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The Comparison of Bay Leaf and Celery Leaf Infusion Effect on Decreasing LDL Level in Dyslipidemic Wistar Rats Model Retnaninggalih, Anjani Putri; Efendi, Erfan; Hairrudin, Hairrudin
Journal of Agromedicine and Medical Sciences Vol 1, No 1 (2015)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was concluded that bay leaf and celery leaf infusion could reduce the LDL level in dyslipidemic wistar rat but there was no difference on the capability of the two different leafs on reducing LDL level. Keywords: dyslipidemia, LDL, bay leaf, celery leaf, wistar rats  
Pengaruh Induksi Racun Ubur-Ubur (Physalia utriculus) terhadap Fungsi Oksigenasi dari Eritrosit pada Mencit Jantan Vita Alfiatul Hasanah; Al Munawir; Erfan Efendi
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Jellyfish is one of the animals that is responsible for poisoning in human. The poisoning jellyfish commonly found is Physalia utriculus. Jellyfish poison is potential to cause hemolysis on blood. The purpose of this study was to determine the influence of jellyfish (Physalia utriculus) poisoning induction toward the oxygenation function of the male mice erythrocytes. The method was true experimental design with post test only control group design. Eight male mice were devided into two groups: control and treatment groups with a dose of jellyfish poison 30 mg/kgBW. The observation was conducted by using a pulse oxymeter. The result showed average level of oxygen saturation in the control group minute 0; 15; 30; 60; 120; 240; 480; 720; 1440 were 55%; 54%; 63,75%; 70%; 65,25%; 67,5%; 65,75%; 72%; 55%, respectively. While in the treatment group were 61,25%; 62,75%; 59,75%; 58,5%; 51,75%; 58%; 57%; 75,75%; 47%, respectively. The statistical bivariate correlation test has a correlation coefficient value (r) 0,383. The significance value is (p) 0,309 (p>0,05). The conclusions of this study was jellyfish (Physalia utriculus) poisoning induction has no significant effect toward the change of oxygenation function of the male mice erythrocytes. Keywords: jellyfish, jellyfish poison (Physalia utriculus), erythrocytes, oxygen saturation
Perbandingan Komplikasi Malunion pada Pasien Fraktur Humerus Pasca Terapi Operatif dan Non-Operatif di RS Bina Sehat Djaya Mario Eri Surya Alfonsus; Muhamad Hasan; Erfan Efendi
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Humerus fracture is a quite common fracture. Fracture of diaphyseal humerus is 1,2 % of all cases of fracture. The treatment of humeral shaft fracture can use 2 different approaches, operative treatment and conservative treatment. This research aimed to compare the complication of malunion in patients with operative and conservative treatment. This was an observational analytic study on patients at the Bina Sehat Hospital. Samples were divided into 2 groups, operative and non-operative. Both groups were examined by measuring the lenght of the humerus after fracture comparing with its contralateral, the ability of the internal rotation, the ability of the external rotation, and angulation inspection. Statistical test showed a difference humerus shortening between 2 groups reached 0.873 cm. The difference between 2 groups on the ability of internal rotation reached 11.4710. The difference between 2 groups on ability of external rotation reached 16.608o. And the result for angulation assessment also showed significant difference between 2 groups. In conclutson, there was a significant difference in complications of malunion between operative and non-operative groups.   Keywords: humerus fracture, operative treatment, non operative treatment, comparative malunion
Analisis In Vivo Aktivitas Antihipertensi dari Protein Biji Melinjo (Gnetum gnemon) Terhidrolisis Yeni Tri Puspitaningrum; Erfan Efendi; Tri Agus Siswoyo
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Hypertension is a serious health problem and requires a good handling. An alternative treatment for hypertension is required due to the treatment of hypertension took a long period of time causing unwanted side effects. Melinjo seed hydrolyzed-proteins have an ACE-inhibitor activity, an antihypertensive effect. This study aimed to determine the antihypertensive effects of melinjo seed hydrolyzed-proteins in hypertensive rats. Wistar rats induced with prednisone 1,5 mg/kg body weight and 2% NaCl for 7 days and then treated. There were 7 groups: a normal group K, a group K(-) which is a hypertensive rats without treatment, a group K(+) which is hypertensive rats with captopril 2,5 mg/kg body weight on day 8th, and four treatment groups P1, P2, P3, and P4 which are hypertensive rats with melinjo seed hydrolyzed-proteins with a dose of 5, 10, 20, and 30 mg/kg body weight on day 8th, respectively. Blood pressure was measured before and after treatment every 1 hour for 5 hours. The results showed that melinjo seed (Gnetum gnemon) hydrolyzed-proteins can decrease blood pressure in hypertensive rats.   Keywords: Antihypertensive, Gnetum gnemon, Hydrolized-Protein, Blood Pressure
Efek Penambahan Vitamin C terhadap Aktivitas Klindamisin dalam Menghambat Pertumbuhan Streptococcus pneumoniae secara In Vitro Bagus Dwi Kurniawan; Dini Agustina; Erfan Efendi
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.9744

