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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Berkala Ilmu Kesehatan Kulit dan Kelamin INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry Journal of Tropical Pharmacy and Chemistry JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JCRS (Journal of Community Research and Service) Journal of halal product and research (JHPR) Berkala Ilmiah Kimia Farmasi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Clinical, Analytical, Pharmaceutical, and Pharmacy Community Journal

Esti Hendradi

Departement Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya

Author-ID : 2536238

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Preparation and Characterization of BSA-loaded Chitosan Microspheres Hendradi, Esti; Sari, Retno; Anggai, Rifka Anggraini
Health Notions Vol 2 No 9 (2018): September 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model Anti-Inflammatory Drug Hendradi, Esti; Isnaeni, Isnaeni; Mahmudah, Rifaatul
Health Notions Vol 2 No 9 (2018): September 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freeze-drying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content.

Formulation and evaluation of erythropoietin-alginate microspheres at different amount of drug Hariyadi, Dewi; Hendradi, Esti; Lailiyah, Khoirotul
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research formulate erythropoietin-alginate microspheres and to evaluate characteristics of erythropoietin-alginate microspheres at different amount of drug using aerosolization. Amount of erythropoietin are 10.000 IU (F1); 20.000 IU (F2); 60.000 IU (F3). The mixture of erythropoietin-alginate was sprayed into CaCl2 and was stirred at 1000 rpm for 30 minutes. Formulas resulted spherical shape of microspheres. The size of microspheres was 2.77 Âµm for F1; 3.89 Âµm for F2; and 4.42 Âµm for F3. The results of swelling index showed that swelling index of microspheres increased by increasing the concentration of erythropoietin. The results were in accordance with the size of the microspheres that increased with increasing concentration of drug. The yields of microspheres obtained were respectively 91.92%; 87.53%; 86.50% for F1, F2 and F3. It can be concluded that the particle size of microspheres, swelling index increased by increasing concentration of erythropoietin. In contrast, yield of microspheres decreased by increasing drug concentration. In conclusion, formula of microspheres were potential in terms of characteristics and may recommend for further in vivo study.Â

OPTIMASI SEDIAAN TRANSDERMAL PATCH NATRIUM DIKLOFENAK TIPE MATRIKS Hendradi, Esti; Isnaeni, .; Fridayanti, Aditya; Pujianti, Efrin
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 3 (2011)
Publisher : Indonesian Research Gateway

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The study was designed to investigate the optimation of preparation of transdermal patch sodium diclofenac matrix type. In this study, matrix-type base containing diclofenac sodium were prepared using polymeric combination of EC N-20 and PVP K-30 in different ratios ( 9:1 (Formula I); 8:2 (Formula II); 7:3 (Formula III)) and 6:4 (Formula IV). The moisture content was calculated as a difference between initial and final weight with respect to final weight. The homogeneity of patch surface was determined using Scanning Electron Microscope (SEM) Released test using dissolution tester were carried out in 500 mL of phosphate buffer salin pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. The concentration of sodium diclofenac released was determined using spectrophotometric method at l 276 nm. Data was analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0.05). It is concluded that the polymeric combination EC N-20 and PVP K-30 in composition 7:3 (Formula III) was the best formulation. ABSTRAK Telah dilakukan penelitian tentang optimasi sediaan transdermal patch natrium diklofenak tipe matriks. Pada penelitian ini, basis matriks mengandung natrium diklofenak dibuat dengan kombinasi polimer etilselulose (EC) N-20 dan polivinilpirolidon (PVP) K-30 dengan berbagai perbandingan yaitu 9:1 (Formula I); 8:2 (Formula II); 7:3 (Formula III)) dan 6:4 (Formula IV). Moisture content (MC) ditentukan dengan cara berat awal dikurangi berat akhir dan dibagi dengan berat akhir. Homogenitas permukaan patch ditentukan dengan menggunakan Scanning Electron Microscope (SEM). Uji pelepasan natrium diklofenak dilakukan dengan alat disolusi dan menggunakan dapar fosfat salin pH 7,4 ± 0.05 sebanyak 500,0 mL, kecepatan pengadukan 50 rpm dan percobaan dilakukan pada suhu 37 ± 0,5°C. Kadar natrium diklofenak yang terlepas ditentukan dengan metoda spektrofotometer pada panjang gelombang (l) 276 nm. Data yang diperoleh dianalisa secara statistik menggunakan program SPSS dengan derajat kepercayaan 95% (α = 0,05). Kesimpulan yang didapatkan adalah komposisi polimer EC N-20 dan PVP K-30 dengan perbandingan 7:3 (Formula III) adalah formula yang terbaik.

