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All Journal ACTA VETERINARIA INDONESIANA Jurnal Fitofarmaka Indonesia Justek : Jurnal Sains Dan Teknologi Journal of Tropical Pharmacy and Chemistry Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Farmagazine Jurnal Farmasi JCDD Jurnal Karya Abdi Masyarakat
Erni Rustiani
Pakuan University
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Efektivitas Herbal Cair Kombinasi Daun Pepaya dan Kelopak Bunga Rosella Sebagai Antihipertensi ERNI RUSTIANI; Moerfiah .; Pungky Umi Sa’diyah
Acta VETERINARIA Indonesiana Vol. 8 No. 1 (2020): Januari 2020
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (904.181 KB) | DOI: 10.29244/avi.8.1.10-17

Abstract

Hipertensi terjadi apabila tekanan darah sistol lebih dari 129 mmHg dan tekanan darah diastol lebih dari 90 mmHg. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian herbal cair kombinasi tersebut terhadap penurunan tekanan darah pada tikus putih jantan Sprague-Dawley yang diinduksi larutan NaCl 5%. Hewan uji yang digunakan terdiri dari 20 ekor tikus dengan bobot 200-300 gram dan dibagi menjadi 5 kelompok perlakuan. Kelompok perlakuan terdiri dari dosis I (0,27 mL/200 gBB), dosis II (0,54 mL/200 gBB), kontrol positif I (obat herbal merk X 6,48 mg/200 gBB), kontrol positif II (kaptopril 1,35 mg/200 gBB) dan kelompok kontrol negatif yang hanya diberikan akuades. Berdasarkan penelitian yang dilakukan dapat dinyatakan bahwa pemberian herbal cair dapat menurunkan tekanan darah pada tikus setelah 18 hari penggunaan. Dosis II (0,54 mL/200 gBB) merupakan dosis paling baik untuk menurunkan tekanan darah pada tikus putih jantan Sprague-Dawley dengan lama waktu pemberian paling baik untuk sistol pada hari ke-10 dan diastol hari ke-15.
EFEKTIVITAS ANTIHIPERGLIKEMIA TABLET CAMPURAN EKSTRAK DAUN PEPAYA DAN DAUN SALAM PADA TIKUS Sprague dawley Erni Rustiani; Min Rachminiwati; Lia Suryani
Jurnal Fitofarmaka Indonesia Vol 4, No 2 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (890.834 KB) | DOI: 10.33096/jffi.v4i2.264

Abstract

Plants which have a potential effect as antihyperglycemic are papaya leaf and bay leaf. Papaya leaf and bay leaf have a bioactive flavonoid component, which was suggested to have reduction effect on blood glucose. The purpose of this research was to examine the effectiveness of papaya leaf and bay leaf extract, which have been formulated in tablet form to decrease blood glucose level on diabetic Sprague dawley rats induced by alloxan. Twenty male rats were divided into four groups, Each group consists of five rats, namely group I as a positive control (metformin 12.6 mg/200g BW), group II (oral tablet 1.282 mg/200g BW), group III (oral tablet 2.564 mg/200g BW) as extract treatment group, and group IV as negative control. The treatment was carried out for 28 days. The result of this research showed that tablet of papaya leaf and bay leaf extract can be used as antihyperglycemic with the most effective dose was 2.564 mg/200g BB (group III) and the treatment for twelve days.
Pengembangan Mikrogranul Mukoadhesif Ekstrak Kayu Manis Dengan Kombinasi Polimer Karbopol Dan Gelatin Sri Wardatun; Erni Rustiani; Opi Damahyanti
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.238 KB) | DOI: 10.33096/jffi.v7i1.477

