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All Journal Jurnal Insan Farmasi Indonesia
Christe Mareta Ardika Sari
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics

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OPTIMASI KOMBINASI HPMC DAN CARBOPOL DALAM FORMULA SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL BIJI PEPAYA (Carica papaya L.) SERTA UJI AKTIVITAS ANTIBAKTERI TERHADAP Escherichia coli Christe Mareta Ardika Sari; Disa Andriani; Didik Wahyudi
Jurnal Insan Farmasi Indonesia Vol 3 No 2 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i2.563

Abstract

Papaya seeds (Carica papaya L.) have antibacterial activity because they contain terpenoid, karpain and flavonoid compounds. Flavonoids have OH groups that can damage bacterial cell walls. The dry powder of papaya seeds was extracted by maceration method using 80% ethanol. The purpose of this study was to determine the optimal combination of HPMC and carbopol concentrations in the hand sanitizer gel of papaya seed ethanol extract which can influence the in vitro inhibition of Escherichia coli bacteria. The data analysis used in this study was one way ANOVA and then continued with the Post Hoc Tests. The results of the study obtained a yield of 6.933%. The optimum formula obtained is RUN 8 with a concentration of HPMC: Carbopol (0.25gram: 0.75gram). The results of antibacterial activity against Escherichia coli bacteria obtained an average of 44.25 mm from the two samples. The statistical results obtained stated that there was no significant difference between the concentration of A and ciprofloxacin as a positive control. Keywords: HPMC, Carbopol, papaya seeds (Carica papaya L.), Gel hand sanitizer, Escherichia coli
PERBANDINGAN EKSTRAKSI JAMUR TIRAM (Pleurotus ostreatus) DAN JAMUR KANCING (Agaricus bisporus) Christa Marthaningsih Prisida; Christe Mareta Ardika Sari; Tarasia Gandes Belani; Lusia Murtisiwi
Jurnal Insan Farmasi Indonesia Vol 2 No 2 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v2i2.326

Abstract

Mushrooms contain polysaccharides with the main components namely β-glucan and α-mannan. Polysaccharides can be useful as immune enhancers because beta-glucans can increase phagocytic activity and cytokine production. β- (1,3) -glukan has the ability to activate the cellular and humoral immunity system which is a component of the body's immune system. β- (1,3) -glukan increases the antimicrobial activity of mononuclear and neutrophil cells and increases the functional activity of macrophages. Polysaccharides from oyster mushrooms and button mushrooms can be extracted using the Yap & Ng method. The purpose of this study was to compare the yield of extracts produced from oyster mushrooms and button mushrooms. The method used in this research is water extraction method based on Yap & Ng. Data analysis of this study was carried out by calculating the percentage of extracts of oyster mushrooms and button mushrooms, then compared. The results of this study indicate that the yield of oyster mushroom extract is0,013% while the yield of button mushroom extract is 0,0055%. This shows the yield of oyster mushroom extract is greater than the yield of button mushroom extract if extracted by the Yap & Ng method.
Co-Authors Christa Marthaningsih Prisida Didik Wahyudi Disa Andriani Lusia Murtisiwi Tarasia Gandes Belani