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All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Penelitian Sains (JPS) Matematika dan Sains Medical Journal of Indonesia Jurnal Penelitian Sains (JPS) IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) BERITA BIOLOGI JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry IJEMS (Indonesian Journal of Environmental Management and Sustainability) Seminar Nasional Lahan Suboptimal Molekul: Jurnal Ilmiah Kimia BIOVALENTIA: Biological Research Journal Jurnal Ilmiah Bakti Farmasi SWARNA Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES)
Miksusanti Miksusanti
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Sriwijaya University, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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SIFAT ANTIKAPANG EKSTRAK ZAT WARNA BUNGA KNOP (Gomphrena globosa L) Miksusanti, ; Setiawaty Yusuf,
Matematika dan Sains Vol 18, No 2 (2011)
Publisher : Matematika dan Sains

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Abstract

The aims of research was to study the color subtance of knop flower as antifungi. It was extracted by maceration using ethanol solvent. Antifungi assay against Aspergillus flavus and Aspergillus niger was conducted using contact method. Results of research showed that adding of color substance of knop flower extract of 30% decreased cell mass of A. flavus of 47.22% and A. niger of 25%. The MIC value were 45% for A. Flavus and 48% for A. niger.
Antibacterial activity of temu kunci tuber (kaempheria pandurata) essential oil against Bacillus cereus Miksusanti, Miksusanti; J, Betty S.L.; Syarief, Rizal; Pontjo, Bambang; Mulyadi, Gatot T.
Medical Journal of Indonesia Vol 18, No 1 (2009): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.109 KB) | DOI: 10.13181/mji.v18i1.331

Abstract

Aim The mechanism of temu kunci tuber essential oil potential as antimicrobial agent has not been reported. To analyze the mechanism of antibacterial activity of temu kunci tuber essential oil from Yogyakarta on B.cereus. Antibacterial activity of essential oil were analyzed for its ability to disrupt bacterial cell membrane, that caused cell leakage and altered the morphology of the bacteria. Leakage was measured by analyzing the Ca+2, K+ ion outflow using an atomic adsorption spectrometry (AAS), and protein and nucleic acid using an ultraviolet spectrophotometer (UVS) on 280 nm and 260 nm respectively. Alterations in morphology were assessed using scanning electron microscopy (SEM).Results Minimum inhibitory concentration (MIC) of temu kunci essential oil on B.cereus was 0.12% (v/v). Treatment of B. cereus using 1MIC and 2MIC showed significant leakage compared to control (P<0.05). The K+ and Ca+2 ion leakage from the bacterial cells were between 10.32-35.57% and 15.05-41.54% respectively and showed significant difference compared to control (P<0.05). The absorbance observed by UVS for protein and nucleic acid leakage were 0.6330-0.8670 at 280 nm and 0.4320-0.8307 at 260 nm, respectively, and were significantly different compared to control (P<0.05). Exposure of 1 MIC temu kunci essential oil on B.cereus caused thickening as well as irregularities on the cell wall. At 2 MIC cells seemed transparent, empty looking and showed a ghost-like appearance.Conclusion Kaempheria pondurata essential oil could cause leakage and alter the morphology of the bacteria. (Med J Indones 2009; 18:10-7)Keywords: leakage, morphology
KERUSAKAN DINDING SEL Escherichia coli OLEH MINYAK ATSIRI TEMU KUNCI (Kaempferiapandurata) Miksusanti, Miksusanti; Jennie, Betty Sri Laksmi; Ponco, Bambang; Trimulyadi, Gatot
BERITA BIOLOGI Vol 9, No 1 (2008)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (924.201 KB) | DOI: 10.14203/beritabiologi.v9i1.775

