Yovita Hartantri
Department Of Internal Medicine, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung 40161

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A Phenotypic Comparison between HIV Positive and HIV Negative Tuberculous Meningitis Patients Ita Anggraini; Yovita Hartantri; Ahmad Rizal
Makara Journal of Health Research Vol 21, No 3 (2017): December
Publisher : Universitas Indonesia

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Abstract

Background: Tuberculous meningitis (TBM) is the most common type of meningitis found in humans and the Human Immunodeficiency Virus (HIV) is a major risk factor of TBM. This study aimed to identify phenotype differences, such as clinical manifestations, cerebrospinal fluid (CSF) findings, and chest x-ray results between HIV positive and HIV negative TBM patients. Methods: This was a comparative analytical study of 123 TBM patients. The patients were divided into two groups based on their HIV status, and their phenotypes were compared. A retrospective cross sectional designed study was carried out in case report form using a TBM cohort and Rifampicin dose finding study in the neurological ward at the Dr. Hasan Sadikin General Hospital Bandung, between January 2015 and August 2016. Categorical data was analysed using Chi square tests and the alternative Fisher&rsquo;s Exact test and Mann-Whitney test was used for numerical data. P-values were significant if p < 0.05. Results: Of the phenotypic parameters, only the CSF results had statistical difference. HIV positive subjects had higher CSF to blood glucose ratios (0.42 vs. 0.18; p = 0.001) and fewer leukocyte cells (41 vs. 199; p < 0.001). Conclusions: CSF findings of TBM patients&rsquo; revealed differences between HIV positive and negative patients, whilst clinical manifestations and chest x-ray results showed no differences.
Gambaran Hasil Terapi TB Paru pada Pasien TB-HIV di RSUP dr.Hasan Sadikin Bandung Tahun 2012-2014 Dinka Anni Zamy; Bony Wiem Lestari; Yovita Hartantri
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
Publisher : Faculty of Medicine Universitas Indonesia

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Tuberkulosis (TB) merupakan penyakit infeksi oportunistik yang sering dijumpai pada pasien Human Immunodeficiency Virus (HIV). Berkaitan dengan tingginya kejadian TB pada penderita HIV World HealthOrganization (WHO) mencanangkan program penanggulangan TB-HIV. Penelitian ini bertujuan untukmengetahui hasil terapi TB Paru pada pasien TB-HIV yang dirawat inap dan rawat jalan di RSUP dr.HasanSadikin. Penelitian deskriptif kuantitatif ini menggunakan sumber data dari rekam medis pasien TB-HIV diinstalasi rawat inap dan rawat jalan RSUP dr.Hasan Sadikin Bandung Tahun 2012-2014. Karakteristik sosiodemografi meliputi usia, jenis kelamin, pendidikan, pekerjaan, status pernikahan, dan tempat tinggal. Terdapat60 (84,5%) subjek yang berusia 20-40 tahun, laki-laki 50 (70,4%) subjek, lebih banyak dari perempuan.Subjek dengan pendidikan SMA sebanyak 33 (46,4%) orang dan subjek yang tidak bekerja 20 (71,8%) orang,47 (66,2%) subjek sudah menikah dan subjek yang berdomisili di Bandung 56 (78,9%) orang. Luaran terapipada pasien ko-infeksi TB-HIV yang sembuh berjumlah 17 (23,9%) subjek, sembuh lengkap 14 (19,7%)subjek, putus pengobatan 24 (33,8%) subjek, pindah sebanyak 8 (11,3%) subjek, dan meninggal 8 (11,3%)subjek dan tidak terdapat luaran terapi gagal. Hasil luaran terapi TB paru pada pasien ko-infeksi TB-HIVdi instalasi rawat inap dan rawat jalan di RSUP dr.Hasan Sadikin yang banyak adalah putus pengobatandibandingkan dengan luaran terapi sembuh. Kata kunci: Koinfeksi, TB-HIV, luaran terapi TB. Overview Treatment Results of Pulmonary TB in TB-HIV Patients atdr. Hasan Sadikin Hospital Bandung In 2012-2014 Abstract Tuberculosis (TB) is commonly found as an opportunistic infection in patients with Human Immunodeficiency Virus (HIV). Due to the high incidence of TB in people with HIV, World Health Organization (WHO) declared TB-HIV program. This study aims to determine the results of pulmonary TB therapy inhospitalized and ambulatory TB-HIV patients at dr. Hasan Sadikin Hospital. This quantitative descriptivestudy was done by using the medical records of inpatient and outpatient TB-HIV data in 2012-2014. Sociodemographiccharacteristicsinclude age,gender,education,occupation, marital status, andresidence. Therewere60 (84.5%) subjects aged 20-40 years old, comprised of 50 male (70.4%) subjects, which more thanwomen. Subjects with a high school education were 33 (46.4%), unemployed were 20 subjects (71.8%), 47(66.2%) of subjects were married and lived in Bandung were 56 (78.9%) people. The outcomes therapy inpatients co-infected with TB-HIV were as followed 17 (23.9%) of subjects were cured, 14 (19.7%) of subjectsfully recovered, 24 (33.8%) of the subjects were dropped out from treatment, 8 (11.3%) of the subjects movedaway, 8 (11.3%) of the subjects passed away, and there was no failure therapy. More patients were found outto be dropping out of treatment compared with to the cured patients in Pulmonary TB treatment outcomes inpatients co-infected with TB-HIV at the inpatient and outpatient care of dr. Hasan Sadikin. Keywords: co-infection, TB-HIV, TB treatment outcomes.
A Phenotypic Comparison between HIV Positive and HIV Negative Tuberculous Meningitis Patients Anggraini, Ita; Hartantri, Yovita; Rizal, Ahmad
Makara Journal of Health Research
Publisher : UI Scholars Hub

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Abstract

Background: Tuberculous meningitis (TBM) is the most common type of meningitis found in humans and the Human Immunodeficiency Virus (HIV) is a major risk factor of TBM. This study aimed to identify phenotype differences, such as clinical manifestations, cerebrospinal fluid (CSF) findings, and chest x-ray results between HIV positive and HIV negative TBM patients. Methods: This was a comparative analytical study of 123 TBM patients. The patients were divided into two groups based on their HIV status, and their phenotypes were compared. A retrospective cross sectional designed study was carried out in case report form using a TBM cohort and Rifampicin dose finding study in the neurological ward at the Dr. Hasan Sadikin General Hospital Bandung, between January 2015 and August 2016. Categorical data was analysed using Chi square tests and the alternative Fisher’s Exact test and Mann-Whitney test was used for numerical data. P-values were significant if p < 0.05. Results: Of the phenotypic parameters, only the CSF results had statistical difference. HIV positive subjects had higher CSF to blood glucose ratios (0.42 vs. 0.18; p = 0.001) and fewer leukocyte cells (41 vs. 199; p < 0.001). Conclusions: CSF findings of TBM patients’ revealed differences between HIV positive and negative patients, whilst clinical manifestations and chest x-ray results showed no differences.