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All Journal Majalah Patologi Indonesia Indian Journal of Forensic Medicine & Toxicology
Endang Joewarini
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Health Professions Public Health

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Analisis Ekspresi Cyclin D1 dan COX-2 pada Berbagai Grading Histopatologik Karsinoma Endometrioid Ovarium Erwin Sunardi; Endang Joewarini
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.971 KB) | DOI: 10.55816/mpi.v29i2.421

Abstract

BackgroundOvarian endometrioid carcinoma accounts for 10-15% of ovarian carcinomas, representing the second most common form ofovarian epithelial malignancy. Epithelial cell lines stably transfected to overexpress COX-2 exhibit a higher proliferation rate and aninhibition of apoptosis by prolongation of the G1 phase of the cell cycle through effects on Cyclin D1. The aim of this study is toanalyzed the correlation and differences between Cyclin D1 and COX-2 expressions in various histopathology grading ovarianendometrioid carcinoma.MethodsAn analitycal obsevational design with cross-sectional approach on sample from 23 paraffin blocks in Anatomical PathologyLaboratory Dr. Soetomo General Hospital. Microscopic slide stained with Cyclin D1 and COX-2 antibody. The imunohistochemistryexpression are evaluated and analyzed using Kruskal Wallis and Spearman test.ResultsThere were no differences Cyclin D1 expression in each grade, there were no differences COX-2 expression in each grade, therewas no correlation between Cyclin D1 and COX-2 expression all histopathologic grading, but have correlation expression in grade 3ovarian endometrioid carcinoma.ConclusionThis study showed that Cyclin D1 and COX-2 expression have no significant differences in various histopathological grading ovarianendometrioid carcinoma, and no correlation between Cyclin D1 and COX-2 expression all grade ovarian endometrioid carcinoma
Systemic Effects of Occlusal Disharmony on Corticosterone Serum Levels in Rattus Norvegicus Suhartini; Endang Joewarini; Ida Bagus Narmada
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15007

Abstract

Background: Mastication process occurs over time and it can lead to occlusal reduction of the teeth. Thiscauses reducing occlusal contact of teeth and it will lead to disharmony occlusion disorders. The occlusiondisharmony is recognized by the body as a stressor that systemically affects the homeostasis in the body,especially the production of hormones.Objective: The aim of this study was to determine the systemic effect of occlusal disharmony on corticosteroneserum levels in Rattus norvegicus.Method: The research method of this study used experimental design and conducted among 7 male RattusNorvegicus in each groups. In intervention group, an occlusal reduction was ± 1 mm in all molars andfor control group did not given any intervention. Moreover, at 1st day, 7th day, 14th day and 21st day wastaken 2 cc of blood via infraorbital vein. The measurement of Corticosterone levels used Enzyme LinkedImmunosorbent Assay (ELISA).Result: Anova test results showed that corticosterone levels was significant difference between each groups(p <0.05). Tukey HSD test showed there was a significant difference between intervention group and controlgroup on 1st day, in intervention group on 7th day (p <0.05).Conclusion. The results of this study showed that there were differences of corticosterone serum levelsamong mice who experienced occlusion disharmony so it concluded that the dental occlusion disharmonyhad a systemic impact to corticosterone serum levels in Rattus norvegicus
Co-Authors Erwin Sunardi Ida Bagus Narmada Suhartini