Abstract

Antibacterial activity of temu kunci (Kaempferiapandurata) essential oil against Escherichia coli Kl.l was analyzed. Activity of antibacterial essential oil was analyzed through its ability to leak the Escherichia coli Kl.l cell wall and altering it.Minimum Inhibitory Concentration (MIC) of temu kunci essential oil is 0.11% (v/v). Further studies were conducted using the concentration of 1 MIC and 2 MIC.Leakage phenomena were monitored with atomic adsorption spectrometry (AAS), and ultraviolet spectrophotometry(UV).Alteration of cell wall was analyzed with scanning electron microscopy (SEM).The optical density values observed by UV spectrophotometer for protein and nucleic acid leakage were 0.3813-0.6573 at 280 nm and 0.2186-0.5603 at 260 nm.The result showed that K. pandurata essential oil could leak the inorganic ion Ca 17-53%, and K* 9-43% from the bacteria and alter the cell wall of the bacteria.
THE DETERMINANT FACTOR OF URINARY STONE FORMATION ON PALM OIL PROCESSING WORKERS AT PTPN VII BETUNG Sukmawati, Sukmawati; Novrikasari, Novrikasari; Miksusanti, Miksusanti
BIOVALENTIA: Biological Research Journal Vol. 5 No. 1 (2019)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.084 KB) | DOI: 10.24233/BIOV.5.1.2019.124

Abstract

High temperature of work environment affects fluid and electrolyte balance of workers. It is also affecting the urine production by increasing its concentration and if it lasts for a long time causes urinary crystallization. This work was aimed to analyze the determinant factor of urinary stone formation within palm processing workers at PTPN VII Betung. Population sample in this work is 103 workers which represents total population of workers at PTPN VII of Betung unit. Research was designed quantitatively using cross-sectional study. Data collection was carried out using several instruments i.e. questioner, interview and observation. The obtained data was processed through univariate, bivariate and multivariate analysis. Result shows the number of workers with a positive urinary crystallization are 18 workers (17.5%). Characteristic of respondent are typically aged < 45 years (68%), hydration status was not dehydrated (53.2%). Multiple logistic regression analysis result shows hydration status variable (OR = 5.508) affects the formation of urinary stone with worker’s age as confounder
Penentuan Kadar Asam Lemak Bebas dan Kandungan Jenis Asam Lemak dalam Minyak yang Dipanaskan dengan MetodeTitrasi Asam Basa dan Kromatografi Gas Budi Untari; Miksusanti; Al Ainna
Jurnal Ilmiah Bakti Farmasi Vol 5 No 1 (2020): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

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Abstract

Asam lemak bebas merupakan parameter penentu mutu minyak goreng sawit. Penelitian ini bertujuan untuk mengetahui kadar asam lemak bebas pada minyak goreng serta untuk melihat kandungan asam lemak pada minyak goreng akibat pengaruh pemanasan. Penentuan kadar asam lemak bebas dilakukan dengan metode titrasi asam basa dan kandungan asam lemak dilakukan dengan metode kromatografi gas. Sampel dipanaskan dengan variasi waktu 5 dan 15 menit dengan masing-masing suhu 80, 100, 150 dan 200°C. Kadar asam lemak bebas dikatakan normal atau aman jika tidak melebihi nilai kadar asam lemak bebas SNI yaitu 0,30%. Hasil analisis kadar asam lemak bebas kontrol masih aman atau normal <0,30%, sampel waktu 5 menit masih aman atau normal <0,30%. Sampel waktu 15 menit dengan suhu 80 dan 100°C masih aman atau normal. Sampel suhu 150 dan 200°C tidak aman atau tidak normal >0,30%. Waktu pemanasan dan suhu pemanasan dapat meningkatkan kadar asam lemak bebas. Hasil analisis kromatografi gas kandungan asam lemak kontrol (sebelum pemanasan) terdapat 17 jenis asam lemak dengan kandungan tertinggi asam oleat 44,39% dan asam palmitat 38,28%. Sampel yang paling rusak yaitu waktu pemanasan 15 menit dengan suhu 200°C memiliki 17 jenis asam lemak dan kandungan asam oleat menurun menjadi 41,86% sedangkan asam palmitat meningkat menajadi 39,28%. Berdasarkan analisis SPSS dan Minitab lama waktu pemanasan dan tinggi suhu pemanasan berpengaruh nyata terhadap peningkatan kadar asam lemak bebas dari minyak goreng.
Mode of Action Temu Kunci (Kaempferia pandurata) Essential Oil on E. coli K1.1 Cell Determined by Leakage of Material Cell and Salt Tolerance Assays MIKSUSANTI MIKSUSANTI; BETTY SRI LAKSMI JENIE; BAMBANG PONTJO PRIOSOERYANTO; RIZAL SYARIEF; GATOT TRIMULYADI REKSO
HAYATI Journal of Biosciences Vol. 15 No. 2 (2008): June 2008
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (44.681 KB) | DOI: 10.4308/hjb.15.2.56

