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Pengembangan Sediaan Serbuk Antidiabetes dari Kombinasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) dan Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.) Rizki Yulianti; Partomuan Simanjuntak; Anny Victor Purba
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.859 KB) | DOI: 10.33096/jffi.v7i1.593

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglicemic. Mangosteen (Garcinia mangostana L.) and Salam (Syzygium polyanthum (Wight) Walp.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extract in decreasing blood sugar levels of diabetic rats. The rats divided into 6 groups: group I (normal control) without treatment, group II (negative control), group III (positive control), group IV (extract of mangosteen with dose of 400 mg), group V (extract of salam leaf with dose of 400 mg) and group VI (combination of mangosteen 200 mg and salam leaf 200 mg). Data were analyzed by One-Way Anova, followed by PostHoc Bonferroni analysis. Then the combination of the extract was formulated in powder dosage form blended with PVP, Sucralose and Lactose. The evaluation included physical test are organoleptic, water content and flowability time. The results showed that the combination of the extracts of mangosteen and salam leaf comprising half doses of eact extract could lower blood glucose levels significantly (P<0.05) with better efficacy than each single extract and the combination of extracts able to produce powder dosage form with the requirement (organoleptic, water content and flowability time).
Pengembangan Pewarna Rambut dari Ekstrak Kental Gambir (Uncaria gambir Roxb.) dalam Sediaan Setengah Padat LATIRAH LATIRAH; TETI INDRAWATI; ANNY VICTOR PURBA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1327.363 KB)

Abstract

Gambier (Uncaria gambir Roxb.) is one of the alternatives used as a natural colouring agent in foods and drinks. The aim of this research was to develop extract gambier as a hair dye. Gambier extract was obtained by macerated with water in base condition (pH 8-10). The resulting extract was evaluated for hair adhesion, organoleptic, physical, chemical and irritation test to rabbit’s skin. Viscous gambier extract has 0HUE value of 338.73 ± 0.116 (purple), can be processed into permanent hair colour cream with 0HUE value of 42.167 ± 0.231 (red), pH 8, ammoniac odor, produce red yellowish hair with 0HUE value of 53.43 ± 0.060, fulfil requitment for microbiology, not iritant to rabbit's skin has density of 0.903 0.006 g/L and viscosity of 13,100 ± 0.000 cP.
Pengembangan Produk Gel Sabun Wajah Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) dan Daun Sosor Bebek (Kalanchoe pinnata (Lam.) Per.) sebagai Anti Bakteri Penyebab Jerawat ANARISA BUDIATI; ANNY VICTOR PURBA; SHIRLY KUMALA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.098 KB)

Abstract

Averrhoa bilimbi L. fruits and Kalanchoe pinnata (Lam.) Per. leaves are useful as anti bacterial. The extracts containing the compound bufadienolides have the potential to be used as an anti bacterial. The purpose of this study to fi nd the best formula of the preparation facial wash gel with the active substance from the combination of extracts. Search methods extract concentration using the agar diff usion to obtain regional Diameter Inhibition (DDH) of each extract and the combinations. Research conducted with 3 forrmula containing extracts with diff erent concentrations. The results of the evaluation of the preparation at room temperature storage does not change the color, shape and scent. Retrieved best formula is the formula I containing a concentration of 0.7% resulting extract preparations light green and scented perfume. The results of the evaluation of the formula I at room temperature after 3 month storage include: high foam in hard water 17 mL, high foam in distilled water >25 mL, the specifi c gravity 1.0386 g/cm3, surface tension 19, 3627 dyne/cm, viscosity 853,33-1103,33 cPs, pseudoplastis fl ow properties, pH 5.16, anti bacterial test results using Diameter test Inhibitory Region shows constraints on Staphylococcus aureus by 5,0±0 mm.
Pemodelan Statistik Pemberian Air Susu Ibu (ASI) Eksklusif Berdasarkan Faktor Demograli SARAH ZAIDAN; SWASONO R. TAMAT; NURITA ANDAYANI; ANNY VICTOR PURBA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Exclusive breastfeeding is defined as giving breast milk to a baby without any additional drink, food or beverages during the first 6 months after birth. Today there is a decline in exclusive breastfeeding, and among others, one reason is the increase in the participation of mothers in the workforce, especially in urban areas. Many factors that affect the regularity of exclusive breastfeeding by working mothers, one of which, is the demographic factor. This study aims to obtain profile data of exclusive breastfeeding by working mothers and statistical modelling of exclusive breastfeeding by working mothers based on demographic factor, by conducting a survey on 384 respondents. This research uses descriptive analysis and logistic regression analysis with SPSS software version 15.0. Descriptive analysis showed that most mothers working in Jakarta (61.2%) did not give exclusive breastfeeding. Logistic regression statistical analysis showed that age, occupation, distance to work, and travel time to the workplace of working mothers are dominant factors that influence exclusive breastfeedings, with the p-value is smaller than the p value (Sig) = 0.05.
Pengembangan Krim Pewarna Rambut Permanen Mengandung Ekstrak Daun Ketapang (Terminalia catappa L) dan Ekstrak Daun Jambu Biji (Psidium guajava L) Erny Marleny Effendy; Shelly Taurhesia; Anny Victor Purba
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 16 No. 02 Desember 2019
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1260.491 KB) | DOI: 10.30595/pharmacy.v16i2.5859

