I Gusti Ayu Sri Mahendra Dewi
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia

Published : 49 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Hubungan Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia Katrin Rotua Simbolon; I Gusti Ayu Sri Mahendra Dewi; Ni Putu Sriwidyani; Luh Putu Iin Indrayani Maker; Herman Saputra; I Made Muliarta
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (724.217 KB) | DOI: 10.15562/ism.v12i2.1037

Abstract

Background: Lymph Node Metastasis (LNM) is considered the most important prognostic factor in breast cancer. The progress of lymphatic metastasis is thought to involve the proliferation of lymphatic vessels (lymphangiogenesis), Lymph Vessel Invasion (LVI), and lymph node metastasis step by step. This study aims to evaluate the association between LVD with LVI and regional LNM in invasive breast carcinoma of no special type.Methods: This study used a cross-sectional analytical study, using a sample of 38 paraffin-embedded tissue from the patient with invasive breast carcinoma of no special type in Sanglah General Hospital, Bali, Indonesia, in 2018. The sample will be used to assess LVD and LVI by D2-40 immunohistochemistry. Expression of D2-40 with vigorous-intensity was evaluated on the membrane and cytoplasm of lymphatic endothelial cells to determine the definition of lymphatic vessels. Lymph vessel density was determined by counting the number of lumens of peritumoral lymphatic vessels in five fields of view with the densest lymphatic vessel lumen using a Leica microscope (DM750, 400x, area 0.225mm2). Data were analyzed using SPSS version 24 for Windows.Results: The LVD cut-off value is 16.5 lymphatic vessel lumens/0.225 mm2 (65.4% for sensitivity and area Under the Curve (AUC)=70.2%). Then cases were classified into the category of high LVD (?16,5 lymphatic vessel lumen/0,225 mm2) and low LVD (<16.5 lymphatic vessels lumen/0,225 mm2). The study found a statistically significant association between LVD and lymph vessel invasion (PR=3.6; p=0.043; 95%CI=0.88-14.78) and regional lymph node metastases (PR =1.7; p=0.02; 95%CI=1.03-2.79).Conclusion: This study proved an association between LVD with lymph vessel invasion and regional lymph node metastases.  Latar Belakang: Metastasis Kelenjar Getah Bening (KGB) dianggap sebagai faktor prognostik yang paling penting pada kanker payudara. Perkembangan metastasis limfatik diduga melibatkan proliferasi pembuluh limfatik (limfangiogenesis), Lymph Vessel Invasion (LVI) atau invasi limfatik, dan metastasis kelenjar getah bening secara bertahap. Penelitian ini bertujuan untuk mengevaluasi hubungan antara Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik.Metode: Penelitian ini menggunakan metode analitik potong lintang dengan sampel 38 blok parafin dari pasien karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia tahun 2018. Penilaian LVD dan LVI dengan pulasan imunohistokimia D2-40. Ekspresi D2-40 dengan intensitas yang kuat dievaluasi pada membran dan sitoplasma sel endotel limfatik untuk menetapkan definisi pembuluh limfatik. Lymph vessel density ditentukan dengan menghitung jumlah lumen pembuluh limfatik peritumoral pada lima lapangan pandang yang memiliki lumen pembuluh limfatik terpadat, menggunakan mikroskop Leica (DM750, 400x, luas area 0,225mm2). Data dianalisis dengan SPSS versi 24 untuk Windows.Hasil: Nilai cut-off LVD adalah 16,5 lumen pembuluh limfatik/0,225 mm2 (sensitivitas 65,4% dan Area Under the Curve (AUC)=70,2%). Kemudian kasus dikategorikan menjadi LVD tinggi (?16,5 lumen pembuluh limfatik / 0,225 mm2) dan LVD rendah (<16,5 lumen pembuluh limfatik / 0,225 mm2). Hasil analisis statistik menunjukkan bahwa terdapat hubungan antara LVD dengan invasi limfatik (PR=3,6; p=0,043; IK 95%=0,88-14,78) dan metastasis KGB regional (PR=1,7; p=0,02; IK 95%=1,03-2,79).Kesimpulan: Penelitian ini membuktikan bahwa terdapat hubungan antara LVD dengan invasi limfatik dan metastasis KGB regional. 