Abstract

The essential oil of Kaempferia pandurata consist of terpen and oxygenated terpen that exhibits broad-spectrum antimicrobial activity. It’s mode of action against the gram-negative bacterium E. coli K1.1 has been investigated using a range of treatments. The mode action of the essential oil were analyzed by it’s ability to leakage E. coli K1.1 cell, to change permeability of the cell, and to alter salt tolerance of the cell. Ion leakage from the cell were analyzed by atomic absorption spectrophotometer. Salt tolerance assays was conducted by investigating the ability of E. coli K1.1 treated with temu kunci essential oil to grow on NA supplemented with NaCl. Protein and acid nucleic leakage were analyzed by UV spectrophotometer. There were inorganic compound leakage (potassium, calcium ion) and organic compound leakage (nucleic acid, protein) from cytoplasmic membrane, after exposing this organism to essential oil of Kaempferia pandurata. The more concentration of oil added, the more leakage was observed due to the loss of absorbing material such as nucleic acid (260 nm) and protein (280 nm), the loss of potassium and calcium ion, and loss of the salt tolerance of E. coli K1.1. Key words: essential oil, E. coli K1.1, leakage, salt tolerance assay
Studi Penyerapan Procion pada Limbah Kain Tajung Menggunakan Serbuk Batang Eceng Gondok Nova Yuliasari; Miksusanti Miksusanti; Dian Dian
Jurnal Penelitian Sains Vol 13, No 2 (2010)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (443.049 KB) | DOI: 10.56064/jps.v13i2.150

Abstract

Penelitian penyerapan zat warna kimiawi jenis procion pada limbah kain tajung menggunakan serbuk batang eceng gondok telah dilakukan. Konsentrasi procion dianalisis menggunakan spektrofotometer UV-Vis. Parameter yang diteliti adalah waktu kontak, berat serbuk eceng gondok dan pH untuk mendapatkan kondisi optimum. Kondisi optimum perlakuan 50 mL 100 mg/L procion, terjadi pada waktu kontak selama 30 menit, berat serbuk eceng gondok 25 mg dan pH 7. Uji statistik menggunakan ANOVA menunjukkan seluruh parameter menghasilkan data persentase penyerapan yang berbeda nyata. Konsentrasi procion awal pada limbah sebesar 441,02 mg/L. Limbah yang telah diperlakukan pada kondisi optimum memiliki konsentrasi procion menurun menjadi 222,57 mg/L. Persentase penyerapan procion dalam limbah pada kondisi optimum sebesar 49,53%.
Penurunan Kebutuhan Oksigen Kimiawi Limbah Jumputan Menggunakan Lumut Hati Nova Yuliasari; Miksusanti Miksusanti; Endang Setiyowati
Jurnal Penelitian Sains Vol 14, No 1 (2011)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.207 KB) | DOI: 10.56064/jps.v14i1.123

Abstract

Telah dilakukan penelitian penurunan nilai kebutuhan oksigen kimiawi (KOK) terhadap limbah jumputan menggunakan lumut hati yang tumbuh di pohon. Nilai KOK diukur melalui metoda spektrofotometri. Lumut kering dalam bentuk serbuk yang berukuran 100 mesh dikontakkan dengan 50 mL media limbah. Nilai KOK limbah awal sebesar 193,5 mg/L. Kondisi optimum penyerapan senyawa organik adalah selama waktu kontak 60 menit, berat  serbuk lumut 25 mg dan pada pH 7. Kondisi optimum penyerapan menghasilkan penurunan nilai KOK sebesar 74,84%, yaitu menjadi 48,69 mg/L.
Aktivitas Campuran Ekstrak Kulit Manggis (Garcinia mangostana L.) dan Kayu Secang (Caesalpina sappan L.) terhadap Bacillus cereus Miksusanti Miksusanti; Fitrya Fitrya; Nike Marfinda
Jurnal Penelitian Sains Vol 14, No 3 (2011)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.314 KB) | DOI: 10.56064/jps.v14i3.214

