Articles
<![CDATA[The association of CAG repeat length polymorphisms of androgen receptor gene and spermatogenesis impairment in several Indonesian men ]]>
<![CDATA[Soeharso, Purnomo]]>;
<![CDATA[Arfianti, Arfianti]]>;
<![CDATA[Moeloek, Nukman]]>
<![CDATA[ Medical Journal of Indonesia Vol 13, No 4 (2004): October-December ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Indonesia ]]>
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DOI: 10.13181/mji.v13i4.154
<![CDATA[Spermatogenesis impairment is the main cause of infertility in men. Androgen is believed to play a critical role in regulating spermatogenesis. Androgen acts by binding to the androgen receptor (AR) which is a protein regulator of DNA transcription. Exon 1 of AR gene contains a CAG repeat length polymorphism and it is believed to interfere AR function. This study includes DNA isolation from peripheral blood and amplification of CAG repeat fragments by PCR method. CAG repeat lengths were determined by electrophoresis on 6% denaturing gel polyacrylamide. We found that the mean CAG repeat lengths were 24,3 ± 3,4 in oligozoospermic/azoospermic men and 22,7 ± 2,7 in normozoospermic men. The difference in CAG repeat length between the two groups was statistically significant (p = 0,031, t-test). Nevertheless, there was no correlation between CAG repeat lengths and sperms concentration (rs = -0,038; p = 0,775). This result suggest that the expansion of CAG repeat length was not the main cause of spermatogenesis impairment. (Med J Indones 2004; 13: 215-20)Keywords: androgen receptor, CAG repeat, IVF/ICSI, male infertility.]]>
<![CDATA[Akurasi Indeks Antropometri Obesitas dalam Mempediksi Kontrol Glicemic Pasien Diabetes Mellitus Tipe 2 di Puskesmas Kota Pekanbaru ]]>
<![CDATA[Arfianti, Arfianti]]>;
<![CDATA[Deyana, Frilly]]>;
<![CDATA[Rosdiana, Dani]]>;
<![CDATA[Ardini, Nadiah Yamanza]]>;
<![CDATA[Armi, Wahyuli]]>;
<![CDATA[Kesumah, Dewi Iramayana Sandra]]>
<![CDATA[ Majalah Kedokteran Bandung Vol 50, No 3 (2018) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Padjadjaran ]]>
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DOI: 10.15395/mkb.v50n3.1361
<![CDATA[Diabetes melitus (DM) tipe 2 adalah penyakit metabolik yang ditandai dengan peningkatan kadar gula darah. Kontrol gula darah merupakan salah satu tujuan utama tata laksana pasien DM. Obesitas merupakan faktor risiko utama dari DM tipe 2. Tujuan penelitian ini adalah mengetahui hubungan indeks antropometri dengan kontrol gula darah pada pasien DM tipe 2 yang dirawat jalan di puskesmas Kota Pekanbaru. Desain penelitian yang digunakan adalah observasional analitik dengan pendekatan cross-sectional. Sampel pada penelitian ini meliputi 103 pasien DM tipe 2 yang diperoleh dari Puskesmas Sidomulyo dan Simpang Tiga Kota Pekanbaru pada bulan Mei–Juni 2018.Subjek penelitian paling banyak perempuan (58,3%) dan berusia ≥45 tahun (96,1%). Tingkat pendidikanterbanyak adalah SMA (42,7%) dan 54,4% tidak bekerja. Riwayat diabetes ditemukan pada 68,9% subjek dan 85,4% subjek tidak memiliki riwayat merokok. Sebanyak 98,1% pasien diabetes mendapat obat hipoglikemik oral dan 84,5% pasien diabetes memiliki kadar gula darah tidak terkontrol. Penelitian ini menunjukkan bahwa obesitas berdasar atas IMT dan WC tidak berhubungan dengan kontrol gula darah. Sebaliknya, obesitas berdasarkan WHR (p=0,014) dan WHtR (p=0,015) memiliki hubungan dengan kontrol gula darah pada pasien DM. Namun WHR dan WHtR secara tunggal memiliki akurasi yang sangat lemah dalam memprediksi kontrol gula darah pada penderita DM tipe 2.Accuracy of anthropometric Indexes of Obesity to Predict Glycemic Control among Type 2 Diabetic Patients in Primary Health Care in PekanbaruType 2 diabetes mellitus (DM) is a metabolic disease characterized by elevated blood sugar levels. Glycemic control is the main goal of DM patient management. Obesity is a major risk factor for DM. This study aimed to investigate the