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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran
Agung Biworo
Bagian Farmakologi Fakultas Kedokteran Universitas Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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POTENSI JUS BUAH PARE (Momordica charantia L.) SEBAGAI PENGHAMBAT HEMOGLOBIN TERGLIKASI IN VITRO Widyanto, Muhammad Topan; Suhartono, Eko; Biworo, Agung
Jurnal Berkala Kedokteran Vol 11, No 1 (2015): Februari 2015
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i1.194

Abstract

Bitter gourd  (Momordica charantia) is a fruit that is potentially has the ability to inhibit glycated hemoglobin thus can reduce blood sugar level. The aim of this study is to test the potency of bitter gourd juice as a glycated hemoglobin inhibitor. This is a quasi experimental study with non randomized posttest-only with control group design method, using a reaction model of diabetes consisted of two groups; bitter gourd juice as the test group and gliclazide as the standard group, divided into 10%, 20%, and 30% concentration. IC50 value is used to determine the potency as a glycated hemoglobin inhibitor. The result of this study shows that the value of r = 0,990 with an IC50 value of 69,239%, whereas for glikazid 17,268%. The positive value of r indicates a positive relation between concentration and its potency as a glycated hemoglobin inhibitor. The result thus indicates that bitter gourd juice has a potency as a glycated hemoglobin inhibitor Keywords: glycated hemoglobin, bitter gourd (Momordica charantia), gliclazide
HUBUNGAN MINUMAN ISOTONIK DENGAN KONSUMSI OKSIGEN MAKSIMAL PADA MAHASISWA JPOK UNLAM BANJARBARU Azizah, Azizah; Biworo, Agung; Asnawati, Asnawati
Jurnal Berkala Kedokteran Vol 11, No 1 (2015): Februari 2015
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i1.182

Abstract

Maximum oxygen consumption (VO2 max) is the maximum number of individual oxygen that can be used during the exercise and is one of the good measurements of cardiorespiratory fitness. Isotonic drink is one of the drinks that supplies the energy and fluid balance during the exercise.  This research aims to determine whether there is a relationship of isotonic drink with maximum oxygen consumption. This research uses quasi experimental  pretest and posttest design.  The population of this research are the students of JPOK UNLAM Banjarbaru, who were divided into two groups based on before and after giving isotonic drinks. The method of retrieval research subjects is by purposive sampling method, with 33 respondents of the research subjects. The measurement of VO2 max is conducted by using multistage fitness test. The average value of VO2 max before giving isotonic drinks was 45,05 ml/kg/minute and after giving it became 49,34 ml/kg/minute. The paired t test with confidence level 95% showed significant differences in both of the data with the value of p = 0,000, it can be concluded that isotonic drinks can increase VO2 max. Keywords:  isotonic, VO2 max.
Perbandingan Vo2 Maksimal Pada Siswa Dan Siswi Kelas V Sekolah Dasar: Di Desa Tabanio Kecamatan Takisung Kabupaten Tanah Laut Kalimantan Selatan Noor, Krisna Augustian; Huldani, Huldani; Biworo, Agung
Jurnal Berkala Kedokteran Vol 9, No 1 (2013): April 2013
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i1.923

