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Uji Perbandingan Aktivitas Antidiabetes Brotowali (Tinospora crispa (L) Miers.) dengan Metformin pada Mencit (Mus Musculus) Putih Jantan Monik Krisnawati
Jurnal Dunia Farmasi Vol 5, No 1 (2020): Edisi Desember
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v5i1.4734

Abstract

Pendahuluan: Diabetes mellitus merupakan penyakit metabolik dengan karakteristik hiperglikemia akibat kelainan sekresi insulin, kerja insulin, atau keduanya. Pengobatan penyakit diabetes mellitus dapat menggunakan Obat Hipoglikemik Oral (OHO) seperti Metformin ataupun obat tradisional seperti Brotowali (Tinospora crispa (L) Miers). Aktivitas antidiabetes batang Brotowali berkaitan dengan adanya kandungan alkaloid, flavonoid, glikosida, dan terpen Tujuan: Untuk mengetahui dan membandingkan aktivitas antidiabetes antara Brotowali dengan Metformin pada mencit jantan. Metode: Penelitian eksperimental pre and post test control group design, menggunakan 15 ekor mencit yang diberi beban glukosa dan dibagi menjadi 3 kelompok yaitu, kelompok kontrol negatif (aquadest), kelompok kontrol positif (Metformin) dengan dosis 65 mg/kg BB, dan kelompok zat uji (kapsul Brotowali) dengan dosis 130 g/Kg BB. Hasil: Kapsul Brotowali memiliki aktivitas antidiabetes pada mencit putih jantan yang dilihat dari rerata penurunan kadar glukosa darah, namun penurunan  kapsul Brotowali lebih lambat dibandingkan  kelompok perlakuan Metformin pada menit ke 90 yakni 165,6 mg/dl. Kesimpulan: Kapsul Brotowali terbukti memiliki aktivitas antidiabetes yang ditunjukkan dengan hasil analisis statistik keseluruhan nilai signifikansi lebih kecil dari 0,05 dengan nilai t hitung lebih besar dari t tabel.
Uji Sifat Fisik Dan Aktivitas Antibakteri Krim Ekstrak Etanol Daun Bidara (Ziziphus Spina-Christi L.) Terhadap Propionibacterium Acnes ATCC 6919 Monik Krisnawati
Journal of Health (JoH) Vol 8 No 2 (2021): Journal of Health - Juli 2021
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v8n2.p56-66.2021

Abstract

Acne is a chronic inflammatory disease of the polysebaceous region characterized by the appearance of comedones, papules, pustules, nodules, and cysts. Bidara contains phenolics and flavonoids which are useful as anti-inflammatory, antioxidant, antimicrobial, and prevent tumors. Other chemical constituents of Bidara that play a role in treatment are alkaloids, phenols, flavonoids, and terpenoids. This study aims to determine the effect of the concentration of the ethanolic extract of Bidara leaves (Ziziphus-Spina Christi L.) on the physical properties of the cream and the antibacterial activity of the Bidara leaf cream against the bacteria Propionibacterium acnes ATCC 6919 made in type O/W (Oil in Water) using a vanishing cream with 3 kinds of concentration, namely 10%, 12.5%, and 15%. Physical properties (organoleptic, spreadability, adhesion, and protection) and antibacterial activity against Propionibacterium acnes were measured using the well diffusion method. The results of the test of physical properties and antibacterial activity were analyzed using statistical tests with a 95% confidence level. The results of the physical properties test showed that the cream of ethanol extract of Bidara leaves had the aroma of Bidara leaves, greenish color, semisolid form, and homogeneous texture. The cream of ethanol extract of Bidara leaves with a concentration of 15% showed the greatest dispersion and adhesion at 6.9 cm and 6 seconds. The protection ability of bidara ethanol extract cream at the overall concentration was shown up to 5 minutes.
Gambaran Pelayanan Informasi Obat (PIO) Terhadap Kepuasan Pasien di Apotek Afi Farma Bantul Monik Krisnawati
Jurnal Indonesia Sehat Vol. 1 No. 03 (2022): JURINSE, Desember 2022
Publisher : SAMODRA ILMU: Lembaga Penelitian, Penerbitan, dan Jurnal Ilmiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.867 KB)

Abstract

Background: Drug information service is one of the pharmaceutical activities carried out by pharmacists. Provision of drug information is impartial, critically evaluated and with the best evidence in all aspects of drug use to other health professionals, patients or the public. Satisfaction is a customer's emotional reaction to the perceived service quality with the expected service quality. Patient satisfaction is a vitally indispensable indicator to improve drug information service. Purpose: The aim of this research is to determine patient satisfaction with drug information service at the Apotek Afi Farma. Method: This research was used the Quantitatif which is using the Cross Sectional Approach. The total respondent are 70 peoples. Data analysis was carried out using a quantitative descriptive analysis approach. Result: The results showed that the quality of Drug Information Services (PIO) at Apotek Afi Farma on the five dimensions had positive values, namely the dimensions of tangible, reliability, and responsiveness. On the other hand, the assurance and empathy dimensions show a zero value. Conclusion: Patients have been very satisfied with drug information services on the dimensions tangible, reliability, and responsiveness as well as satisfaction on the dimensions of assurance and empathy.