association between anthropometric indexes and glycemic control in DM patients visiting primary health care facilities in Pekanbaru. This was a cross-sectional analytical observational study on 103 type 2 DM patients from Sidomulyo and Simpang Tiga public health centers in Pekanbaru during the period of May-June 2018. More female subjects participated in this study (58.3%) with overall average age of ≥45 years (96.1%). The highest level of education of the subjects was senior high school (42.7%) and most subjects were unemployed (54.4%). The family history of DM was found in 68.9% subjects and majority had no smoking history (86.4%). As many as 98.1% DM patients were taking oral hypoglicemic drugs. Most of the DM patients had uncontrolled glycemic status (84.5%). This study showed that BMI-based and WC-based obesity was not associated with glycemic control in DM patients. On the other hand, the association between obesity based on WHR (P = 0.02; OR = 5.26) and WHtR (P = 0.008; OR = 6.82) and glycemic control in DM patients was statistically significant. However, WHR dan WHtR alone has no discrimination power to predict glycemic control among type 2 diabetic patients.]]>
<![CDATA[Hubungan Kadar Vitamin D dan Gangguan Fungsi Hati pada Pasien Hepatitis B Kronik ]]>
<![CDATA[Hendri, Sherin Alifia]]>;
<![CDATA[Arfianti, Arfianti]]>
<![CDATA[ Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Riau ]]>
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DOI: 10.26891/JIK.v15i1.2021.12-20
<![CDATA[Vitamin D plays an important role in the pathogenesis of chronic hepatitis B (CHB) through regulating immune response. This study aimed to determine the relationship between vitamin D levels and impaired liver function in CHB patients. This was an observational analytical study conducted from March to October 2019. We included 36 CHB patients aged 38.31±12.98 years and consisted of 16 men and 20 women. Vitamin D levels were measured by enzyme-linked immune assay (ELISA) method while albumin and bilirubin levels were examined by colorimetric assay. Vitamin D levels were in normal limits in 80.6% and insufficiency/deficiency in 19.4% of CHB patients. ALBI ratio scores were good in 75% and moderate-poor in 25% of subjects. Furthermore, there was no significant association between vitamin D levels and the ALBI ratio. In conclusion, this study shows that there is no relationship between plasma vitamin D levels and impaired liver function in CHB patients.]]>
<![CDATA[POLYMORPHISM OF INTERLEUKIN-10 (-819) GENE IS NOT ASSOCIATED WITH LIVER DAMAGE AMONG CHRONIC HEPATITIS B PATIENTS ]]>
<![CDATA[Ramadhani, Nur'aina ID]]>;
<![CDATA[Arfianti, Arfianti]]>
<![CDATA[ JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA ]]>
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DOI: 10.33508/jwmj.v3i3.3340
<![CDATA[Introduction: Chronic hepatitis B (CHB) is characterized by chronic liver inflammation andhepatocellular damage caused by hepatitis B virus (HBV), leading to fatal liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). Liver damage causes elevated levels of serum alanine aminotransferase (ALT). Previous studies have shown that IL-10 gene polymorphism (-819 C/T) is linked to several diseases, including inflammatory, autoimmune diseases, and cancer. Purpose: To investigate the relationship between IL-10 gene polymorphisms (-819 C/T) and liver damages in chronic hepatitis B patients at Arifin Achmad Regional Hospital, RiauProvince.Method: This study was an analytical study with a cross-sectional approach. Liver damages were examined by measuring ALT levels, and IL-10 gene polymorphisms were analyzed using Amplification-Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR). Results: There were 74 subjects included in this study, aged 45.47±13.42 years old,consisting of 43 males (58.1%) and 31 females (41.9%). Of 74 subjects, 35 CHB patientswere presented without complication, 26 CHB patients were complicated with cirrhosis, and 13 CHB patients were complicated with hepatoma. The genotype of the IL-10 (-819) gene polymorphism in this study was found as follows: CT genotype in 34 subjects (45.9%), TT genotype in 30 subjects (40.5%), and CC genotype in 10 subjects (13.5%). There was nosignificant relationship between IL-10 gene polymorphisms (- 819) and liver damage inchronic hepatitis B patients (p> 0.05).Conclusion: IL-10 gene polymorphism (-819) may not contribute to liver damages amongCHB patients.]]>
