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Moestikaningsih .
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Prevalensi Infeksi Human Papilloma Virus Tipe 16 dan 18 serta Lesi Prakanker dari Pemeriksaan Pap smear Berbasis Cairan pada Pasien dengan Infeksi Human Immunodeficiency Virus Iin Indrayani Maker Luh Putu; Moestikaningsih .; Ketut Suwiyoga; Mona Mariana
Majalah Patologi Indonesia Vol 23 No 2 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Bali province is the sixth highest Human Immunodeficiency Virus (HIV) prevalence in September 2012, which was 5871 cases, among them were 1227 women. HIV infected women with latent Human Papilloma Virus (HPV) in cervical uterine will have 10-20 times risk to develop cervical precancerous and cancer. The high risk group of HPV including HPV type 16 and 18. The aim of this study is to get the epidemiologic data of HPV type 16 and 18 prevalency and precancerous cervical lesion prevalency from liquid based pap smear of HIV infected women. Methods This was a descriptive prospective cross sectional study. Fifty samples were collected by concecutive sampling from liquid based pap smear of HIV infected women. Two smears were made from each sample, stain with Papanicolaou, then examination of HPV (especially type 16 and 18) was conducted by Polymerase Chain Reaction (PCR) from the remaining sample of each patient. The results of pap smear and PCR examination were grouped into whether there is positive or negative of HPV infection, type of HPV, positive or negative precancerous lesion and age groups. Results From 50 samples, 60% were HPV positive (13.3% type 16, 10% type 18, and 6.7% type 16 and 18). From 30 HPV positive samples, there were 11 (11.3%) precancerous lesions, and from 20 HPV negative samples, there were 1 (5.0%) precancerous lesions. The youngest HPV infected women with precancerous lesion was 19 years old. Conclusion Prevalency of HPV was found in more than half HIV infected samples, which type 16 was found higher than type 18. Precancerous lesions were higher in HIV with HPV infected women. Key words : Cervical precancerous lesion, Human immunodeficiency virus, human papilloma virus, liquid based pap smear, PCR, type 16 and 18
Ekspresi Protein Ki-67 pada Biopsi Kolonoskopi Adenoma dan Karsinoma Kolorektal Ni Made Maharini Rahayu; Moestikaningsih .; Ketut Mulyadi
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Neoplastic lesion in colorectal could be adenoma and colorectal carcinoma (CRC). An invasion in muscularis mucosa is a criteria for colorectal carcinoma. Diagnosis is formed with histopatologic interpretation. In colorectal-biopsy preparation interpretation, determining limited invasion is sometimes difficult so that it needs other diagnostic tools. The aim of this study was to evaluating the difference of Ki-67 mean expression in colorectal adenoma and CRC. Methods This study was cross-sectional study on colorectal adenoma and CRC. Cases were diagnosed by colonoscopy-biopsy between 2011 and 2012. It did re-interpretation of HE preparation of adenoma or colorectal carcinoma diagnosis and determination of the degree of differentiation of those adenoma and colorectal carcinoma. Immunohistochemical Ki-67 staining was interpreted with light microscope. The percentage of the stained tumour cells was counted. The difference of mean in Ki-67 expression of colorectal adenoma and CRC was analyzed with t-test with significance level at p
Laporan Kasus: Melanoma Maligna pada Gingiva Regio Mandi-bulla Luh Putu Iin Indrayani Maker; Moestikaningsih .
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Primary oral malignant melanoma is a very rare case (0.2-8%), and because of it’s hidden location and asymptomatic, it was often found at a late stage. This kind of case was never been reported in the past 10 years in Denpasar. Malignant melanoma, especially the pigmented variant, was easily diagnosed from histopathology specimen. But many variations occurred, and could be mistaken with nevus (nevoid melanoma) or mesenchymal spindle cell tumour, so immunohistochemistry examination is needed to confirmed it. In certain cases, cell block from FNAB aspirate material could help the patient to spent a lower cost to get a diagnostic material, considering the possibility of using immunohistochemistry procedure from cell block material. The case that we reported here was clinically, Radiologic, FNAB, histopathologically and immunohistochemistry for HMB45 and S100 from cell block was confirmed the primary malignant melanoma of right gingival mandible with a late stage. Key words : cell block, FNAB, histopathology, immunohistochemistry, malignant melanoma
Ekspresi P16INK4a pada Squamous Cell Carcinoma Serviks Uteri dan Cervical Intraepithelial Neoplasia 1, 2, 3 Luh Yeni Laksmini; Moestikaningsih .; Gede Raka Widiana; Ni Putu Sriwidyani; Ketut Mulyadi
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Cervical cancer is the second most common cancer in female in the world. In Bali, in 2008, cervical cancer is the second most common malignancy after breast cancer. This cancer has known to develop from precancerous lesions, cervical intraepithelial neoplasia (CIN).There is difficulty to determine grade of dysplasia of the uterine cervix and to predict wheather the lesion has potency of progression. The expression of P16INK4a has correlation with degree of cervical dysplasia and carcinoma. The aim of this study is to evaluate expression of P16INK4a in squamous cell carcinoma (SCC) of cervix uteri and CIN1, CIN2, CIN3. Methods A cross sectional analytic study was performed on 60 samples that divided into 10 CIN1, 10 CIN2, 10 CIN3, and 30 SCC. Samples were tooken from block paraffin archive from Private Laboratory in Denpasar and Anatomical Pathology Laboratory Sanglah Hospital, during January 1st 2011 until Juny 30th 2013. Immunostaining was performed to determine the expression score of P16INK4a. Expression of P16INK4a was determined by for scoring system base on staining grade and intensity. The result was analyzed by Kruskal Wallis test with level of significance α at p
Co-Authors I Gde Raka Widiana I Ketut Suwiyoga Ketut Mulyadi Luh Putu Iin Indrayani Maker Luh Yeni Laksmini Mona Mariana Ni Made Maharini Rahayu Ni Putu Sriwidyani