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All Journal Medical Laboratory Technology Journal Anakes: Jurnal Ilmiah Analis Kesehatan
Chairlan Chairlan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Detection of Mycobacterium tuberculosis by Microscopic Technique of Sputum AFB and ICT (Cocktail Antigen) TB Retno Martini Widhyasih; Annisa Husnun Hanifah; Chairlan Chairlan; Dewi Inderiati
Medical Laboratory Technology Journal Vol. 5 No. 2 (2019): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1723.421 KB) | DOI: 10.31964/mltj.v5i2.246

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. The diagnosis of pulmonary TB in general still relies on microscopic examination with a sputum smear for Acid Fast Basil (AFB). Microscopic examination to detect M. tuberculosis has high specificity, but the sensitivity is 35-70%. The sputum culture method is the gold standard for the diagnosis of pulmonary TB but requires a long time, which is 6-8 weeks. In recent years ICT (Immuno Chromatography Test) has been introduced to identify potential and useful TB antigens to help diagnose pulmonary TB. Antigens detected were ESAT-6, CFP-10, CFP-21, and MPT-64. This study aims to compare the results of the examination of specimens of suspect TB sputum with the ICT method and AFB. This study based on observational with analytic design cross-sectional on 56 samples of Stored Biological Material suspects TB that were examined by the AFB method and the ICT method (Cocktail Antigen). Statistical test results Fisher Exact (α = 0.05) showed no difference between microscopic examination of smear sputum and ICT (Cocktail Antigen) TB (p = 1,000). Nevertheless, the use of ICT reagents for the diagnosis of pulmonary TB still needs to be further investigated, especially to find out the exact causes of false positive and false negative reactions.
Respons C-Reactive Protein (CRP) dan Laju Endap Darah (LED) Sebagai Petanda Inflamasi Pada Pasien Covid-19 Sumiati Bedah; Chairlan Chairlan; Indah Nurwita Sari
Anakes : Jurnal Ilmiah Analis Kesehatan Vol 7, No 2 (2021): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v7i2.660

Abstract

Coronavirus Disease 2019(COVID-19) adalah penyakit yang disebabkan oleh Coronavirusjenis baru SAR-Cov-2. Penderita COVID-19 sering mengalami respons imun akibat inflamasi. C-Reactive Protein (CRP) dan Laju Endap Darah (LED) merupakan biomarker adanya inflamasi. Tujuan dari penelitian ini adalah untuk mengetahui respons CRP dan LED pada pasien COVID-19 di RSUD Koja Jakarta Utara.  Penelitian menggunakan metode deskriptif analitik berupa data rekam medik pasien COVID-19 di RSUD Koja Jakarta Utara pada bulan September 2020-Februari 2021. Didapatkan hasil dari 70 pasien COVID-19 infeksi lebih banyak dialami Lansia usia 46-65 tahun yaitu sebanyak 42 orang (60,0%). Sebanyak 65 orang (92,85%) mengalami kenaikan kadar CRP di atas  nilai normal ( 0,5 mg / dL) dan lima  orang (7,15 %) dengan kadar CRP normal.  Disamping itu hampir seluruh,  69 pasien  (98,57%) COVID-19 mengalami  kadar LED di atas nilai normal.  Kadar LED di atas nilai normal paling banyak terjadi pada lansia berusia antara 46-65 tahun sebanyak 42 orang (60,00%) baik laki laki maupun perempuan.  COVID-19 lebih banyak menginfeksi Lansia usia 46-65 tahun kemungkinan dipengaruhi imun tubuh telah mulai berkurang dan adanya  penyakit degeneratif  seperti Hipertensi ataupun Diabetes Mellitus sebagai komorbid. Dari hasil penelitian ini, dapat dinyatakan pemeriksaan CRP dan LED bermanfaat untuk digunakan sebagai penanda adanya inflamasi pada infeksi COVID-19, sehingga direkomendasikan untuk digunakan sebagai uji laboratorium  yang mudah, sederhana, cepat dan murah. Kata Kunci        : COVID-19, CRP, LED.
Co-Authors Annisa Husnun Hanifah Dewi Inderiati Indah Nurwita Sari Retno Martini Widhyasih Sumiati Bedah