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Potensi Jarak Pagar (Jatropha curcas) sebagai Larvasida Hayati Pencegah Penyakit Demam Berdarah Dengue Dyah Iswantini; Adi Riyadhi; Upik Kesumawati; Rosihan Rosman; Djumali Mangunwidjaja; Min Rahminiwati
Jurnal Ilmu Pertanian Indonesia Vol. 16 No. 1 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

Recently, Indonesia has big problem caused by dengue haemorraghic fever with A. aegypti as vector. Potential medicine and vaccine for curing this disease have not been found. The effective method to prevent this disease is the use of A. aegypti larvicidal. The chemical larvicidal has disadvantage for evironmental aspect. To solve this problem, the biological larvicidal has a good chance to develop. Indonesia has megadiversity which can be developed as biological larvicidal. Crude aqueous extracts and ethanol extracts of Jatropha curcas (Jarak pagar) seed and oil of Jatropha curcas were evaluated for larvicidal potential against the Aedes aegypti mosquito. Among all extracts, Jatropha curcas oil possessed a highest activity against the 3th instar larvae of Aedes. LC50 values of Jatropha curcas oil was 1507 ppm for 24 h and 866 ppm for 48 h. It was suggested that the Croton tiglium oil and Jatropha curcas oil possess larvicidal properties that could be developed and used as biological larvicidal. 
KORELASI FOLIKEL DOMINAN AKIBAT PENYUNTIKAN HORMON PREGNANT MARE SERUM GONADOTROPIN (PMSG) DENGAN PENINGKATAN RESPONS BERAHI PADA KAMBING KACANG Andriyanto A; Amrozi A; Min Rahminiwati; Arief Boediono; Wasmen Manalu
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i1.2779

Abstract

Penelitian ini bertujuan mengetahui pengaruh penyuntikan pregnant mare serum gonadotropin (PMSG) terhadap peningkatan respons berahi kambing kacang. Sebanyak 20 ekor kambing kacang betina dewasa kelamin dibagi secara acak ke dalam 5 perlakuan dosis penyuntikan PMSG, yaitu 0,0 (K1); 1,0 (K2); 7,5 (K3); 15,0 (K4); dan 20,0 (K5) IU/kg bobot badan dan diulang 4 kali. Hasil penelitian menunjukkan bahwa pada K3, K4, dan K5 terjadi peningkatan jumlah folikel dominan, total diameter folikel dominan, total volume folikel dominan, dan konsentrasi estrogen dalam serum darah (P0,05), serta menunjukkan gejala berahi yang lebih jelas dibandingkan K1. Konsentrasi estrogen dalam serum darah memiliki korelasi positif dengan jumlah folikel dominan, total diameter folikel dominan, total volume folikel dominan, onset berahi, durasi berahi, perubahan vulva menjadi merah, kebengkakan vulva, peningkatan respons betina terhadap pejantan, dan pergerakan ekor pada saat berahiatau fleging berturut-turut sebesar 53,10; 82,60; 48,80; 53,0; 45,50; 39.40; 32,60; 32,60; dan 80,20% dengan pola kuadratik. Dari hasil penelitian disimpulkan bahwa penyuntikan PMSG pada dosis 7,5; 15,0; dan 20,0 IU/kg bobot badan mampu meningkatkan konsentrasi estrogen dan respons berahi kambing kacang.
EFEKTIVITAS KOMBINASI EKSTRAK DAUN MENGKUDU (Morinda citrifolia ) dan ASAM KANDIS SEBAGAI PENURUN BERAT BADAN PADA TIKUS PUTIH JANTAN GALUR Sprague-Dawley Shinta Suci Anggraena; Min Rahminiwati; E. Mulyati Effendi
EKOLOGIA Vol 17, No 1 (2017): JURNAL ILMIAH ILMU DASAR DAN LINGKUNGAN HIDUP
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.354 KB) | DOI: 10.33751/ekol.v17i1.810

Abstract

This study aimed to determine the effect of a combination of extracts of Noni leaves (Morinda citrifolia L) and fruit kandis (Garcinia cowa Roxb) on body weight of male rats induced by high- fat calories food Test animals were used 25 rats male Sprague Dawley strain age of 2 months with body weight 200 g. White mice were divided into 5 groups of 4 rats each. The treatment committed agains an obesity rats. The treatment group consisted of rats doses of 1 (8,75mg/kgBB noni leaves ekstract and sour fruit kandis 7mg/kgBB), dose II (4,75 mg/kgBB noni leaves ekstract and sour fruit kandis 3,5mg/kgBB), dose III (17,5 mg/kgBB noni leaves ekstract and sour fruit kandis 14mg/kgBB), the positive control group were given Orlistat and negative group were only given food to eat and drink. The observed parameters include weight loss, abdominal width, body length, skin fold, body mass indeks. The results showed that noni leaf extract and fruit kandis can be used as a weight loss with the most effective dose is 17,5 mg /kg BB noni leaf + 14 mg/kg BB fruit kandis with the most effective treatment is 14 days.Key words : Noni Leaf and fruit kandis, Feeding a High-Fat Calories, Obesity Parameters, Rats male Sprague Dawley.
Bioprospeksi ekstrak jahe gajah sebagai anti-crd: kajian aktivitas antibakteri terhadap Mycoplasma galliseptikum dan e. coli in vitro Min Rahminiwati; Aulia Andi Mustika P.; Siti Saadah; . Andriyanto; . Soeripto; Unang P.
Jurnal Ilmu Pertanian Indonesia Vol. 15 No. 1 (2010): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

CRD is chronic respiratory disease in chicken caused by infection of Mycoplasma gallisepticum (M gallisepticum) and E. coli. Rio-prospective of jahe for controlling the disease was investigated through the study of antibacterial activity against M. gallisepticum of fresh ginger juice extract and fraction of hexan, ethyl acetate, methanol and water against M. gallisepticum and E. coli. The results showed that the juice of fresh ginger inhibited the growth of M. gallisepticum with the minimum inhibitory concentration that could inhibit the growth was 10 °/o. The fractions that effectively inhibited the growth of M. gal/isepticum are hexan fraction and water fraction with the smallest inhibition zone was found at concentration of at least 8 % and 10 % respectivelly.TLC examination results of hexan fraction showed a purple spot with Rf value of 0.9 and a dark blue spot with Rf value of 0.36. Based on Rf values and color reference, the first spot was suggested zingiberen and the second spot was gingerol. All fractions that were examined, did not show any inhibitory activity against thegrowth of E coli. Thus the extract of fresh ginger was only to be used to control the respiratory disease causedby M. gallisepticum but not coli.
PERBANDINGAN POTENSI ANALGETIK EKSTRAK ETANOL DAN AIR UMBI RUMPUT TEKI (Cyperus rotundus L.) TERHADAP TIKUS Sprague Dawley Erni Rustiani; Min Rahminiwati; Tia Mutiara
EKOLOGIA Vol 17, No 2 (2017): JURNAL ILMIAH ILMU DASAR DAN LINGKUNGAN HIDUP
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.736 KB) | DOI: 10.33751/ekol.v17i2.762

Abstract

The aim of this study is to compare the potential of ethanolic and water extracted of teki grasstuber on white male rat strain Sprague Dawley at two months of age and 200 g of body weight. The rats were divided among four groups. Each group consists of six rats. The groupswere ethanolic and water extracted of teki grass tuber, positive control group (Paracetamol) and a negative control group (distilled water). Analgesic potency was tested by inducing pain stimuli previously to the animals, in the form of heat stimuli by putting it ona hot plate with the temperature of 55C. The responses of rats observed were licking and moving or lifting of their legs. Observations were made for 1 minute, before and after administration of pain stimulus at 15, 30, 45 and 60 minute. The results showed that ethanol and water extract at an effective dose of 49 mg / 200 g of BW, gave relatively the same effect as an analgesic or positive control group.Keywords : analgesic, ethanol and water extract of teki grass tuber, pain
Studi agrobiofisik kamandrah (croton tiglium L.) dan penentuan potensi awal kamandrah sebagai larvasida hayati pencegah penyakit demam berdarah dengue Dyah Iswantini; Rosihan Rosman; Upik Kesumawati; Djumali Mangunwidjaja; Min Rahminiwati; Adi Riyadhi
Jurnal Ilmu Pertanian Indonesia Vol. 14 No. 2 (2009): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

The aim of the research is to obtain the ecological condition and propagation of kamandrah (Croton tiglium L.) and determination of its potency as biological larvacidal for preventing dengue haemorraghic fever. Agrobiophysic study indicated that Croton tiglium L. plant need full sunlight(> 70 %). low intensity of sunlight could decrease the ability of plant to produce seed. The plant could grow well on podzolic land (30-50 m upon sea surface). Seed of kamandrah from Ampah has growth percentage of 43.8 °/o, height of 27.5 em, stem diameter of 5 em, total leaves of 10, and total primary branches of 2. Phytochemical assay resulted that among other part of Kamandrah, Kamandrah seed has highest alkaloid content. Because alkaloid compound has high larvicidal activity, kamandrah seed has high potency as larvicide. Among all of extracts of part of plant, oil of Croton tiglium L. has the highest potency as biological larvacidal with 863.67 ppm of LC50 for 24 hours of treatment.
Ekstrak secang berukuran nano dengan kaolin sebagai pembawa Irmanida Batubara; Zaenal Abidin; Min Rahminiwati
Jurnal Ilmu Pertanian Indonesia Vol. 16 No. 2 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

Sappanwood extracts reported had antiacne activity with brazilin as active component. To develop antiacne formula from sappanwood extract, nanoparticle sappanwood with kaolin nanosize as carrier was developed. Carrier used was montmorillonite yellow, brown montmorillonite, yellow kaolin from Cicalengka, white kaolin from Cicalengka, kaolin from Bangka Belitung, and kaolin from Wonosari. The best carrier for active components of Sappanwood was selected based on UV-Vis spectroscopy, thin layer chromatography, liquidchromatography tinggi.dan performance antijerawat activity test. The most potent kaolin as Sappanwood carrier was kaolin from Bangka Belitung with percent inhibiton of DPPH scavenging reaction about 78% at 50 mg kaolin.
Induksi Ekstrak Pegagan Secara in vitro terhadap Proliferasi dan Diferensiasi Sel-Sel Otak Besar Anak Tikus (IN VITRO INDUCTION OF CENTELLA ASIATICA (PEGAGAN) EXTRACT ON THE PROLIFERATION AND DIFFERENTIATION OF NEWBORN RAT CORTEX CEREBRI CELLS) Ita Djuwita; Min Rahminiwati; Latifah Kosim Darusman; Siti Sa’diah
Jurnal Veteriner Vol 14 No 2 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The aim of the study was to analyze the potency of Centella asiatica extract to induce proliferation andneurogenesis process of newborn rats cortex cerebri.   Research has been conducted on in vitro culture ofthree days old rat (Sprague Dawley) cerebrum cells in DMEM (Dulbecco’s Modiûed Eagle’s Medium)containing 10% NEAA (Non Essential Amino Acid), 1 mM NaHCO3, 10% NBCS (Newborn Calf Serum)and 50 µg/mL gentamycin (mDMEM), with and without Centella asiatica (CA) leaf extracts. The experimentwas set in five groups of treatment consisted of positive control (mDMEM+30 µg/mL asiaticoside (AC)),negative control (mDMEM), and mDMEM with three concentration of CA extract i.e. 100 ppm, 200 ppmand 400 ppm. Culture was done in 5% CO2 incubator at 37oC for six days. The parameters observed werecells proliferation based on Population Doubling Time (PDT), neuron and glia composition, and the lengthof axon and dendrite. Cells concentration were counted using Newbauer hemocytometer.  Neuron and gliacells were determined based on morphology after Hematoxylin-Eosin staining, and the length of axon anddendrite were measured using eyepiece micrometer. Data were analyzed using ANOVA and Duncan test.The results showed that Centella asiatica extract at concentration 100 ppm could induce neurogenesisand increased the axon length growth.  However, at concentration 200 and 400 ppm, CA extract  inhibitedthe neuronal cells proliferation and the axonal growth (P<0,05). In conclusion, induction of Centella asiaticaextracts at concentration of 100 ppm on the cortex cell cerebrum cells culture increase the axon lengthgrowth and tends to induce neurogenesis; however at higher concentration CA extract was neurotoxic.
Profil Kinetik dan Efektivitas Enrofloksasin yang Dikombinasikan dengan BioATP dalam Mengatasi Coxiella burnetii (KINETIC PROFILE AND EFFECTIVITY OF ENROFLOXACINE WITH BIO ADENOSIN TRIPHOSPHATE SUPPLEMENTATION AGAINST COXIELLA BURNETII) Andriyanto .; Agus Setiyono; Min Rahminiwati; Neni Nuryani; Unang Patriana
Jurnal Veteriner Vol 14 No 3 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Coxiella burnetii belongs to rikettsia group living obligate intracellularly and as the agent of zoonosisQ fever. Enrofloxacine is an antibiotic in quinolon group used to treat infection of C. burnetii in chicken,goat, calve, pig, dog, cat,  and horse. From ruminant practical experience, enrofloxacine if combined withBioATP  can enhance the enrofloxacine activity. Research for the effecivity of enrofloxacine and BioATP totreat C. burnetii has never been carried out. The research was conducted to explore effect of enrofloxacinewith supplementation BioATP against C. burnetii. Enrofloxacine pharmacokinetic study was carried outby using simental beef as an experimental animals. The effectivity of BioATP supplementation onenrofloxacine activity to treat C. burnetii was tested by using Vero cell tissue culture. The results showedthat combination of enrofloxacine and BioATP increased kinetic profile of enrofloxacine in term of onset,duration, pharmacology intensity, and bioavailaibility. Enrofloxacine had activity to treat C. burnetii withvalue of minimal inhibitory concentration (MIC) at 1-2 ppm and value of minimal bactericidal concentrationat 4 ppm. Supplementation of BioATP improved the effectivity of enrofloxacine in treating C. burnetii.
DAYA HAMBAT EKSTRAK HEKSAN, ETIL ASETAT DAN ETANOL DARI DAUN ASAM KANDIS (Garcinia parvifolia (Miq.) Miq.) TERHADAP AKTIVITAS ENZIM ?-GLUKOSIDASE SECARA IN VITRO Min Rahminiwati; Ike Yulia Wiendarlina; Ceristianto Ceristianto
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 6, No 2 (2016): Fitofarmaka Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.069 KB) | DOI: 10.33751/jf.v6i2.755

Abstract

ABSTRAKSalah satu penyebab peningkatan kadar gula darah pada penderita penyakit diabetes mellitus adalah tingginya aktivitas pemecahan karbohidrat menjadi glukosa oleh enzim ?-glukosidase. Beberapa penelitian menunjukan bahwa daun asam kandis diketahui memiliki kandungan senyawa xanthone yang mampu menghambat aktivitas enzim ?-glukosidase. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes ekstrak heksan, etil asetat dan etanol daun asam kandis (Garcinia parvifolia (Miq.) Miq.) dengan mengukur daya hambat ekstrak daun asam kandis terhadap aktivitas enzim ?-glukosidase secara in vitro. Pengujian daya hambat terhadap aktivitas ?-glukosidase dihitung berdasarkan nilai IC50 dengan senyawa acarbose sebagai pembanding (kontrol positif). Hasil uji daya hambat ekstrak daun asam kandis terhadap aktivitas enzim ?-glukosidase menunjukan bahwa aktivitas inhibisi (IC50) dicapai pada pemberian ekstrak heksan, etil asetat dan etanol daun asam kandis berturut-turut sebesar 226,4 24,18 ppm, 46,96 10,48 ppm, dan 7,32 2,14 ppm. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol berpotensi paling tinggi sebagai inhibitor enzim ?-Glukosidase.Kata Kunci: Antidiabetes, asam kandis, inhibitor ?-glukosidase