Hubungan antara ekspresi Epidermal Growth Factor Receptor (EGFR) dengan berbagai parameter klinik dan patologis Triple Negative Breast Cancer (TNBC) di RSUP Sanglah, Bali, Indonesia Volman Tampubolon; Ni Putu Sriwidyani; Luh Putu Iin Indrayani Maker; I Gusti Ayu Sri Mahendra Dewi; Ni Made Mahastuti; I Made Muliarta
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (543.529 KB) | DOI: 10.15562/ism.v12i3.1189

Abstract

Background: Triple Negative Breast Cancer (TNBC) is a heterogeneous group of breast cancer. Some cases show a good outcome; others show higher recurrence and metastasis. There are several molecular subtypes of TNBC. Basal-like 2 (BL-2) subtype involves Epidermal Growth Factor (EGF) signaling pathway, enriched with many growth factor receptors such as EGFR. This study aims to determine the association between EGFR expression and various clinicopathological parameters in TNBC patients in Sanglah Hospital Denpasar.Methods: This study was an analytical cross-sectional study involving 35 patients TNBC who were examined histopathologically at the Anatomical Pathology Laboratory in Sanglah Hospital Denpasar from January 1st 2016 to December 31st 2020. Re-evaluation of the specimen was conducted to assess histopathological diagnosis, grade, tumor size (T), Lymphovascular Invasion (LVI) and nodal status (N). EGFR expression was evaluated by immunohistochemistry staining and then interpreted based on the intensity and continuity of the stained cell membrane. The association between EGFR expression and clinicopathological parameters was analyzed with a Chi-Square test with a 0.05 significance level.Result: The result of this study showed the age range of TNBC patients was 29-70 years with mean age was 49.7±11.4 years. There were significant association between EGFR expression with T (p=0.008; PR = 2.7; 95%CI 1.4-5.1), LVI (p=0.018; PR = 3.0; CI95% 1.300-7.137) and N (p=0.033; PR=2.7; CI95% 1.121-6.543). There were no significant association between EGFR expression with age (p=1.000), grade (p=0.689) and Ki67 index (0.689).Conclusion: It can be concluded that there are associations between EGFR expression with T, LVI and N. There was no association between EGFR expression with age, grade and Ki67 index.  Latar Belakang: Triple negative breast cancer (TNBC) merupakan kelompok kanker payudara yang heterogen. Sebagian kasus menunjukkan survival yang baik, namun sebagian lainnya dengan rekurensi dan metastasis yang lebih tinggi. Terdapat beberapa subtipe molekuler dari TNBC, salah satunya subtipe Basal-like 2 (BL2) yang melibatkan jalur pensignalan Epidermal Growth Factor (EGF), melalui berbagai reseptor factor pertumbuhan, salah satunya EGFR. Penelitian ini bertujuan untuk mengetahui hubungan antara ekspresi EGFR dengan berbagai parameter klinikopatologi pada kasus TNBC di RSUP Sanglah Denpasar.Metode: Penelitian ini merupakan studi analitik potong lintang dengan besar sampel 35 kasus TNBC yang diperiksa histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar dari 1 Januari 2016 hingga 31 Desember 2020. Evaluasi ulang preparat dilakukan untuk menilai diagnosis histopatologi, grade, ukuran tumor (T), Lymphvascular Invasion (LVI) dan status nodal (N). Ekspresi EGFR dinilai dengan pewarnaan imunohistokimia selanjutnya di interpretasi berdasarkan intensitas dan kuntinuitas membran  sel yang terpulas. Hubungan antara ekspresi EGFR dengan parameter klinikopatologi dianalisis dengan uji Chi-Square dengan nilai kemaknaan p<0,05.Hasil: Hasil penelitian ini menunjukkan rentang usia pasien TNBC 29-70 tahun dan rerata 49,7±11,4 tahun. Terdapat hubungan bermakna antara ekspresi EGFR dengan T (p=0,008; RP=2,7; IK95% 1,4-5,1), LVI (p=0,018; RP = 3,0; IK 95% 1,300-7,137), dan N (p=0,033; RP=2,7; IK95% 1,121-6,543). Tidak terdapat hubungan bermakna antara umur (p=1,000), grade (p=0,689) dan indeks Ki67 (p=0,689).Simpulan: Hasil dari penelitian ini adalah terdapat hubungan antara ekspresi EGFR dengan ukuran tumor, LVI dan status nodal (N). Tidak terdapat hubungan antara ekspresi EGFR dengan umur, grade dan indeks Ki67.          