Preparation and Characterization of Ba-Alginate Microspheres Containing Ovalbumin Hariyadi, Dewi Melani; Hendradi, Esti; Irawan, Mukhlis Bayu
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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The use of microspheres nowadays is important in the pharmaceuticals formulation. The aim of the present research was to evaluate physical characteristics of ovalbumin-loaded alginate microspheres using aerosolisation technique at various concentrations of alginate and BaCl2. Alginate microspheres were characterized in terms of encapsulation efficiency, yield, particle size, surface morphology and protein integrity. The comparative study between concentrations of BaCl2 and alginate polymer was investigated. Increasing concentration of alginate polymer from 2.5 to 3.5% reduced their particle size and formed smoother and spherical microspheres. Increasing Ba2+ concentration, simultaneous increased the encapsulation efficiency and yield. Scanning electron microscope (SEM) photomicrographs revealed that with the increase in the electrolyte concentration the density of the cross link is also increased. Smoother surface was demonstrated when the electrolyte concentration is increased from 0.5M to 0.75M. Formula prepared using 0.75M BaCl2 and 3.5% alginate polymer resulted the highest encapsulation efficiency (92%), the highest microspheres yield (73%) and the smallest microspheres size (3.73µm). Most of the formulations maintain the integrity of ovalbumin after 2 hours incubation in pH 1.2 followed by 8 hours incubation in pH 7.4. The different formulations produced different physical characteristics of ovalbumin-loaded alginate microspheres.

Efek Perbandingan Surfaktan dan Kosurfaktan Terhadap Karakteristik dan Efisiensi Penjebakan Ovalbumin Dalam Mikroemulsi Hendradi, Esti; Yuwono, Mochammad
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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ABSTRACT: The study was conducted to investigate the effect of composition of surfactant (Span 80 and Tween 80) and cosurfactant (butanol) on characteristics and ovalbumin entrapment in the microemulsion water in oil (w/o).The composition of surfactant (Span 80 and Tween 80) and cosurfactant (butanol) used were 6:3, 7:3 and 8:3. Evaluation was conducted on the surface tension, viscosity, droplet size, pH and the efficiency of ovalbumin trapping in microemulsion system. Results were analyzed by statistic using one way analysis of variance (ANOVA) with 95% confidence level (α = 0,05). From the results it was concluded that the composition of surfactant and cosurfactant 7:3 resulted in the best microemulsion. Keywords: microemulsion, surfactant, cosurfactant, butanol, ovalbumin ABSTRAK : Penelitian ini dilakukan untuk mengetahui pengaruh komposisi surfaktan (Span 80 dan Tween 80) dan kosurfaktan (butanol) terhadap karakteristik dan penjebakan ovalbumin dalam mikroemulsi minyak dalamm air (w/o). Perbandingan surfaktan (Span 80 dan Tween 80) dan kosurfaktan (butanol) adalah 6:3, 7:3 dan 8:3. Evaluasi yang dilakukan meliputi tegangan permukaan, viskositas, ukuran droplet, pH dan efisiensi penjebakan ovalbumin dalam sistem mikroemulsi. Hasil dianalisis dengan statistik menggunakan ANOVA dengan tingkat kepercayaan 95% (α = 0,05). Dari hasil penelitian ini disimpulkan bahwa bahwa perbandingan surfaktan dan kosurfaktan sebesar 7:3 menghasilkan mikroemulsi yang terbaik. Kata Kunci: mikroemulsi, surfaktan, kosurfaktan, butanol, ovalbumin

Preparation and Characterization of Ba-Alginate Microspheres Containing Ovalbumin Hariyadi, Dewi Melani; Hendradi, Esti; Irawan, Mukhlis Bayu
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

The use of microspheres nowadays is important in the pharmaceuticals formulation. The aim of the present research was to evaluate physical characteristics of ovalbumin-loaded alginate microspheres using aerosolisation technique at various concentrations of alginate and BaCl2. Alginate microspheres were characterized in terms of encapsulation efficiency, yield, particle size, surface morphology and protein integrity. The comparative study between concentrations of BaCl2 and alginate polymer was investigated. Increasing concentration of alginate polymer from 2.5 to 3.5% reduced their particle size and formed smoother and spherical microspheres. Increasing Ba2+ concentration, simultaneous increased the encapsulation efficiency and yield. Scanning electron microscope (SEM) photomicrographs revealed that with the increase in the electrolyte concentration the density of the cross link is also increased. Smoother surface was demonstrated when the electrolyte concentration is increased from 0.5M to 0.75M. Formula prepared using 0.75M BaCl2 and 3.5% alginate polymer resulted the highest encapsulation efficiency (92%), the highest microspheres yield (73%) and the smallest microspheres size (3.73Âµm). Most of the formulations maintain the integrity of ovalbumin after 2 hours incubation in pH 1.2 followed by 8 hours incubation in pH 7.4. The different formulations produced different physical characteristics of ovalbumin-loaded alginate microspheres.

