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All Journal PHARMACON KOVALEN: Jurnal Riset Kimia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) KACANEGARA Jurnal Pengabdian pada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) RANDANG TANA - Jurnal Pengabdian Masyarakat Jurnal Dunia Farmasi Jurnal Ilmiah Medicamento Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding SIMKESNAS Acta Holistica Pharmaciana Borneo Journal of Pharmacy
Pande Made Desy Ratnasari
Sekolah Tinggi Farmasi Mahaganesha
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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ANALISIS PERBEDAAN BIAYA MEDIK LANGSUNG PASIEN DIABETES MELITUS TIPE 2 Pande Made Desy Ratnasari; Tri Murti Andayani; Dwi Endarti
Jurnal Insan Farmasi Indonesia Vol 2 No 2 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v2i2.414

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease that requires high costs for lifelong therapy. Direct medical costs associated with the cost of antidiabetic and complications. The aim of the study was to determine the difference in direct medical costs based on antidiabetic prescribed and complications. The study design was cross-sectional. Data was taken retrospectively based on medical records and financial data in September 2017 at Panembahan Senopati Hospital Bantul Yogyakarta. Subjects in this study were 200 patients with inclusion criteria were type 2 DM outpatient, aged ≥18 years and received routine antidiabetic at least 3 months before the study. Exclusion criteria are patients with pregnant or breastfeeding. Analysis of differences in direct medical costs based on antidiabetic prescribed and complications using the Kruskal Wallis while sociodemographic were reviewed descriptively. The results showed 48.5% of patients with type 2 DM received combination oral and insulin. The most common complication was macrovascular (19.5%). The average direct medical cost was Rp489.005.00. There is a difference in direct medical costs based on antidiabetic prescribed (p=0.000) and complications (p=0.000). Patients receiving combination with oral and insulin and patients with macrovascular and microvascular complications have the highest direct medical costs.
Aplikasi Antibakteri Nanopartikel Perak (NPAg) Hasil Biosintesis dengan Ekstrak Air Daun Kemangi: Application of Antibacterial from Silver Nanoparticles (AgNPs) Biosynthesis with Basil Leaf Extract Gusti Ayu Dewi Lestari; Pande Made Desy Ratnasari; James Sibarani
KOVALEN: Jurnal Riset Kimia Vol. 8 No. 1 (2022): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2022.v8.i1.15771

Abstract

Nanotechnology is a technology that can be used to overcome several environmental problems. Synthesis of silver nanoparticles (AgNPs) mediated with basil leaf bioreductant with a concentration 0.5% at a temperature of 25⁰C has been carried out. The result of biosynthesis of AgNPs was analyzed using a UV-Vis spectrophotometer in which the SPR band showed the maximum wavelength of 429 nm. The size of AgNPs was determined by a Particle Size Analyzer (PSA), which its size was 86.83 nm. The morphology and elemental content of AgNPs were confirmed using SEM-EDS showing that the shape of AgNPs was irregularly spherical crystals while the EDS results showed a dominant peak at 3 keV indicating silver content. AgNPs showed strong antibacterial activity against Escherechia coli and moderate against Staphylococcus aureus.
ANALISIS HUBUNGAN KEPATUHAN PENGOBATAN TERHADAP KONTROL GLIKEMIK PASIEN DIABETES MELITUS TIPE 2 DI INSTALASI RAWAT JALAN RUMAH SAKIT “X” BULELENG Pande Made Desy Ratnasari; I Gusti Ayu Indira Ardeliani; Agustina Nila Yuliawati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (406.684 KB) | DOI: 10.36387/jiis.v6i2.739

