Andika Andika
Mahasiswa program sarjana Jurusan Sosiologi FISIP Universitas Lampung

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Perbandingan Nilai Ekonomi Material B-PANEL dan Bata Ringan LEIBEL pada Bangunan Komersial Subekti, Bambang; Senjaya, Erlandi; Andika, Andika; A, Yura; Denden, Denden
REKA KARSA Vol 2, No 3
Publisher : Institut Teknologi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.561 KB) | DOI: 10.26760/rekakarsa.v2i3.590

Abstract

Perbandingan Nilai Ekonomi Material B-PANEL dan Bata Ringan LEIBEL pada Bangunan Komersial
MAKNA ADAT NYAMBAI DAN PERUBAHANNYA Andika, Andika; Nurdin, Bartoven Vivit
JURNAL SOSIOLOGI Vol 14, No 1 (2012)
Publisher : JURNAL SOSIOLOGI

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Abstract

This research intend to assess nyambai tradition and the alterationon marga Liwa Lampung Barat. Lampung society culture have a unique in implementation procedures. However the implementation and nyambai tradition implementation procedures has been changes. This research in influenced by Van Gennep (1960) argument about Rites of passage and Clifford Geertz (1973) argument about meaning and symbolic. Qualitative research methods are used to understand the meaning of nyambai tradition and the changes. Location of this research carried out in the Padang Cahya village Liwa Lampung Barat. Data collection techniques were used is observasi partisipant and depth interviews. The results of this research indicate that nyambai tradition it is a constitute cultural identity, avidence the persistence of Aristocratic form of solidaritty and decency, as well as the changes status of single to marriage life. The changes that happened to the nyambai procesion is ; procedure dress up, dress motif, the tools used in nyambai procession, and nyambai process implementation. Keywords : meaning, tradition, nyambai and changes
使用笔画笔顺教学提高国立初中第十学校学生的汉字书写能力 Ina, Ina; Khiong, Bun Yan; Andika, Andika
Jurnal Pendidikan dan Pembelajaran Khatulistiwa Vol 7, No 9 (2018): September 2018
Publisher : Jurnal Pendidikan dan Pembelajaran Khatulistiwa

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AbstractChinese letters have important role in teaching chinese language, and it is also difficult. In teaching and learning proses, the students face many difficulties. This is caused by the differences between Indonesian Language and Chinese language. Indonesian Language uses the alphabet as its letters while Chinese uses scratches/lines and the rule of scratch. The students of Junior High School No. 10 Pontianak (SMPN 10 Pontianak) also had many difficulties in learning Chinese Language. From that problems, the researcher chose the school as the subject to conduct the research using the method of teaching Chinese scratches and its rules.The result of the research shows that percentage of writing Chinese letter had improved. Before the treatment, the percentage of teaching was only 43%, and after the treatment the improvement increased to 63%. This result of the research proves that the method used in this research improves the students' ability in writing Chinese letters.  Keyword : Chinese letters, Scratch, The rule of scratch
THE EFFECT OF FISHBOWL TECHNIQUE AND STUDENTS’ INTEREST TOWARD THE EIGHT GRADE STUDENTS’ SPEAKING ABILITY OF SMP XAVERIUS 1 PALEMBANG Andika, Andika
English Community Journal Vol 2, No 2 (2018): English Community Journal
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/ecj.v2i2.1316

Abstract

This study was purposed at investigating the effect of Fishbowl technique and students’ Interest toward the eighth Grade students’ speaking ability. The population of this study was 300 students of SMP Xaverius 1 Palembang. From the population, there were 30 students taken as sample of experimental group and 30 students were as control group. The sample was taken using two stages random sampling. In carrying out the research, the writer used a factorial group design. Finnaly the calculation using a two-way ANOVA was used to measure an interaction between fishbowl technique and students interest on their speaking ability. Test of Between-Subjects Effects analyses, the significant value of the techniques (fishbowl and conventional) and the students’ interest were 0.422, the probability sig. of technique was 0.175, and the interaction between high and low interest was 0.097 which higher than the significant level of p-value 0.05, it meant that there was no a significant interactions between students’ interest and techniques. So, the research hypothesis that stated “there is no an interaction between fishbowl technique and interest toward students’ speaking ability” was accepted and the null hypothesis was not rejected based on the data finding on chapter four.
Molecular Docking Study of Flavonoid Compounds in The Guava Leaves (Psidium Guajava L) Which Has Potential as Anti-Inflammatory COX-2 Inhibitors Ahsana, Dina; Andika, Andika; Nashihah, Siti
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): JULI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.4704

