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Immobilization of Pepsin onto Chitosan Silica Nanobeads with Glutaraldehyde as Crosslink Agent Sari Edi Cahyaningrum; Maria Monica Sianita
Bulletin of Chemical Reaction Engineering & Catalysis 2014: BCREC Volume 9 Issue 3 Year 2014 (SCOPUS Indexed, December 2014)
Publisher : Department of Chemical Engineering - Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.048 KB) | DOI: 10.9767/bcrec.9.3.7060.263-269

Abstract

Glutaraldehyde crosslinked chitosan - silica nanobeads have been used as a support in the immobiliza-tion process of pepsin. The effect of pH, pepsin concentration, and temperature on the characteristics of both free and immobilized pepsin had been investigated in this study. The results showed that the im-mobilized pepsin has wider pH range, better capacity, performance and stability to high temperatures compared with those of free pepsin. The immobilized pepsin can be used for 8 to 10 times at which the activity remains 20%, whereas the free pepsin can only be used once. These results suggested promis-ing applications of immobilized enzyme as biocatalyst. © 2014 BCREC UNDIP. All rights reserved.Received: 1st July 2014; Revised: 3rd September 2014; Accepted: 3rd September 2014How to Cite: Cahyaningrum, S.E., Sianita, M.M. (2014). Immobilization of Pepsin onto Chitosan Silica Nanobeads with Glutaraldehyde as Crosslink Agent. Bulletin of Chemical Reaction Engineering & Catalysis, 9 (3): 263-269. (doi:10.9767/bcrec.9.3.7060.263-269) Permalink/DOI: http://dx.doi.org/10.9767/bcrec.9.3.7060.263-269
IPTEK BAGI MASYARAKAT (IBM) PELAKU USAHA BAWANG MERAH GORENG DI JATIREJO NGANJUK Cahyaningrum, Sari Edi; Heryastuti, Nuniek; Hidajati, Nurul
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol 4, No 2 (2019)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ja.v4n2.p91-97

Abstract

Intention of activity of this Pengabdian pada Masyarakat (PKM) is to conduct activity of training and is adjacent of partner Industri Kecil Menengah (IKM) in developing the effort shallot fry. Partner during the time have run the effort shallot fry traditionally, yielded to be product to be sold to whole sale. Special goals to be got by partner are skilled way of making shallot fry which with quality evaluated from health side and competent sell. Owning knowledge and earn system applied of management marketing and its business activity, owning good packaging and also have permission legality of is effort. Efektivity and of optimalization of program through giving of training and adjacent in making of shallot fry, giving training of managemen of marketing, assisting to make packaging desain and manage permission legality is effort. Results of this activity indicate that partner very enthusiastic followed of training phase and is adjacent effort which is conducted. Partner feel to like because its effort permission of its fair to middling quality of goodness, its legality also have fufilled big sebagain so that partner feel balmy to run the effort. Ability to produce shallot fry to be expected increasing so that will push society create employment and improving economics and production.
PEMBUATAN SABUN CUCI TANGAN SEBAGAI UPAYA PEMUTUSAN PENYEBARAN RANTAI COVID – 19 DI KABUPATEN TUBAN Herdyastuti, Nuniek; Taufikurrohmah, Titik; Rusmini, Rusmini; Mustaji, Mustaji; Cahyaningrum, Sari Edi
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol 6, No 2 (2021)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ja.v6n2.p161-166

Abstract

Virus Corona ini telah melanda sekitar 152 negara di dunia yang tersebar di semua benua termasuk negara Indonesia. Propinsi Jawa Timur menempati urutan tertinggi jumlah positip Covid 19 dan dikategorikan dalam zona merah di 32 kota dan kabupaten termasuk Tuban. Pencegahan penyebaran virus corona dapat dilakukan dengan cara menjaga jarak aman, menggunakan masker dan mencuci tangan dengan air mengalir atau menggunakan sabun. Sabun cuci tangan mengandung bahan antiseptic yang dapat membunuh virus. Universitas Negeri Surabaya mempunyai potensi dosen-dosen yang mempunyai kemampuan untuk membuat sabun cuci tangan. Kegiatan ini bertujuan untuk membuat sabun cuci tangan untuk memutus rantai penyebaran Covid 19 khususnya di Kabupaten Tuban. Telah berhasil memproduksi sabun cuci tangan kemasan 500 mL sebanyak 500 buah dan telah diserahkan ke Kabupaten Tuban melalui Unit Crisis Center Unesa. Bantuan diterima oleh Bupati Tuban dan didistribusikan ke masyarakat Tuban yang membutuhkan. Kata Kunci: sabun cuci tangan, Covid-19, Tuban
ADSORPTION OF Mg(II) ION FROM AQUEOUS SOLUTION ON CHITOSAN BEADS AND CHITOSAN POWDER Sari Edi Cahyaningrum; N Narsito; Sri Juari Santoso; Rudiana Agustini
JOURNAL OF COASTAL DEVELOPMENT Vol 13, No 3 (2010): Volume 13, Number 3, Year 2010
Publisher : JOURNAL OF COASTAL DEVELOPMENT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (59.972 KB)

