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All Journal Indian Journal of Forensic Medicine & Toxicology
Bilqis Inayatillah
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Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats Tamam Jauhar; Bilqis Inayatillah; Maftuchah Rochmanti; Achmad Basori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14461

Abstract

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which canlead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterizedby decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti-hyperglycemia and antioxidant effects because of its large amount of polyphenoliccomponents . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascenaby measuring the lipid profile using various doses. Methods: This research is experimental study withrandomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groupswere Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2(500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL(11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBWafter 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemicdrugs.
Hypoglycemic Effects of Rosa damascena Mill. Ethanolic Extract on Blood Glucose Levels and Diameter of Langerhans Pancreatic Islets Bilqis Inayatillah; Tamam Jauhar; Gondo Mastutik; Alphania Rahniayu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14679

Abstract

Background: Diabetes mellitus is a chronic disorder caused by elevated levels of high blood glucose(hyperglycemia). This chronic hyperglycemia causes ROS to accumulate and oxidative stress to increase.Rosa damascena is a plant that contains high levels of antioxidants and polyphenols, but this is not widelyknown to the public. Purpose: The aim of this study is to understand the hypoglycemic effects from Rosadamascena on blood glucose levels and diameter of Langerhans pancreatic islets. Method: Thirty Wistaralbino rats (200-225gr) were divided into 6 groups. Group 1 was a normal control (KN), group 2 washyperglycemic (KD), group 3 was metformin 250 mg/kg BW (KM), group 4 was treatment extract 250 mg/kg BW (P1), group 5 was treatment extract 500 mg/kg BW (P2) group 6 was treatment extract 1000 mg/kg BW (P3). All animals in the group were injected with STZ 50 mg/kg BW, except for group 1. Result:Data were analyzed statistically using SPSS- 22 software with the Kruskall-Wallis test (p<0.05). The resultshowed that ethanolic extract of Rosa damascena has decreased blood glucose levels in days-14 (382±21,97) with 250 mg/kg BW (P1) compare with another treatment group. In histological observed there areno significant different between group (p>0.05). This is showing that ethanolic extract of Rosa damascenahas inability to repaired the diameter of Langerhans pancreatic islets. Conclusion: Ethanolic extract of Rosadamascena decreased blood glucose levels but did not repaired the diameter of Langerhans pancreatic islets.
Co-Authors Achmad Basori Alphania Rahniayu Gondo Mastutik Maftuchah Rochmanti Tamam Jauhar