Garuda - Garba Rujukan Digital

Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.

Pengaruh Pemberian Sari Kacang Hijau (Vigna radiata (L.) R. Wilczek) Terhadap Densitas Tulang dan Jumlah Osteoklas pada Tikus(Rattus norvegicus) yang Diovariektomi Yeyen, Arnita; Bahtiar, Anton; Soetanto, Sriangky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Greenbean (Vigna radiata (L.) R. Wilczek) contained phytoestrogen suspected has a potential effect as an preventive and alternative treatment of osteoporosis. This study is proposed to determine the effect of extracts of greenbean juice (Vigna radiata (L.) R. Wilczek) on bone density by measuring calcium levels using Atomic Absorption Spectrofotometry (AAS) from femur and the number of osteoclasts collected from histological object which made from ovariectomized rat tibia. Ovariectomy method conducted to represent the osteoporosis condition on 36 female Sprague Dawley rats were divided into 7 groups. Group 1 noticed as Sham was the rat control with surgery without ovariectomy and distilled water, group 2 as negative control is given distilled water and ovariectomized rat control, group 3 as positive control was given estradiol and ovariectomized rat control, group 4 as positive control was given vitamin E and ovariectomized rat control. Group 5, 6, and 7 were given 50 g/100 ml the greenbean juice with volume variation 5 ml/200 gBW, 2.5 ml/200 gBW, and 1.25 ml /200 gBW. Six groups had ovariectomized except sham group and rested for 20 days. Greenbean juice was given orally once daily started from day 21 until day 50. Calcium concentration and osteoclast measurement process taken on day 51. The results of bone calcium levels and osteoclast number showed that greenbean juice did not give significant differences among ovariectomized rats.

Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.

Pengaruh Pemberian Sari Kacang Hijau (Vigna radiata (L.) R. Wilczek) Terhadap Densitas Tulang dan Jumlah Osteoklas pada Tikus(Rattus norvegicus) yang Diovariektomi Yeyen, Arnita; Bahtiar, Anton; Soetanto, Sriangky
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Greenbean (Vigna radiata (L.) R. Wilczek) contained phytoestrogen suspected has a potential effect as an preventive and alternative treatment of osteoporosis. This study is proposed to determine the effect of extracts of greenbean juice (Vigna radiata (L.) R. Wilczek) on bone density by measuring calcium levels using Atomic Absorption Spectrofotometry (AAS) from femur and the number of osteoclasts collected from histological object which made from ovariectomized rat tibia. Ovariectomy method conducted to represent the osteoporosis condition on 36 female Sprague Dawley rats were divided into 7 groups. Group 1 noticed as Sham was the rat control with surgery without ovariectomy and distilled water, group 2 as negative control is given distilled water and ovariectomized rat control, group 3 as positive control was given estradiol and ovariectomized rat control, group 4 as positive control was given vitamin E and ovariectomized rat control. Group 5, 6, and 7 were given 50 g/100 ml the greenbean juice with volume variation 5 ml/200 gBW, 2.5 ml/200 gBW, and 1.25 ml /200 gBW. Six groups had ovariectomized except sham group and rested for 20 days. Greenbean juice was given orally once daily started from day 21 until day 50. Calcium concentration and osteoclast measurement process taken on day 51. The results of bone calcium levels and osteoclast number showed that greenbean juice did not give significant differences among ovariectomized rats.

Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet dan Niosom Anwar, Effionora; Djajadisastra, Joshita; Yanuar, Arry; Bahtiar, Anton
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by α-amylase enzyme (Liquezym EX®) at variable temperature and time incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to prepare niosom, a tablet filler, binder and disintegrator on direct compress tablet, a sugar coated tablet material. All of the product used active compound as amodel and the quality were evaluated according to the 4thed. of Indonesian Pharmacopeae and other valid references. The result shows that maltodextrin DE 1–5 could be used as a tablet binder which was processed by wet granulation on 2-5% concentration, as a tablet binder and filler which was processed by direct compress on 30-35%; maltodextrin DE 10-15 could be used as a proniosom carrier then continued to niosom preparation with surfactant composition of 2 mmol (1 mmol for span 60 and 1 mmol for cholesterol). The surfactant and drug concentration of 100 mmol/lt and 5 mmol/lt subsequently was proved to loading the drug as much as 81.28%. Maltodextrin DE 15-20 could be used as a tablet filler, binder and disintegrator at 84%, and starch hydrolyzed of DE 35-40 as a sugar coating which was more economical than sugar.

Title

Found 5 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 5 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 5 Documents
Search