<![CDATA[Pengaruh Kelainan Refraksi terhadap Prestasi Belajar Murid Sekolah Dasar X Pekanbaru ]]>
<![CDATA[Yulia Wardany]]>;
<![CDATA[Nurul Humairah Arfiza]]>;
<![CDATA[Arfianti Arfianti]]>
<![CDATA[ Jurnal Kesehatan Melayu Vol 1, No 2 (2018): April 2018 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Riau ]]>
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DOI: 10.26891/jkm.v1i2.2018.81-87
<![CDATA[Prestasi belajar dipengaruhi oleh faktor internal dan eksternal. Salah satu faktor internalnya adalah kesehatan mata. Anak yang mengalami kelainan refraksi berpotensi untuk mengganggu prestasi belajar. Penelitian ini bertujuan untuk mengetahui pengaruh kelainan refraksi terhadap prestasi belajar siswa SD X Pekanbaru. Design penelitian ini adalah penelitian analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan metode total sampling pada 555 murid. Pemeriksaan visus digunakan untuk mendeteksi kelainan refraksi sedangkan ranking di sekolah digunakan sebagai acuan prestasi belajar siswa. Prevalensi kelainan refraksi ditemukan pada 16%. Hasil uji statistik tidak memperlihatkan adanya perbedaan prestasi belajar pada anak dengan atau tanpa kelainan refraksi. Oleh karena itu, penelitian ini menyimpulkan tidak adanya pengaruh kelainan refraksi terhadap prestasi belajar pada murid sekolah dasar.]]>
<![CDATA[Hubungan Kadar Vitamin D dan Gangguan Fungsi Hati pada Pasien Hepatitis B Kronik ]]>
<![CDATA[Sherin Alifia Hendri]]>;
<![CDATA[Arfianti Arfianti]]>
<![CDATA[ Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Riau ]]>
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DOI: 10.26891/JIK.v15i1.2021.12-20
<![CDATA[Vitamin D plays an important role in the pathogenesis of chronic hepatitis B (CHB) through regulating immune response. This study aimed to determine the relationship between vitamin D levels and impaired liver function in CHB patients. This was an observational analytical study conducted from March to October 2019. We included 36 CHB patients aged 38.31±12.98 years and consisted of 16 men and 20 women. Vitamin D levels were measured by enzyme-linked immune assay (ELISA) method while albumin and bilirubin levels were examined by colorimetric assay. Vitamin D levels were in normal limits in 80.6% and insufficiency/deficiency in 19.4% of CHB patients. ALBI ratio scores were good in 75% and moderate-poor in 25% of subjects. Furthermore, there was no significant association between vitamin D levels and the ALBI ratio. In conclusion, this study shows that there is no relationship between plasma vitamin D levels and impaired liver function in CHB patients.]]>
<![CDATA[Risk Factor Analysis of Overnutrition Among Elementary School Children in Pekanbaru: An Urban-rural Perspective ]]>
<![CDATA[Arfianti Arfianti]]>
<![CDATA[ Jurnal Kesehatan Masyarakat Nasional Volume 13, Issue 4, May 2019 ]]>
Publisher : <![CDATA[Faculty of Public Health Universitas Indonesia ]]>
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DOI: 10.21109/kesmas.v13i4.2639
