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All Journal Jurnal Fitofarmaka Indonesia ANNALES BOGORIENSES Dinamisia: Jurnal Pengabdian Kepada Masyarakat JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Sainstech Farma: Jurnal Ilmu Kefarmasian Pharmaceutical Sciences and Research (PSR)
Berna Elya
Fakultas Farmasi, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Uji Akvitas dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu pada Pertumbuhan Rambut Kelinci Febriani, Amelia; Elya, Berna; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT :Hair loss affects one’s self image and emotional well-being. It is a very real and serious aesthetic concern for everyone. Leaves and flowers of Hibiscus are traditionally known to potentiate hair growth promotion. In this study we determine the hair growth promotion activity of hibiscus leaves using 2.5%, 5% and 10% of hibiscus leaf extract in the form of hair tonic. We also assessed the physical stability and safety of the hair tonic. Hair growth promotion activity assay was carried out by applying hair tonic on the rabbit’s back and measured hair length, hair thickness, hair weight and hair density. Physical stability assessment was performed at low (4°C ± 2°C), room (25°C ± 2°C) and high (40°C ± 2°C) temperature as well as the cycling test. Safety test was done by eye irritation test with HET-CAM and skin irritation test with patch test method. The results showed that hair tonic contains 10% of leaf extract have hair growth activity promotion better than the minoxidil 2%. Physical stability test showed extract of hibiscus leaf hair tonic has good physical stability. Results of safety test showed that there’s no skin irritation occurred while eye irritation test showed positive eyes iritation. Keywords: hibiscus leave, hair growth, hair tonic, HET-CAM, patch test  ABSTRAK: Kerontokan rambut yang sering diakhiri kebotakan merupakan problema estetis yang sangat dikhawatirkan setiap orang. Daun dan bunga kembang sepatu telah diakui memiliki aktivitas pertumbuhan rambut berdasarkan penggunaan tradisional. Pada penelitian ini, 2,5%, 5% dan 10%  ekstrak daun kembang sepatu diformulasikan dalam bentuk hair tonic karena penggunaannya lebih mudah dan tidak lengket seperti sediaan semisolid. Tujuan penelitian ini adalah untuk mengetahui aktivitas pertumbuhan rambut ektrak etanol daun kembang sepatu  stabilitas fisik dan keamanannya. Uji aktivitas pertumbuhan rambut dilakukan dengan mengoleskan sediaan hair tonic pada punggung kelinci dan diukur panjang rambut, ketebalan rambut (diameter rambut), kelebatan rambut (bobot rambut) dan kepadatan rambut (densitas rambut). Uji stabilitas fisik dilakukan pada penyimpanan suhu rendah (4oC±2oC), suhu ruang (25oC±2oC) dan suhu tinggi (40oC±2oC) serta  cycling test. Uji keamanan dilakukan dengan uji iritasi mata dengan metode HET-CAM dan uji iritasi kulit dengan metode patch test. Hasil menunjukkan bahwa sediaan hair tonic ekstrak daun kembang sepatu 10% memiliki aktivitas pertumbuhan rambut yang lebih baik dibandingkan kontrol positif minoksidil 2%. Hasil uji stabilitas fisik menunjukkan sediaan hair tonic ekstrak daun kembang sepatu memiliki stabilitas fisik yang baik. Dari hasil uji keamanan iritasi kulit  tidak terjadi iritasi, sedangkan hasil uji iritasi mata menunjukkan sediaan mengiritasi mata.Kata Kunci: daun kembang sepatu, pertumbuhan rambut, hair tonic, HET-CAM, patch test 
Identification Of Aquatic Plant Species From Bantimurung Waterfall And Their Phytochemical Compounds Analysis Nugraha, Media Fitri Isma; Maharani, Fasya Hadaina; Novita, Hessy; Rajamuddin, Muh Alias L; Yunita, Rossa; Reflinur, Reflinur; Enggarini, Wening; Julzarika, Atriyon; Elya, Berna Elya
ANNALES BOGORIENSES Vol 23, No 1 (2019): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3132.928 KB) | DOI: 10.14203/ann.bogor.2019.v23.n1.41-48

Abstract

A total of 21 aquatic plant species were collected from Bantimurung waterfall areas, South Sulawesi, Indonesia, in October 2017. These plant materials were subjected to both species and phytochemicals identification. The aims of this study were to determine the species or taxonomic rank of Indonesian aquatic plants collected from Bantimurung waterfall, South Sulawesi, Indonesia and to identify their chemical compounds (phytochemicals) as a candidate for new herbal medicine. Plant genetic materials used in this study were collected from Bantimurung Bulusaraung waterfall and were then identified based on standard botanical techniques for species identification in the Herbarium Bogoriense, Research center for Biology Indonesian Institute of Science (LIPI), Cibinong, West Java. The samples were subjected to the phytochemistry screening such as alkaloids, flavonoids, tannins, saponins, glycosides, terpenoids and anthraquinone followed the procedures of Indonesian Materia Medika and Harborne.  Results showed that all collected aquatic plant samples were able to be identified, including their species names. Phytochemical screening of each sample revealed the presence of glycoside in all of the tested species. However, no alkaloids, anthraquinones, and terpenoids were observed in those tested plant samples. Of the total 21 aquatic plants, 14 species contained flavonoids, 8 species contained phenol compound, and 10 species contained saponins. Among these species Donnax canniformis possessed good antioxidant activity, which correlated to its total phenolic and flavonoid contents. Our results would be beneficial for any future effort in the development of new herbal drugs derived from aquatic plants.
Uji Akvitas dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu pada Pertumbuhan Rambut Kelinci Febriani, Amelia; Elya, Berna; Jufri, Mahdi
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1237.566 KB) | DOI: 10.35617/jfi.v8i1.234