Abstract

Pneumonia is one of the lower respiratory tract infection involving respiratory bronchioles and alveoli that mostly caused by Streptococcus pneumoniae.Clindamycin is one of the drug of choice for pneumoniae. This drugs inhibits the growth of S. pneumoniae by producing ROS (Reactive Oxygen Species). Recent study has shown that vitamin C could generate ROS leading to DNA-damage on bacteria. The aims of this study was to know the possible benefit effect of adding vitamin C towards clindamycin inhibition activity against the growth of S. pneumoniae in vitro. This research was conducted by using 7 groups which consist of negative control (aquades), positive control (clindamycin), and test group 1 until 5 that given the combination of clindamycin and vitamin C as follows 2,5 mg/ml; 5 mg/ml; 10 mg/ml; 20 mg/ml; and 40 mg/ml. The inhibition effect of growing S. pneumoniae shown by the inhibition zone diameter. The average of inhibition zone on negative control, positive control, and test group were 5; 24,12; 24,62; 26,08; 27,58; 28,74; and 29,76 mm. These result show a significant correlation based on Pearson test (the coefficient correlation’s result is +0,910). The logarithmic regression revealed the minimal concentration of vitamin C was 1,767 mg/ml. It can be concluded that vitamin C increased the activity of clindamycin by inhibiting the growth of S.pneumoniae in vitro. Keywords: Streptococcus pneumoniae, ROS, Clindamycin, Vitamin C
Pengaruh Ekstrak Albumin Ikan Gabus (Chana striata) terhadap Kadar IFN-γ Pasien Tuberkulosis Paru dengan Pengobatan Fase Intensif (The Effect of Albumin Snakehead Fish (Chana striata) Extract on IFN-Y of Pulmonary Tuberculosis Patients during Intens Henggar Allest Pratama; Erfan Efendi; Rini Riyanti
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but not statistically signicant if compared with the decrease of control group (p=0.061). It can be concluded that albumin snakehead fish (Chana striata) extract in dose of 1500 mg/day had not able to decrease IFN-γ levels of pulmonary tuberculosis patients during intensive phase medication yet.   Keywords: tuberculosis, albumin, snakehead fish, IFN-γ
Pengaruh Induksi Toksin Ubur-ubur (Physalia physalis) terhadap Gambaran Histopatologi Paru-paru Tikus Wistar Sayyidah Auliany Aminy; Al Munawir; Erfan Efendi
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Physalia physalis adalah salah satu jenis ubur-ubur beracun yang dapat menimbulkan dyspnea setelah tersengat. Hal ini menunjukkan adanya efek pneumotoxic toksin Physalia physalis. Penelitian ini bertujuan untuk mengetahui efek pneumotoxic protein toksin ubur-ubur Physalia physalis secara in vivo pada tikus Wistar. Penelitian menggunakan sampel tikus galur Wistar jantan dengan berat rata-rata 150 gram dengan 1 kelompok kontrol (K) dan 3 kelompok perlakuan (P), masing-masing kelompok terdiri atas 6 ekor tikus. Kelompok K diinjeksi dengan larutan PZ; P1, P2 dan P3 masing-masing diinjeksi protein toksin ubur-ubur Physalia physalis dengan dosis 10 mg/KgBB, 20 mg/KgBB dan 30 mg/KgBB. Setelah 6 jam organ paru-paru tikus diambil dan direndam dengan formalin 10% dan dilakukan pembuatan preparat histologi, kemudian dilakukan pengamatan secara mikroskopik dan ditentukan tingkat perubahan histopatologi paru-paru dengan menggunakan skor. Hasil penelitian menunjukkan terjadinya perubahan histopatologi pada paru-paru tikus Wistar berupa infiltrasi sel radang, edema paru, degenerasi dan apoptosis sel-sel penyusun paru. Hasil uji statistik Kruskal-wallis menunjukkan data memiliki perbedaan signifikan (p=0,001). Terdapat perbedaan yang signifikan pada perubahan histologi paru-paru antara kelompok K dengan P1, P2 dan P3. Dapat disimpulkan bahwa toksin ubur-ubur Physalia physalis mempengaruhi gambaran histopatologi paru-paru tikus Wistar.   Kata kunci: Toksin, ubur-ubur, Physalia physalis, Histopatologi, paru- paru.
The Relationship of Delayed Appendectomy to the Incidence of Surgical Site Infection (SSI) in Acute Appendicitis Patients: A Narrative Review Wahyuning Ati Ashari; Enny Suswati; Erfan Efendi
Media Penelitian dan Pengembangan Kesehatan Vol 31 No 3 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/mpk.v31i3.4775