Abstract

Type 2 Diabetes mellitus (T2DM) is a chronic disease that requires long-term treatment. There were problems related to antidiabetic medication adherence. Medication adherence directly affects patient’s blood glucose level. The aim of this study was to analyze the association between the medication adherence and glycemic control among T2DM patients. The study was an observational with cross sectional design. Participants were 90 of T2DM outpatient at “X” Buleleng General Hospital in July-September 2020. T2DM patients were included if age ?18 years, received the same antidiabetic for three months before the study, sign informed consent, fill out the questionnare and have fully medical record data. Patient are excluded if having weak general condition, were pregnant or breastfeeding. Data was collected through interview using the Probabilistic Medication Adherence Scale (ProMAS) questionnaire and based on patient’s medical records. Data were analyzed with Kruskall-Wallis test. The results showed that most of patients were male (55.6%), aged 46-65 years (61.1%), had DM for 5-10 years (46.7%), elementary school (37.8%), with comordbidities (50%) and without complications (77.8%). Majority of patients (42.2%) showed moderate-high medication adherence and the majority of patients (66.7%) has uncontrolled blood glucose. Based on statistical tests, there was no association between medication adherence with patient’s glycemic control (p=0.168). In dispite of it, finding showed that the level of medication adherence had an impact on glycemic control. Patients with high medication adherence showed better glycemic control.
Analisis Outcome Klinis Berdasarkan Kualitas Hidup dan Biaya Medik Langsung Pasien Diabetes Melitus Tipe 2 Pande Made Desy Ratnasari; Tri Murti Andayani; Dwi Endarti
Jurnal Sains Farmasi & Klinis Vol 7, No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.02 KB) | DOI: 10.25077/jsfk.7.1.15-22.2020

Abstract

Diabetes Melitus (DM) tipe 2 merupakan penyakit kronis yang membutuhkan terapi untuk mengontrol glukosa darah. Pengontrolan glukosa darah yang buruk berdampak pada penurunan kualitas hidup dan peningkatan biaya. Tujuan penelitian adalah menganalisis perbedaan outcome klinis yaitu kadar Glukosa Darah Sewaktu (GDS) selama 3 bulan berdasarkan kualitas hidup dan biaya medis langsung. Outcome klinis dikatakan terkontrol apabila GDS <200 mg/dL dan tidak terkontrol apabila GDS ≥200 mg/dL. Rancangan penelitian ini adalah cross sectional dengan jenis observasional. Kriteria inklusi mencakup pasien DM tipe 2 yang memperoleh antidiabetik yang sama minimal 3 bulan di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul pada September 2017. Kriteria eksklusi meliputi kondisi hamil atau menyusui. Pengambilan data dilakukan melalui pengisian kuesioner, rekam medis dan bagian keuangan. Data demografi dianalisis secara deskriptif sedangkan outcome klinis diolah menggunakan uji Kruskal Wallis. Hasil penelitian menunjukkan sebanyak 129 dari 200 pasien menunjukkan outcome klinis tidak terkontrol (64,5%) dengan rata-rata nilai kualitas hidup yang baik (65,7±7,7) serta mengeluarkan biaya medis langsung sebesar Rp 489.005. Terdapat perbedaan outcome klinis berdasarkan kualitas hidup (p=0,000) pada domain fungsi fisik (p=0,034), kepuasan pribadi (p=0,000), kepuasan pengobatan (p=0,000) dan frekuensi gejala penyakit (p=0,012) serta berdasarkan biaya medis langsung (p=0,012). Pasien dengan outcome klinis terkontrol menunjukkan kualitas hidup yang lebih tinggi dan mengeluarkan biaya lebih rendah.
Analisis Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Berdasarkan Pola Peresepan Antidiabetik dan Komplikasi Pande Made Desy Ratnasari; Tri Murti Andayani; Dwi Endarti
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7130.477 KB) | DOI: 10.22146/jmpf.45862