Gambaran Klinikopatologik Penyakit Prostat di RSUP Sanglah Denpasar Tahun 2018-2020 Ida Ayu Jelantik Astuti; Ni Wayan Winarti; Ni Putu Sriwidyani; I Gusti Ayu Sri Mahendra Dewi
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Prostate disease is one of the diseases with a high incidence among elderly men. . In establishing the diagnosis of prostate disease, histopathological and laboratory examinations are vital. These histopathological results can be grouped into 3, namely benign lesions, PIN, and carcinoma. This study aims to determine the clinicopathological description of prostate diseases at Sanglah Hospital Denpasar from 2018-2020. The cross-sectional research was conducted using the descriptive and analytic method. Samples were selected based on several inclusion and exclusion criteria. Data were analyzed using SPSS version 26 to obtain a general clinicopathological picture based on age, histopathological diagnosis, the relationship between age and histopathological, diagnosis, PSA level, and the relationship between PSA level with histopathological diagnosis, and grade group carcinoma. The results showed that the prostate disease with the most patients at Sanglah Hospital Denpasar from 2018-2020 occurred between the age of 70-79 years by 39,0% with the dominant histopathological diagnosis being benign prostate 240 (74,3%), followed by PIN 27 (8,4%), and carcinoma 56 (17,3%). There was no relationship found between age, mean age and histopathological diagnosis with p=0,881 and p=0,119. The highest PSA level was > 20ng/mL. It was found that the PSA level was significantly associated with histopathological diagnoses with a value of p=0,000. The most prevalent grade group characteristic was grade group 5 with 36 (64,3%). Keywords: Prostate Disease, Clinicopathologic, PSA Level
KARAKTERISTIK KLINIKOPATOLOGI LESI NEOPLASTIK TIROID DI RSUP SANGLAH DENPASAR BALI PERIODE 2016-2020 Ida Ayu Krisna Cantika Dewi; Ni Putu Sriwidyani; I Gusti Ayu Sri Mahendra Dewi; Ni Wayan Winarti
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Thyroid neoplastic lesion can be either benign or malignant/cancerous. Thyroid cancer is a type of cancer that is increasing worldwide and is the most common endocrine gland malignant in Indonesia. The purpose of this study is to determine the clinicopathological characteristics of thyroid neoplastic lesion at Sanglah General Hospital Denpasar Bali for the 2016-2020 period based on age, sex, histopathological type, and location of lesion. This research is a descriptive study with a cross sectional approach. The data used are secondary data of patients with thyroid neoplastic lesion that registered for histopathological examination at the Anatomical Pathology Laboratory of Sanglah Hospital Denpasar in 2016-2020. The data collection technique used was total sampling which result in of 407 data meeting the inclusion criteria. The results show that the most common thyroid neoplastic lesion is found in the age group of 41-50 years (25.3%), female sex (77.4%), histopathological type of papillary thyroid carcinoma (79.9%), and location of the lesion is multiple (combination of two or more locations) as much as 36.9%. The conclusions that can be drawn from this study are thyroid neoplastic lesion patients at Sanglah General Hospital Denpasar for the period 2016-2020 have the most clinicopathological characteristics aged 41-50 years, female sex, papillary thyroid carcinoma histopathology, and multiple lesion locations. The results of this study can be developed and become the basis for other research with more varied variables or other research methods such as analytical research. Keywords: Thyroid Neoplastic Lesion, Clinicopathological Characteristics, Histopathological Type
KARAKTERISTIK KLINIKOPATOLOGI TUMOR SINONASAL DI RSUP SANGLAH PERIODE 2016-2020 Ida Ayu Meilasari Dewi; Ni Putu Sriwidyani; I Gusti Ayu Sri Mahendra Dewi; Ni Wayan Winarti
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tumor sinonasal merupakan tumor yang melibatkan kavum nasi dan sinus paranasal. Berdasarkan pertumbuhannya dibedakan menjadi tumor jinak dan tumor ganas. Menurut prevalensi, kasus tumor jinak sinonasal jarang terjadi, namun keganasan sinonasal menempati peringkat kedua keganasan kepala leher di Asia. Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi tumor sinonasal di RSUP Sanglah Denpasar pada tahun 2016-2020 berdasarkan usia, jenis kelamin, lokasi tumor, dan tipe histopatologi. Penelitian dilakukan dengan rancangan cross-sectional, menggunakan data sekunder pasien tumor sinonasal yang melakukan pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar. Sampel dikumpulkan dengan teknik total sampling, kemudian diolah menggunakan SPSS versi 23. Penelitian mendapatkan 166 kasus tumor sinonasal (jinak dan ganas) yang memenuhi kriteria penelitian. Tumor sinonasal terbanyak terjadi pada rentang usia 51-60 tahun dan 61-70 tahun dengan jumlah masing-masing 41 (24,7%), lebih banyak mengenai laki-laki (65,7%), lokasi tumor tertinggi pada daerah sinonasal (57,2%), dan tipe histopatologi yang paling sering adalah squamous cell carcinoma (22,9%) untuk tumor ganas serta inverted type sinonasal papilloma (18,1%) untuk tumor jinak. Disimpulkan bahwa tumor sinonasal sering terjadi pada usia 51-60 tahun dan 61-70 tahun, jenis kelamin laki-laki, berlokasi di sinonasal, dengan tipe squamous cell carcinoma dan inverted type sinonasal papilloma. Kata kunci : tumor sinonasal, karakteristik klinikopatologi, tipe histopatologi Sinonasal tumours are tumours that occur in the nasal cavity and paranasal sinuses. Based on its growth, classified into benign tumours and malignant tumours. According to prevalence, cases of benign sinonasal tumors are rare, but sinonasal malignancies are the second most common after head and neck malignancy in Asia. The purpose of this study was to determine the clinicopathological characteristics of sinonasal tumors at RSUP Sanglah Denpasar in 2016-2020 based on age, gender, location of the tumour, and histopathological type. The study was conducted with cross-sectional design, using secondary data from sinonasal tumor patients who underwent histopathological examination at the Anatomical Pathology Laboratory, RSUP Sanglah Denpasar Samples were collected by total sampling technique, then processed using SPSS version 23. The study found 166 cases of sinonasal tumours (benign and malignant) that met the research criteria. Sinonasal tumours were most common in the age range of 51-60 years and 61-70 years (24.7%), more common in males (65.7%), the highest tumour location was in the sinonasal (57.2%), and the most common histopathological type was squamous cell carcinoma (22.9%) for malignant tumours and inverted type sinonasal papilloma (18.1%) for benign tumours. It was concluded that most sinonasal tumours occur at the age of 51-60 years and 61-70 years, male gender, located in the sinonasal, with squamous cell carcinoma type and inverted type sinonasal papilloma. Keywords : sinonasal tumour, clinicopathological characteristics, histopathological type
KARAKTERISTIK KLINIKOPATOLOGI PENYAKIT HIRSCHSPRUNG DI RSUP SANGLAH DENPASAR TAHUN 2019-2020 Ida Bagus Ardya Kurnia Wilananda; I Gusti Ayu Sri Mahendra Dewi; Ni Wayan Winari; Ni Putu Sriwidyani
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT Hirschsprung's disease is an abnormal condition of the colon with characteristics of the Meissneri submucosus, myenteric plexus and Aurbachi plexus without parasympathetic ganglion cells. Manifestations of Hirschsprung's disease are seen in the discharge of meconium that does not come out within 24 hours. Then there are signs of obstruction to the gastrointestinal tract, vomiting bile, constipation, and irregular bowel movements. In 2017, 2.5 million children died in the first month of life worldwide. 47% of deaths of children under the age of 5 years occur in newborns, which is about 7,000 deaths. Cases of Hirschsprung's disease itself occur in 1:5000-7000 births, with cases in boys 4 times more than girls. This study aims to determine the clinicopathological characteristics of Hirschsprung's disease at Sanglah Hospital Denpasar in 2019-2020 based on clinical symptoms, age, gender, and location of the aganglionic bowel segment. This study was carried out in 2021 at the Sanglah Hospital Denpasar Anatomical Pathology (PA) installation, using data from the years 2019-2020. It was conducted using a cross-sectional method, with secondary data in the form of patient data available at the Sanglah Hospital Denpasar PA Laboratory, and total sampling. SPSS version 26 was used to analyze the data. The results of this study showed that there were 78 patients with Hirschsprung's disease at Sanglah Hospital Denpasar in 2019-2020 and all of them met the criteria of inclusion. Most cases of Hirschsprung's disease in Sanglah Hospital Denpasar experienced the most flatulence, namely 38 cases with a percentage of 36.5%. Cases were dominated by patients within age of 0-12 months with total of 64 people with 82.1% percentage, and dominated by men as many as 50 people with 64.1% percentage. The aganglionic most frequently found in the rectum as many as 49 people with a percentage of 62.8%. It was concluded from the study result that Hirschsprung's disease patients at Sanglah Hospital in 2019-2020 were mostly male, mostly in the age range 0-12 months, with the most clinical symptoms being flatulence, and the most common aganglionic location found in the rectum. This result may then be used as a basis and also study material for further related research and learning Keywords : Hirschsprung's disease, congenital megacolon, aganglionic, clinicopathological characteristics