Abstract

A basic investigation on the removal of Mg(II) ion from aqueous solution by chitosan beads was conducted in a batch adsorption system. The influence of different experimental parameters; pH, agitation period and different concentration of Mg(II) ion was evaluated. A pH 7.0 was found to be an optimum pH for Mg(II) adsorption onto chitosan powder and chitosan beads. The Langmuir and Freundlich adsorption isotherm models were applied to describe the isotherms and isotherm constants for the adsorption of Mg(II) onto chitosan powder and chitosan beads. Results indicated that Mg(II)  uptake could be described by the Langmuir adsorption model. The maximum adsorption capacities of Mg(II) ion onto chitosan powder and chitosan beads were 7.20 and 17.39 mol gâ^’1, respectively. The rate of adsorption Mg(II) on chitosan powder and chitosan beads  were 16.0.10-4 min-1 and  48.00 . 10-4  min-1, respectively.      
PELATIHAN PEMBUATAN SARI KEDELAI REMPAH UNTUK PENINGKATAN DAYA TAHAN TUBUH DALAM MENGHADAPI PANDEMI Covid-19 Wikandari, Prima Retno; Yuanita, Leny; Cahyaningrum, Sari Edi; Herdyastuti, Nuniek
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol 6, No 2 (2021)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ja.v6n2.p155-160

Abstract

Coronavirus disease-19 (Covid-19) adalah penyakit yang memberikan resiko kematian yang sangat tinggi. Alternatif pencegahan adalah dengan konsumsi susu kedelai berempah karena dapat meningkatkan imun dan kaya antioksidan. Kegiatan ini bertujuan untuk (1) memberikan pengetahuan tentang Covid-19 dan cara penanggulangannya, (2) memberikan keterampilan pembuatan sari kedelai berempah, dan (3) melakukan sosialisasi produk kepada masyarakat oleh peserta latih. Metode pelatihan dilakukan secara daring dan diunggah melalui youtube https://youtu.be/mb_6H2biczA, dilanjutkan praktek mandiri dan sosialisasi produk hasil praktek mandiri kepada masyarakat sekitar. Hasil kegiatan menunjukkan peserta latih memberikan respon bahwa materi pengetahuan tentang Covid-19 dan cara pembuatan sari kedelai adalah penting dan cara penyajiannya sangat menarik. Sebanyak 86.7 % peserta menyatakan bahwa materi adalah baru, dan 60% peserta menjawab akan mempraktekkan hasil pelatihan. Satu orang peserta telah mampu menginisiasi tetangganya untuk berwirausaha dan telah menerima pesanan. Sebanyak 86.7 % peserta latih telah melakukan sosialisasi kepada keluarga (46.7%), tetangga (33.3%) dan teman kantor  (13.3%). Tanggapan peserta sosialisasi terhadap  produk sari kedelai rempah menyatakan suka (46.7%) sampai sangat suka (53.3%), Respon peserta sosialisasi menyatakan bahwa mereka menyatakan kegiatan ini cukup manfaat (33.3%) hingga sangat manfaat (66.7%) dan 100 % berkeinginan untuk mengetahui pembuatan sari kedelai rempah.Kata Kunci: Covid-19, imunitas, sari kedelai berempah, pelatihan
Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug Sari Edi Cahyaningrum; Nuniek Herdyastuti; Nur Qomariah
Indonesian Journal of Chemistry Vol 15, No 1 (2015)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.852 KB) | DOI: 10.22146/ijc.21218

Abstract

The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug. The microparticles were evaluated for surface morphology, functional groups, size particles, drug content and swelling index. The drug release kinetic was investigated at gastric and intestinal artificial pH. The results showed that isoniazid-calcium alginate-chitosan has majority particle diameter of 1001-1500 nm. The release mechanism of isoniazid was through combination of erosion and diffusion.
IMMOBILIZATION OF PAPAIN ON CHITOSAN Sari Edi Cahyaningrum; Narsito Narsito; Sri Juari Santoso; Rudiana Agustini
Indonesian Journal of Chemistry Vol 8, No 3 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1177.439 KB) | DOI: 10.22146/ijc.21609

