Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Jurnal Gizi dan Pangan
Dewi Rahmayani Rahman
Departemen Gizi Masyarakat, Fakultas Ekologi Manusia (FEMA), Institut Pertanian Bogor, Bogor 16680
Health Professions

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Potensi selada air (Nasturtium officinale R. Br) sebagai antioksidan dan agen anti proliferasi terhadap sel MCF-7 secara in vitro Dewi Rahmayani Rahman; Rimbawan Rimbawan; Siti Madanijah; Sri Purwaningsih
Jurnal Gizi dan Pangan Vol. 12 No. 3 (2017)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.893 KB) | DOI: 10.25182/jgp.2017.12.3.217-224

Abstract

This study aimed to determine the potential of watercress extract as an antioxidant and antiproliferation against cancer cells in vitro. Cells used in this study were breast cancer culture cells (MCF-7) and vero cells. Watercress was extracted using water solvent and 70% ethanol. Phytochemical test was performed on both types of extract. Toxicity test was measured using BSLT method, assessment of antioxidant activity was measured using DPPH method and inhibitory proliferation in cancer cell was measured using MTT Assay method. Analysis of the data using ANOVA, if there is a significant difference between treatments will be followed up with Duncan test. The results of phytochemical tests showed that watercress extracts had bioactive content namely flavonoids, tannins, saponins, and steroids. The result of BSLT test showed that the strongest extract toxicity was 70% ethanol extract with LC50 value of 406.02 ppm and had the highest antioxidant activity with IC50 value of 102.26 ppm, while proliferation inhibitory test found in MCF-7 breast cancer cells had IC50 value of 1.696 μg / ml and not toxic to vero cells. Result showed that the ethanolic extract of Nasturtium Officinale gave a significant effect on MCF-7 breast cancer cells inhibition (p=0,015) at concentration 50, 400, 800 and 1000 ppm. The mechanism of proliferative inhibition was associated with phytochemical content present in watercress. 
Co-Authors Rimbawan , Siti Madanijah Sri Purwaningsih