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that requires lifelong therapy to control blood glucose. The long term use and different mechanism of action antidiabetic have the potential cause side effects and discomfort that affects the quality of life. This study aimed to determine differences in the quality of life of patients with T2DM based on antidiabetic prescribed and complications at the Outpatient of Panembahan Senopati Bantul Yogyakarta Hospital in September 2017. This research is observational with a cross-sectional design. Quality of life data is taking concurrently using the Diabetes Quality of Life Clinical Trial Questionnaire and patient's medical record. This study involved 200 T2DM patients who received antidiabetic at least 3 months before study, aged ≥18 years and agreed to inform concent. Sociodemographic data, antidiabetic prescribed and complications were described descriptively. Differences in the quality of life based on antidiabetic prescribed and complications using the Kruskal Wallis test which was further analyzed using the post hoc by Mann Whitney test. The results showed the majority of patients received oral combination with insulin (48.5%) and dominated by macrovascular complications (19.5%). The average value of patient's quality of life is 65.7. There was difference quality of life based on antidiabetic prescribed in the domain of treatment satisfaction (p=0.000) between oral monotherapy with combination of oral and insulin (p=0.000) and insulin monotherapy with combination of oral and insulin (p=0.002). There were differences in quality of life based on complications in the mental health domain (p=0.003) between macrovascular and microvascular (p=0.011) and between microvascular and without complications (p=0.001).
Knowledge and Quality of Life in Type 2 Diabetes Mellitus Patients also its Related Factors Agustina Nila Yuliawati; Pande Made Desy Ratnasari; Putri Riski Rosalina
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.68631

Abstract

Knowledge is important to control blood sugar and prevent complications, and subsequently have an impact on the quality of life (QOL) of type 2 diabetes mellitus (T2DM) patients as a response to their health. This study was aimed to determine the correlation between the level of knowledge and QOL in type 2 DM (T2DM) patients, as well as its related factors. This cross-sectional study was conducted in a Public Hospitals, Buleleng, Bali on September 2020. The inclusion criteria included T2DM outpatients aged ≥ 18-year-old, getting similar therapy for at least 3 months, filling out the questionnaire completely, being able to communicate well, and not in a pregnant/breastfeeding condition. Data were obtained by medical records, questionnaires DKQ-24 (knowledge) and EQ-5D-5L (QOL). The correlation between knowledge and QOL of T2DM patients and its related factors were analyzed using bivariate statistical tests. The findings of the 150 respondents showed that the majority of the patients were ≥ 60-year-old (53.3%), female (50.7%), first educational level (64%), not working (54%), low income (49.3%), >5 years of T2DM duration (44%), no complications (75.3%), taking 4-6 item medicines (66.7%), moderate knowledge level (70.7%) with QOL based on the utility score 0.892±0.154 and VAS 59.73±20.07. Statistical tests showed there was a significant correlation between knowledge and QOL based on utility value (p=0.01), but not with VAS value (p=0.165). These was reinforced by age which has a significant correlation with knowledge (p=0.042), also employment status and complications condition which have a significant correlation with QOL (p<0.05). Patients with a higher level of knowledge have a better QOL, despite different backgrounds.
Hubungan Kepatuhan Pengobatan Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Disertai Hipertensi dan Menjalani Hemodialisis Agustina Nila Yuliawati; Pande Made Desy Ratnasari; I Gusti Ayu Santhi Pratiwi
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.69974

Abstract

End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) could experience several problems, then reducing their quality of life (QOL). Medication adherence (MA), including HD is very important to improve the patient's QOL. This study aimed to analyze the correlation between MA and QOL and its related factors in ESRD patients. This cross-sectional study was conducted at a Public Hospital, Buleleng, Bali in September 2020. A sample of 89 people was obtained by the purposive sampling technique. The inclusion criteria for this study were ESRD patients aged ≥18 years, undergoing HD, filling out the questionnaire completely, and being able to communicate well. Data were collected using ERSD-AQ and EQ-5D-5L questionnaire, also medication records. Data analysis were performed by Perason’s rank correlation, Spearman’s rho, Kendall’s tau-b/c, Mann-Whitney U, or Kruskal Wallis test (CI 95%). Findings showed that mostly respondents were <60 years old (66.3%), male (71.9%), less than high school educational (68.5%), not working (69.7%), lower income (55.1%), having an ESRD duration of <3 years (67.4%), taking ≤6 item medicines (96.6%), having a mean (±SD) QOL-based on a utility value of 0.779±0.172 and a visual analog scale (VAS) of 60.79±18.04. Hence, there was no significant correlation between MA and QOL, as well as patient characteristics to MA (p>0.05).). Otherwise, patients aged <60 years, high levels of education and income, as well as the number of drug items received, tend to have a better QOL (p<0.05).
Analisis Luaran Klinik Pasien Diabetes Melitus Tipe 2 Berdasarkan Peresepan Antidiabetik dan Komplikasi Pande Made Desy Ratnasari; Tri Murti Andayani; Dwi Endarti
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.242 KB) | DOI: 10.22146/farmaseutik.v16i2.50566