Abstract

In this study, papain was immobilized on chitosan with Mg(II) cosslinked agent. Studies on free and immobilized papain systems for determination of optimum pH, optimum temperatur, thermal stability and reusability were carried out. The results showed that free papain had optimum pH 6.5 and optimum temperature 55 °C while the immobile papain hadoptimum pH 8 and optimum temperature 80 °C. The thermal stability of the immobilized papain, relative to that of the free papain, was markedly increased. The immobilized papain can be reused for at least six times.
IPTEK BAGI MASYARAKAT (IBM) PELAKU USAHA BAWANG MERAH GORENG DI JATIREJO NGANJUK Sari Edi Cahyaningrum; Nuniek Heryastuti; Nurul Hidajati
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2019)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ja.v4n2.p91-97

Abstract

Intention of activity of this Pengabdian pada Masyarakat (PKM) is to conduct activity of training and is adjacent of partner Industri Kecil Menengah (IKM) in developing the effort shallot fry. Partner during the time have run the effort shallot fry traditionally, yielded to be product to be sold to whole sale. Special goals to be got by partner are skilled way of making shallot fry which with quality evaluated from health side and competent sell. Owning knowledge and earn system applied of management marketing and its business activity, owning good packaging and also have permission legality of is effort. Efektivity and of optimalization of program through giving of training and adjacent in making of shallot fry, giving training of managemen of marketing, assisting to make packaging desain and manage permission legality is effort. Results of this activity indicate that partner very enthusiastic followed of training phase and is adjacent effort which is conducted. Partner feel to like because its effort permission of its fair to middling quality of goodness, its legality also have fufilled big sebagain so that partner feel balmy to run the effort. Ability to produce shallot fry to be expected increasing so that will push society create employment and improving economics and production.
Characterization and Anti-Bacterial Activity Testing of the Nano Hydroxyapatite-Clove (Eugenia Caryophyllus) Against Streptococcus Mutans Bacteria Akbar, Achmad Fitriadi; Cahyaningrum, Sari Edi
Indonesian Journal of Chemical Science Vol 11 No 1 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v11i1.51037

Abstract

Hydroxyapatite is one of the materials as a source of calcium and phosphate in the tooth remineralization process. Several studies have shown that hydroxyapatite produces strong antibacterial activity against caries-causing bacteria. Dental caries are one of the tooth scrapings suffered by many people. Dental caries are caused by Streptococcus mutans. In addition to hydroxyapatite, essential oil derived from cloves also has a good antimicrobial function. The eugenol content in cloves can kill bacteria that are resistant to antibiotics. This study aims to determine the results of the physicochemical characterization and antibacterial test of Streptococcus mutans in the clove-hydroxyapatite nanoformulation. This study used a nano-hydroxyapatite-clove test material with various compositions of 0.5 mL, 1 mL, 2 mL, 3 mL, and 4 mL of clove oil, 1% hydroxyapatite, Tween, and propylene glycol. The results of FT-IR characterization showed OH, C-H, C-O, C=O, PO43-, and CO32- functional groups. In PSA testing, the smallest size is indicated by the variation in the composition of 1ml clove oil, which is 16.07nm. The measurement of the antibacterial activity test showed that the hydroxyapatite-clove nanoformulation was able to inhibit the growth of Streptococcus mutans bacteria, with normally distributed data (p=0,05) and produce a significant probability,000 (p<0,05).
Potential Antibacterial Activity of Hydroxyapatite Composite And Green Betel Leaf Extract (Piper betle L.) Against Streptococcus mutans Bacteria Lawarti, Riska Amelia; Cahyaningrum, Sari Edi
Indonesian Journal of Chemical Science Vol 11 No 1 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v11i1.51059

Abstract

Dental caries is a common oral disease and the main bacteria causing it is Streptococcus mutans. Hydroxyapatite is a material consisting of calcium and phosphate components that have dual abilities as remineralizing and antibacterial agents. In addition to hydroxyapatite, phenolic compounds and tannins in green betel leaf extract also have antimicrobial functions. Tannins and phenols act as poisons for microbes by inhibiting the enzyme activity of interfering microbes. The purpose of this study was to determine the physicochemical character and antibacterial activity of Streptococcus mutans from oral hydroxyapatite preparations and green betel leaf extract. In this study, hydroxyapatite and green betel leaf extract were used as oral preparations with variations in the addition of green betel leaf extract 0.1; 0.3; 0.5; 0.7 and 1 gram. The results of the FTIR analysis explain the absorption bands of the functional groups PO43-, OH and CO32- from hydroxyapatite, as well as the C=O and C-O groups from green betel leaf extract which have shifted the wave number, indicating that there has been a bond between hydroxyapatite and metabolite compounds in betel leaf extract. green. In PSA testing, the smallest particle size was indicated by the variation of hydroxyapatite composite and 0,3 gram green betel leaf extract, which was 690.08 nm. Testing the antibacterial activity of the hydroxyapatite-green betel leaf extract composite showed inhibitory activity against Streptococcus mutans bacteri.