Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

1.857

P-Index

This Author published in this journals

All Journal Folia Medica Indonesiana Jurnal NERS Indonesian Journal of Biotechnology Dental Journal (Majalah Kedokteran Gigi) Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Orthopaedi and Traumatology Surabaya (JOINTS)

Ferdiansyah Mahyudin

(SCOPUS ID: 57148390100), Department Of Orthopaedic And Traumatology, Faculty Of Medicine, Universitas Airlangga/ Dr. Soetomo General Hospital, Surabaya

Author-ID : 2536932

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

Published : 15 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Characteristics of Renal Cell Carcinoma Patients in RSUD Dr Soetomo Surabaya in 2014-2017 Ferdiansyah Rusdhy; Wahjoe Djatisoesanto; Dyah Erawati; Dyah Fauziah
Health Notions Vol 3, No 12 (2019): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn31206

Renal Cell Carcinoma is a type of malignant renal tumour. According to GLOBOCAN 2012 data, it ranked 17th on the most common malignancy in Indonesia with an incidence rate of 1.5 per 100000 citizens. Mortality rates for men is 1.6 per 100000, while it is 0.8 per 100000 case for women. The clinical symptoms of flank pain, flank mass, and hematuria, are usually only found in patients with later stages of cancer development. This descriptive study aims to present data on characteristics of Renal Cell Carcinoma patients. Data were collected from histopathological medical records of RSUD Dr. Soetomo Surabaya. We found that 25 of 40 patients are male, with most patients aged between 50 to 59 at time of diagnosis. Majority of patients worked as a private sector worker, and had high school level education. They presented with stage 2 tumour, with Clear Cell Renal Cell Carcinoma subtype. All 40 patients were treated by Radical Nephroctomy. Keywords: renal cell carcinoma; characteristics

Clinical Features in Metastatic Bone Disease with and without Pathological Fractures: A Comparative Study Putu Garry; Mouli Edward; Rosy Setiawati; Sjahjenny Mustokoweni; Ferdiansyah Mahyudin
Health Notions Vol 3, No 10 (2019): October
Publisher : Humanistic Network for Science and Technology (HNST)

Background: Pathological fracture complications such as impaired clinical features is suspected to increase the mortality in MBD. In Indonesia, the habit of delayed seeking of medical treatment was common and potentially led to pathological fracture. Aim: This study compared the clinical features between MBD with and without pathological fracture. Methods: This was a retrospective study of MBD at Dr. Soetomo General Hospital in 2011-2015. We compared the clinical features by pain in Visual Analog Scale (VAS); general health presentation represented by laboratory findings; and the history of non-medical treatments. Results: 64 patients had MBD were included in this study. 37 (57.8%) of them presented with pathological fractures, and 27 (42.2%) without. Pain was the most common chief complaint (76.5%). No significant difference found between the MBD with and without pathological fracture in all variables (p=0.122; p=0.64; p=0.823; p=0.417, p=1.000 for VAS, hemoglobin, albumin, calcium, and history of non-medical treatment respectively). This probably associated with the therapy and a variety of primary tumors underlying the MBD. However, 6 out of 10 patients with history non-medical treatment presented with fractures. Conclusion: There's no significant difference in clinical features of MBD from both groups, while those with fractures had worse conditions. Keywords: Metastatic bone disease, Pathological fracture, Clinical features

Femur Pathological Fracture Caused by Metastatic Bone Disease Derived from Foot Squamous Cell Carcinoma Ferdiansyah .; Mouli Edward; Muhammad Hardian Basuki; Deny Mory Aryawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 02 (2017)
Publisher : Universitas Muhammadiyah Surabaya

Background : Bone is an organ and the most common site that prone to metastatic cancer and cause serious morbidity. Besides, metastatic cancer to bone will limit skeletal function so that decrease quality of life and even death that most of them caused by its complication.Objective : Reporting a rare case about Squamous Cell Carcinoma that cause femur pathological fracture caused by Metastatic Bone Disease.Material and Method : Case report in women patients 55 years old with femur close fracture one-third middle caused by Metastatic Bone Disease in RSUD Soetomo Surabaya, period May 2015-March 2016.Data is taken retrospectively from medical record through interview, physical examination, radiological examination, and laboratory.Result and Discussion : Patients are treated in hospital because of femur close fracture one-third middle caused by Metastatic Bone Disease. Based on physical and radiological examination, it is decided being done by skin traction first. The next plan is surgery. Patients are treated with interlocking nail left femur. Evaluation after surgery is done with medical rehabilitation, that is ROM exercise. Until now, 9 months after surgery, patients still control routinely to be done chemotherapy and there is improvement in patient’s condition.Conclusion : Metastatic process in bone often cause pathological fracture. Bone Metastatic is common from Breast, Lung, Prostate and Kideney Cancer. There was no publication before about Bone Metastatic Disease come from Squamous Cell Cancer. Mirel’s score is used as guiding in fixation prior to the next treatment. Decision of surgery is considered through patient’s objective and subjective appraisal that can be calculated in Abdurrahman score system.

