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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Medfarm: Jurnal Farmasi dan Kesehatan
Rizal Fauzi Nurdianto
Student Of Medical Faculty Universitas Wijaya Kusuma Surabaya
Chemistry Health Professions Medicine & Pharmacology Public Health

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PERAN KAPSAISIN PADA PENGHAMBATAN TERJADINYA KANKER Fery Setiawan; Arif Rahman Nurdianto; Rizal Fauzi Nurdianto; Heribertus Agustinus B Tena; Jenny Sunariani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 2 (2021): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v10i2.62

Abstract

Kapsaisin (8-methyl-N-vanillyl-6-nonanenamide) adalah rasa pedas utama dalam batang cabai yang dikonsumsi secara umum. Fungsi utama kapsaisin adalah mengurangi rasa nyeri dan inflamasi neurogenik, selain itu juga memiliki efek anti-tumor. Reseptor kapsaisin dan substansi lain yang terkait dengan kapsaisin telah diidentifikasi dan dikloningkan. Reseptor ini adalah reseptor vaniloid subtipe 1 (VR-1), yang membentuk saluran kation non-selektif dalam membran plasma yang memediasi beberapa efek pleitropik. Kapsaisin dan substansi analog yang sejenis mempunyai efek anti-proliferatif dalam sel kanker manusia melalui induksi siklus sel fase G0/G1 sehingga proliferasi sel terhenti dan terjadi apoptosis pada beberapa sel yang mengalami transformasi. Kemampuan untuk menginduksi apoptosis merupakan aktivitas supresi plasma membran NADH-oksidoreduktase (PMOR), enzim yang mentransfer elektron dari sitoplasmik NADH melalui ko-enzim Q (ubikuinon) ke akseptor elektron eksternal, seperti oksigen. Selain menginduksi apoptosis melalui PMOR, kapsaisin juga menginduksi peningkatan p21, Bax, dan Poly ADP Ribose Polymerase (PARP). Mekanisme antitumor kapsaisin secara utama dengan melakukan stabilisasi dan aktivasi gen p53. Kapsaisin secara substansial memperpanjang siklus hidup p53 dan secara signifikan meningkatkan aktivitas transkripsional p53. PMOR diperkirakan terlibat dalam pengaturan pertumbuhan sel dan proliferasi dengan menjaga rasio NADH+/NADH yang sesuai dengan kebutuhan sel.
Description of complaints/clinical symptoms and examination results of the SARS-CoV-2 rapid test in Brata Medika Laboratory Clinic Pare - Kediri in February 2021 Acivrida Mega Charisma; Arif Rahman Nurdianto; Rizal Fauzi Nurdianto; Fery Setiawan; Heribertus Agustinus Tena
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 2 (2022): Journal Qanun Medika Vol 6 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i2.9734

Abstract

 SARS-CoV-2 antigen rapid test is one of the examinations widely used for early detection of Covid-19 infection. Rapid test is considered to have more advantages, is faster, and is cheaper than molecular PCR testing, and more accurate than rapid antibody tests. Its weakness is especially in detecting samples with small quantities of the virus. The study was conducted using a retrospective method. The data was taken from the patient's medical record of the SARS -CoV-2 antigen rapid swab test at Brata Medika Pare Clinical Laboratory for the period of February 2021. Data inclusion criteria including the examination, complete identity, results of anamnesis examination and rapid test examinations. Data were analyzed in a tabular form containing frequency and percentage. There were 18 (22.5%) patients with positive SARS-CoV-2antigen rapid swab test results, 16 (89%) with complaints/symptoms, and 2 (11%) without complaints/symptoms. Meanwhile, 62 (77.5%) were found with negative SARS-CoV-2 antigen rapid swab test results where 18 (29.0%) were patients with complaints/symptoms and 44 (71.0%) were patients without complaints/symptoms. The high percentage of negative SARS-CoV-2 antigen rapid swab test results in patients with complaints/symptoms (29.0%), it is recommended that a confirmatory examination with the molecular PCR test be carried out. 
Co-Authors Acivrida Mega Charisma Fery Setiawan Fery Setiawan Heribertus Agustinus B Tena Heribertus Agustinus Tena Jenny Sunariani Nurdianto, Arif Rahman