Abstract

ABSTRACT: VO2 maximum is maximum volume that can be processed and O2 consumed by the body that delivered from the lungs to the all of human muscles during physical activities or intense activities until fatugue. Maximum consumption of oxygen was calculated in mililitres/minutes/kilos of body weights. VO2max value was influenced not only by physical characteristhic like age, sex, heights, and weights, but also cardiovascular, respiratory, hematology, and oxydative muscle abilities. The study was conducted by measuring VO2max values for boys and girls grade fifth elementary school in Tabanio village in order to compare both them VO2 max value when they have similarities physical activities cause both of them was helping their parents since childern age. The research approached amount cross-sectional method  with samples from 23 boys and 14 girls who includes criteria in non-probability purposive sampling technique. How to measure that is using Multistage Fitness Test that is run back and trajectory as far as 20 m. The results was analyzed by chi-square test with the value expected count < 5, so that the test using an alternative test, the Fisher’s test with p = 0.724. P-value > 0,05 indicating there are non significant difference between maximum VO2max values for boys and girls fifth grade elementary school in Tabanio village with average results of VO2max value is 28,38 for boys and 25,83 for girls. Keywords: VO2max, gender, physical activity ABSTRAK: VO2 maks adalah jumlah volume maksimal O2 yang dapat diproses dan dikonsumsioleh tubuh yang dihantarkan dari paru-paru ke otot manusia pada saat melakukan aktivitas fisik maupun kegiatan intensif sampai terjadi kelelahan. Konsumsi Oksigen maksimal ini dinyatakan dalam satuan mililiter/menit/kilogram berat badan. Nilai VO2 maks dipengaruhi karakteristik fisik seperti umur, jenis kelamin, tinggi badan, dan berat badan. Selain itu, nilai VO2 maks juga bergantung pada keadaan kardiovaskular, respirasi, hematologi, dan kemampuan oksidatif otot. Penelitian dilakukan dengan mengukur nilai VO2 maks siswa dan siswi kelas V sekolah Dasar di desa Tabanio dengan tujuan untuk mengetahui perbandingan nilai VO2 maks keduanya dilihat dari aktivitas fisik yang sama karena disana baik laki-laki maupun perempuan membantu pekerjaan orangtuanya sejak kecil. Pendekatan penelitian menggunakan metode  cross-sectional dengan jumlah sampel 23 siswa dan 14 siswi yang memenuhi kriteria inklusi dengan menggunakan teknik non-probability purposive sampling. Cara pengukuran memakai Multistage Fitness Test yaitu lari bolak-balik lintasan sejauh 20 m. Data yang dianalisis dengan menggunakan uji chi-square dengan taraf kepercayaan 95 % antara siswa dan siswi terdapat 1 cell dengan nilai expected count < 5, sehingga uji yang dipakai adalah uji alternatifnya, yaitu uji Fisher dengan nilai p = 0,724. Nilai p > 0,05 menunjukkan bahwa tidak terdapat perbedaan bermakna antara nilai VO2 maksimal siswa dan siswi kelas V Sekolah Dasar di desa Tabanio dengan hasil rata-rata nilai VO2 maks 28,38 pada siswa dan 25,83 pada siswi. Kata kunci: VO2 maks, Jenis Kelamin, Aktivitas Fisik
POTENSI BUAH NANGKA (Artocarpus heterophyllus L) SEBAGAI ANTIDIABETES IN VITRO Khairina, Khairina; Suhartono, Eko; Biworo, Agung
Berkala Kedokteran Vol 11, No 2 (2015): September 2015
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i2.142

Abstract

Artocarpus species have been used by traditional medicine of Indonesian. It can be useful as anti-bacterial, anti-diabetic, anti-inflammatory, antioxidant and anti-helmintics. The present study was aimed to test the inhibitory glycated hemoglobin potency of aqueous extract of Jackfuit. This study is a quasi experimental research with non randomized method post test-only group design, which using a model reaction of two groups : extract jackfruit as the test group and glikazid as the control group, with each concentration of 10%, 20%, 30%. Potential inhibitor of glycated hemoglobin jackfruit as determining the amount of IC50. From this research  got IC50 of jackfruit extracts is 56,43% (r=0,999) whereas for glikazid of 17.268 (r = 0.989). The value of r indicates a positive relationship between the concentration and the inhibitor glycated hemoglobin potential. These results indicate that the extract of Jackfruit has potential as an inhibitor glycated hemoglobin. Keywords: glycated hemoglobin,  jackfruit, Artocarpus heterophllus L, glikazid.
PENGARUH LANSOPRAZOL DAN OMEPRAZOL TERHADAP AKTIVITAS ENZIM KATALASE HEPAR TIKUS Sartika, Eria; Suhartono, Eko; Biworo, Agung
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1875

Abstract

Abstract: Lansoprazole and omeprazole is a Proton Pump Inhibitor class of drugs that are often used for the treatment of peptic ulcers. Lansoprazole and omeprazole have an influence on the various target organs exposed. Mechanism of lansoprazole and omeprazole in influencing the activity of the enzyme catalase is competing with absolute catalase enzyme substrate (H2O2) in the binding of the enzyme active site. This study aims to determine the effect of lansoprazole and omeprazole against liver catalase enzyme activity. This study was a laboratory experimental study conducted in three groups, namely the control group (P0), the treatment group (P1) is given lansoprazole 30 mg and a treatment group (P2) given omeprazole 20 mg. The result showed the value of Km of the control group (P0) of 13.482 mmol/dm3, the treatment group (P1) of 11,227 mmol/dm3 and the treatment group (P2) of 6,327 mmol/dm3. Analysis of statistical data shows the regression correlation value of p for P1 was 0,01 adn for P2 was 0,02 (p <0.05) and the R value approaching 1 with a linear graph Lineweaver Burk meaningful. Concluded that lansoprazole and omeprazole may affect the activity of the liver enzyme catalase. Keywords: lansoprazole, omeprazole, enzyme catalase, rat liver Abstrak: Lansoprazol dan omeprazol merupakan obat golongan proton pump inhibitor yang sering digunakan untuk pengobatan tukak lambung. Lansoprazol dan omeprazol memiliki berbagai pengaruh terhadap organ target yang terpajan. Mekanisme lansoprazol dan omeprazol dalam mempengaruhi aktivitas enzim katalase adalah berkompetisi dengan substrat absolut enzim katalase (H2O2) dalam mengikat sisi aktif enzim. Penelitian ini bertujuan untuk mengetahui pengaruh lansoprazol dan omeprazol terhadap aktivitas enzim katalase hepar. Penelitian ini merupakan penelitian quasi eksperimental yang dilakukan pada 3 kelompok, yakni kelompok kontrol (P0), kelompok perlakuan (P1) diberikan lansoprazol 30 mg dan kelompok perlakuan (P2) diberikan omeprazol 20 mg. Hasil penelitian didapatkan nilai Km pada kelompok kontrol (P0) sebesar 13,482 mmol/dm3, pada kelompok perlakuan (P1) sebesar 11,227mmol/dm3 dan pada kelompok perlakuan (P2) sebesar 6,327mmol/dm3. Analisis data statistik korelasi regresi menunjukkan nilai p pada P1 0,01 dan pada P2 0,02 (p<0,05) serta nilai R mendekati 1 dengan grafik linear Lineweaver Burk yang menanjak. Disimpulkan bahwa lansoprazol dan omeprazol dapat mempengaruhi aktivitas enzim katalase hepar mencit. Kata-kata kunci: lansoprazol, omeprazol, enzim katalase, hepar mencit
Potensi ADP dan Katalase dalam Ekstrak Air Lidah Buaya (Aloe vera) sebagai Antiinflamasi pada Model Tikus Luka Terkontaminasi Biworo, Agung; Budianto, Windy Yuliana; Agustina, Rismia; Suhartono, Eko
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i1.1054

Abstract

Lidah buaya (Aloe vera) mengandung enzim antioksidan yang dapat menghambat kerja dari mediator inflamasi dan penghilang rasa sakit. Pada penelitian ini akan diukur aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase ekstrak air Aloe vera serta potensinya sebagai antiinflamasi pada tikus yang mengalami luka terkontaminasi. Penelitian ini menggunakan rancangan post test only control group dengan simple random sampling pada 36 ekor tikus yang terbagi atas 2 kelompok, yaitu kelompok kontrol (P0)  dan perlakuan (P1) merupakan kelompok tikus dengan luka terkontaminasi yang diberikan balutan dengan menggunakan ekstrak air lidah buaya 0,2 mg/g BB. Hasil penelitian menunjukkan bahwa aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase masing-masing 37,8 menit-1 dan 3,145 menit-1 dan rata-rata penurunan intensitas warna kemerahan dari eritema pada kelompok yang diberi ekstrak air lidah buaya (Aloe vera) lebih cepat daripada kelompok kontrol. Diismpulkan bahwa ekstrak air lidah buaya berpotensi sebagai antiinflamasi pada model tikus luka terkontaminasi. Aloe vera contained an antioxidant enzyme that can inhibit the work of the mediators of inflammation and pain. With this research, however, will be measured the antioxidant enzyme activity of ascorbic dependent peroxidase and catalase on water extract Aloe vera and its potential as an anti-inflammatory on rat model wound contaminated. This research uses the post test only control group with simple random sampling techniques, with 36 rats were divided into two groups, namely the control and treatment groups. The control group (P0) is a control group and treatment group (P1)  is a group of mice with wounds contaminated given the wrap by using water extracts of Aloe vera 0.2 mg/g BB. In this study it was concluded that the antioxidant enzyme activity of activity of ascorbic dependent and catalase each 37.8 seconds-1 minute-1 and 3,145. In addition, the decrease in intensity of redness of erythema on the group that was given a water extract of Aloe Vera (Aloe vera) is faster than the control group. It can be concluded that the water extract of Aloe vera as anti-inflammatory potential in a mouse model of contaminated wounds.
Co-Authors Asnawati Asnawati Azizah Azizah Eko Suhartono Huldani Huldani Khairina Khairina, Khairina Krisna Augustian Noor, Krisna Augustian Muhammad Topan Widyanto, Muhammad Topan Rismia Agustina Sartika, Eria Windy Yuliana Budianto, Windy Yuliana