Abstract

Perubahan warna rambut menjadi putih pada usia lanjut sering kurang disukai. Keanekaragaman hayati Indonesia mendorong peneliti untuk melakukan pengembangan pewarna rambut dari ekstrak daun ketapang dan daun jambu biji. Ekstrak daun jambu biji mengandung pyrogallol yang berfungsi sebagai pembangkit warna dan ekstrak daun ketapang mengandung punicalagin sebagai polyphenol yang berfungsi sebagai pewarna. Kedua bahan ini diformulasikan dalam sediaan krim dengan tujuan memudahkan dalam pemakaian. Pada penelitian ini digunakan ekstrak daun jambu biji dengan konsentrasi 12,5% dan ekstrak daun ketapang dengan variasi konsentrasi 10; 12,5; dan 15%. Penambahan logam tembaga sulfat 1% (F5B) terhadap formula optimal menjadikan warna lebih tua. Pengujian warna pada pewarna rambut dengan penambahan logam menggunakan alat kromameter memberikan warna merah dengan nilai a (9,00) warna biru dengan nilai b (3,37) warna yang terrefleksi adalah coklat tua, sedangkan pewarna rambut tanpa penambahan logam memberikan warna merah dengan nilai a (7,36), warna biru dengan nilai b (16,96) warna yang terrefleksikan adalah coklat muda. Hasil uji keamanan menggunakan tiga ekor kelinci dengan metode uji iritasi akut dermal dengan indek iritasi nol (0) dinyatakan aman serta tidak mengiritasi.
Evaluasi manajemen pengadaan dan distribusi obat di dinas kesehatan kota Bandar Lampung periode tahun 2016 Nopiyansyah Nopiyansyah; Anny Victor Purba; Wahyudi Uun Hidayat
Holistik Jurnal Kesehatan Vol 14, No 1 (2020)
Publisher : Program Studi Ilmu Keperawata Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (379.043 KB) | DOI: 10.33024/hjk.v14i1.2088

