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All Journal Nexus Biomedika ad-Dawaa : Journal of Pharmaceutical Sciences
Diding Heri Prasetyo
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Uji Ekstrak Daun Kumis Kucing Dalam Menurunkan Kadar Alanin Transaminase pada Mencit yang Diinduksi Minyak Goreng Pemanasan Berulang Steffi Meidiana; Diding Heri Prasetyo; . sarsono
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Backgrounds: Orthosiphon stamineus Benth leaves contain various antioxidants like flavonoids, organic acids, and terpenoids. The main active chemical substances which are derived from flavonoids, namely sinensetin, and non-flavonoids, namely rosmarinic acids, have antioxidants activities as free radical scavengers. This study aimed to determine the effects of Orthosiphon stamineus Benth leaves extract in decreasing the levels of ALT in male strain Swiss webster mice induced by reheated cooking oil. Methods: This study was an experimental laboratory with a post test only controlled group design. The samples were 25 male strain Swiss webster mice, 2-3 months old and + 25-30 grams weight, each. Samples were taken incidentally sampling, arranged into 5 groups randomly, consisted of 5 mice each group. The control group (K) was administered distilled water and treatment group 1 (P 1) were administered reheated cooking oil. While treatment group 2 (P 2), treatment group 3 (P 3) and treatment group 4 (P 4) were consecutively administered 3.5 mg, 7.0 mg and 14.0 mg/25 gr BW of Orthosiphon stamineus Benth leaves extract and reheated cooking oil for 14 days. On the 15th day, blood samples were drawn from the mice through plexus retroorbitalis using microtubuler tube then their ALT levels were measured. Data were analyzed using One-way ANOVA (? = 0.05) and followed by Post Hoc Multiple Comparisons test (LSD) (? = 0.05). Results: Mean rate of alanin transaminase level in group K, P 1, P 2, P 3 and P 4 were 54.600 + 7.765 U/L; 95.000 + 23.537 U/L; 62.200 + 7.463 U/L; 60.400 + 6.427 U/L and 57.400 + 10.922 U/L, in a row. Conclusions: Orthosiphon stamineus Benth leaves extract decreased alanin transaminase level in mice induced reheated cooking oil. Keywords: ALT, Orthosiphon stamineus Benth leaves extract, reheated cooking oil.
Perbedaan Kadar Kuersetin pada Propolis di Pasaran Wilayah Surakarta Rizky Amalia P; Diding Heri Prasetyo; Sri Hartati H
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Quercetin is one of the active substances in propolis which has many benefits for human health as antioxidant, anticancer, antiallergy, cardioprotector, gastroprotector, lowering blood pressure, and increase the body immunity. Quercetin content in propolis is influenced by geographical factors, differences in the season, climate, plants, bees, and the type of solvent. This study aims to determine differences of quercetin levels of propolis in the market area of ??Surakarta. Methods: This study uses observational analytic methods. Samples of propolis were sold in the market area of ??Surakarta. Sampling was done by purposive sampling as many as six brands of propolis which is divided into 6 groups: P1, P2, P3, P4, P5, and P6. Each group was measured five times. Determination of quercetin in propolis by using UV-Vis spectrophotometer method of Prussian Blue. Data were analyzed for quercetin levels with one-way ANOVA statistical test using the computer program SPSS 17 for windows. Results: Average of quercetin levels of propolis samples obtained results P1 = 9.4440 0.06465 g/mL, P2 = 4.4760 0.08591 g/mL, P3 = 10.2700 0.04000 g/mL, P4 = 7.4120 0.06648 g/mL, P5 = 8.6780 0.03347 g/mL, P6 = 8.4960 0.10877 g/mL with p < 0.001. Conclusion: There are differences of quercetin levels of propolis in the market area of ??Surakarta. Keywords: Propolis, quercetin levels, UV-Vis spectrophotometer, Prussian Blue
Perbedaan Kadar Kuersetin pada Propolis Ekstrak Etanol dan Propolis Ekstrak Air Nurrini Susanti Yulianti; Diding Heri Prasetyo; Sri Hartati H
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Propolis contains flavonoids. One of them is quersetin. Solvent used is propolis extraction influence quercetin level of the extract. This research aims to determine whether there is a difference of Quercetin Level in Ethanol Extract Propolis and Water Extract Propolis. Methods: This research is an experimental research. Subject of this research is propolis from Gejen RT 3 RW 2, Kerjo, Karanganyar. The samples were carried out by purposive sampling. Concentration of quercetin is determined by using UV-Vis spectrophotometer by Prussian-blue methode. Five samples are made for each extract. The data then analized using unpaired t-test by SPSS 17 for windows. Results: Averages of quercetin level in this research are 10,04800,53798 g/mL in Ethanol extract propolis and 1,04400,06804 g/mL in Water Extract propolis with p < 0,05. Conclusions: There are differences in there is a difference of quercetin content in Ethanol Extract Propolis and Water Extract Propolis. Keywords: Propolis, Quercetin level, UV-Vis spectrophotometer, Prussian-blue
Ekstrak Patikan Kebo (Euphorbia hirta L.) Menurunkan Hitung Eosinofil Bronkus pada Tikus Wistar Model Asma Alergi Danus Hermawan; Kisrini Kisrini; Diding Heri Prasetyo
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 2 No 1 (2019)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.723 KB) | DOI: 10.24252/djps.v2i1.6625

Abstract

Paparan alergen pada saluran napas secara berulang memicu terjadinya reaksi asma alergi. Asma alergi diinduksi oleh degranulasi sel mast yang melepaskan mediator proinflamasi seperti histamin, leukotrien, dan prostaglandin yang memicu terjadinya inflamasi bronkus yang ditandai dengan peningkatan eosinofil bronkus. Peningkatan eosinofil bronkus dapat ditekan oleh asam kafeat dan flavonoid. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak patikan kebo terhadap hitung eosinofil bronkus pada tikus Wistar model asma alergi. Subyek penelitian berupa 25 ekor tikus Wistar jantan dengan berat badan ± 200 g dan berumur 6 minggu, dibagi dalam 5 kelompok yaitu: Kontrol (K), Asma alergi (A), ekstrak patikan kebo 10 (P1), 15 (P2), 20 mg/tikus/hari (P3). Hitung eosinofil bronkus postes diukur setelah 28 hari perlakuan. Hitung eosinofil bronkus dianalisis dengan SPSS versi 23.0 menggunakan uji One Way ANOVA dan dilanjutkan uji post hoc multiple comparison Tukey. Tingkat kemaknaan digunakan p<0,05. Hitung eosinofil bronkus tikus P1, P2, dan P3 lebih rendah secara bermakna dibanding tikus Asma Alergi (p<0.05). Patikan kebo mampu menurunkan jumlah eosinofil bronkus pada tikus Wistar model asma alergi.
Co-Authors . sarsono Danus Hermawan Idrus Alwi Kisrini Kisrini Murdani Abdullah Nurrini Susanti Yulianti Rizky Amalia P Sally Aman Nasution Sri Hartati H Steffi Meidiana