Uji Biokompabilitas pada Implan Orthopedi Antara Implan Impor, Implan Lokal dari Material Impor, dan Prototipe Stainless Steel 316L dari Material Lokal Ferdiansyah Mahyudin; Heppy Chandra Waskita; Dwikora Novembri Utomo; Heri Suroto; Tri Wahyu Martanto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACT Demands of orthopedic implants are increasing in Indonesia, but its production are limited and still imported. Stainless steel, especially 316L is one of metal that is used commonly. This research evaluates biocompatibility of stainless steel 316L implant prototype, local implant manufactured using imported stainless steel, and imported stainless steel implant. Cytotoxicity test used mesenchymal human cell with MTT assay. Irritation test, acute toxicity/pyrogenicity test, and implantation test used 24 Wistar rats respectively which were assigned to 4 groups. We evaluate Draize score, weight and rectal temperature changes, and fibrous capsule ring thickness. Cytotoxicity test shows viable cell percentage in stainless steel 316L implant prototype, local implant, and imported implant are 83.7%, 87.5%, and 83.7% respectively. Comparison test using One Way ANOVA shows no significant difference between 3 groups (p>0.05). Iritation test results in 3 groups are grade 0 (no edema and no erythema). Acute toxicity/pyrogenicity test shows no statistically significant difference (p>0.05) among all groups. There is also no significant difference (p>0.05) of fibrous capsule ring thickness on 1 and 4 weeks after implantation. Based on ISO for medical test guide, stainless steel 316L implant prototype is safe and has similar biocompatibility test result compared to local and imported implant.Keywords : stainless steel 316L, biocompatibility, orthopaedic implantCorrespondence to : ferdiansyah@fk.unair.ac.id ABSTRAKKebutuhan implan orthopedi terus meningkat di Indonesia, namun produksinya terbatas dan sebagian besar masih impor dari luar negeri. Stainless steel, utama 316L adalah salah satu metal yang sering digunakan. Penelitian ini mengevaluasi biokompatibilitas dari prototipe implan stainless steel 316L, implan lokal yang diproduksi menggunakan stainless steel impor, dan implan stainless steel impor. Uji sitotoksisitas menggunakan sel mesenkim human dengan MTT assay. Uji iritasi, uji pirogenositas, dan uji implantasi menggunakan 24 tikus Wistar yang terbagi dalam 4 grup. Kami mengevaluasi skor Draize, perubahan berat dan temperatur rektal, dan ketebalan fibrous capsule ring. Uji sitotoksisitas menunjukkan persentase viabilitas sel pada prototipe stainless steel 316L, implan lokal, dan implan impor berturut-turut adalah 83,7%; 87,5%; dan 83,7%. Uji komparasi dengan One Way Anova tidak menunjukkan perbedaan signifikan diantara 3 grup (p>0,05). Hasil uji iritasi 3 grup menunjukkan grade 0 (tidak ada edema dan eritema). Uji pirogenositas tidak menunjukkan perbedaan signifikan pada semua grup (p>0,05). Tidak ada perbedaan signifikan (p>0,05) pula pada ketebalan fibrous capsule ring di minggu ke 1 dan 4 setelah implantasi. Berdasarkan ISO untuk pedoman uji di bidang medis, prototipe stainless steel 316L aman dan memiliki kesamaan hasil uji biokompatibilitas bila dibandingkan dengan implan lokal dan impor.Kata kunci : stainless steel 316L, uji biokompatibilitas, implan orthopaediKorespondensi : ferdiansyah@fk.unair.ac.id

Hemangioma Pedis and Tuberculoma Pedis Sinistra in Children Ferdiansyah MD; Mouly Edward; Muhammad Hardian Basuki; Ahmad Hannan Amrullah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