<![CDATA[The prevalence of childhood overnutrition is increasing in many parts of the world including Indonesia. National basic health research (RISKESDAS) 2010 showed that over-nutrition in urban children (10.4%) was greater than in rural areas (8.1%). The purpose of this study was to analyse risk factors for overnutrition on elementary students in urban and rural areas in Pekanbaru. This was an observasional analytical study with cross-sectional design. This study involved 137 urban and 113 rural students from six elementary schools in Pekanbaru recruited by quota sampling technique. This study was conducted between April-May 2018. The results showed that the proportions of overweight and obesity in urban Pekanbaru were 16.1% and 16.8% respectively, while in rural areas were 12.4% and 9.7%, respectively. Furthermore, outdoor activity and snacking habit were significant contributors of childhood overnutrition in urban area whereas frequency of main meal was associated with childhood overnutrition in rural area. In conclusion, there was no difference in the incidence of overnutrition among elementary students in urban and rural areas in Pekanbaru. This study indicated that obesity risk factors may be different between urban and rural areas in Pekanbaru.]]>
<![CDATA[Pemberdayaan Remaja sebagai Penyuluh Deteksi Dini Kanker Serviks di Kabupaten Siak ]]>
<![CDATA[Arfianti Arfianti]]>;
<![CDATA[Rahmat Azhari Kemal]]>
<![CDATA[ ETHOS (Jurnal Penelitian dan Pengabdian) Vol 9 No.1 (Januari, 2021) Ethos: Jurnal Penelitian dan Pengabdian kepada Masyarakat (Sains & Teknol ]]>
Publisher : <![CDATA[Universitas Islam Bandung ]]>
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DOI: 10.29313/ethos.v9i1.6159
<![CDATA[Abstract. Cervical cancer is the fourth most common cancer in women and one of the leading causes of mortality from cancer. Early-stage cervical cancer is generally asymptomatic, therefore early detection is very important to reduce the number of patients with advanced stage of cervical cancer. Promotive and preventive efforts based on community empowerment are the best strategy to reduce the prevalence of advanced cervical cancer in Indonesia. To increase public awareness about the importance of early detection of cervical cancer requires the involvement of government, private sector and the community. Adolescents have great potential to play an active role as counselors in cervical cancer screening program. The purpose of this activity was aimed to increase the knowledge and skills of adolescents in carrying out their roles as heatlh counselors for early detection of cervical cancer. The training activities was conducted at the Minas Health Center located in the Minas District, Siak Regency on August 27, 2019. The training activities were attended by 24 (twenty four) students who serve as youth health counselor in Minas District. Analysis of training achievement showed a significant increase in the level of knowledge of participants about cervical cancer after counseling from a total knowledge score of 7.67 ± 1.55 to 11.00 ± 2.21 (p <0.001).Keywords: Adolescent, Cervical cancer, Counselor, Early detectionAbstrak. Kanker serviks merupakan penyakit keganasan keempat terbanyak pada wanita dan merupakan salah satu penyebab kematian terbanyak akibat kanker. Kanker serviks stadium dini pada umumnya tidak bergejala sehingga diperlukan program skrining untuk melakukan deteksi dini sehingga pasien tidak datang dalam kondisi kanker serviks stadium lanjut. Upaya promotif dan preventif berbasis pemberdayaan masyarakat merupakan strategi yang terbaik untuk menurunkan jumlah penderita kanker serviks stadium lanjut di Indonesia. Untuk meningkatkan kesadaran masyarakat tentang pentingnya deteksi dini kanker serviks diperlukan keterlibatan semua unsur dari pemerintah, swasta dan masyarakat. Oleh karena remaja merupakan kelompok yang potensial berperan secara aktif sebagai kader penyuluh deteksi kanker serviks maka tujuan kegiatan pengabdian ini adalah untuk meningkatkan pengetahuan dan keterampilan remaja dalam menjalankan peran sebagai penyuluh deteksi dini kanker serviks. Kegiatan pelatihan berlangsung di Puskemas Minas yang berada dalam wilayah Kecamatan Minas, Kabupaten Siak pada tanggal 27 Agustus 2019. Kegiatan pelatihan diikuti oleh 24 (dua puluh empat) siswi yang merupakan kader kesehatan remaja di Kecamatan Minas. Analisis tingkat ketercapaian pelatihan menunjukkan terjadinya peningkatan yang bermakna pada tingkat pengetahuan peserta tentang kanker serviks setelah penyuluhan yaitu dari total skor pengetahuan 7.67 ± 1.55 menjadi 11.00 ± 2.21 (p < 0.001).Kata Kunci: Remaja, Kanker serviks, Penyuluh, Deteksi Dini]]>
