.

POLA PENGOBATAN DAN LUARAN KLINIS PADA PASIEN TERINFEKSI HELICOBACTER PYLORI Yanita Harliana Atharini; Probosuseno Probosuseno; Agung Endro Nugroho
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 6, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.267

Prevalensi Helicobacter pylori (H. pylori) bervariasi di seluruh dunia dan tergantung pada standar kehidupan di wilayah masing-masing. Dalam penanganannya, terdapat beberapa regimen terapi eradikasi yang akan mempengaruhi luaran klinis pasien. Penelitian ini bertujuan untuk mengetahui pola pengobatan dan luaran klinis pasien. Penelitian ini merupakan penelitian multicenter di tiga rumah sakit dengan rancangan observasional analitik retrospektif dengan metode potong lintang, menggunakan data sekunder dari tanggal 1 Januari 2009 hingga 31 Mei 2014. Jumlah pasien yang memenuhi kriteria inklusi dan eksklusi sebanyak 47 pasien. Cara penilaian luaran klinis dengan melihat keluhan yang dirasakan pasien sebelum di terapi dibanding dengan keluhan yang dirasakan pasien setelah di terapi.Karakteristik umum pasien adalah laki-laki (53,2%), usia kurang dari sama dengan 59 tahun (68,1%), peserta askes (57,4%), pendidikan terakhir SLTA (29,8%), dan pekerjaan PNS (23,4%). Sebanyak 37 pasien (78,7%) mendapatkan terapi antibiotik, dan 10 pasien (21,3%) tanpa antibiotik. Kombinasi amoksisilin-klaritromisin merupakan kombinasi paling banyak digunakan (72,3%). Keluhan dirasakan pasien adalah mual (48,93%), nyeri perut (48,93 %), melena (40,42%), muntah (31,91%), nyeri ulu hati (31,91%), buang air besar cair (19,14%), hematemesis (17,02%) dan nafsu makan menurun (17,02%). Terdapat perbedaan signifikan dalam perbaikan luaran klinis antara pasien yang mendapatkan antibiotik dengan yang tanpa antibiotik (p = 0,046; OR=5,438). Lansoprazol-Amoksisilin-Klaritromisin merupakan regimen terapi eradikasi paling banyak digunakan, Perbaikan luaran klinis dipengaruhi oleh penggunaan antibiotik. Jenis kelamin, faktor usia, dan jenis antibiotik tidak memberikan perbedaan signifikan pada luaran klinis, dikarenakan perbaikan luaran klinis dan keberhasilan terapi lebih dipengaruhi oleh tingkat resistensi antibiotik, kepatuhan dalam mengkonsumsi obat, dan reinfeksi.Kata Kunci: Helicobacter pylori, terapi eradikasi, luaran klinis, gejala dispepsia, perbaikan klinis

PERANAN OBAT GOLONGAN STATIN TERHADAP LUARAN STATUS FUNGSIONAL PASIEN STROKE ISKEMIK BERULANG DI RUMAH SAKIT Alexxander Alexxander; Agung Endro Nugroho; Rizaldi T Pinzon
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 6, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.232

Proporsi pasien yang menggunakan statin ketika pertama kali masuk rumah sakit dengan stroke iskemik berulang sangat meningkat dengan cepat. Tetapi masih menjadi kontroversi. Hal tersebut yang melatarbelakangi penelitian ini dilakukan untuk mengetahui peranan terapi statin dengan luaran status fungsional pada pasien stroke iskemik berulang di rumah sakit Bethesda Yogyakarta.Penelitian ini adalah penelitian analisis dengan metode retrospective cohort menggunakan data data rekam medis pasien. Sebagai sampel dipilih kelompok pasien stroke iskemik berulang, baik yang mendapat pengobatan dengan statin ataupun yang tidak mendapatkan pengobatan statin. Kemudian secara retrospektif diamati pengaruh penggunaan statin terhadap luaran status fungsional pasien. Jumlah subyek untuk masing masing kelompok adalah 77 pasien. Luaran baik ditandai dengan nilai mRS 0-3, sedangkan luaran buruk ditandai dengan 4-6. Lokasi penelitian adalah di rumah sakit Bethesda Yogyakarta.Penggunaan statin pada pasien stroke iskemik berulang dapat memberikan luaran status fungsional yang baik di RS Bethesda Yogyakarta (p = 0,022; RR=1,56; IK 95% = 1,056 – 2,305). Selain itu penelitian ini juga memberikan luaran sekunder yaitu variabel usia, GCS, dan kelemahan otot gerak memiliki hubungan bermakna terhadap luaran status fungsional pasien stroke iskemik berulang. Faktor prediktor untuk mendapatkan luaran status fungsional yang baik pada penelitian ini adalah pasien tanpa penggunaan antibiotik, GCS 13-15, penggunaan anti koagulan, pasien tanpa analgetik antipiretik, dan pasien dengan penggunaan anti platelet. Penggunaan statin pada pasien stroke iskemik berulang dapat memberikan luaran status fungsional yang baik di RS Bethesda Yogyakarta.Kata kunci: statin, luaran status fungsional stroke iskemik, statin dan nilai mRS