HISTORY: The girl 15 years old, had main complaint, there was a mass in her pedis since she got 2 years old, look red, no pain although in walk, size equal with the skin. The mass got bigger and pain in walk. The mass get bleedy after had crushed by stone, after that bleedy always happen when there was a contact, although soft touch. Patient had history contact with tuberculosis patient.INTERESTING POINTS FOR DISCUSSION: Tuberculoma is a mass that happened because infected bacil mycobacterium tuberculosis, hemangioma is a soft tissue mass that formed by vascular. hemangioma commonly happened in children about 4-10% in children’s tumor. It happened in a girl 3-5 more times than in a boy. Both of them are rare happen in the same time, especially in pedis. From this case, we can found both type in the same patient.SOLUTION AND RATIONALE: For this case of soft tissue tumor,we use open biopsy. After we found the result , the best treatment for hemangioma and tuberculoma of the pedis for this case is below knee amputation.FINAL OUTCOME: For this case, the best treatment is amputation, and after amputation, the patient never complain about pain anymore, she feel satisfied and overall her quality of life is improving.

The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article Romaniyanto Romaniyanto; Cita Rosita Sigit Prakoeswa; Damayanti Tinduh; Hari Basuki Notobroto; Fedik Abdul Rantam; Dwikora Novembri Utomo; Heri Suroto; Ferdiansyah Ferdiansyah
Indonesian Journal of Biotechnology Vol 26, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.63318

Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.

Cytotoxicity test and characteristics of demineralized dentin matrix scaffolds in adipose-derived mesenchymal stem cells of rats Desi Sandra Sari; Ernie Maduratna; F. Ferdiansyah; I Ketut Sudiana; Fedik Abdul Rantam
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 4 (2018): December 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Demineralized dentin matrix (DDM) scaffold is a substitute material for the bone contained in human teeth. DDM is a scaffold-derived tooth dentine containing type I collagen and bone morphogenetic protein (BMP). While DDM possesses the ability to perform osteoinductive and osteoconductive roles, a cytotoxicity test of DDM scaffold remains extremely important in evaluating the level of toxicity of a material if cultured in cells. Adipose-derived mesenchymal stem cells (ADMSCs) are multipotent in nature because they contain progenitor cells and have the potential for differentiation via adipogenic, osteogenic and chondrogenic pathways. ADMSCs are also known to have high biocompatibility and the ability to combine with other bone material. Purpose: The purpose of this study was to determine the cytotoxicity and characteristics of DDM scaffolds derived from bovine teeth in the ADMSCs of rats cultured in vitro. Methods: This research constituted an experimental study. ADMSCs were isolated from the inguinal fat of rats. Thereafter, DDM was extracted from bovine teeth and formed 355-710 μm-sized particles. DDM scaffolds were assessed using SEM and the effects of DDM scaffolds on the cell viability of ADMSCs at concentrations of 10%, 50%, and 100% analyzed by means of 3-4,5’dimethylihiazol-2-yl,2.5-di-phenyl-tetrazolium bromide (MTT) assay. The results obtained were then analyzed by an ANOVA to establish the difference between the groups. Results: SEM results showed the diameter sizes of the dental tubulis DDM scaffolds to be approximately 4.429 μm and 7.519 μm. The highest cell viability (97.08%) was found by means of an MTT test to be in ADMSCs at a concentration of 10% compared to those at concentrations of 50% and 100%. Conclusion: In conclusion, DDM scaffold derived from bovine teeth with a particle size of 355-710 μm produces a low cytotoxicity effect on ADMSCs.

Intraarticular Allogenic Mesenchymal Stem Cells and Vascular Endothelial Growth Factor Injection in Anterior Cruciate Ligament Reconstruction Dwikora Novembri Utomo; Ferdiansyah Mahyudin; Arif Zulkarnain; Purwati Purwati; Rossy Setyawati
Folia Medica Indonesiana Vol. 56 No. 1 (2020): March
Publisher : Universitas Airlangga

Graft tunnel healing is important for the successful reconstruction of the anterior cruciate ligament by using the hamstring tendon autograft. There are studies that intra graft tunnel Bone Marrow Mesenchymal stem cells (BMSCs) or intra graft tunnel Vascular endothelial growth factor (VEGF) accelerated graft tunnel healing. This study aimed to investigate the effect of using BMSCs+VEGF injected intra-articular on graft tunnel healing. We reconstructed the anterior cruciate ligament (ACL) of 12 rabbits using an autograft hamstring tendon with and without intra-articular BMSCs+VEGF. Histological evaluation was done at 3 and 6 weeks after ACL reconstruction. On the surface between the graft and the bone tunnel obtained collagen fiber thickness or Sharpey fiber is significantly more than the control group (p< 0.05) in the evaluation of 3 weeks and 6 weeks either side of the tibia and the femur. To evaluate the progression of the treatment, treatment group and control group gained progression had significantly when compared to 3 weeks and 6 weeks. It can be concluded that intra-articular injection of VEGF+BMSCs can accelerate the integration of the graft tunnel from histology evaluation on 3 and 6 weeks.