Abstract

Acute appendicitis is one of the most common causes of surgery worldwide. Appendectomy is a skeptical surgical intervention associated with the risk of Surgical Site Infection (SSI). The purpose of this analysis was to describe the relationship between delayed appendectomy in acute appendicitis and the incidence of SSI. Reviewers selected articles containing data on the incidence of SSI due to appendectomy delays for 3 to 48 hours from seven databases, namely Pubmed, Nature, SpringerLink, Science Direct, ProQuest, Oxford Open Access Journal, and Cochrane Library. The data source was secondary data from international articles published in 2011 to 2020 based on the PICO criteria. The data obtained were then grouped and synthesized without meta-analysis/Synthesis Without Metaanalysis (SWiM) descriptively. A total of 2,778 articles were collected, of which 24 studies met the inclusion criteria. A total of 4 articles showed an association between appendectomy delay and SSI while the other 20 articles did not show a relationship between the two. There was no relationship between appendectomy delays for less than 48 hours since hospital admission to surgery with the incidence of SSI, however a delayed for more than 48 hours showed a significant value. The results showed there was no relationship between delayed appendectomy for less than 48 hours since the time the patientwas admitted to the hospital until the surgery took place, but a delayed appendectomy delay for more than 48 hours showed a significant relationship with the incidence of SSI. This narrative review supports early surgical intervention of acute appendicitis cases by considering the severity of the patient to avoid other surgical complications. Abstrak Apendisitis akut menjadi salah satu penyebab pembedahan yang paling sering ditemukan di seluruh dunia. Apendektomi merupakan intervensi bedah skeptis yang berhubungan dengan risiko terjadinya Surgical Site Infection (SSI). Tujuan analisis ini untuk mendapatkan gambaran hubungan antara penundaan apendektomi pada apendisitis akut dengan kejadian SSI. Reviewer memilih artikel yang memuat data kejadian SSI akibat penundaan apendektomi selama 3 sampai 48 jam dari tujuh basis data yaitu Pubmed, Nature, SpringerLink, Science Direct, ProQuest, Oxford Open Access Journal, dan Cochrane Library. Sumber data berupa data sekunder dari artikel internasional yang diterbitkan pada tahun 2011 hingga 2020 berdasarkan kriteria PICO. Data yang didapatkan kemudian dikelompokkan dan disintesis tanpa meta-analisis/Synthesis Without Meta-analysis (SWiM) secara deskriptif. Total artikel yang dikumpulkan adalah 2.778 artikel, sebanyak 24 studi memenuhi kriteria inklusi. Sebanyak 4 artikel menunjukkan hubungan antara keterlambatan apendektomi dengan SSI sedangkan 20 artikel lainnya tidak menunjukkan hubungan keduanya.Tidak ada hubungan penundaan apendektomi kurang dari 48 jam sejak masuk rumah sakit hingga operasi dengan insidensi SSI namun penundaan lebih dari 48 jam menunjukkan nilai yang signifikan. Berdasarkan hasil analisis, disimpulkan bahwa tidak terdapat hubungan penundaan apendektomi selama kurang dari 48 jam sejak pasien masuk rumah sakit hingga proses pembedahan berlangsung tetapi penundaan apendektomi lebih dari 48 jam menunjukkan adanya hubungan signifikan terhadap kejadian SSI. Tinjauan naratif ini mendukung intervensi bedah yang cepat pada kasus apendisitis akut dengan mempertimbangkan tingkat keparahan pasien dan untuk menghindari komplikasi pembedahan lain.
Association between Personal Hygiene and Incidence of Soil-Transmitted Helminthiasis among Workers at Widodaren Plantation in Jember Regency Zulaikha Rizqina Rahmawati; Bagus Hermansyah; Erfan Efendi; Yunita Armiyanti; Yudha Nurdian; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.9593