Abstract

Evaluation of drug management on procurement and distribution at Bandar Lampung Health Authority  Background : Management of public medicine and medical supplies in aimstoen sure continuity, availability and affordability of efficient drug services, availability and affordability of efficient drug services. Procurementis a continuous activity starting from selection, determining the amount needed, adjusting between demand and budget, selecting procurement methods, selecting suppliers, determining contract specifications, monitoring procurement and payment processes.Purpose : To determine the mechanism of drug procurement, drug distribution and delivery problems, constraints faced in the procurement and distribution of drugs.Method: A qualitative descriptive with technique of collecting data through in-depth interviews and reviews of documents on drug procurement and distribution.Results: Procurement of drug scarried out by the Pharmacy Installation of the Bandar Lampung Health Authority  based on usage pattern was not in accordance with the report on the use of the drug request sheets that have been prepared by the Public health centers. There were 78 drug items (44.3%) held more than those proposed, 77 drug items (43.7%) drugs were heldless than proposed, and only 21 medicinal items (12%) drugs that were carried out according to the ones proposed. Based on the results of the interview, problems with the distribution and delivery of drugs sent by the Pharmacy Installation founded problems which were 30 of Public health centers of drug has been sent expire date <1 year, 7 health centers have been sent expired date drugs and 26 health centers have been sent drugs that were not ordered. The most common constraints faced in the procurement and distribution of drugs carried out  are not availabe drugs in pharmaceutical whole sales and drugs sent to the Public health centers not in accor dance with tho serequested by the Public health centers.Conclusion : The procurement of drugs carried out and usage pattern is not in accordance with the report on the use of the drug request sheet that has been prepared successfully, ABC VEN method according to budget, the comordibity method was not appropriate wheres drugs most of which were held clinically not in accordance with the 10 most common diseases that occurred in the Bandar Lampung Health Authority  in 2016.Keywords: Drugs management; Procurement; Distribution; Pharmacy installationPendahuluan: Manajemen obat publik dan perbekalan kesehatan di bertujuan untuk menjamin kelangsungan, ketersediaan dan keterjangkauan pelayanan obat yang efisien, efektif dan rasional serta menjamin kualitas mutu obat. Pengadaan merupakan kegiatan yang berkesinambungan dimulai dari pemilihan, penentuan jumlah yang dibutuhkan, penyesuaian antara kebutuhan dan dana, pemilihan metode pengadaan, pemilihan pemasok, penentuan spesifikasi kontrak, pemantauan proses pengadaan dan pembayaran.Tujuan: Untuk mengetahui mekanisme pengadaan obat, masalah pendistribusian dan pengiriman obat, kendala yang dihadapi dalam pengadaan dan pendistribusian obat.Metode: Penelitian deskriptif kualitatif dengan pengumpulan data melalui wawancara mendalam dan telaah dokumen pengadaan dan pendistribusian obat.Hasil: Pengadaan obat yang dilakukan Instalasi Farmasi Dinas Kesehatan Kota Bandar Lampung berdasarkan pola konsumsi tidak sesuai dengan laporan pemakaian lembar permintaan obat yang telah disusun puskesmas. Terdapat 78 item obat (44,3%) yang diadakan lebih dari yang diusulkan, 77 item obat (43,7%) yang diadakan kurang dari yang diusulkan, dan hanya 21 item obat (12%) yang diadakan sesuai dengan yang diusulkan. Berdasarkan hasil wawancara, masalah pendistribusian dan pengiriman obat yang dikirimkan oleh Instalasi Farmasi Dinas Kesehatan Kota Bandar Lampung yakni 30 puskesmas pernah dikirimkan obat expiredate < 1 Tahun, 7 Puskesmas pernah dikirimkan obat yang sudah expiredate dan 26 puskesmas pernah dikirimkan obat yang tidak dipesan. Kendala yang paling sering dihadapi dalam pengadaan dan pendistribusian obat yang dilakukan oleh Instalasi Farmasi Dinas Kesehatan Kota Bandar Lampung yaitu obat kosong di pedagang besar farmasi dan obat yang dikirimkan ke puskesmas tidak sesuai dengan yang diminta oleh puskesmas.Simpulan: Pengadaan obat yang dilakukan Instalasi Farmasi Dinas Kesehatan Kota Bandar Lampung berdasarkan pola konsumsi tidak sesuai dengan laporan pemakaian lembar permintaan obat yang telah disusun puksesmas, metode ABC VEN sesuai anggaran, metode komordibitas belum sesuai dimana obat yang terbanyak diadakan secara klinis tidak sesuai dengan 10 penyakit terbanyak yang terjadi. 
UJI AKTIFITAS ANALGETIK KOMBINASI EKSTRAK BUAH BELIMBING WULUH (Averrhoa bilimbi L.) DAN DAUN SELEDRI (Apium graveolens L.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) DENGAN METODE GELIAT Rizki Febriyanti; Anny Victor Purba; Partomuan Simanjuntak
Parapemikir : Jurnal Ilmiah Farmasi Vol 7, No 1 (2018): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v7i1.737