Abstract

Penelitian ini bertujuan untuk menganalisa aktivitas antibakteri kombinasi dari ekstrak air kayu secang dan kulit manggis terhadap pertumbuhan bakteri Bacillus cereus. Ekstrak dimaserasi menggunakan pelarut aquademineral dan di- freezdrying. Aktivitas antibakteri diuji menggunakan metode difusi sumur. Parameter yang digunakan ialah diameter zona hambat. Hasil penelitian pada perbandingan kombinasi manggis dan secang 2 : 8, 4 : 6, 5 : 5, 6 : 4, 8 : 2 dengan zona hambat terhadap B. cereus yaitu 18,4, 16,8, 17,3, 13,5, 14,6 mm. Pada penentuan KHM terlihat bahwa campuran ekstrak memiliki aktivitas antibakteri terhadap B. cereus dengan konsentrasi hambat minimum (KHM) adalah 0,075% (750 ppm). Total fenol pada manggis yaitu 94,047 mg/g. Total fenol pada secang yaitu 590,428 mg/g.
Studi Pemanfaatan Tanin dari Buah Pinang sebagai Absorben Cd, Cr dan Zn dalam Air Limbah Industri Pelapisan Seng Almunady T. Panagan; Darsil Basir; Miksusanti Miksusanti
Jurnal Penelitian Sains No 4 (1998)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.962 KB) | DOI: 10.56064/jps.v0i4.239

Abstract

Air limbah industri pelapisan seng mengandung logam berat Cu, Cr dan Zn. Logam berat ini dapat diabsorbsi oleh tanin yang berasal dari buah pinang. Dalam penelitian ini dicari  kondisi dari penyerapan tersebut, meliputi pH dan waktu kontak. Pengukuran kuantitatif logam berat menggunakan spektroskopi serapan atom untuk Zn digunakan panjang gelombang 213,9 nm, slit 0,7 nm bahan bakar air-acetiline, arus lampu 20 mA, kecepatan gas bahan bakar 2,0 l/menit, kecepatan gas pendukung 4 l/menit dengan panjang burner 10 cm. Untuk logam Cr digunakan panjang gelombang 357,9 nm, slit 0,7 nm, bahan bakar air acetylene, arus lampu 10 mA, kecepatan gas bahan bakar 2,4 l/menit, kecepatan gas pendukung 11 l/menit dengan panjang burner 5 cm. Sedangkan untuk logam Cd digunakan panjang gelombang 228,8 nm, slit 0,7 m, bahan bakar air-acetylene, arus lampu 6 mA, kecepatan ga bahan bakar 2,6 i/menit, kecepatan gas pendukung 16 l/menit dan panjang burner 10 cm. Dari hasil penelitian yang telah dilakukan, waktu kontak optimum adalah 120 menit pada pH 7 dimana terjadi pengurangan Cd sebanyak 75%, Cr 50% dan Zn habis seluruhnya.
Co-Authors Adi Supriyadi Adik Ahmadi Agus Syafriansyah Al Ainna Aldes Lesbani Almunadi T Panagan Almunady T. Panagan Annisa Amelia Asmak Asmak Azhar Kholiq Bambang Ponco Bambang Ponco Bambang Ponco, Bambang Bambang Pontjo Priosoeryanto Betty S.L. J Betty Sri Laksmi J Betty Sri Laksmi Jenie Betty Sri Laksmi Jennie Budi Untari Budi Untari Darsil Basir Dasril Basir Dasril Basir Dedi Rohendi Desnelli Desnelli Dian Dian Dian Dwita Maizur Dimas Nur Hidayat Elfita Eli Sahara Eli Sahara Elsa Fitria Apriani Endang Setiyowati Endang Setiyowati Eviyanti Eviyanti Fachrijal Fachrijal Fatma Fitra Yosi Fitrya . Gatot T. Mulyadi Gatot Tri Mulyadi Gatot Trimulyadi GATOT TRIMULYADI REKSO Getari Kasmiarti Harian Saputra Heni Yohandini Herlina Herlina Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Hotdelina S Hotdelina S Ina Suci Pratiwi Indah Solihah Indah Solihah Jefri Liasta Jennie, Betty Sri Laksmi Meisji Liana Sari Nasir Rofiq Nike Marfinda Nova Yuliasari Novian Sutami Novrikasari Novrikasari, Novrikasari NUNI GOFAR Rennie Puspa Novita Rizal Syarief Rizal Syarief Rizal Syarief Setiawan Yusuf Setiawan Yusuf Setiawaty Yusuf Sofia Sandi Sukmawati Sukmawati Susilawati Susilawati Syndi N.K Tridayona Tridayona Trimulyadi, Gatot Wiwin Wiwin Zainal Fanani