Abstract

Diabetes Melitus (DM) tipe 2 merupakan penyakit metabolik kronis yang membutuhkan terapi antidiabetik seumur hidup guna mengontrol glukosa darah serta mencegah terjadinya komplikasi. Peresepan antidiabetik yang diberikan kepada pasien serta terjadinya komplikasi dapat mempengaruhi luaran klinik yaitu glukosa darah sewaktu (GDS). Tujuan penelitian ini untuk mengetahui perbedaan  luaran klinik  berdasarkan peresepan antidiabetik dan jenis komplikasi.  Rancangan penelitian adalah deskriptif analitik dengan desain cross sectional. Subyek penelitian adalah pasien DM tipe 2 dengan usia ≥18 tahun yang memperoleh antidiabetik secara rutin minimal 3 bulan sebelum penelitian Di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul Yogyakarta periode September 2017. Pengambilan data dilakukan secara retrospektif berdasarkan rekam medik dengan teknik purposive sampling. Analisis data demografi dan perbedaan luaran klinik berdasarkan peresepan antidiabetik dilakukan secara deskriptif. Uji Chi-square digunakan untuk melihat perbedaan luaran klinik berdasarkan jenis komplikasi. Hasil penelitian menunjukkan sebesar 48,5% pasien memperoleh kombinasi antidiabetik oral dan insulin, sedangkan terjadinya komplikasi didominasi makrovaskuler (19,5%). Terdapat perbedaan luaran klinik berdasarkan peresepan antidiabetik dan komplikasi (p=0,009). Pasien dengan kombinasi oral serta pasien tanpa komplikasi menunjukkan luaran klinik yang terkontrol paling tinggi.
PENGGUNAAN STATIN DAN ANTIPLATELET SEBAGAI PENCEGAHAN SEKUNDER KOMPLIKASI KARDIOVASKULER PADA PASIEN DIABETES MELITUS TIPE 2 Pande Made Desy Ratnasari; Putu Dian Marani Kurnianta; Anak Agung Ngurah Putra Riana Prasetya
Majalah Farmasi dan Farmakologi Vol. 24 No. 2 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v24i2.10384

Abstract

Resistensi insulin pada pasien diabetes melitus (DM) tipe 2 dapat meningkatkan risiko terjadinya komplikasi kardiovaskuler yang selanjutnya dapat berkontribusi sebagai penyebab utama kematian. Resistensi insulin meningkatkan kerentanan pasien mengalami aterosklerosis dan menimbulkan gangguan pada fungsi platelet di pembuluh darah yang dapat berdampak pada peningkatan risiko komplikasi kardiovaskuler. Sebagai salah satu upaya untuk mencegah dan mengurangi risiko tersebut, Canadian Cardiovascular Society Guidelines tahun 2011 dan American Diabetes Association tahun 2019 merekomendasikan penggunaan golongan statin dan antiplatelet sebagai upaya pencegahan sekunder komplikasi kardiovaskuler pada pasien DM tipe 2. Penelitian ini bertujuan untuk mengetahui gambaran penggunaan statin dan antiplatelet sebagai pencegahan sekunder pada pasien DM tipe 2 dengan komplikasi kardiovaskuler. Penelitian ini bersifat observasional dengan desain cross sectional yang dilakukan pada 110 pasien di RSU Puri Raharja Denpasar Bali periode November 2019. Hasil penelitian menunjukkan bahwa dari 110 pasien yang memenuhi kriteria penggunaan statin, hanya 42 pasien (38,1%) yang menggunakan statin (simvastatin 20 mg; 95,2%). Selain itu, dari total 96 pasien yang memenuhi kriteria penggunaan antiplatelet, hanya 52 pasien (47,3%) yang menggunakan antiplatelet (aspirin 80 mg; 82,7%). Penelitian ini merefleksikan penggunaan statin yang masih rendah dalam upaya pencegahan sekunder komplikasi kardiovaskuler pada pasien DM tipe 2. Meskipun terdapat kecenderungan tingkat penggunaan antiplatelet aspirin yang lebih tinggi daripada statin dalam penelitian ini, pemberian aspirin selanjutnya masih perlu ditingkatkan lagi bersama-sama dengan peningkatan pemberian statin.
KETERCAPAIAN TARGET GLIKEMIK DAN ANALISIS FAKTORFAKTOR TERKAIT PADA PASIEN DIABETES TIPE 2 Putu Dian Marani Kurnianta; Pande Made Desy Ratnasari; Heny Dwi Arini
Majalah Farmasi dan Farmakologi Vol. 25 No. 2 (2021): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v25i2.13037