Abstract

Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the process of transmission requires soil as media to fullfil its life cycle from non-infective forms to infective forms. The number of infections is influenced by personal hygiene. Personal hygiene consists of the habit of washing hands, cutting nails, eating, defecating and ownership of latrines, and the use of personal protective equipment. This study used a cross sectional research design conducted at Widodaren Plantation with 68 people of samples. Stool examination was determined by kato-katz method, sedimentation, and floatation to detect the presence of Soil-Transmitted Helminth (STH) eggs, while personal hygiene was assessed using questionnaires. Questionnaire and stool examination datas were processed using SPSS data analysis with chi-square method. The results of this study found 26 respondents who were positive for soil-trasmitted helminthiasis infection. The most frequent worm species obtained in this study were Ascaris lumbricoides (57.7%), followed by multiple infections between Hookworm and A. lumbricoides (21.3%), and Hookworm (19.2%). In the chi-square analysis the results were significant between personal hygiene and soil-transmitted helminthiasis with p value of 0,000 (p <0.05). So, it can be concluded that a bad personal hygiene factor has a significant relationship to the incidence of Soil-Transmitted Helminthiasis at Widodaren Plantation. Keywords: Personal hygiene, STH, plantation
The correlation between Mother's Knowledge About Language Stimulation and Language Development Of Toddlers in Lengkong, Mumbulsari, Jember Mardhiyyah Nurul Hasanah; Dwita Aryadina Rachmawati; Erfan Efendi
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.9628

Abstract

Abstract The first three years of age is an important period for the development of children’s languange. Early stimulation as a parent especially mother to promote children’s development needs to be done. Before doing stimulation, the mothers need sufficient knowledge about development stimulation so mothers can do stimulation properly to their children. The aim of this study is to analyze the correlation between the mother’s knowledge about language stimulation and language development of toddlers in Lengkong , Mumbulsari, Jember. An analitic observational study with cross sectional study design which the subjects were 70 mother who have toddlers at Lengkong, Mumbulsari, Jember who met inclusion and exclusion criteria. The result of spearman correlation test between mother’s knowledge about language stimulation and language development of children aged 1-3 years is p=0,000 (p<0.005) which mean there is significant correlation between the mother’s knowledge about language stimulation and language development of children aged 1-3 years in Lengkong , Mumbulsari, Jember. Keywords: knowledge, stimulation, language development.