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Uji Aktivitas Antidiabetes Ekstrak Etanol Akar Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) terhadap Tikus Putih Jantan yang Diinduksi Diet Tinggi Lemak dan Fruktosa Annisa Amriani S; Fitrya Fitrya; Rennie Puspa Novita; Dapid Caniago
Jurnal Penelitian Sains Vol 23, No 2 (2021)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.283 KB) | DOI: 10.56064/jps.v23i2.635


The purpose of this research to study the antidiabetic activity of extract in type 2 diabetes mellitus rats induced by high fat and fructose diet. Induction is done by giving fructose 1800 mg/kgBW and high fat (15% pork oil and 5% duck egg yolk) 15 g/rat for 30 days. Male Wistar albino rats are used as animal models which divide into 6 group, normal (aquadest), negative control (Na CMC 0,5%), positive control (Metformin 151,20 mg/kgBW), and 3 test (ethanol extract of kabau root 100, 200, and 400 mg/kgBW). Preprandial blood glucose levels are measured using DTN-410-K photometer, on day 0, 30, 35, 40, and 45. The result of AUC30-45 and percentage of decreasing blood glucose level for positive control group are 1727,01 and 73,29%, and 3 test group (100 mg/kgBW, 200 mg/kgBW, dan 400 mg/kgBW) are 1893,32 and 43,50%; 1849,14 and 51,41%; 1789,15 and 62,16%. This point indicate that ethanol extract of kabau root has an antidiabetic activity and there is no significant difference compared with metformin (p>0,05). According to the relation between percentage of blood glucose level with dose, value of ED50 is 194,64 mg/kgBW. Keywords: ethanol extract, kabau root, antidiabetic, high fat and fructose diet
Secondary Metabolite from Endophytic Fungi Aspergillus Sp. The Leave Of Kunyit Putih (Curcuma zedoaria (Berg) Roscoe) Muharni Muharni; Fitrya Fitrya; Widia Purwaningrum; Ahmad Yogi Nugraha
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.312 KB) | DOI: 10.20884/


The compound from endophytic fungi of Aspergillus sp. from leaves of kunyit putih (Curcuma zedoaria (Berg.) Roscoe) has been isolated. Isolation begins with cultivation ofAspergillus sp. in 18 L PDB’s media (Potato Dextrose Broth) for 28 days. The liquid cultivation medium was extracted by partitioning method using ethylacetate and then evaporated. The extract was separated and purified by chromatography techniques. Elucidation stucture of the isolated compound was analysis by spectroscopic method NMR 1D and 2D. Antibacterial activity of isolated compound was tested using the disc diffusion method at concentrations 2500, 1000, 500, and 125 ppm. The isolated compounds obtained in the form of a yellow oil (24.30 mg). The 13C NMR spectrum indicated 24 signals of carbon and base on analysis spectrum DEPT 135 showed 5 signal methynes carbon, 1 signals methylene, 9 signals of methyl and 9 signals quarternary carbon. These signals from 1H and 13C-NMR suggested that this compound contained aromatic group and four carbonyl. The isolated compound show antibacterial activity at concentration 2500 ppm which inhibition zone for E. coli, S. dysenteriae, S. aureus, B. subtilis were 10.3 ; 8.3; 8.4; and 7.8 mm, respectively. Based on the analysis result of NMR 1D and 2D, the compound was methyl 6-(5'-(2"-acetoxy-2”-methylpropanoyl)-3"- methyl-2'-(3"'-methylbutanoyl)phenyl)-3-methylbutanoate and has weak antibacterial activity.
Preparation and Characterization of Petai Pods Extract (Parkia speciosa Hassk.) Loaded Ethosomes Fitrya Fitrya; Najma Annuria Fithri; Annisa Amriani; Annisa Haryati; Dina Permata Wijaya
Science and Technology Indonesia Vol. 6 No. 1 (2021): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1542.739 KB) | DOI: 10.26554/sti.2021.6.1.19-24


Preparation of petai pods extract (Parkia speciosa) into ethosome aim to increased penetration through the skin. The method of cold is used in preparing petai pods extract encapsulation by ethosome with variation in concentration of soya lecithin, propylene glycol, and ethanol. The proportion of optimum formula ethosome consisted were 0,2 g soya lecithin, 1 ml propylene glycol, and 4 ml ethanol that response values obtained pH of 4,74, viscosity of 0,950 cP, %EE of 74,326%, and stability of 7,288%. The resulted of optimum formula obtained were PDI of 0,23, zeta potential of -7,5 mV, and particle size of 818,7 nm. Ethosome showed spheric particle using Transmissin Electron Microscopy. The diffusion analysis showed highest on ethosome of petai pods extract (9,525%) than petai pods extract (5,466%). The interaction study used FTIR show no chemical interaction extract pods and ethosome components