Gambaran Klinikopatologik Lupus Nefritis di RSUP Sanglah Denpasar tahun 2016-2020 Ida Ayu Ista Nariswari; Ni Wayan Winarti; Ni Putu Sriwidyani; I Gusti Ayu Sri Mahendra Dewi
E-Jurnal Medika Udayana Vol 11 No 10 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT Systemic lupus erythematosus (SLE) is one of the most common autoimmune diseases in the community. One of common clinical manifestations of SLE is Lupus Nephritis (LN). The World Health Organization (WHO) notes that there are five million people with lupus in the world and there are 100,000 more new sufferers every year. In Indonesia in 2016 it was reported that 2,166 patients were hospitalized with a diagnosis of SLE and 550 of them died. This study aims to determine the characteristics of LN patients at Sanglah Hospital Denpasar in 2016-2020 based on age, gender, histopathological class (categorized according to ISN/RPS), and proteinuria level and to determine the relationship between proteinuria level and histopathological class and the relationship between age and histopathological class. This research was conducted at the Anatomical Pathology (PA) laboratory of Sanglah Hospital Denpasar in 2021 with a cross-sectional method, using secondary data that available at the PA laboratory of Sanglah Hospital Denpasar, then processed using SPSS ver. 26. The results showed that the total number of LN patients at Sanglah Hospital Denpasar in 2016-2020 was 28 cases. Most cases were found at age range of 26-35 years (11 cases or 39.3%) and most were female (23 cases or 82.1%). The most common proteinuria level found was +3 (8 cases or 28.6%) and the most common histopathological class was class IV (13 cases or 46.4%). Chi square test showed no significant relationship between proteinuria level and LN histopathological class (p=0.069) nor between age and LN histopathological class (p=0.202). It was concluded that LN patients at Sanglah Hospital in 2016-2020 were mostly women, aged 26-35 years, with a proteinuria level of +3 and included class IV LN. Since there is no correlation between age or proteinuria level with histopathological class, it is recommended that histopathological biopsy be performed in all cases of suspected LN so that patients receive adequate therapy based on the level of kidney damage. Keywords : Lupus nephritis, age, gender, proteinuria level, histopathological class according to ISN/RPS
The Validity Assessment of E-Cadherin Expression to Differentiate Ductal and Lobular Type Invasive Breast Carcinoma I Gusti Ayu Sri Mahendra Dewi
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (498.577 KB)

Abstract

Introduction: Currently, breast cancer is one of the leading causes of cancer related death in women worldwide. The diagnosis of breast cancer still depends on biopsy to determine the histopathological subtype and the nature of the cancer. However, the subtypes alone could not differentiate between lobular and ductal carcinoma. Therefore, this study aimed to evaluate the validity of E-cadherin expression as biomarker to differentiate ductal and lobular invasive breast carcinomas. Methods: An analytic observational cross sectional study was conducted using 47 biopsy samples of ductal and lobular type invasive breast carcinoma examined at Anatomical Pathology Laboratory Faculty of Medicine, Udayana University/ RSUP Sanglah Denpasar in 2017. The samples were evaluated using H & E staining while E-cadherin expression was examined by using Immunohistochemistry technique (IHC). Pearson chi-square was performed to analyze the data with p-value less than 0.05 was considered significant or valid. Result: Descriptive statistics showed that the samples were homogeneous in term of age between ductal and lobular types (p=0.668). Breast cancer was found to be more prevalent on the left breast compared to the right one in both in ductal and lobular types. IHC staining showed that E-cadherin expression was significantly lower in lobular types (9.1% positive) compared to ductal (60.0% positivity) and, thus, can be used to differentiate them (p=0.000). Conclusion: E-cadherin expression was a valid biomarker to differentiate ductal and lobular type invasive breast carcinoma. More comprehensive study with larger number of samples is required to assess the generality of this findingKeywords: E-cadherin, Breast carcinoma, Ductal type, Lobular type.
