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All Journal VALENSI Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society
Takeshi Katayama
Department of Applied Biological Science, Faculty of Agriculture, Kagawa University
Agriculture, Biological Sciences & Forestry Chemistry

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Hypoglycemic Effect of Mahogany (Swietenia macrophylla King) Bark Extracts in Alloxan-induced Diabetic Rats Syamsul Falah; Mega Safithri; Takeshi Katayama; Toshisada Suzuki
Wood Research Journal Vol 1, No 2 (2010): Wood Research Journal
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51850/wrj.2010.1.2.89-94

Abstract

In this study, in vivo hypoglycemic activity of mahogany (Swietenia macrophylla) bark extracts was evaluated against alloxan-induced diabetic rats. The hypoglycemic effect was compared to that of standard glibenclamide. Oral administration of hot water and methanol extracts at a dose of 250 mg/kg body weight for thirteen days of daily treatment to diabetic rats was found to possess significant dose dependant hypoglycemic effect in diabetic rats. It less active than that of glibenclamide at dose of 3.22 mg/kg. However, the hot water extract showed significant hypoglycemic activity compared to that standard drug.  Phytochemical analysis of hot water and methanol extracts has shown posistive  test for the presence of  alkaloids, flavonoids, tannins, saponins, dan terpenoids. Histopathological studies of pancreas revealed its significant effect of β-cell count. Therefore, the hot water extract could serve as good adjuvant to other oral hypoglycemic agents and seems to be promising for the development of phytomedicines for diabetes mellitus.  
Hypoglycemic Effect of Mahogany (Swietenia macrophylla King) Bark Extracts in Alloxan-induced Diabetic Rats Syamsul Falah; Mega Safithri; Takeshi Katayama; Toshisada Suzuki
Wood Research Journal Vol 1, No 2 (2010): Wood Research Journal
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51850/wrj.2010.1.2.89-94

Abstract

In this study, in vivo hypoglycemic activity of mahogany (Swietenia macrophylla) bark extracts was evaluated against alloxan-induced diabetic rats. The hypoglycemic effect was compared to that of standard glibenclamide. Oral administration of hot water and methanol extracts at a dose of 250 mg/kg body weight for thirteen days of daily treatment to diabetic rats was found to possess significant dose dependant hypoglycemic effect in diabetic rats. It less active than that of glibenclamide at dose of 3.22 mg/kg. However, the hot water extract showed significant hypoglycemic activity compared to that standard drug.  Phytochemical analysis of hot water and methanol extracts has shown posistive  test for the presence of  alkaloids, flavonoids, tannins, saponins, dan terpenoids. Histopathological studies of pancreas revealed its significant effect of β-cell count. Therefore, the hot water extract could serve as good adjuvant to other oral hypoglycemic agents and seems to be promising for the development of phytomedicines for diabetes mellitus.  
Antioxidant, Cytotoxic Activities and Total Phenolic Content of Four Indonesian Medicinal Plants Waras Nurcholis; Bambang Pontjo Priosoeryanto; Edy Djauhari Purwakusumah; Takeshi Katayama; Toshisada Suzuki
Jurnal Kimia Valensi Jurnal Valensi Volume 2, No.4, Mei 2012
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.104 KB) | DOI: 10.15408/jkv.v2i4.267

Abstract

The crude ethanol extracts of four Indonesian medicinal plants namely Curcuma xanthorrhiza Roxb.,Phyllanthus niruri Linn., Andrographis paniculata Ness., and Curcuma aeruginosa Roxb. wereexamined for their antioxidant (radical scavenging) activity using 2, 2-diphenyl-2-picrylhydrazyl(DPPH) free radical and cytotoxicity using brine shrimp lethality test (BSLT). The total phenoliccontent was used the Folin-Ciocalteu method. IC50 values for DPPH radical scavenging activityranged from 14.5 to 178.5 μg/ml, with P. niruri having the lowest value and therefore the mostpotent, and C. aeruginosa having the highest value. LC50 values for BSLT ranged from 210.3 to593.2 μg/ml, with C. xanthorrhiza and A. paniculata having the lowest and highest values,respectively. The total phenolic content of the Indonesian plants ranged from 133.0 ±3.7 to863.3±54.7 mg tannic acid equivalent per 1 g extract, with C. aeruginosa and P. niruri having thelowest and highest values, respectively. A positive correlation between free radical scavengingactivity and the content of phenolic compounds was found in the four of Indonesian medicinal plants.
Co-Authors Bambang Pontjo Priosoeryanto Edy Djauhari Purwakusumah MEGA SAFITHRI Syamsul Falah Toshisada Suzuki Waras Nurcholis