<![CDATA[Putative and pretreatment drug resistance mutations in reverse transcriptase gene among untreated chronic hepatitis B patients at Arifin Achmad Regional District Hospital, Riau, Indonesia ]]>
<![CDATA[Arfianti Arfianti]]>;
<![CDATA[Fauzia Andrini Djojosugito]]>;
<![CDATA[Maisaroh Maisaroh]]>;
<![CDATA[Hendra Asputra]]>;
<![CDATA[Dita Kartika Sari]]>;
<![CDATA[Tubagus Odih Rhomdani Wahid]]>
<![CDATA[ Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana ]]>
Publisher : <![CDATA[Indonesian Society for Biochemistry and Molecular Biology ]]>
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DOI: 10.32889/actabioina.68
<![CDATA[Background: Mutations within the hepatitis B virus (HBV) reverse transcriptase (RT) gene have been associated with drug resistance against nucleos(t)ide analogs (NAs). Objective: This study aimed to identify mutations in the RT gene among patients with chronic hepatitis B (CHB) before receiving antiviral therapy and its relationship with the HBV genotypes. Methods: A total of 26 HBV DNA was extracted from the blood plasma of CHB patients. HBV RT gene was amplified and sequenced using the Sanger dideoxy sequencing method. The HBV genotype was determined through phylogenetic analysis using the Maximum Likelihood method. Results: The study subjects comprised 14 CHB patients without complications and 12 CHB patients with cirrhosis/hepatoma. CHB patients with cirrhosis/hepatoma were older than those without complications. The HBV genotypes comprised 15 (57.7%) genotype C and 11 (42.3%) genotype B. All treatment-naïve CHB patients did not demonstrate any classical NA resistance mutations within the RT gene. However, several putative and pretreatment resistance mutations, including F221Y, N238H, and V224I, were high frequency in more than 40% of study subjects. In addition, F221Y and N238H/Q mutations were frequently observed in genotype B, while V224 I was only found in patients infected with genotype C (p=0.000). Conclusions: There was no evidence of classical RT gene mutations associated with NA resistance in treatment-naïve patients with CHB. However, several putative and pretreatment mutations were identified as genotype-specific mutations and may contribute to antiviral resistance against NAs.]]>
<![CDATA[KARAKTERISTIK FUNGSI HATI BERDASARKAN RATIO ALBUMIN-BILIRUBIN PADA PENDERITA HEPATITIS B KRONIK ]]>
<![CDATA[Arfianti Arfianti]]>;
<![CDATA[Fauzia Andrini Djojosugito]]>
<![CDATA[ Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Tribhuwana Tunggadewi ]]>
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DOI: 10.33366/jc.v9i2.2096
<![CDATA[Hepatitis B kronik (HBK) merupakan penyakit nekroinflamasi hati yang disebabkan oleh infeksi virus hepatitis B (VHB). Penderita HBK berisiko mengalami gangguan fungsi hati yang ditandai oleh gangguan sintesis albumin and sekresi bilirubin. Ratio albumin-bilirubin (ALBI) dilaporkan berhubungan dengan prognosis penderita sirosis. Penelitian ini bertujuan untuk mengkarakterisasi ratio ALBI pada penderita HBK di Rumah Sakit Umum Daerah (RSUD) Arifin Ahmad Provinsi Riau. Populasi penelitian ini adalah 75 pasien HBKdi Poli Penyakit Dalam RSUD Arifin Achmad Provonsi Riau yang terdiri dari 36 penderita HBK tanpa sirosis, 26 penderita HBK dengan sirosis dan 13 penderita HBK dengan hepatoma. Kadar albumin dan bilirubin total serum diukur menggunakan kit komersial dan dikelompokkan menjadi 3 grade. Hasil penelitian menunjukkan rerata umur penderita HBK adalah 45.313.3 tahun (minimum-maksimum, 18-73 tahun), dan penderita HBK dengan sirosis dan hepatoma lebih tua secara bermakna dibanding penderita HBK tanpa sirosis (P]]>