Abstract

ABSTRAKInflamasi yang bersifat progresif cenderung akan merusak dan menimbulkan beberapa permasalahan dalam tubuh. Enzim COX-2 merupakan salah satu mediator yang berkontribusi besar dalam terjadinya inflamasi progresif. Penelitian secara eksperimental daun jambu biji (Psidium guajava L.) terbukti memiliki aktivitas anti-inflamasi diduga karena banyak terkandung senyawa flavonoid, namun masih belum ada penelitian aktivitasnya terhadap penghambatan COX-2 selektif. Tujuan dari penelitian ini yaitu untuk mengetahui potensi senyawa flavonoid memiliki aktivitas anti-inflamasi penghambat COX-2 selektif menggunakan uji penambatan molekul. Metode: 31 senyawa flavonoid daun jambu biji didapat dari studi literatur beberapa penelitian in-vitro dan kode protein ID: 6COX yang digunakan pada penelitian penambatan molekular ini dilakukan energi minimisasi terlebih dahulu. Selanjutnya digunakan software docking Autodock4 dengan metode semi-flexible dan Lamarckian Genetic Algorithm (LGA). Semua senyawa flavonoid juga dilakukan prediksi Absorpsi, Distribusi, Metabolisme, Ekskresi, Toksisitas (ADMET). Hasil: secara keseluruhan diperoleh semua 31 senyawa uji flavonoid daun jambu biji berpotensi sebagai inhibitor COX-2 dan beberapa senyawa uji diantaranya memiliki nilai docking ∆G terbaik yang berasal dari Epicatechin-3-O-Gallate sebesar -9,31 kcal/mol, disusul oleh Gallocatechin sebesar -8,97 kcal/mol serta Tamarixetin -8,83 kcal/mol. Residu asam amino SER 353, TYR 385, SER 530, GLN 192 dan ARG 120 juga banyak berkontibusi dalam terbentuknya ikatan hidrogen. Kesimpulan: Epicatechin-3-O-Gallate merupakan senyawa uji yang memiliki potensi besar sebagai anti-inflamasi inhibitor COX-2 selektif karena memiliki kekuatan dan kestabilan ikatan yang tinggi dengan energi docking terendah saat ditambatkan pada protein target. Kata kunci : Penambatan Molekuler; Autodock4; Psidium guajava L; Antiinflamasi Inhibitor ; COX-2; Flavonoid.ABSTRACTProgressive inflammation tends to damage and cause several problems in the body. The COX-2 enzyme is one of the mediators that have a significant contribution to progressive inflammation. Experimental study, guava leaves (Psidium guajava L.), have anti-inflammatory activity, presumably because they contain many flavonoid compounds. However, the lack of those research on their action against selective COX-2 inhibition. The purpose of this study is to determine the potential for flavonoid compounds to have anti-inflammatory activity of selective COX-2 inhibitors using molecular docking. Method: 31 flavonoids compound of guava leaves found on some literature studies of a systematic literature review and protein code ID: 6COX used on this molecular docking study by applying minimization energy at first. Next, using Autodock4 docking software with semi-flexible and Lamarckian Genetic Algorithm (LGA) methods. All flavonoid compounds also used screening Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) prediction. Results: Overall results obtained that all 31 compounds of guava leaf flavonoids can potentially be COX-2 inhibitors. One of them has the best docking value with ∆G from Epicatechin-3-O-Gallate of -9.31 kcal/mol is high than the Gallocatechin of -8.97 kcal/mol and -8.83 kcal/mol Tamarixetin. The amino acid residues SER 353, TYR 385, SER 530, GLN 192, and ARG 120 contributed significantly to form hydrogen bonds. Conclusions: Epicatechin-3-O-Gallate has significant potential as an anti-inflammatory selective COX-2 inhibitor because it has high bond strength and stability with the lowest energy binding when attached to the target protein.Keywords : Molecular Docking; Autodock4; Psidium guajava L; Inhibitor Anti-inflammatory; COX-2; Flavonoids.
The Positive Impact of Product Quality, Price, and, Promotion on Purchasing Decision of Toyota Innova Cars Winardy, Ingrid; Yanti Purba, Purnama; Chaniago, Charles; Andika, Andika
International Journal of Social Science and Business Vol 5, No 2 (2021): May
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/ijssb.v5i2.35512

