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All Journal International Journal of Public Health Science (IJPHS) Proceedings of KNASTIK Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Communications in Science and Technology Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Arif Budi Setianto
Universitas Ahmad Dahlan
Engineering Health Professions Medicine & Pharmacology

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INDENTIFIKASI IRITASI KULIT MANUSIA MENGGUNAKAN METODE JARINGAN SARAF TIRUAN LEARNING VECTOR QUANTIZATION Fadlil, Abdul; Setianto, Arif Budi; Purnamasari, Putri
Proceedings of KNASTIK 2010
Publisher : Duta Wacana Christian University

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Abstract

Jaringan saraf telah berhasil dipakai dalam bidang klasifikasi pola. Makalah ini menyajikan suatu metode baru untuk mengidentifikasi Iritasi kuit manusia. Metodologi yang diusulkan menggunakan jaringan saraf learning vector quantization sebagai pengklasifikasi untuk pengidentifikasi kulit manusia. Normalisasi histogram dari citra kulit digunakan sebagai vektor ekstraksi ciri untuk membedakan antara pola non iritasi dan pola iritasi. Sistem identifikasi ini dilatih menggunakan sekumpulan data citra kulit non-iritasi dan iritasi masing-masing 10 citra. Selanjutnya diuji dengan data citra kulit non-iritasi dan iritasi masing-masing 12 citra. Hasil-hasil percobaan kami menunjukkan bahwa unjuk kerja sistem cukup akurat yaitu 83,3%.
Black cumin seed oil preparation consumption potentially improves adaptive cellular immune response among healthy volunteers Titiek Hidayati; Akrom Akrom; Arif Budi Setianto
International Journal of Public Health Science (IJPHS) Vol 11, No 2: June 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i2.21425

Abstract

Oxidative stress and inflammatory reactions are the pathological mechanisms for most degenerative diseases. The black cumin seed oil (BCSO) contains compounds that can act as antioxidants and immunomodulators. Consuming BCSO is thought to improve antioxidant and immunomodulatory parameters in obese people. This study investigated the effect of BCSO consumption on antioxidant and immunomodulatory activity in healthy volunteers. We conducted a quasi-experimental study on 12 healthy volunteers in Yogyakarta, Indonesia. We asked the volunteers to consume BCSO for twenty days. We measured blood pressure, body mass index (BMI), malondialdehyde (MDA) level, Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) activity, CD4Th, and IFN-γ expression before and after consuming BCSO. We carried out the average difference test of the parameters before and after consumption of BCSO by dependent t-test. The results showed that 3x1 BCSO preparation for 20 days reduced MDA levels and increased CDTh and IFN-γ. Consuming BCSO for 20 days potentially improve the adaptive cellular immune response parameters.
AKTIVITAS REPELLENT FORMULASI SEDIAAN SPRAY KOMBINASI MINYAK ATSIRI SERAI (Cymbopogon winterianus), DAUN KEMANGI (Ocimum basilicum) DAN NILAM (Pogostemon Cablin) BESERTA UJI PREFERENSINYA Faikah Dyah Utami; Arif Budi Setianto
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.085 KB) | DOI: 10.36387/jiis.v6i1.631

Abstract

Plants that are played as mosquito repellents, one of which is plants that contain essential oils, such as lemongrass, basil and patchouli. As an effort to make it easier to use, this research will make a spray repellent preparation with a combination of active ingredients from essential oils of lemongrass, basil and patchouli. The research methods included making a spray repellent using essential oils of lemongrass, basil, patchouli every 0.1 ml (5 concentrations %), 0.2 ml (10% concentration), 0.3 ml (15% concentration) and the additives 1ml Propylene glycol and 5 ml 96% Ethanol which functions as a solvent. The experiment used five treatments, namely: Negative control (Kn), Formula A (0.1ml), Formula B (0.2ml), Formula C (0.3ml), and Positive Control (Kp). The parameters tested included pH test, patch test, organoleptic, specific gravity, emulsion stability, preference and percentage of protective power. The protective power test was carried out 10 times from each treatment for 6 hours of observation (0-1 hours, 1-2 hours, 2-3 hours, 3-4 hours, 4-5 hours and 5-6 hours). The results showed that the best spray expulsion treatment was formula B with a concentration of 10% (0.2 ml)
The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer Ari Wahyudi; Dwi Utami; Arif Budi Setianto
Communications in Science and Technology Vol 5 No 2 (2020)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.5.2.2020.213