Abstract

Bukti-bukti ilmiah menunjukkan keterkaitan antara rendahnya ketercapaian target glikemik selama pengobatan DM tipe 2 dengan risiko komplikasi kronik. Apabila kegagalan pengobatan tersebut diabaikan, maka ancaman global yang dihadapi akan terus meningkat. Oleh karena itu, penelitian cross sectional ini bertujuan untuk menyelidiki kegagalan pengobatan, khususnya ketercapaian target glikemik berupa tingkat kejadian dan faktor-faktor yang mempengaruhinya pada pasien DM tipe 2 di daerah Gianyar. Data rekam medik dari salah satu rumah sakit di Gianyar, Bali, selama periode 2016-2020, diseleksi berdasarkan kriteria inklusi yang meliputi pasien rawat jalan berusia ≥18 tahun, terdiagnosis DM tipe 2 pertama kali, tidak berpindah fasilitas kesehatan selama enam bulan, dan memperoleh antidiabetika oral atau insulin secara konsisten. Penentuan status kegagalan pengobatan berdasarkan target kontrol glikemik oleh ADA. Pada sejumlah total 145 subjek yang terlibat, proporsi kegagalan pengobatan DM tipe 2 mencapai 64,83%. Hasil analisis deskriptif enam faktor pada penelitian ini menunjukkan bahwa kegagalan pengobatan cenderung terjadi pada laki-laki (59,57%), usia ≤60 tahun (75,53%), subjek yang tidak bersekolah (39,36%), subjek dengan komplikasi (7,45%), subjek berpenyakit penyerta (51,06%), dan pengguna insulin (58,51%). Berdasarkan Uji χ2 atau Uji Fisher’s Exact (p<0,05, 95%), penelitian ini mempresentasikan hubungan signifikan antara faktor usia dan faktor penggunaan antidiabetika terhadap tingginya kegagalan pencapaian target glikemik selama pengobatan.
Co-Authors Agustina Nila Yuliawati Anak Agung Ngurah Putra Riana Prasetya Dewa Ayu Putri Lestari Dewi Elizabeth Oriana Jawa La Gede Arya Rizky Artana Gusti Ayu Dewi Lestari Heny Dwi Arini I Gusti Ayu Dwi Gangga Pratiwi I Gusti Ayu Indira Ardeliani I Gusti Ayu Santhi Pratiwi I Putu Yuda Pratama James Sibarani Kadek Duwi Cahyadi Laili Kurnia Rizqy Mahadri Dhrik Mahadri Dhrik Ni Kadek Mirah Rahayu Ni Ketut Taman Ni Luh Putu Satria Maharani Ni Luh Putu Sri Utami Ni Made Dewi Jayanti Putri Riski Rosalina Putu Dian Marani Kurnianta Repining Tiyas Sawiji Tri Murti Andayani Tri Murti Andayani