Ahmad Husain Asdie
Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada

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Treating depression in diabetic patients: Latihan pasrah diri (LPD) revisited Agus Siswanto; Arief Kurniawan Siregar; Ahmad Husain Asdie
Acta Interna The Journal of Internal Medicine Vol 6, No 1 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.529 KB) | DOI: 10.22146/actainterna.27007


The condition accompanying depression will always be progressing into poor prognosis if the depression itself is not recognized and treated properly. Among diabetic patients, depression was associated with increased mortality and poor quality of life . It was observed that diabetes and depression has a bidirectional relationship, where the clinical course of both conditions are affecting each other. Despite the effectiveness of psychological and psychopharmacological interventions in treating depressive symptoms in diabetic patients, the effect of such interventions on glycemic control is still inconsistent. Complementary alternative medicine (CAM) alone or in combination with standard medical treatment, targeting both depression and diabetes, appears to be promising. Latihan Pasrah Diri (LPD) has been recognized as a type of relaxation technique under CAM. It is initially directed to provide adequate relieve of depression using both religious and relaxative approach. Among patients with comorbid diabetes and depression, this approach has long been known and utilized over the counter, but its formal practice is seldom advocated, whereas, many clinical trials has been conducted locally to reveal its potential use. Combined with standard therapy, LPD is expected to show its beneficial effects.
Effect Of Latihan Pasrah Diri (Lpd) Plus Fluoxetin Compared With Fluoxetin Alone To Improve Fructosamine Level In Tipe 2 Diabetes Mellitus Patients With Depression Symptoms Natsir Muin; Agus Siswanto; Ahmad Husain Asdie
Acta Interna The Journal of Internal Medicine Vol 7, No 1 (2017): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.52 KB) | DOI: 10.22146/actainterna.48402


ABSTRACTBackground. Depression is a risk factor for diabetes and diabetes increase the risk for depression. Depression contributes to progression of diabetes mellitus. Examination of fructosamine is used to monitor blood sugar control for 2-3 weeks (according to age albumin). LPD evoke the relaxation response, which expected to improve symptoms of stress or depression.Objective. To determine the decrease in fructosamine levels in the group of patients with diabetes mellitus with depression symptoms after administration of fluoxetine alone compared with a combination of fluoxetine and LPD.Methods. This research conducted in Dr.Soeradji Tirtonegoro General Hospital, in May to August 2014. Distribution of data tested using the Shapiro-Wilk test. The differences between fructosamine and BDI (Beck Depression Inventory) before and after treatment tested with a pair t-test if normally distributed or Wilcoxon test if it was not normally distributed. The decrease in fructosamine and BDI both groups compared by independent t-test if normally distributed or Mann Whitney U test if not normally distributed. Differences were considered significant if p <0.05 with a confidence interval of 95%.Result. There was a significant decrease in fructosamine levels in treatment group from 293.90±140.042 to 239.01±133.13 after treatment with p value 0.017 (p <0.05). Control group from 263.13±163.65 to 219.01±149.33 with p value 0.001 (p<0.05). The decrease of fructosamine levels not differ in the treatment group 67.24±102.71 than the control group 71.14 ± 72.77 with p value = 0.902 (p> 0.05).Conclusion. LPD had no effect on fructosamine levels of type 2 diabetes mellitus patients with depression symptoms.Keywords: LPD, symptoms of depression, fructosamine, BDI (Beck Depression Inventory)
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Disorders caused by iodine deficiency remains aglobal health problem in the world with a prevalenceof 30.6% in 2007 (De Benoist et al., 2003; De Benoistet al., 2008). The causing factors are not only limitedto iodine deficiency. Instead, other factors of IDD aregoitrogenic substances; one of them is thiocyanateresulted from cyanide detoxification. The workmechanism of thiocyanate disrupts thyroid functionby inhibiting the uptake of the iodine and interfereswith the thyroid peroxidase (TPO) activities (Gaitan,1990; Taurog, 1970; Van Etten, 1969; Stoewsand,1995; Virion et al., 1980 cit Chandra & Ray, 2001;Chandra et al., 2004; Delange, 2000; Erdogan, 2003;Gibbs, 2006; Sinebeeh, 2007; Semba & Delange,2008). In addition, small amount of cyanide is alwaysavailable in many kinds of plants commonlyconsumed by community. Goitrogenik source foodsare easily accessible by the community because theprices are cheap or they can be self-planted (Nio,1989; Chandra et al., 2004).Some studies mention that most of the goitrogenicsubstances do not cause clinical effects except theyare going along with iodine deficiency. Therefore,the consumption of goitrogenic substances becomesetiologic agent in an endemic area (Zimmermann etal., 2008). Jember is one of regencies in East Javawhich experiences an increase in TGR from 21.94%in 2003 to 23.57% in 2007. Most of its districts areincluded in the category of endemic goiter area(Jember regency Health Department, 2007). Theresults of previous studies made by the researchersshow that goitrogenic substance as a causativefactor of IDD in Jember, through one of theindicators of urinary iodine levels, is included in thecategory of normal and tend to be high. In addition,urinary thiocyanate levels goiter group are higherthan those in non-goiter group (Ningtyias, 2006;Ningtyias et al., 2007; Ningtyias et al., 2008).Consumption pattern of goitrogenic source food inJember of at least 3-5 times per week with anaverage consumption of 505 μg per day is a riskfactor of IDD in Jember (Megawati, 2007; Ningtyiaset al., 2008). The existence of these substances willdisrupt the process of the formation of thyroidhormones; therefore, it needs to be eliminated, orthe levels are reduced, so that the food ingredientscontaining goitrogenic substances are safe forconsumption. This study used local wisdom to solveproblems of nutrition, that is, one of the habits ofpeople in Jember to boil vegetables for freshvegetables for overcoming nutritional problem ofIDD because the boiling process can reducecyanogenic levels up to 93% (Murdiana, 2001). Bythe decrease in cyanogenic levels, it is expected thatgoitrogenic substance intake into the body willdecrease indicated by the decreasing biomarkers ofgoitrogenic substance of urinary thiocyanate levels.
Peran Faktor-faktor Psikologis terhadap Depresi pada Pasien Diabetes Mellitus Tipe 2 Jenita DT Donsu; M Noor Rochman Hadjam; Ahmad Husain Asdie; Rahmat Hidayat
Jurnal Psikologi Vol 41, No 2 (2014)
Publisher : Faculty of Psychology, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.087 KB) | DOI: 10.22146/jpsi.6953


Depression has strong relationship with diabetes mellitus and the aspect of psychology has influence toward the diabetes patient as control. This research aimed to find out the role of psychological factors in dealing with depression suffered by patient of DM-2 and to see the dynamics of both direct and indirect relationship of psychological factors toward the depression of DM-2 patient. The main model is a model that can bring effect of mediation between social support and depression caused by DM-2. Optimism can provide mediating effect of the relationship between social support and self-esteem. Resilience can provide mediating effect of the relationship between social support and self-esteem. Similarly, self-esteem acts as the mediator of the relationship between optimism and resilience toward the depression of DM-2 patient. The result of estimation parameter test showed the direct relationship between social support toward optimism (0.717), resilience (0.811), self-esteem (0.269) and depression (-0.210) and the direct role to depression (-0.397). The higher social support and self-esteem will cause the higher optimism and resilience. On the other hand, the role of self-esteem showed negative coefficient. On the other hand, the role of self-esteem to depression showed a negative coefficient is, the higher self-esteem will be followed by the decrease of depression in patient with DM-2. Keywords: depression, optimism, resilience, self-esteem, social support, DM-2