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All Journal Medical Journal of Indonesia Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Medicinus : Jurnal Kedokteran JBN (Jurnal Bedah Nasional) Majalah Patologi Indonesia The New Ropanasuri Journal of Surgery Indonesian Journal of Medical Sciences and Public Health
Primariadewi Rustamadji
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Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Medicinus

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Karakteristik Histopatologik dan Imunofenotipik Kanker Payudara di Rumah Sakit Cipto Mangunkusumo Jakarta, Indonesia Primariadewi Rustamadji; Stephanie Marisca
Medicinus Vol 6, No 3 (2017): June 2017 - September 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i3.1147

Abstract

Introduction: Breast cancer can be classified into luminal A, luminal B, Her2+, dan basal-like molecular subtype according to genetic profile and immunophenotype. The aim of this study is to assess histopathologic and immunophenotype characteristics of breast cancer in Cipto Mangunkusumo Hospital Jakarta, Indonesia.Material and methods: This study is a cross-sectional retrospective study. The sample was 2632 breast cancer case in Department of Anatomical Pathology Cipto Mangunkusumo Hospital from the year 2011 until 2015. ER, PR, Her2, Top2 α, and Ki67 immunohistochemical stain was then grouped into luminal A (ER+/PR+/Her2-/Ki67<20%) subtype, luminal B (ER+/PR+/Her2-/Ki67≥20%) subtype, Her2+ (ER-/PR-/Her2+) subtype, and basal-like (ER-/PR-/Her2-) subtype. Kendall’s Tau analysis was done to assess association between sample characteristics and molecular subtype, association between top2α positive and molecular subtype.Result: The most prevalent to the less prevalent breast cancer molecular subtype was luminal B (43,9%), Her2+ (14,6%), luminal A (14,0%), and basal-like (11,3%). There was a significant association between the tumor stage and breast cancer subtype (p=0,0001). There is also a significant association between Top2α expression and molecular subtype (p=0,0001).Conclusion: The most prevalent breast cancer molecular subtype was luminal B. There was an association between breast cancer molecular subtype and a higher degree and Top2α expression.
Co-Authors Ahmad Tjarta Akmal Taher Arleni Bustami Benedikta D. Saraswati Bethy Suryawati Hernowo Bethy Suryawati Hernowo Bramastha Aires Rosadi Darmiati, Sawitri Debbie Yournita Dewi SUKMAWATI Diah Rini Handjari Diah Setiawati Dwi A. Suryandari Eka Susanto Ening Krisnuhoni Esti DS Soetrisno Esti Soetrisno Fransiscus D. Suyatna Fransiscus D. Suyatna Harliansyah Haryana, Sofia M Ineke Anggreani Joedo Prihartono Joedo Prihartono Jusman, Sri W Kartini, Diani Kelvin Setiawan Kristina Anna Bethania Luluk Yunaini Megatia, Ika Mpu Kanoko Mpu Kanoko Muchlis Ramli Murdani Abdullah Nunung Ainur Rahma Nunung Ainur Rahmah Nurjati C Siregar Puji Sari Ria Kodariah Rianto Setiabudy Samuel Johny Haryono Samuel Johny Haryono Santoso Cornain Setyawati Budiningsih Sonar S. Panigoro Stephanie Marisca Terry Renata Lawanto