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All Journal Majalah Kedokteran Andalas Majalah Patologi Indonesia
Susanto Winarko
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Health Professions Medicine & Pharmacology Public Health

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Penurunan Aktivitas Proliferasi Sel Adenokarsinoma Mamma Mencit C3H akibat Pemberian Ekstrak Etanol Lengkuas (Alpinia galanga) Susanto Winarko; Yanwirasti .; Aswiyanti Asri; Salmiah Agus
Majalah Patologi Indonesia Vol 23 No 2 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.318 KB)

Abstract

Background WHO data in 2011 showed that deaths from breast cancer in Indonesia reached 20,052 peoples of all deaths. This is partly due to the high cost of treatment, so that many people are turning to alternative therapies such as traditional plants. Lengkuas (Alpinia galanga (L) Wild is the traditional material that is cheap and easily available in Indonesia. Lengkuas-containing active substances I-acetoxychavicol acetate (ACA), and according to past research has anti-cancer properties by inhibiting the activity through the inhibition of cell proliferation pathways nuclear factor kappa B (NFƙB). To investigate the effect of ethanol extract of lengkuas against mammary adenocarcinoma cell prolifferation activities in C3H mice with various dose levels. Methods This study was an experimental study using C3H mice with post-test only research design controlled group design. Experimental animals consisted of 32 C3H mice were inoculated with tumor cells and then divided into 4 groups: control group (K) and three treatment groups (P1, P2 and P3) were given graded doses of ethanol extract of lengkuas 225 mg/kgBW/day, 450 mg/kgBW/day and 675 mg/kgBW/ day for 2 weeks. After all mice were terminated, examined the proliferative activity of tumor cells with Ki-67 antibody. Differences in proliferative activity between the groups were tested using one-way anova followed by post hoc Bonferroni test. Results There were significant differences in proliferative activities (p=0.000) among the four groups. By the post hoc Bonferroni analysis was found the significant differences in proliferative activities between the control group P1, with P2 controls, P3 control group, between P1 with P3 group, P2 with P3 group (p=
UJI DIAGNOSTIK SEDIAAN POTONG BEKU TUMOR PAYUDARA DI LABORATORIUM PATOLOGI ANATOMI PADANG Aswiyanti Asri; Susanto Winarko
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.374 KB) | DOI: 10.22338/mka.v38.i1.p7-11.2015

Abstract

AbstrakKanker payudara menempati urutan pertama tumor ganas pada wanita di Sumatera Barat dan merupakan penyebab kematian sebanyak 1.41% dari total kematian. Pemeriksaan potong beku menjadi salah satu pilihan dalam menegakkan diagnosis tumor payudara karena cepat dan akurasi yang cukup tinggi. Penelitian ini bertujuan untuk mengetahui akurasi sediaan potong beku pada tumor payudara yang didiagnosis di Laboratorium Patologi Anatomi di Padang, dengan konfirmasi histopatologi (blok parafin). Sebanyak 72 kasus tumor payudara yang dilakukan pemeriksaan potong beku, dikumpulkan dari laboratorium Patologi Anatomi RSUP Dr. M. Djamil dan RS Siti Rahmah Padang dari 1 Januari 2010 sampai dengan 31 Desember 2012. Data berupa hasil pemeriksaan potong beku dan histopatologi (blok parafin) dicatat, diolah dan dilakukan uji diagnostik dengan tabel kontingensi 2x2, kemudian dilakukan penghitungan sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, dan akurasi. Hasil uji diagnostik potong beku terhadap histopatologi pada kasus tumor payudara didapatkan sensitivitas 100%, spesifisitas 95,65%, nilai prediksi positif 98%, nilai prediksi negatif 100%, akurasi 98.6%. Pemeriksaan potong beku sangat sensitif dan spesifik yang sangat bermanfaat untuk diagnosis tumor payudara yang cepat dan akurat.AbstractBreast cancer is the most common cancer among female in West Sumatera and cause of 1.41% of the death. Frozen section examination of breast has been used as a diagnostic procedure because this method need less time and have high level of accuracy. The aim of this study is to evaluate the accuracy of frozen section examination with histopathologic confirmation.The study has been done retrospectively in 72 samples of breast tumor at the Anatomic Pathology of Dr.M.Djamil Public Hospital and Siti Rahmah Hospital Padang from January 1, 2008 to December 3, 2012. The result of frozen section and histopathology examination was collected and analyzed for counted the sensitivity and specificity value, positive predictive value, negative predictive value and accuracy value using contingency table 2 x 2. The result showed a 100% sensitivity, 95.65% specificity, 98% positive predictive value, 100% negative predictive value and 98.6% accuracy. Frozen section examination is a highly sensitive and specific test that can be useful for diagnostic choice of breast tumor and it is time less and accurate.
Co-Authors Aswiyanti Asri Salmiah Agus Yanwirasti .