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The phenomenon of declining purchasing decisions can be seen from the fact that sales targets have not been achieved, product quality is not good, prices are not competitive, and promotional strategies are not yet attractive. This study aims to analyze the contribution of product quality, price, and promotion factors to the purchase decision of Toyota Innova at PT Perintis Perkasa. This research is a descriptive study using a quantitative approach. This study involved a sample of 131 consumers who were selected using a simple random sampling technique. Data were collected by providing an instrument in the form of a questionnaire. In addition to questionnaires, data were also collected through observation, interviews, and documentation studies. The data that has been collected is then analyzed using multiple linear regression analysis. The results of data analysis showed that the significance obtained was 0.001 (Sig < 0.05). These results indicate that H0 is rejected and Ha is accepted. Based on these results, it can be concluded that, partially and simultaneously, product quality, price, and promotion have a positive and significant contribution to purchasing a car with the Toyota Innova brand at PT Perintis Perkasa.
Epigenetic Diet to Modulate Immune Response against SARS-CoV-2 Andika, Andika; Ahdyani, Risa; Erlina, Linda; Azminah, Azminah; Yanuar, Arry
Pharmaceutical Sciences and Research Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

The COVID-19 pandemic has spread to various parts of the world and caused many deaths. The victims are infected by SARS-CoV-2, a new type of coronavirus that has appeared since December 2019 and caused respiratory symptoms, fever, coughing, and shortness of breath. In addition to social distancing, wearing masks and washing hands, diet is important as a defense of the body against SARS-CoV-2. In this review, researchers conducted epigenetic diet studies that could potentially inhibit SARS-CoV-2, and can be consumed and used on a daily basis.
Discovery of SARS-CoV-2 RNA-dependent-RNA-polymerase (RdRp) Inhibitor from Sambiloto (Andrographis paniculata) Based on Molecular Docking and ADMET Prediction Approach Ahsana, Dina; Pratama, Rizki Rahmadi; Meily, Alfisyahriatunnida; Andika, Andika
Pharmaceutical Sciences and Research Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

The rapid spread of the coronavirus disease 2019 (COVID-19) has led to the development of therapeutic inhibitor drug of SARS-CoV-2, which can inhibit the viral enzyme RNA-dependent-RNA-polymerase (RdRp), thereby preventing the replication, transcription, and synthesis of RNA virus in the host cells. Previous in-vitro studies revealed that Andrographis paniculata has the potential to inhibit the virus. Therefore, this study aims to isolate the specific compounds of Andrographis paniculata, which play a role in inhibiting SARS-CoV-2 RdRp using molecular docking. A total of 19 compounds were identified in previous literature studies, while remdesivir and favipiravir were used as the positive control. All compounds and proteins were applied to minimize and optimize energy. Furthermore, the docking method was carried out using Autodock 4.2.6 software with a specific grid box containing the active site of RdRp (ID: 6M71), and the Lamarckian Genetic Algorithm was used to determine the conformation. The best docking was screened on ADMET prediction and the binding energy was evaluated. There are 18 compounds of Andrographis paniculata including the top three, namely andrographolactone (∆G = -8.86 kcal/mol), andrographolide (∆G = -7.74 kcal/mol), and andrographidine-A (∆G = -7.68 kcal/mol), which showed the strongest binding affinity to the SARS-CoV-2 RdRp protein compared to other compounds and the positive control remdesivir (∆G = -5.73 kcal/mol) and favipiravir (∆G = -5.20 kcal/mol). Furthermore, active amino acids play a role in this interaction by forming strong hydrogen bonds, such as TYR 619, LYS 621, ASP 760, and ASP 623. Andrographolactone has the highest potential as SARS-CoV-2 RdRp inhibitor, hence, it can be used as a novel therapeutic candidate.