Abstract

Senyawa bahan alam umumnya memiliki kelarutan yang rendah dan absorpsi yang lemah dalam tubuh. Pengembangan formula mikrogranul mukoadhesif dari ekstrak kayu manis dengan polimer karbopol dan gelatin bertujuan untuk meningkatkan kelarutan dan absorpsi ekstrak kayu manis dalam tubuh. Pada penelitian ini, mikrogranul mukoadhesif diformulasikan menggunakan ekstrak kayu manis dengan tiga formulasi yang berbeda yaitu penggunaan karbopol 934 P 5%: gelatin tipe B 4% (F1),  karbopol 934P 5%: gelatin tipe B 5%   (F2) dan karbopol 934 5%:  gelatin tipe B 6% (F3). Hasil penelitian menunjukkan bahwa kombinasi karbopol 934P 5%: gelatin tipe B 5% (F2)merupakan formulasi mikrogranul mukoadhesif yang menghasilkan kadar asam sinamat paling tinggi setelah uji wash off menggunakan jaringan lambung (6,48%) dan usus tikus (55,21%). Hasil evaluasi fisik terhadap mikrogranul meliputi uji sudut diam, kadar air, laju alir granul, uji wash off, morfologi dan ukuran partikel menunjukkan bahwa mikrogranul mukoadhesif dari F2 menghasilkan kualitas granul paling baik. 
FORMULASI TABLET HISAP CAMPURAN KATEKIN GAMBIR DAN JAHE DENGAN JENIS PENGIKAT PVP DAN GOM ARAB Erni Rustiani; Dwi Indriati; Linda Actia
Jurnal Fitofarmaka Indonesia Vol 6, No 1 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1152.625 KB) | DOI: 10.33096/jffi.v6i1.465

Abstract

Gambir mempunyai kemampuan dapat membunuh ataupun menghambat pertumbuhan bakteri. Jahe memiliki kandungan flavonoid dan gingerol yang mempunyai aktivitas antibakteri untuk mulut dan gusi. Penelitian ini bertujuan untuk membuat sediaan tablet hisap kombinasi katekin gambir dan jahe dengan variasi jenis pengikat PVP dan Gom arab. Hasil penelitian menunjukkan bahwa formula terbaik dari setiap jenis pengikat yaitu formula dengan pengikat gom arab 10% dan formula dengan pengikat PVP K-30 7%. Berdasarkan kemudahan dalam proses granulasi dipilih formula dengan konsentrasi PVP K-30 7% sebagai formula terbaik dengan hasil rata-rata keseragaman bobot tablet 2,0406 g, ukuran tebal 58,9 mm, diameter 21,95 mm, kekerasan 23,63 kp, friabilita 0,14% dan waktu hancur 28 menit 62 detik. Hasil pengujian kadar flavonoid total terhadap ekstrak kering jahe sebesar 2,71 % dan sediaan tablet hisap 2,32%.
PENGEMBANGAN TABLET EFERVESEN KOMBINASI BROKOLI DAN PEGAGAN DENGAN KOMBINASI ASAM DAN BASA Yuliana Kusumawati; Erni Rustiani; Almasyuhuri Almasyuhuri
Jurnal Fitofarmaka Indonesia Vol 4, No 2 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (890.837 KB) | DOI: 10.33096/jffi.v4i2.266

Abstract

Brocoli and pegagan is a plant that is easy to get and efficacious as antidemensia. The objective of this study was to formulate the plant into an effervescent tablet preparation and to determine the best formula with acid concentration variation. Dry extract of brocoli and pegagan is made by the method of escape then dried with vacuum dryer. The preparation is made by wet granulation method of 3 formula with weight of 4 gram per tablet. The granule test includes moisture content. Result of granule water content ˂5%. Granules are printed in special chambers and conditions and tested for quality. The result of uniform weight test of all formula meets the requirements of Pharmacopoeia Indonesia III; Hardness of tablets 12.06-12.52 kP; Friability of tablets 0.083-0.74%; Test of dissolution time of efervesen tablet ˂ 5 minutes. Preferred test results showed formula III with citric acid concentration: 1: 2 tartaric acid most preferred; Test result of asiatikosida content of pegagan extract is 0.08% and efervesen 0.005% tablet; Test results for vitamin C content of broccoli extract 13.859% and efevesen tablet 16.995%. The results of the physical quality test of effervescent tablets showed that the three formulas met the specified requirements. Stability test results for 8 weeks showed that the effervesen tablet of formula 3 met the requirements of physical quality during storage.
Formulasi Sediaan Emulgel Ekatrak Etanol 70% Daun Talas (Colocasia esculenta (L.) Schott) Dengan Variasi Konsentrasi Karbopol 940 Erni Rustiani; Septia Andini; Mareda Apriani
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROSIDING SEMINAR NASIONAL KEFARMASIAN
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.150

