Afiati Afiati
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Imunoekspresi CK-7 dan CK-20 pada Karsinoma Musinosum Ovarium Primer di RSUP Dr. Hasan Sadikin Bandung Lili Sumarni; Hasrayati Agustina; Afiati Afiati
Majalah Patologi Indonesia Vol 27 No 1 (2018): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

LatarbelakangKarsinoma musinosum ovarium (KMO) merupakan subtipe karsinoma ovarium, yang sering mempunyai prognosis buruk. Ada dua bentuk KMO yang sering ditemukan, yaitu bentuk primer (KMOP) dan sekunder atau metastasis (KMOS). Untuk membedakan terapi tumor primer (KMOP) dan sekunder/metastasis perlu dilakukan pemeriksaan menggunakan CK-7 dan CK-20. Penelitian ini bertujuan untuk menganalisis imunoekspresi CK-7 dan CK-20 pada KMO.MetodePenelitian ini menggunakan desain penelitian potong lintang dengan data deskriptif retrospektif pada kasus KMO yang secara klinis didiagnosis tumor primer ovarium di RSUP dr. Hasan Sadikin Bandung periode Januari 2013 sampai dengan Juni 2016. Pada seluruh kasus dilakukan pemeriksaan histopatologi dan imunohistokimia CK-7 dan CK-20 dan dilihat parameter klinis yaitu ukuran dan lateralitas. KMOP didiagnosis bila ukuran lebih dari dari 10 cm dan unilateral, sedangkan KMOS bila ukuran kurang dari 10 cm dan bilateral.HasilHasil penelitian ini menunjukkan dari 49 kasus KMO, sebanyak 17 kasus (34,7%) adalah karsinoma musinosum ovarium sekunder (KMOS) {CK-7(-), CK-20(+)} dan 32 kasus (65,3%) adalah KMOP {CK-7(+), CK-20(-)}. Seluruh kasus KMOP (100%) dan sebagian besar kasus KMOS (88,2%) berukuran lebih besar dari 10 cm. Tidak terdapat hubungan antara ukuran tumor (p=0,29 ) dan lateralitas (p=0,94) yang signifikan dengan KMOP dan KMOS.KesimpulanPulasan imunohistokimia (IHK) CK-7 dan CK-20 dapat digunakan untuk menegakkan diagnosis KMOP.
Hepatoprotective Effect of Solanum melongena/Eggplant against Acute Hepatitis Nabhan Komara; Herri S. Sastramihardja; Afiati Afiati
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

   Background: Hepatitis is a liver inflammation that can be acute or chronic and may cause damage to hepatocytes such as necrosis.. Hepatocyte necrosis can be inhibited by antioxidants such as flavonoids found in Solanum melongena fruit. This study aimed to determine the hepatoprotective effect of Solanum melongena fruit infusion to inhibit hepatocytes damage in CCl4-induced rats.Methods: Twenty five male Wistar rats were randomly divided into five groups, and adapted for 7 days before the experimental study. Negative and positive groups were given aquadest, Group III−V were given Solanum melongena fruit infusion containing 1.125 grams, 2.25 grams and 4.5 grams orally for 9 days. At the 9th day, all rats were induced by 8 mL/kgBW of 10% CCl4 in paraffin, except for the negative group. Rats were sacrificed on the 11th day, and liver biopsy preparations were made. Hepatocyte necrosis was counted and was analyzed by Kruskal-Wallis test and Mann-Whitney test. Results: The study showed that the percentage of necrotic hepatocytes in group III, IV a nd V were lower than in the positive group. Using Mann-Whitney test, there were significant differences in negative group, group III, and group V (p<0.05). Meanwhile, unsignificant difference was seen between the positive group and group IV (p>0.05). Kruskal-Wallis test showed that there weresignificantly differences among groups (p<0.05). Conclusions: Solanum melongena fruit infusion has hepatoprotective effects against acute hepatitis in rat model histopathologically.Keywords: CCl4, flavonoids, hepatocyte, necrosis, Solanum melongena DOI: 10.15850/amj.v2n1.434