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All Journal Juke Jurnal Litbang: Media Informasi Penelitian, Pengembangan dan IPTEK
Nanang Wiyono
Fakultas Kedokteran, Universitas Sebelas Maret
Education Health Professions Medicine & Pharmacology

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THE EFFECT OF ETHANOLIC EXTRACT OF CENTELLA ASIATICA (L) URBAN ADMINISTRATION TOWARDS THE THICKNESS OF PYRAMIDAL LAYER IN THE CA1 REGION OF HIPPOCAMPUS OF SPRAGUE DAWLEY RATS AFTER CHRONIC RESTRAIN STRESS Anggraeni Janar Wulan; Brian Wasita; Nanang Wiyono
JUKE Unila Vol 4, No 8 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.527 KB)

Abstract

Background: Stress has been shown can change the structure of the brain, especially in the cornu ammonic (CA) I region of hippocampus. Centella asiatica or pegagan as herbal neuroprotector was investigated. The study aimed to determine the effect of ethanolic extract of C. asiatica to the thickness of pyramidal layer in the CA1 region in rats subjected to chronic restrain stress (CRS). Method: This experimental study used post test only group design. Thirty five rats were divided into 6 groups: non stress group (control) and stress only group pulvis gum arabicum (PGA), positive control group (treated with fluoxetin 10mg/kgBW), and 3 treatment groups are treated with C. asiatica 150, 300, and 600mg/kgBW respectively. All groups except non stress group were subjected to CRS, for 6 hours per day for 21 days. Fluoxetin, PGA, and C. Asiatica were applied 30 minutes before CRS done. Rats were sacrificed at the end of 24th day and were perfused transcardially. Processed brain tissue stained with toluidine blue, and measured with Image Raster program. Result: The thickness of pyramidal layer in the CA1 region are increasing significantly in treatment groups which treated with 150 and 300 kg/BW of C. asiatica, but not significant which treated with 600mg/kgBW ethanolic extract of C. asiatica. Conclusion: Ethanolic extract of C. asiatica can improve thickness of pyramidal layer in the CA1 region of hippocampus of Sprague Dawley rats after chronic restrain stress. [JuKe Unila 2014; 4(8):202-207]
Penggunaan Salam Smart dalam Meningkatkan Kesehatan Mental dan Penerapan Protokol Kesehatan pada Kelompok Pengajian Tri Rejeki Andayani; Budiyanti Wiboworini; Nanang Wiyono; Farida Hidayati
Jurnal Litbang: Media Informasi Penelitian, Pengembangan dan IPTEK Vol 17, No 2 (2021): Desember
Publisher : Badan Perencanaan Pembangunan Daerah (BAPPEDA) Kabupaten Pati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33658/jl.v17i2.281

Abstract

ENGLISHThe covid-19 pandemic that has occurred for a long time brings changes in the entire order of human life, including religion. Religious and social activities, like "pengajian" must immediately adapt to the new norms. An educational program is needed to ensure that every activity in "pengajian" group complies with the health protocols and reduces the potential for the emergence of new Covid-19 clusters. "Salam Smart" Program is a Healthy and Happy Life Strategy in the pandemic period. It is hoped to increase the implementation of health protocols and mental health of the members of this community. This study aimed to describe the contribution of “Salam Smart” Program on mental health improvement and the implementation of health protocols in the "pengajian" group. There were 29 participants to determine the effectiveness of the program. Data were collected using the Prokesmen Scale consisting of subscales i.e. the Health Protocol Scale (Reliability 0.875), and the Mental Health Scale (Rel = 0.796). The descriptive quantitative data analysis was applied and resulted that there was an increase of 2.62 in the application of health care and 3.92 in mental health. It can be concluded that the “Salam Smart” Education Program can be carried on as a strategy to live a healthy and happy life during the pandemic.  INDONESIAPandemi Covid-19 yang cukup panjang tentunya membawa perubahan pada seluruh tatanan kehidupan manusia, termasuk agama. Kegiatan keagamaan dan sosial harus segera beradaptasi dengan norma-norma baru. Untuk memastikan setiap kegiatan sesuai dengan protokol kesehatan dan mengurangi potensi munculnya klaster Covid-19 baru dari kelompok pengajian, perlu diadakan program edukasi. Melalui Program “Salam Cerdas” sebagai Strategi Hidup Sehat dan Bahagia di Masa Pandemi. Program ini diharapkan dapat meningkatkan penerapan protokol kesehatan dan kesehatan jiwa para anggota komunitas pengajian. Ada 29 peserta untuk menentukan efektivitas program. Pengumpulan data menggunakan Skala Prokesmen yang terdiri dari subskala yaitu Skala Protokol Kesehatan (Reliabilitas 0,875), dan Skala Kesehatan Jiwa (Rel = 0,796). Analisis data deskriptif kuantitatif digunakan dan hasilnya menunjukkan bahwa ada peningkatan 2,62 dalam penerapan perawatan kesehatan dan 3,92 dalam kesehatan mental. Dapat disimpulkan bahwa Program Pendidikan “Salam Cerdas” dapat dijadikan sebagai strategi untuk hidup sehat dan bahagia di masa pandemi.
Co-Authors Anggraeni Janar Wulan Brian Wasita Budiyanti Wiboworini Farida Hidayati Tri Rejeki Andayani