Abstract

Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by using X-ray diffraction analysis, and was followed by the investigation of the mechanical properties of MFA and its cocrystal, i.e. tensile strength and deformation parameter. The correlation of crystal structure with mechanical properties was determined by crystal packing motif and slip plane analysis from single crystal data by using Mercury 3.6. The tensile strength of MFA was acceptance at 20.0 MPa, and dropped at more than 25.0 MPa. A better tableting performance was observed in MFA-NIC cocrystal which had the tensile strength 1.5 times higher than MFA at 12.5 MPa and gradually increased with an increasing pressure up to 2.5 times at 22.5 MPa. The flat slip plane of MFA-NIC cocrystal was predicted as the key factor in the improvement of its mechanical properties, compared to zigzag slip plane of MFA. In conclusion, MFA-NIC cocrystal had the better mechanical properties than pure MFA due to its flat slip plane and it becomes potential to be explored in further development of solid dosage form.
OPTIMASI CAMPURAN AVICEL 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET DISPERSI PADAT TADALAFIL DENGAN METODE GRANULASI BASAH Mohamad Reski Manno; Arif Budi Setianto
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 2 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v19i2.6667

Abstract

INTISARI Pengembangan formula obat dalam industri farmasi sangatlah penting, dimana komposisi formula yang optimum dapat mempengaruhi sediaan farmasetis yang memenuhi persyaratan sesuai CPOB. Tadalafil merupakan obat yang berkhasiat sebagai terapi disfungsi ereksi yang diformulasikan dalam sediaan padat berupa tablet dengan metode granulasi. Penelitian ini bertujuan untuk mendapatkan formula optimum tablet dispersi padat tadalafil dengan campuran avicel 101 dan laktosa sebagai bahan pengisi dengan metode granulasi basah. Granul dispersi padat tadalafil dibuat dengan perbandingan kosentrasi bahan pengisi avicel 101 dan laktosa yaitu 5:5, 4:6, dan avicel 101 tanpa kombinasi laktosa. Evaluasi sediaan meliputi uji waktu alir granul, uji sudut diam, uji pengetapan, kadar air granul, uji kekerasan, uji keseragaman bobot, uji keseragaman ukuran, kerapuhan dan waktu hancur tablet. Hasil penelitian menunjukan bahwa formula dengan kombinasi avicel 101 dan laktosa sebagai bahan pengisi dapat menghasilkan formula granul dan tablet dengan karakteristik yang baik.Kata kunci: (Avicel 101, Granul, Laktosa, Tablet, Tadalafil)
Herbal supplementation improves clinical outcomes among diabetes mellitus patients Akrom Akrom; Titiek Hidayati; Arif Budi Setianto
International Journal of Public Health Science (IJPHS) Vol 12, No 2: June 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i2.22534

Abstract

Hyperglycemic conditions are still common in diabetes melllitus (DM) patients with routine therapy. Rural communities in the Special Region of Yogyakarta habitually consume herbal medicines. Herbal nutritional supplements (MHM) were developed as additional therapy to increase the success of achieving therapeutic targets for DM patients. This study aimed to identify the clinical picture of DM patients who were given MHM at public health center (PHC) in the rural areas of Bantul Regency, Yogyakarta Special Region. This retrospective study was conducted on 94 DM patients with routine therapy. Patients who met the inclusion and exclusion criteria and had agreed to the informed consent were divided into two groups. Patients in the treatment group were asked to consume herbal supplement preparations (MHM) for 20 days. On day 21, each group measured clinical outcome parameters (blood pressure, blood glucose levels, triglycerides, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), liver enzymes, urea, and creatinine). The mean difference test between the two groups (t-test) was carried out using a 95% confidence level. The results showed that the consumption of MHM herbal nutritional supplements for 20 days reduced blood sugar levels, Hb A1C levels, and urea levels (p<0.05). There were no differences in blood pressure, pulse, cholesterol, triglyceride, HDL, LDL, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and creatinine levels between the two groups (p>0.05). Administration of MHM for 20 days increased clinical outcomes in blood sugar, HbA1c, and urea levels in DM patients at PHC.
Co-Authors Abdul Fadlil Akrom, Akrom Ari Wahyudi Dwi Utami Faikah Dyah Utami Mohamad Reski Manno Putri Purnamasari Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati