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The status of probiotics supplementation during pregnancy Wibowo, Noroyono; Mose, Johanes C.; Karkata, Made K.; Purwaka, Bangun T.; Kristanto, Herman; Chalid, Maisuri T.; Yusrawati, Yusrawati; Sitepu, Makmur; Kaeng, Juneke J.; Bernolian, Nuswil; Prasmusinto, Damar; Irwinda, Rima
Medical Journal of Indonesia Vol 24, No 2 (2015): June
Publisher : Faculty of Medicine Universitas Indonesia

Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.

Pereira Suture: an Alternative Compression Suture to Treat Uterine Atony Setiyono, Agung B; Aziz, Alamsyah; Sulistyono, Agus; Mose, Johanes C
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the use of Pereira suture as a conservative surgical management in postpartum hemorrhage due to uterine atony. Methods: The study was performed in the Department of Obstetrics and Gynecology, Temanggung General Hospital, Central Java, Indonesia. Data was retrieved retrospectively from medical records, from January 2011 until December 2013. Results: Pereira suture was done in four cases of uterine atony with failed conservative management, and the procedure was found to be successful in all cases. Conclusion: Pereira suture is an alternative surgical procedure for the treatment of uterine atony after failed conservative management. [Indones J Obstet Gynecol 2015; 3: 177-182] Keywords: pereira suture, postpartum hemorrhage, uterine atony

Pereira Suture: an Alternative Compression Suture to Treat Uterine Atony Setiyono, Agung B; Aziz, Alamsyah; Sulistyono, Agus; Mose, Johanes C
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the use of Pereira suture as a conservative surgical management in postpartum hemorrhage due to uterine atony. Methods: The study was performed in the Department of Obstetrics and Gynecology, Temanggung General Hospital, Central Java, Indonesia. Data was retrieved retrospectively from medical records, from January 2011 until December 2013. Results: Pereira suture was done in four cases of uterine atony with failed conservative management, and the procedure was found to be successful in all cases. Conclusion: Pereira suture is an alternative surgical procedure for the treatment of uterine atony after failed conservative management. [Indones J Obstet Gynecol 2015; 3: 177-182] Keywords: pereira suture, postpartum hemorrhage, uterine atony

Preeclampsia after the Seven Quantum Leap Prediction Mose, Johanes C
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Correlation between Protein-with-Molecular-Weight-53 (p53), Burkit Cell Lymphoma 2 (Bcl2), and Fas Ligand (FasL) and Vascular-Cell-Adhesion-Molecule-1 (VCAM-1) mRNA Expression Levels in a Pathogenesis Study of Preeclampsia Teguh, Mintareja; Karkata, Made Kornia; Wirakusumah, Firman Fuad; Mose, Johanes Cornelius; Satari, Mieke Hemiawati; Septiani, Leri
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : International Journal of Integrated Health Sciences

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Objective: To determine the role of protein-with-molecular-weight-53 (p53), burkit cell lymphoma 2 (Bcl2),Â Fas ligand (FasL) mRNA, and vascular cell adhesion molecule 1 (VCAM-1), known as the apoptosis-related molecular pathway, in preeclamptic patients. Â Â Â Methods: Observation on the correlation between the mRNA levels of p53, Bcl2 and FasL and VCAM-1 in 31 subjects at 28-42 weeks gestational age was performed in this study using the real time reverse transcriptase-polymerase chain reaction (RT-PCR).Â Â Â Results: The results showed that p53 mRNA increased (>1.2350 ng/Î¼L) in the preeclampsia group compared to the normal pregnancy group (p=0.010), Bcl2 mRNA was lower (â‰¤0.9271 ng/Î¼L) in the preeclampsia group than the control group (p=0.041). There was also a tendency of increased FasL mRNA expression (>0.5509 ng/Î¼L) in the preeclampsia group compared to the normal pregnancy group (p=0.300). The level of VCAM-1 elevated (>890.08 ng/mL) in the preeclampsia group compared to the normal pregnancy group (p=0.001). In preeclampsia, the correlation between the Bcl2/p53 ratio and VCAM-1 was r=0.541 (p=0.002), whereas the correlation in normal pregnancy was r=0.099 (p=0.595). Â Â Â Conclusions: There are correlations between the mRNA expression levels of p53 and Bcl2 as an intrinsic pathway of apoptosis along with the VCAM-1 levels in the incidence of preeclampsia. However, no correlation is found between FasL mRNA expression and the incidence of preeclampsia.Keywords: Bcl2, FasL, p53, Preeclampsia, VCAM-1DOI: 10.15850/ijihs.v2n1.273

Perbedaan Parameter Hematologi pada Penderita Tuberkulosis Paru Terinfeksi Mycobacterium Tuberculosis Galur Beijing dengan Galur Non-Beijing Sundari, Rini; Parwati, Ida; Mose, Johanes Cornelius; Setiabudiawan, Budi
Majalah Kedokteran Bandung Vol 49, No 1 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Tuberkulosis (TB) merupakan penyakit inflamasi kronik, tingginya kasus TB dapat disebabkan oleh perbedaan virulensi antargalur Mycobacterium tuberculosis (MTB). Penelitian ini bertujuan untuk menganalisis berbagai manifestasi hematologi yang terjadi pada penderita TB paru yang terinfeksiÂ galur Beijing dan non-Beijing MTB. Sampling penelitian dilakukan di Rumah Sakit Dr. H.A. Rotinsulu Bandung, RSU Cibabat Cimahi, Balai Besar Kesehatan Paru Masyarakat (BBKPM) Bandung, Puskesmas Batujajar, Puskesmas Padalarang, dan Puskesmas Cimareme pada Juni 2014â€“Januari 2015. Penelitian diikuti oleh 74 penderita TB paru BTA (+) terdiri atas 61% pria dan 39% wanita yang berusia 18â€“63 tahun. Berdasar atas spoligotyping diperoleh 24 (32%) terinfeksi galur Beijing dan 50 (68%) galur non-Beijing. Pemeriksaan laju endap darah (LED) menggunakan metode Westergreen, parameter hematologi lain menggunakan haematology analyzer. Kadar hemoglobin galur Beijing 8,6â€“14,8 g/dL dan galur non-Beijing 8,1â€“16,5 g/dL, anemia ini lebih banyak ditemukan pada penderita yang terinfeksi galur Beijing (17 dari 24) dibanding dengan galur non-Beijing 31 dari 50. Nilai absolut eritrosit tidak ada perbedaan, kecuali red blood cell distribution width (RDW). Hasil antara Beijing dan non-Beijing didapatkan hasil LED 94,0 (35,03) vs 89,9 (29,96) mm; leukositosis tidak berbeda namun 67% neutrofilia dan 17% limfopenia pada galur Beijing, 0% dan 30% pada galur non-Beijing; jumlah trombosit 46% (416,3+161,7)x1.000 sel/mm3 vs 122-834 (407,0+154,8)x1.000 sel/mm3 dengan trombositosis 63% vs 46%. Penderita terinfeksi galur Beijing menunjukkan anemia, LED, dan trombositosis lebih tinggi dibanding dengan non-Beijing; hal ini berarti penderita terinfeksi galur Beijing mengalami inflamasi yang lebih berat. [MKB. 2016;49(1):35â€“41]Kata kunci: Beijing, non-Beijing, profil hematologiThe Differences of Haematology Profile in Patients with Lung Tuberculosis Infected by Mycobacterium tuberculosis Beijing Strain and non-Beijing StrainTuberculosis (TB) is a chronic inflammation disease; a high numbers of tuberculosis cases can be caused by virulence potential of each Mycobacterium tuberculosis (MTB) strain. The event of inflammation process influences the hematopoietic system which gives various hematology examination results. This study was conducted in order to analyze various forms of hematological manifestation occur in patients with lung TB caused by MTB Beijing strain and non-Beijing strain infections.Â This study was performed on 74 lung TB-infected patients with positive acid-fast bacilli, consisting of 61% males dan 39% females whose age ranged from 18 to 63 (32.6+12.2) years old. Spoligotyping was performed, resulting in 24 (32%) Beijing strain and 50 (68%) non-Beijing strain infections. Hematological examination was performed using hematology analyzer and erythrocyte sedimentation rate (ESR) with Westergreen method. Hemoglobin level ranged from 8.6 to14.8 (11.8) g/dL and 8.1-16.5 (12.0) g/dL from Beijing strain and non-Beijing strain, respectively, with more anemia was found in Beijing strain patients (71%) compared to non-Beijing strain (62%). There was no differences in absolute erythrocyte count, except in red blood cell distribution width (RDW).Â The comparison of ESR result between Beijing and non-Beijing in ESR resulting in 94.0 (35.03) vs 89.9 (29.96) mm with no difference in leukocytosis, yet 66.7% neutrophilia and 16.7% lymphopoiesis in Beijing strain patients, 0% and 30% consecutively in non-Beijing strain. The number of thrombocyte is 68-882 (416.3+161.7)x1000 cells/mm3 vs 122â€“834 (407.0+154.8)x1000 cells/mm3 with thrombocytosis in 63% vs 46%. Beijing strain patients shows anemia, and higher ESR and thrombocytosis. These show that patients infected by Beijing strains experience more severe inflammation. [MKB. 2016;49(1):35â€“41]Key words: Beijing strain, non-Beijing strain, haematology profile

Perbedaan Kadar Adiponektin, Asimetrik Dimetilarginin Plasma, dan Respons Vasodilatasi Arteri Brakialis antara Dewasa Muda dengan Riwayat Bayi Berat Lahir Rendah dan Normal Purnomowati, Augustine; K.S. Kariadi, Sri Hartini; Achmad, Tri Hanggono; C. Mose, Johanes; Setianto, Budhi
Majalah Kedokteran Bandung Vol 44, No 1 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (929.954 KB)

Adiponektin mempunyai efek antiaterogenik, antiinflamasi, sensitizer insulin, dan berperan penting dalam mengatur pertumbuhan janin. Hipoadiponektinemia dapat menyebabkan disfungsi endotel. Risiko penyakit kardiovaskular meningkat pada subjek dengan riwayat bayi berat lahir rendah (BBLR). Penelitian ini bertujuan menganalisis perbedaanÂ kadar adiponektin, asimetrik dimetilarginin (ADMA) plasma dan respons vasodilatasi arteri brakialis melalui tes flow mediated brachial artery (FMBA) antara dewasa muda dengan riwayat BBLR dan bayi berat lahir normal (BBLN), serta korelasi kadar adiponektin dengan fungsi endotel pada BBLR. Penelitian kohor retrospektif dilakukan periode November 2009â€“Januari 2010 berasal dari Growth Study Cohort Tanjungsari Kabupaten Sumedang. Sebanyak 134 subjek dipilih secara simple random, terdiri atas 67 BBLR dan 67 BBLN yang karakteristik umumnya sama. Analisis multivariat melalui Hotellingâ€™s trace menunjukkan FMBA, kadar ADMA, dan adiponektin berbeda bermakna (p<0,001) antara BBLR dan BBLN. Analisis simultaneous confidence interval menunjukkan kadar adiponektin plasma dan FMBA bermakna lebih rendah (p=0,015 dan p<0,001) pada BBLR dibandingkan dengan BBLN. Korelasi tidak bermakna antara kadar adiponektin dan ADMA (r=-0,16; p=0,176) dan FMBA (r=0,13; p=0,281) BBLR. Kecil peran adiponektin pada disfungsi endotel, mungkin variabel lain berperan, seperti tumor necrosis factor Î±. Simpulan, terdapat perbedaan kadar adiponektin plasma dan FMBA antara dewasa muda dengan riwayat BBLR dan BBLN, tetapi kecil peran adiponektin pada disfungsi endotel dewasa muda dengan riwayat BBLR. [MKB. 2012;44(1):1â€“6].Kata kunci: Adiponektin, asimetrik dimetilarginin, BBLR, tes flow mediated brachial arteryDifferences of Plasma Adiponectine, Asymmetric Dimethylarginine andÂ Brachial Artery Vasodilatation Response in Young Adult with Low andÂ Normal Birth Weight HistoryBeside an anti-atherosclerotic, anti-inflammation effect, and a sensitizer insulin, adiponectin also play an important role in fetal growth. Hypoadiponectinemia may lead to endothelial dysfunction. Low birth weight (LBW) has increase risk of cardiovascular disease. The aim of this study was to analyze the differences of plasma adiponectin, asymmetric dimethylarginine (ADMA) level and vasodilatation response of brachial artery by doing flow mediated brachial artery (FMBA) test between young adults with LBW and normal birth weight (NBW), and the role ofadiponectin level in endothelial function of the LBW. This was a retrospective cohort study during November 2009â€“ January 2010, 134 subjects were randomly selected from the Growth Study Cohort of Tanjungsari Sumedang. They consisted of 67 LBW and 67 NBW young adults, with similar basic characteristics. A multivariate analysisÂ via Hotellingâ€™s trace showed that there was a significant difference (p<0.001) for FMBA, ADMA, and adiponectin level, but simultaneous confidence interval measurements indicated that the rate of FMBA and the level of plasma adiponectin were significantly lower (p<0.001, p=0.015, respectively) in LBW compared to NBW. The correlation between adiponectin and ADMA level (r=-0.16, p=0.176), and FMBA (r=0.13, p=0.281) in LBW were not significant, suggesting a small role of plasma adiponectin in endothelial dysfunction of young adults with LBW, other variables could play a role such as tumor necrosis factor Î±. In conclusions, the level of plasma adiponectin and FMBA are different between LBW and NBW, but the role of adiponectin may be small in endothelial dysfunction in young adults with LBW. [MKB. 2012;44(1):1â€“6].Key words: Adiponectin, asymmetric dimethylarginine, flow mediated brachial artery, LBW testÂ DOI:Â http://dx.doi.org/10.15395/mkb.v44n1.72

PERBANDINGAN KADAR SOLUBLE fms-LIKE TYROSINE KINASE 1 (sFlt1) SERUM KEHAMILAN NORMAL DENGAN PREEKLAMSI BERAT SERTA HUBUNGANNYA DENGAN TEKANAN DARAH DAN DERAJAT PROTEINURIA Siddiq, Amillia; Mose, Johanes C.; Irianti, Setyorini
Majalah Kedokteran Bandung Vol 41, No 3
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Prediksi dan deteksi dini preeklamsi sangat diperlukan untuk mengurangi angka morbiditas dan mortalitas maternalÂ dan perinatal. Penelitian ini bertujuan mengetahui perbedaan kadar sFlt1 serum kehamilan normal denganÂ preeklamsi berat (PEB) dan mengetahui hubungan antara kadar sFlt1 serum dan tekanan darah serta derajat proteinuria. Dilakukan studi observasional analitik secara potong silang. Kadar sFlt1 diperiksa dengan ELISA.Â Analisis statistik menggunakan uji chi kuadrat, uji t, uji Mann-Whitney, koefisien korelasi Rank Spearman, serta ujiÂ diagnostik untuk mencari nilai penentu kadar sFlt1. Karakteristik subjek penelitian pada kelompok PEB dan kelompokÂ kontrol tidak berbeda bermakna (p>0,05). Terdapat perbedaan bermakna antara kadar sFlt1 serum kelompok PEBÂ dan kelompok kontrol (3.827Â±471 pg/mL dan 2.708Â±441 pg/mL; p<0,05). Terdapat hubungan positif bermakna antara kadar sFlt1 dan tekanan darah sistolik (p=0,042; p<0,05) dan antara kadar sFlt1 dan tekanan darah diastolikÂ (p=0,041; p<0,05). Terdapat hubungan bermakna antara kadar sFlt1 dan derajat proteinuria (p=0,012; p<0,05). NilaiÂ penentu kadar sFlt1 untuk membedakan penderita PEB dengan hamil normal 2.815 pg/mL dengan sensitivitas 97,1%, spesifisitas 42%, dan akurasi 69,6%. Terdapat perbedaan bermakna antara kadar sFlt1 pada PEB danÂ kehamilan normal. Terdapat hubungan bermakna antara kadar sFlt1 dan tekanan darah sistolik, diastolik, sertaÂ dengan derajat proteinuria. Nilai penentu (cut-off point) kadar sFlt1 adalah 2.815 pg/mL.Kata kunci: sFlt1, preeklamsi berat, tekanan darah, proteinuria, hamil normalCOMPARISON OF SERUM SOLUBLE fms-LIKE TYROSINE KINASE 1 (sFlt1)Â LEVEL IN NORMAL PREGNANCY AND SEVERE PREECLAMPSIA AND ITSÂ ASSOCIATION WITH BLOOD PRESSURE AND DEGREE OF PROTEINURIAPrediction and early detection of preeclampsia is very important to reduce maternal and perinatal morbidity andÂ mortality. This research was to find out the difference of serum sFlt1 level between normal pregnancy and severeÂ preeclampsia (SPE) and to determine the correlation of serum sFlt1 level with blood pressure as well as the degree ofÂ proteinuria. This was an analytic observational cross sectional study. Measurement of serum sFlt1 level using ELISA. >Statistical analysis was performed by using chi square, t test, Mann-Whitney test, Spearman Rank correlationÂ coefficient and diagnostic test for cut-off point determination.The characteristics of the subjects in both groups wereÂ not statistically different (p>0.05). There was a significant difference in sFlt1 level between SPE group and controlÂ group (3,827Â±471 pg/mL and 2,708Â±441 pg/mL subsequently; p<0.05). There were significant association between sFlt1 level and systolic blood pressure (p=0.042; p<0.05 ); between sFlt1 level and diastolic blood pressure (p=0.041;Â p<0.05); and between sFlt1 level and degree of proteinuria (p=0.012; p<0.05). The cut-off point of sFlt1 level toÂ differentiate SPE from normal pregnancy was 2,815 pg/mL with sensitivity of 97.1%, specificity 42% and accuracy ofÂ 69.6%.There is statistically significant difference of sFlt1 level in SPE compared to normal pregnancy. SignificantÂ association is noted between sFlt1 level and systolic and diastolic blood pressure, as well as degree of proteinuria.Â The cut-off point of sFlt1 level is 2,815 pg/mL.Keywords: sFlt1, severe preeclampsia, blood pressure, proteinuriaÂ DOI:Â http://dx.doi.org/10.15395/mkb.v41n3.241

Pengaruh pelatihan kader posyandu dengan modul terintegrasi terhadap peningkatan pengetahuan, sikap dan keikutsertaan kader posyandu Sri Wahyuni; Johanes C. Mose; Udin Sabarudin
Jurnal Riset Kebidanan Indonesia Vol 3, No 2 (2019): Desember
Publisher : AIPKEMA (Asosiasi Institusi Pendidikan Kebidanan Muhammadiyah-'Aisyiyah Indonesia)

Latar belakang: Jumlah Posyandu di Indonesia semakin bertambah setiap tahunnya, tetapi tidak sebanding dengan penambahan kader posyandu, hal ini terbukti dari data yang menunjukan bahwa rata-rata jumlah kader aktif adalah 3-4 orang pada setiap Posyandu. Sedikitnya jumlah kader aktif menggambarkan peran serta masyarakat yang masih rendah, maka perlu diupayakan penambahan jumlah kader posyandu melalui pelatihan. Tujuan penelitian : Untuk mengukur pengaruh pelatihan kader posyandu dengan modul terintegrasi terhadap peningkatan pengetahuan, sikap dan keikutsertaan kader posyandu. Metode : Menggunakan desain penelitian Quasy experiment pre-test and post-test with control group. Penelitian ini dilakukan di Manonjaya, menggunakan data primer terhadap ibu yang tidak bekerja dan mempunyai waktu luang sebanyak 30 orang pada setiap kelompok. Data kemudian dianalisis secara univariat, bivariat, dan multivariat. Hasil : Data menunjukan sebelum diberikan pelatihan pada kedua kelompok pengetahuan sebesar 80,4 dan 81,2, serta sikap sebesar 69,7 dan 71,9, kemudian setelah pelatihan pengetahuan menjadi 88,1 dan 87, sikap menjadi 85,5 dan 75. Keikutsertaaan responden berturut-turut pada post-test 1 dan post-test 2 antara kelompok intervensi dan kelompok kontrol sebanyak 25 orang dan 22 orang. Simpulan : Pelatihan kader Posyandu dengan modul terintegrasi terbukti lebih meningkatkan pengetahuan dan sikap responden, tetapi tidak lebih baik dalam meningkatkan keikutsertaan kader.

Hubungan antara Obesitas dengan Faktor Luaran Bayi pada Preeklamsia Berat Arifa Rakhmana Abdullah; Johanes Cornelius Mose; Yudi Mulyana Hidayat
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.427

Tujuan: Membandingkan luaran berat badan dan panjang badan lahir bayi serta lama perawatan antara kelompok obesitas dan tidak obesitas pada penderita preeklamsia berat. Metode: Desain penelitian menggunakan metode cohort retrospective dengan menggunakan data sekunder berupa rekam medis. Populasi penelitian adalah ibu hamil penderita preeklamsia berat yang melahirkan di Rumah Sakit Umum Pusat Dr. Hasan Sadikin pada periode 1 Januari 2015 – 31 Desember 2019, dengan teknik pengambilan sampel purposive dan didapatkan total 86 sampel.Hasil: Nilai rata-rata berat lahir kelompok obesitas secara signifikan (P 0.00) lebih berat 908.13 gram dibandingkan kelompok tidak obesitas (95% CI 513.81;1302.46 gram) dan nilai rata-rata panjang badan kelompok obesitas secara signifikan (P 0.00) lebih panjang 4.23 cm dibandingkan kelompok tidak obesitas (95% CI 1.49;6.48 cm). Nilai tengah lama perawatan kedua kelompok tidak menunjukkan perbedaan signifikan (P 0.48) dimana pada kelompok tidak obesitas, lama perawatan 4 hari sedangkan kelompok obesitas 5 hari. Kesimpulan: Terdapat perbedaan yang signifikan secara statistik terhadap luaran bayi berupa berat lahir dan panjang badan lahir bayi antara kelompok obesitas dan tidak obesitas pada penderita preeklamsia berat, namun tidak terdapat perbedaan yang signifikan secara statistik terhadap lama perawatan antara kelompok obesitas dan tidak obesitas pada penderita preeklamsia berat.Comparison of Neonatal Outcomes and Length of Stay Based on Obesity Status in Severe PreeclampsiaAbstractObjective: To compare the outcome of neonatal birth weight and length as well as the length of stay between the obese and non-obese groups in patients with severe preeclampsia.Methods: This study used a retrospective cohort method and secondary data from medical record.. The population in this was 2055 pregnant women with severe preeclampsia who gave birth at the General Hospital Dr. Hasan Sadikin period January 1st, 2015 to December 31st, 2019. The sample in this study uses purposive sampling method and the total sample is 86 samples. Result: The results showed that the mean birth weight of the obese group was significantly (P 0.00) heavier 908.13 grams compared to the non-obese group (95% CI 513.81; 1302.46 grams) and the mean birth length of the obese group was significantly (P 0.00) longer 4.23 cm compared to the non-obese group (95% CI 1.49; 6.48 cm). The median length of stay between the two groups did not show a significant difference (P 0.48), in the non-obese group, the length of stay was 4 days while the obese group was 5 days.Conclusion: There was a statistically significant difference in neonatal outcomes in terms of birth weight and birth length between the obese and non-obese groups in patients with severe preeclampsia, but there was no statistically significant difference in the length of stay between the obese and non-obese groups in patients with severe preeclampsia.Key word : Obesity, neonatal outcomes, length of stay, severe preeclampsia

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