Modern and Classic Wound Dressing Comparison in Wound Healing, Comfort and Cost Ferdiansyah Mahyudin; Mouli Edward; M Hardian Basuki; Yunus Basrewan; Ansari Rahman
Jurnal Ners Vol. 15 No. 1 (2020): APRIL 2020
Publisher : Universitas Airlangga

Introduction: Wound care has also developed rapidly after the dissemination of the concept of TIME (Tissue, Infection, Moisture, and Wound Edge) in modern dressing (MD). The aim of this study was to compare modern dressings (MDs) and classic dressings (CDs) in terms of patient comfort, cost effectiveness and wound healing.Methods: A prospective study design with total of 25 participants. The sampling technique used was consecutive sampling. Patient comfort was assessed through the frequency of wound care and pain scale using the Visual Analogue Scale (VAS). Cost-effectiveness was assessed using direct and indirect costs. Wound healing was assessed using the Bates-Jensen Wound Assessment Tool (BWAT) score. The data was analyzed using the independent t and Mann-Whitney tests.Results: In terms of comfort, the mean for the number of times that wound care was performed and the pain scale in the participants using MD was (3.07 ± 0.88 times and VAS 4.59 ± 0.72, respectively), which is less compared to using CD (4.60 ± 1.84 times each and VAS 5.43 ± 0.75). Referring to the indirect and direct costs, MD (13.67 ± 6.09 and 527.63 ± 84.47, respectively) has the same cost-effectiveness as CD (14.00 ± 7.64 and 482.68 ± 98.08, respectively). In terms of healing, the mean of the BWAT score in MD (31.26 ± 1.69) was better compared to CD (33.07 ± 1.65).Conclusion: The application of MD has the same cost-effectiveness as CD with a more satisfactory outcome for the wounds in terms of comfort and healing.

THE CLINICAL AND RADIOLOGICAL OUTCOME OF BOVINE HYDROXYAPATITE (BIO HYDROX) AS BONE GRAFT Arifin Arifin; Ferdiansyah Mahyudin; Mouli Edward
Journal Orthopaedi and Traumatology Surabaya Vol. 9 No. 1 (2020): April 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v9i1.2020.9-16

Background: A bone graft is a transplanted material to enhance the bone healing response through the osteogenic, osteoconductive, and osteoinductive process on the tissue. Bone autograft has long been the gold standard with the susceptibility of limited supply from the donor and the morbidity risk. The limitation presented by both autograft and allograft has led to the development of bovine hydroxyapatite (BHA). This research was conducted to evaluate the clinical and radiological outcomes of bovine hydroxyapatite as a bone graft. Methods: This research is a descriptive study using a consecutive sampling design of all trauma patients who received bovine hydroxyapatite in our hospital institution between the period of 2016 to 2018 as the samples. The bovine hydroxyapatite was obtained from the tissue bank in our hospital institution. The results were evaluated clinically and radiologically. The data was tabulated and analyzed descriptively. Results: From the 56 patients who underwent surgery and were given the bovine hydroxyapatite, most of the results were 80.36% excellent, 12.5% good, 3.57% fair, and 3.57 % poor. Conclusion: Bovine hydroxyapatite can be considered as an alternative for bone graft in supporting the bone healing process.

Co-Authors Ahmad Hannan Amrullah Ansari Rahman Arif Zulkarnain Arif Zulkarnain, Arif Arifin Arifin Arius Suwondo Caesar Haryo Bimoseno Cita Rosita Sigit Prakoeswa Damayanti Tinduh Deny Mory Aryawan Desi Sandra Sari Dwikora Novembri Utomo Dyah Erawati DYAH FAUZIAH, DYAH Ernie Maduratna Fedik Abdul Rantam Hari Basuki Notobroto Henry Dominica Heppy Chandra Waskita Heri Suroto I Ketut Sudiana Kadek Seta Prawira M Hardian Basuki Mouli Edward Mouly Edward Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki Purwati Purwati Purwati Purwati Putu Garry Rizky Agung Satria Romaniyanto Romaniyanto Rossy Setyawati Rosy Setiawati Setyawati, Rossy Sjahjenny Mustokoweni, Sjahjenny Tri Wahyu Martanto wahjoe djatisoesanto Yesa Suwandani Yunus Abdul Bari Yunus Basrewan

Title

Found 15 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 15 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 15 Documents
Search