Abstract

Daun talas diketahui mengandung senyawa flavonoid yang berkhasiat sebagai antibakteri dan antiinflamasi. Ekstrak daun talas dibuat menjadi sediaan emulgel karena bentuk emulgel merupakan sistem penghantaran obat yang baik untuk zat aktif yang bersifat semisolid. Emulgel merupakan gabungan dari dua sediaan emulsi dan gel. Pemakaian secara topikal diharapkan mampu mencapai konsentrasi efektif pada jaringan target. Penelitian ini membuat sediaan emulgel ekstrak daun talas dengan bahan pembentuk gel (gelling agent) karbopol 940. Sebanyak empat formula dibuat dengan variasi konsentrasi karbopol 940 yaitu 0,5% (F1); 1% (F2); 1,5% (F3) dan 2%(F4). Ekstraksi daun talas menggunakan metode maserasi dengan pelarut etanol 70%. Emulgel dibuat dalam 3 tahapan yaitu tahap pembuatan emulsi, pembuatan gel dan Tahap inkorporasi (penggabungan) emulsi ke dalam gel. Hasil sediaan emulgel setelah pengujian stabilita Freeze thaw dan penyimpanan pada suhu ruangan 25-300C menunjukkan mutu yang baik berdsrkan uji organoleptik, ph, sentrifugasi dan viskositas. Sedangkan kadar flavonoid emulgel setelah 8 minggu pada formula 1 berbeda dari formula lainnya (p-value 0,001 < 0,05). Kesimpulannya bahwa pembuatan emulgel ekstrak daun talas dapat menggunakan polimer karbopol 940 (1-2%).Kata Kunci : Daun Talas, Emulgel, Karbopol 940
Development of Snack Bar (Snack Bar) In Rich In Calcium With Fortification Of Shell Flour Kijing (Anadonta Woodiana) Mindiya Fatmi; Erni Rustiani
Journal of Science Innovare Vol 1, No 01 (2018): Journal of Science Innovare
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.749 KB) | DOI: 10.33751/jsi.v1i01.681

Abstract

Shellfish flour has a proximate content including moisture content, ash content, fat content, protein content and calcium levels. Shellfish flour containing rich calcium can be added in the manufacture of food products such as Snack Bar to increase the nutritional value. The research includes making snack bar barbecue with several types of sweeteners such as honey, palm sugar and sorbitol. Based on the results of proximate and minerals test, it was found that snack bar preparations were made with ash content (2.25, 2.04, 1.88), total fat content (20,34,20,75,24,20) and kalisum (823,78; 506,21; 814,06) which is higher than the positive control. lower protein and phosphorus content than positive controls, and total carbohydrates that approach positive controls. Keywords: Shellfish Flour, Snack-Bar, Sweetener, Proximate Tes
AVOCADO SEEDS (Persea americana Mill.): FORMULATIONS OF ELIXIR VARIED BY SOLVENTS COMPOSITION Septia Andini; Lusi Indriani; Erni Rustiani
Journal of Science Innovare Vol 3, No 1 (2020): Journal of Science Innovare
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jsi.v3i1.2805

Abstract

Kidney stones disease is asignificant health problem in the world and Indonesia is no exception. Traditionally, avocado seeds can be used as a laxative medicine for kidney stones disease. Elixiris a clear and sweet hidroalkohol solution intended for oral use and a flavor is usually added to enhance the taste. This study was to determine theformula of the avocado seed elixir which has the best quality and the level of flavonoids.Elixir testing was performedusing several methods such as organoleptic, limpidity, viscosity, pH and specific weightas well as total flavonoids. The result showed that the best elixir formula was the Formula I which composed of 7%avocado seed extract, 5% ethanol, 10% propylene glycol, 40% sirupus simplex, 0.1%, essence mint and 100%aquadestilata ad. Furthermore, Elixirhad a brown color, mint aroma and pretty sweettaste. The test results showed that elixir had a viscosity of 7.92 cP; pH of 5.65; specific weight of 1.0413 g/mL andtotal flavonoids of 2.1020%.
THE TABLET FORMULATIONS EFERVESEN EXTRACT OF CINNAMON BARK WITH VARIATIONS IN THE TYPE OF SWEETENER Septia Andini; Erni Rustiani; Dwi Indriati
Journal of Science Innovare Vol 1, No 02 (2018): Journal of Science Innovare, September 2018
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.34 KB) | DOI: 10.33751/jsi.v1i02.999