Abstract

Rasa sakit merupakan gejala awal dari munculnya suatu penyakit sering terjadi di masyarakat danpernah dialami oleh hampir semua orang. Adanya efek samping berbahaya yang ditimbulkan oleh obatkimia, akhir-akhir ini penggunaan bahan alam sebagai obat cenderung meningkat. Seledri (Apiumgraveolens L.) dan Belimbing wuluh (Averrhoa bilimbi L.) memiliki kandungan yang sama yaituflavonoid yang memiliki aktifitas sebagai analgetik. Flavonoid di dalam kedua tanaman tersebut didugadapat berfungsi sebagai analgetik karena dapat menghambat sintesis prostaglandin yang mengakibatkantidak terjadinya pelepasan mediator-mediator nyeri. Tujuan penelitian ini adalah untuk mengetahuiaktivitas analgetik pada ekstrak buah belimbing wuluh, ekstrak daun seledri, dan kombinasi keduanya.Belimbing wuluh dan seledri dimaserasi menggunakan etanol 70%. Pengujian aktivitas analgetik keduaekstrak dan kombinasinya menggunakan dosis 500 mg/kg BB. Jika berat mencit rata-rata 20 g BB makavariasi dosisnya 10 mg/20 g BB. Untuk kombinasi kedua ekstrak dibuat perbandingan ekstrak belimbingwuluh : ekstrak seledri 1:3, 2:2, dan 1:3. Kelompok pertama diberi CMC Na 0,5% sebagai kontrol negatif,kelompok kedua diberi parasetamol 1% sebagai kontrol positif, kelompok selanjutnya diberi larutan ujiekstrak sebagai kontrol ekstrak. Setelah 30 menit, diberikan larutan penginduksi asam asetat 3%kemudian mengamati geliat mencit. Hasil menunjukkan bahwa kombinasi ekstrak belimbing wuluh :ekstrak seledri 1:3 memiliki aktivitas analgetik yang paling baik dibanding aktivitas ekstrak tunggalmaupun kombinasi yang lainnya.Kata Kunci : ekstrak belimbing wuluh, Averrhoa bilimbi L., ekstrak daun seledri, Apium graveolens L.,aktivitas analgetik
Penentuan Kadar Fenol Total Dan Uji Aktivitas Antioksidan Kombinasi Ekstrak Herba Pegagan (Centella asiatica L. Urban) Dan Buah Mahkota Dewa (Phaleria macrocarpa(Scheff.) Boerl.) Purgiyanti Purgiyanti; Anny Victor Purba; Hendig Winarno
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1395

Abstract

Many diseases that were originally caused by free radicals, so that free radicals and antioxidants observed extensively in the world of health. Gotu kola herb and fruit Mahkota Dewa were supposed to have antioxidant activity that can reduce the activity of free radicals. The purpose of this study was to determinethe total phenol content and the antioxidant activity of the combination of herbal extracts of Gotu kola (Centella asiatica L. Urban) and Mahkota Dewa fruit (Phaleria macrocarpa (Scheff.) Boerl.) Gotu kola herb extracts and Mahkota Dewa fruit extracts obtained by maceration using ethanol 70% with the ratio between crude drug powder and solvent was 1: 5. The antioxidant activity was determined by DPPH (2,2-diphenyl-1 picrylhydrazyl). Total phenol content was determined using UV-Vis spectrophotometry reagent Folin- Ciocalteau the results expressed in gallic acid equivalents (mg GAE / 100 g extract). The result shows that the combination of the ethanol extract of Centellaasiatica herb and Mahkota Dewa fruit in the ratio of 1: 1 has a total phenol content of 3.67 mg GAE / 100 g of extract and active as an antioxidant with IC50 value of 67.07 mg / mL, and vitamin C as active comparison as an antioxidant with IC50 value of 8.81 mg / mL. This study shows that a combination of herbal extracts between Gotu Kola and MahkotaDewa have potentials as natural antioxidants.Keywords— Gotu Kola herb, Mahkota Dewa fruit, total phenols, Folin-Ciocalteau,DPPH