Efek Perbandingan Surfaktan dan Kosurfaktan Terhadap Karakteristik dan Efisiensi Penjebakan Ovalbumin Dalam Mikroemulsi Hendradi, Esti; Yuwono, Mochammad
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

ABSTRACT: The study was conducted to investigate the effect of composition of surfactant (Span 80 and Tween 80) and cosurfactant (butanol) on characteristics and ovalbumin entrapment in the microemulsion water in oil (w/o).The composition of surfactant (Span 80 and Tween 80) and cosurfactant (butanol) used were 6:3, 7:3 and 8:3. Evaluation was conducted on the surface tension, viscosity, droplet size, pH and the efficiency of ovalbumin trapping in microemulsion system. Results were analyzed by statistic using one way analysis of variance (ANOVA) with 95% confidence level (Î± = 0,05). From the results it was concluded that the composition of surfactant and cosurfactant 7:3 resulted in the best microemulsion. Keywords: microemulsion, surfactant, cosurfactant, butanol, ovalbumin ABSTRAK : Penelitian ini dilakukan untuk mengetahui pengaruh komposisi surfaktan (Span 80 dan Tween 80) dan kosurfaktan (butanol) terhadap karakteristik dan penjebakan ovalbumin dalam mikroemulsi minyak dalamm air (w/o). Perbandingan surfaktan (Span 80 dan Tween 80) dan kosurfaktan (butanol) adalah 6:3, 7:3 dan 8:3. Evaluasi yang dilakukan meliputi tegangan permukaan, viskositas, ukuran droplet, pH dan efisiensi penjebakan ovalbumin dalam sistem mikroemulsi. Hasil dianalisis dengan statistik menggunakan ANOVA dengan tingkat kepercayaan 95% (Î± = 0,05). Dari hasil penelitian ini disimpulkan bahwa bahwa perbandingan surfaktan dan kosurfaktan sebesar 7:3 menghasilkan mikroemulsi yang terbaik. Kata Kunci: mikroemulsi, surfaktan, kosurfaktan, butanol, ovalbumin Â Â

OPTIMASI SEDIAAN TRANSDERMAL PATCH NATRIUM DIKLOFENAK TIPE MATRIKS Hendradi, Esti; Isnaeni, .; Fridayanti, Aditya; Pujianti, Efrin
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

The study was designed to investigate the optimation of preparation of transdermal patch sodium diclofenac matrix type. In this study, matrix-type base containing diclofenac sodium were prepared using polymeric combination of EC N-20 Â and PVP K-30 in different ratios ( 9:1 (Formula I); 8:2 (Formula II); 7:3 (Formula III)) and 6:4 (Formula IV). The moisture content was calculated as a difference between initial and final weight with respect to final weight. The homogeneity of patch surface was determined using Scanning Electron Microscope (SEM) Released test using dissolution tester were carried out in 500 mL ofÂ phosphate buffer salin pH 7.4 Â± 0.05 at temperature 37 Â± 0.5Â°C with speed of swirl 50 rpm. The concentration of sodium diclofenac released was determined using spectrophotometric method at l 276 nm. Data was analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (Î± = 0.05). Â It is concluded that the polymeric combination EC N-20 and PVP K-30 in composition 7:3 (Formula III) was the best formulation. ABSTRAK Telah dilakukan penelitian tentang optimasi sediaan transdermal patch natrium diklofenak tipe matriks. Pada penelitian ini, basis matriks mengandung natrium Â diklofenak dibuat dengan kombinasi polimer Â etilselulose (EC) N-20 Â dan polivinilpirolidon (PVP) K-30 dengan berbagai perbandingan yaitu 9:1 (Formula I); 8:2 (Formula II); 7:3 (Formula III)) dan 6:4 (Formula IV). Moisture content (MC) ditentukan dengan cara berat awal dikurangi berat akhir dan dibagi dengan berat akhir. Homogenitas permukaan patch ditentukan dengan menggunakan Scanning Electron Microscope (SEM). Uji pelepasan natrium diklofenak dilakukan dengan alat disolusi dan menggunakan dapar fosfat salin Â pH 7,4 Â± 0.05 sebanyak 500,0 mL, kecepatan pengadukan 50 rpm dan percobaan dilakukan pada suhu 37 Â± 0,5Â°C. Kadar natrium diklofenak yang terlepas ditentukan dengan metoda spektrofotometer pada panjang gelombang (l) 276 nm. Data yang diperoleh dianalisa secara statistik menggunakan program SPSS dengan derajat kepercayaan 95% (Î± = 0,05). Â Kesimpulan yang didapatkan adalah komposisi polimer EC N-20 dan PVP K-30 dengan perbandingan Â 7:3 (Formula III) adalah formula yang terbaik.