PERBANDINGAN EFEK TERAPI KOMBINASI 2 OBAT DENGAN 3 OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS Meta Kartika Untari; Agung Endro Nugroho; Fredie Irijanto
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 4, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.290

Hipertensi merupakan penyakit pembuluh perifer yang dialami oleh pasien penyakit ginjal kronik sebagai konsekuensi kerusakan progresif fungsi ginjal. Target kontrol tekanan darah predialisis <140/90 mmHg. Penelitian dilakukan di Instalasi Hemodialisis di RS Akademik UGM, RSUD Sleman, dan RSAU dr. S. Hardjolukito Yogyakarta selama bulan April-Juni 2014. Pengambilan data dilakukan dengan melihat profil tekanan darah pada rekam medik. Pengolahan data menggunakan uji t berpasangan untuk mengetahui apakah ada perbedaan tekanan darah yang diberi kombinasi 2 antihipertensi dibandingkan sesudah diberi 3 antihipertensi pada pasien hemodialisis. Analisis bivariat untuk mengetahui faktor-faktor yang berhubungan dengan pencapaian target tekanan darah sistolik <140 mmHg. Subyek pada penelitian ini sebanyak 24 pasien hemodialisis, pria sebanyak 14 pasien (58,3%), berusia rata-rata 46,12 tahun, usia termuda adalah 23 tahun dan tertua 61 tahun, menjalani hemodialisis 2 kali/minggu (91,7%), memiliki beberapa komorbid, dengan komorbid terbanyak adalah diabetes melitus (25%). Pasien yang mengalami penurunan tekanan darah sesudah diberi kombinasi 2 antihipertensi sebanyak 8 pasien (33,33%) dan sesudah diberi kombinasi 3 antihipertensi sebanyak 87,5%. Hasil pengujian statistik terhadap tekanan darah sistolik menunjukkan signifikansi 0,00 (< 0,05) dan tekanan darah diastolik 0,098 (>0,05). Pasien yang dapat mencapai target tekanan darah sistolik <140 mmHg hanya 6 pasien (25%) dan tidak ada faktor karakteristik yang menunjukkan hubungan dengan pencapaian target tekanan darah sistolik <140 mmHg. Penambahan kombinasi antihipertensi memberikan penurunan tekanan darah sistolik lebih baik. Kata kunci: Penyakit ginjal kronik, hemodialisis, tekanan darah, antihipertensi, tekanan darah sistolik

Co-Authors Alexxander Alexxander Crisna Wardhani Deka Rotama Fredie Irijanto Gunawan Pamudji Widodo Ika Yuni Astuti INDRAWATI FITRIANA Kazutaka Maeyama Khoerul Anwar Lina Widiyastuti Marchaban Marchaban Maulita Cut Nuria Mega Karina Putri Meta Kartika Untari Mohd. Aspollah Hj. Sukari Noor Cahaya Nurul Maziyyah Probosuseno Probosuseno Puji Astuti risha fillah fithria Rizaldi T Pinzon Ronny Martien S. Sardjiman Sudarsono Sugeng Riyanto Suwidjiyo Pramono Suwijiyo Pramono Yance Anas Yanita Harliana Atharini Yunita Midkha

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