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All Journal Science and Technology Indonesia Jurnal Penelitian Sains INDRA: Jurnal Pengabdian kepada Masyarakat

Rennie Puspa Novita

Unknown Affiliation

Author-ID : 2484694

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Uji Aktivitas Antidiabetes Ekstrak Etanol Akar Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) terhadap Tikus Putih Jantan yang Diinduksi Diet Tinggi Lemak dan Fruktosa Annisa Amriani S; Fitrya Fitrya; Rennie Puspa Novita; Dapid Caniago
Jurnal Penelitian Sains Vol 23, No 2 (2021)
Publisher : Faculty of Mathtmatics and Natural Sciences

The purpose of this research to study the antidiabetic activity of extract in type 2 diabetes mellitus rats induced by high fat and fructose diet. Induction is done by giving fructose 1800 mg/kgBW and high fat (15% pork oil and 5% duck egg yolk) 15 g/rat for 30 days. Male Wistar albino rats are used as animal models which divide into 6 group, normal (aquadest), negative control (Na CMC 0,5%), positive control (Metformin 151,20 mg/kgBW), and 3 test (ethanol extract of kabau root 100, 200, and 400 mg/kgBW). Preprandial blood glucose levels are measured using DTN-410-K photometer, on day 0, 30, 35, 40, and 45. The result of AUC30-45 and percentage of decreasing blood glucose level for positive control group are 1727,01 and 73,29%, and 3 test group (100 mg/kgBW, 200 mg/kgBW, dan 400 mg/kgBW) are 1893,32 and 43,50%; 1849,14 and 51,41%; 1789,15 and 62,16%. This point indicate that ethanol extract of kabau root has an antidiabetic activity and there is no significant difference compared with metformin (p>0,05). According to the relation between percentage of blood glucose level with dose, value of ED50 is 194,64 mg/kgBW. Keywords: ethanol extract, kabau root, antidiabetic, high fat and fructose diet

Furosemide self nano emulsifying drug delivery system (SNEDDS) formulation comprising of capryol-90, polysorbate-80, and peg-400 with simplex-lattice-design Najma Annuria Fithri; Mardiyanto Mardiyanto; Rennie Puspa Novita; Vicky Andrean
Science and Technology Indonesia Vol. 2 No. 4 (2017): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Preparation of SNEDDS aims to improve solubility and absorption of furosemide in the body to reduce the dosage and minimize the side effects of drugs. Ternary diagram constructed from composition mixture produced nanoemulsion in the range of 20-40% of capryol-90, 20-40% polysorbate-80 and 40-60% PEG-400. Formulations of SNEDDS using Design-Expert®10 with simplex-lattice-design method in the study was aimed to investigate the effect of SNEDDS each component's proportions towards test responses. Emulsification time, drug content and viscosity were best demonstrated by run-7 with consecutive values of 131.68±2.14 seconds, 99.89±2.68% and 0.87±0.0043 mm2/s. The optimum formula was obtained through entering test response parameter data of all thirteen formula. Drug content and emulsification time was 107.0 ± 1.44% and 155.59±1.56 seconds with viscosity value 0.91±0.00 mm2/s. From the physical stability studies, SNEDDS formulas were stable and did not show phase separation when exposed to temparature stress testing.

Hepatoprotective effect of ethanol extract of matoa leaves (Pometia pinnata) against paracetamol-induced liver disease in rats Yosua Maranatha Sihotang; Eka Windiasfira; Hendro David Ginola Barus; Herlina Herlina; Rennie Puspa Novita
Science and Technology Indonesia Vol. 2 No. 4 (2017): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

The hepatoprotective effects of matoa leaves were evaluated by paracetamol-induced injury in rat’s hepatocytes. The ethanolic extract of matoa leaves (EEML) at doses of 200, 300, 500 mg/kg, po and silymarin at dose of 100 mg/kg, po were given for seven days. Silymarin was given as the reference drug. Hepatoprotective effect was studied by measuring the level of AST, ALT, ALP and total protein in serum. In vivo, oral treatment with EEML at dose of 500 mg/kg significantly reduced AST, ALT, ALP in serum whereas total protein was not significantly reduce in each groups. These results indicate that the hepatoprotective action of EEML is likely related to its potent antioxidative activity. Neutralizing reactive oxygen species enhancing the activity of original natural hepatic-antioxidant enzymes may be the main mechanisms of EEML against paracetamol-induced injury. Keywords: Matoa Leaves (Pometia pinnata), Paracetamol, Silymarin, Hepatoprotection

Edukasi herbal dan pengolahan minuman herbal sebagai peningkat sistem imun untuk mencegah infeksi COVID-19 Indah Solihah; Rennie Puspa Novita; Riana Sari Puspita Rasyid
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v3i1.144

The COVID-19 situation at the global and national levels is still at very high risk. A good immune system is needed to protect us from COVID-19. Eating healthy meals and increasing antioxidant consumption can help us to boost the body's immune system. Some herbs in Indonesia that are useful in boosting the immune system based on the Traditional Medicine Formulary are included red ginger, lime, cinnamon, and garlic. The Red ginger rhizome contains gingerol and shogaol, cinnamon bark contains cinnamaldehyde, lime has a high vitamin C content, and garlic bulbs contain ajoene. All of these compounds can synergistically improve the immune system. These ingredients are widely available and are processed into antioxidant herbal drinks that increase the immune system. The activity was carried out using the lecture method, discussion, and pretest-posttest to measure the level of participant knowledge. After the implementation of the activity, public knowledge increased regarding herbal ingredients, their processing, and preparation. As many as 100 percent of respondents were recognized the types of immune system enhancing herbs, 72 percent were understood how to process herbs, and 92 percent were understood how to prepare these herbs.

Co-Authors Annisa Amriani S Dapid Caniago Eka Windiasfira Fitrya Fitrya Hendro David Ginola Barus Herlina . Indah Solihah Mardiyanto Mardiyanto Najma Annuria Fithri Riana Sari Puspita Rasyid Vicky Andrean Yosua Maranatha Sihotang

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