PENDIDIKAN KOGNITIF DAN AFEKTIF DAGUSIBU UNTUK PENCEGAHAN RESISTENSI ANTIBIOTIK DI SMA SURABAYA Abhimata Paramanandana; Dini Retnowati; Andang Miatmoko; Dewi Isadiartuti; Sugiyartono1; Mohammad Agus Sjamsur Rijal; Dwi Setiawan; Esti Hendradi; Tutiek Purwanti; Noorma Rosita; Dewi Melani Hariyadi; Tristiana Erawati; Ardhani Dwi Lestari1; Helmy Yusuf; Retno Sari
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Antibiotics are not only used for humans, but also often used for cattle and livestock which are then been consumed by humans. This over prescribed and missed used of antibiotic is a major factor in antibiotic resistance. Antibiotic resistance is a condition where bacteria are unable to be treated with antibiotics. In fact, the use of antibiotics is the first response in curing infectious diseases (by bacteria) and preventing infectious diseases spreading. With antibiotic resistance, preventing infectious diseases by bacteria became harder. This community service activity came up with a slogan "Antibiotic Resistence Awareness Movement" was carried out in Surabaya 10 Public High Schools and Surabaya 17 Public High Schools with 60 students per school using several methods, namely: (a) giving lecture material using LCD projectors ) the implementation of poster making competitions, and (c) poster presentations that have been made that are accompanied by question and answer, and (d) evaluation activities in the form of written tests covering pre-test and post-test. Concerning the results of posters results, poster presentations and improving the results of this posttest can be concluded as a result of an increase in understanding and or knowledge of students of SMA 10 and SMA 17 Surabaya

Co-Authors Abhimata Paramanandana Abhimata Paramanandana Adeltrudis Adelsa Danimayostu Aditya Fridayanti Afif Nurul Hidayati Ameliana, Lidya Andang Miatmoko Anggai, Rifka Anggraini Ardhani Dwi Lestari1 Arya Putra Damari Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Desya Shafa Namira Dewi Hariyadi Dewi Isadiartuti Dewi Melani Hariyadi Diah Mira Indramaya Dini Retnowati Dwi Murtiastutik Dwi Setiawan Dyah Rahmasari Evy Ervianti Evy Ervianti Firdausiah Fania Dwi Putri Putri Frida Magdalena Fridayanti, Aditya Hariyadi, Dewi Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Iskandar Zulkarnain Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Karina Dyahtantri Pratiwi Khoirotul Lailiyah Lailiyah, Khoirotul Linda Astari M. Yulianto Listiawan Mahmudah, Rifaatul Marissa Astari Rubianti Mochammad Yuwono Mohammad Agus Sjamsur Rijal Mufariha Mufariha Muhammad Al Rizqi Dharma Fauzi Muhammad Faris Adrianto Noorma Rosita Pepy Dwi Endraswari, Pepy Dwi Pratiwi Pudjiastuti Pujianti, Efrin Pujianti, Efrin Qurrotu A’yunin Rahmadewi Rahmadewi Rahmadhanniar, Erwinda Rahmi Annisa Raudatul Patimah Retno Sari Retno Sari Retno Sari Rifaatul Mahmudah Rifka Anggraini Anggai Riyana Noor Oktaviyanti Riyanto Teguh Widodo Sawitri Sawitri Sayyidati Aqilah Siti Wafiroh Sugiyartono Sugiyartono Sugiyartono1 Tri Susanti Tristiana Erawati Tutiek Purwanti Uswatun Chasanah Uswatun Chasanah Yusuf Wibisono Yusuf, Helmy

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