Abstract

Cinnamon Bark contains flavonoids, tannins, alkaloids, and phenols. Phenolic compounds contained in cinnamon is a sinamat acid is effective as anti diabetic. This research aims to determine the formula preparations tablets efervesen extract of cinnamon bark with a certain type of sweetener that favored the panelists and the levels of sinamat acid in efervesen tablets and extracts. The formula is made with different types of sweeteners such as aspartame stevia 1.5%, 3.5% and 1% sukralosa. The results of the analysis showed no difference in sweeteners influence against the parameters of color and scent but the effect on the parameters of taste every formula. Formula tablets efervesen extract of cinnamon bark that is favored by panelists based on based on the parameters of taste is formula 1 with the sweetener aspartame concentration of 1.5% and a formula 3 with sweetener sukralosa concentration 1% preferred formula panelists. The results of the analysis of the levels of sinamat acid in extract of cinnamon bark obtained the level of 471, 13 mg/g as for Formula 1 tablet efervesen acquired the levels of 369.76 mg/gram
PERBANDINGAN EFEKTIVITAS ANALGETIK EKSTRAK ETANOL DAN EKSTRAK AIR DAUN UNGU PADA MENCIT (Mus musculus L.) Nhadira Nhestricia; Min Rahminiwati; Erni Rustiani; Fitri Dwiputri
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 9, No 2 (2019): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.772 KB) | DOI: 10.33751/jf.v9i2.1609

Abstract

Nyeri adalah perasaan sensorik atau emosional berupa perasaan tidak nyaman yang berhubungan dengan kerusakan dari suatu jaringan. Obat analgesik adalah obat yang memiliki aktivitas mengurangi rasa nyeri tanpa menghilangkan kesadaran. Penelitian ini bertujuan untuk membandingkan efek analgetik ekstrak etanol 96% dan ekstrak air, menentukan dosis ekstrak daun ungu yang paling efektif dan menentukan jangka waktu efek analgesik ekstrak obat pada mencit putih jantan (Mus musculus L.). Hewan coba  digunakan sebanyak 20 ekor mencit putih jantan yang dibagi menjadi 5 kelompok perlakuan mulai P1 sampai P5. Hasil penelitian menunjukkan ekstrak daun ungu dengan pelarut etanol 96% mempunyai efektivitas analgesik setara dengan kontrol positif. Sediaan paling paling efektif sebagai analgesik adalah Ekstrak Etanol Daun ungu 12 mg/20 g BB dengan nilai rata-rata lama mencit menahan rasa nyeri selama 16,08 detik yang diberikan pada kelompok P3, sedangkan kontrol positif Asetosal 1,82 mg/20 g BB memberikan waktu  rata-rata 17,47 detik  untuk menahan rasa sakit pada mencit.
Co-Authors Alciee Santika Susanti Almasyuhuri Almasyuhuri Asri Wulandari Aulia Fitriani Cyntia Wulandari Dwi Indriati Dwi Indriati E. Mulyati Effendi Ella Noorlaela Fitri Dwiputri Kyky Widayanti Lia Suliawati Lia Suryani LIANA ARSYANTI Linda Actia Lusi Agus Setiani Lusi Indriani Mareda Apriani Melliavita Putri Min Rachminiwati Min Rahminiwati Mindiya Fatmi Mira Miranti MOERFIAH . Nhestricia, Nhadira Opi Damahyanti Pipih Agustina Pungky Umi Sa’diyah Retnosari Andrajati Rini Ambarwati Sara Nurmala SATA YOSHIDA SRIE RAHAYU Septia Andini Sri Wardatun Trirakhma Sofihidayati Trirakhma Sofihidayati Ulfa Nur Awinda Wiendarlina, Ike Yulia Yuliana Kusumawati Zaddana, Cantika