Case Report: Gastric Wall Thickening: Radiological Diagnostic Challenges in Gastric Malignancy Putu Ayu Winda Wirastuti Giri; Nyoman Srie Laksminingsih; Firman Parulian Sitanggang; I Gusti Ayu Sri Mahendra Dewi; I Wayan Juli Sumadi; Luh Putu Iin Indrayani Maker
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.819 KB) | DOI: 10.30742/jikw.v10i1.983

Abstract

Gastric abnormalities show nonspecific gastrointestinal symptoms and similarly radiological findings. Intra and extra luminal gastric wall thickening are the most common finding in benign and malignant pathologic process. This aim of this case report was to describe several characteristics such as the location and size of the lesion, involvement of the gastric wall and surrounding structures, calcifications, and contrast enhancement pattern which can assist in radiological diagnosis. Several cases at our institution have similar gastrointestinal complaints, however, there were different lesions characteristic found in contrast enhanced abdominal CT scan. The first case 72-years-old man experienced hematemesis with radiologic finding diffuse gastric mucosal thickening as well as homogenous contrast enhancement but without calcification.  The second case 37-years-old man complaint dizziness and melena with radiologic finding large tumor more than 10 cm in size, amorph calcification and heterogenous contrast enhancement. The last 60-years-old man case experienced melena and hematemesis, from abdominal CT scan showed irregular gastric mucosal thickening with heterogenous contrast enhancement and fat stranding around the lesion, without calcification. Methods used in these cases were contrast-enhanced abdominal CT scan, esophagogastroduodenoscopy (EGD), and biopsy in order to determine the diagnosis. Contrast-enhanced abdominal CT scan plays a vital role in describing the lesion characteristics which affects the determination of treatment options and future prognosis.
Co-Authors Anak Agung Ayu Ngurah Susraini and I G. Alit-Artha annie minerva datui Desak Made Cittarasmi Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Diah Widityasari, Diah E. Joewarini Efrisca M Br Damanik Firman Parulian Sitanggang Gde Ngurah Idraguna Pinatih Herman Saputra Herman Saputra Herman Saputra Herman Saputra I Gusti Alit Artha I Gusti Bagus Lulut Premana Mulia I Gusti Bagus Mulia Agung Pradnyaandara I Gusti Ngurah Bagus Rai Mulya Hartawan I Kadek Adi Purnama Sandhi I Ketut Suwiyoga I Made Gotra I Made Muliarta I Made Muliarta I MADE MULIARTA . I Made Naris Pujawan I Made Wirya Sastra I Wayan Juli Sumadi I Wayan Juli Sumadi IB Caka Gunantara Ida Ayu Eugenia Natasha Blanco Oka Ida Ayu Ista Nariswari Ida Ayu Jelantik Astuti Ida Ayu Krisna Cantika Dewi Ida Ayu Meilasari Dewi Ida Bagus Ardya Kurnia Wilananda Ivana Juliarty Sitanggang Jovi Carina Handoko Kadek Agus Suhardinatha Putra Kadek Dwi Pradnyawati kadek pramesti dewi Katrin Rotua Simbolon Luh Ayu Widayanti Luh putu Iin Indrayani Luh Putu Iin Indrayani Maker Made Dwi Hartayati Moestikaningsih Moestikaningsih Ni Ketut Ari Widhiasih, Ni Ketut Ari Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Winari Ni Wayan Winarti Nur Silfiah Nyoman Srie Laksminingsih Popi Imelda Margareth Sitompul Putu Ayu Widya Pramesti Putu Ayu Winda Wirastuti Giri Putu Dony Astika Wiguna Putu Risky Yoga Pradnyana Shameni Subramaniam Silvia Nuhyil Indriani Sylvi Diahningrum Tjandra Kristiana Volman Tampubolon