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All Journal Biospecies Biota Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Biologi Papua
Linus Y. Chrystomo
Jurusan Biologi FMIPA Uncen
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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Journal : Jurnal Biologi Papua

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Peran Herpetofauna dalam Bidang Kesehatan: Peluang dan Tantangan Indrayani, Ervina; Chrystomo, Linus Y.; Wasaraka, Zainal Arifin; Karim, Aditya Krishar
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Publisher : Jurnal Biologi Papua

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Abstract

Skin secretions and venom from many species of amphibi (frogs and toads) and reptil (group of herpetofauna) from different famillies contain a wide range of unique physiological compounds with biological activity such as peptide, protein, non-protein, and enzyme. They are potent for drug development. The compounds, known as mode of action have practical application as pharmaceutical agents, diagnostic reagents or preparative tools. Peptides with potential anticancer, fibrinolityc, antibacterial, antifungal, antidiabetic activity play important roles in human health. This review introduces roles of herpetofauna for drugs development, potential therapeutic values and their application in human health and disease.Key words: Herpetofauna, skin secretion, venom, drugs development, health.
Skrining Fitokimia dan Uji Aktivitas Sitotoksik dari Tumbuhan Sarang Semut (Myrmecodia beccarii Hook.f.) Asal Kabupaten Merauke Mardany, Modustriarti P.; Chrystomo, Linus Y.; Karim, Aditya K.
JURNAL BIOLOGI PAPUA Vol 8, No 1 (2016)
Publisher : JURNAL BIOLOGI PAPUA

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Abstract

Sarang semut (Myrmecodia beccarii Hook.f.) is a famous medicinal plant of Papua, which has traditionally potential in treating a wide variety of mild and severe illnesses, such as cancers and tumors, gout, coronary heart disease, hemorrhoids, tuberculosis, migraines, rheumatism, and leukemia. The purposes of this study were to determine the content of the active compound group and the cytotoxic activity of sarang semut plants from Merauke Region. The extraction was done by maceration using 96 % ethanol. The concentration of ethanolic extract were 0, 25, 50, 75, 100 ppm. The results of the study showed that the cytotoxic activity determine using BSLT (Brine Shrimp Lethality Test) method have a high cytotoxic activity with LC50 values of 22.86 ppm and containing the active compound namely flavonoids, tannins and saponins separately. The ethanolic extract of tuber of sarang semut (M. beccarii) has a high cytotoxic activity against larvae of Artemia salina Leach according BSLT method. Key words: Active compound, M. beccarii, cytotoxic activity, Merauke.
Co-Authors Aditya K. Karim Aditya Krishar Karim Aditya Krishar Karim Ervina Indrayani Hartanto , L. Nugroho Ign Joko Suyono Kumiko Terada Kumiko Terada L. Hartanto Nugroho Maklon Warpur Modustriarti P. Mardany, Modustriarti P. Subagus Wahyuono Sumardi , Issirep Tsutomu Nohno Tsutomu Nohno Wahyuono , Subagus Zainal Arifin Wasaraka