Abstract

ABSTRACT :Hair loss affects oneâ??s self image and emotional well-being. It is a very real and serious aesthetic concern for everyone. Leaves and flowers of Hibiscus are traditionally known to potentiate hair growth promotion. In this study we determine the hair growth promotion activity of hibiscus leaves using 2.5%, 5% and 10% of hibiscus leaf extract in the form of hair tonic. We also assessed the physical stability and safety of the hair tonic. Hair growth promotion activity assay was carried out by applying hair tonic on the rabbitâ??s back and measured hair length, hair thickness, hair weight and hair density. Physical stability assessment was performed at low (4°C ± 2°C), room (25°C ± 2°C) and high (40°C ± 2°C) temperature as well as the cycling test. Safety test was done by eye irritation test with HET-CAM and skin irritation test with patch test method. The results showed that hair tonic contains 10% of leaf extract have hair growth activity promotion better than the minoxidil 2%. Physical stability test showed extract of hibiscus leaf hair tonic has good physical stability. Results of safety test showed that thereâ??s no skin irritation occurred while eye irritation test showed positive eyes iritation. Keywords: hibiscus leave, hair growth, hair tonic, HET-CAM, patch test  ABSTRAK: Kerontokan rambut yang sering diakhiri kebotakan merupakan problema estetis yang sangat dikhawatirkan setiap orang. Daun dan bunga kembang sepatu telah diakui memiliki aktivitas pertumbuhan rambut berdasarkan penggunaan tradisional. Pada penelitian ini, 2,5%, 5% dan 10%  ekstrak daun kembang sepatu diformulasikan dalam bentuk hair tonic karena penggunaannya lebih mudah dan tidak lengket seperti sediaan semisolid. Tujuan penelitian ini adalah untuk mengetahui aktivitas pertumbuhan rambut ektrak etanol daun kembang sepatu  stabilitas fisik dan keamanannya. Uji aktivitas pertumbuhan rambut dilakukan dengan mengoleskan sediaan hair tonic pada punggung kelinci dan diukur panjang rambut, ketebalan rambut (diameter rambut), kelebatan rambut (bobot rambut) dan kepadatan rambut (densitas rambut). Uji stabilitas fisik dilakukan pada penyimpanan suhu rendah (4oC±2oC), suhu ruang (25oC±2oC) dan suhu tinggi (40oC±2oC) serta  cycling test. Uji keamanan dilakukan dengan uji iritasi mata dengan metode HET-CAM dan uji iritasi kulit dengan metode patch test. Hasil menunjukkan bahwa sediaan hair tonic ekstrak daun kembang sepatu 10% memiliki aktivitas pertumbuhan rambut yang lebih baik dibandingkan kontrol positif minoksidil 2%. Hasil uji stabilitas fisik menunjukkan sediaan hair tonic ekstrak daun kembang sepatu memiliki stabilitas fisik yang baik. Dari hasil uji keamanan iritasi kulit  tidak terjadi iritasi, sedangkan hasil uji iritasi mata menunjukkan sediaan mengiritasi mata.Kata Kunci: daun kembang sepatu, pertumbuhan rambut, hair tonic, HET-CAM, patch test 
UJI IN VITRO DAN IN SILICO SENYAWA 5,7,2’,5’-TETRAHYDROXY FLAVAN-3-OL TERHADAP ENZIM ALPHA GLUCOSIDASE Frengki Frengki; Deddi Prima; Fatma Sri Wahyuni; Daan Khambri; Henny Vanda; Noni Zakiah; Jamilah Abbas; Berna Elya
Jurnal Fitofarmaka Indonesia Vol 5, No 2 (2018): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (872.784 KB) | DOI: 10.33096/jffi.v5i2.416

Abstract

Several of Calophyllums genus have been searched and proven as medicinal plants and Calophyllum macrophyllum is one of its genus. We have been isolated a compound from ethyl acetate fraction of the stem-bark. The compound was flavan-3-ol (5,7,2’,5’-tetrahydroxy flavan-3-ol). This research aimed to determine inhibition antidiabetic activity and affinity of its compound on α-glycosidase enzyme. In vitro antidiabetic effect shown by IC50 9.10 µg/ml and docking by Arguslab 4.01 shown by ΔG -10,24 kkal/mol as in silico test. The inhibition activity of flavan-3-ol against the α-glucosidase enzyme that is very strong shows its promising potential as a candidate for antidiabetic drugs.
Pengaruh Metode Ekstraksi Terhadap Kandungan Senyawa Polifenol dan Aktivitas Antioksidan pada Rubus fraxinifolius Yesi Desmiaty; Berna Elya; Fadlina Chany Saputri; Iis Irawatty Dewi; Muhammad Hanafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.654 KB) | DOI: 10.35814/jifi.v17i2.755

Abstract

Rubus fraxinifolius can be founded in the mountainous regions of West Java. Previous studies have shown that this plant has potent antioxidant activity. The content of polyphenol compounds in this species contributes substantially to antioxidant activity, and the extraction method will affect the content of the compound. In this study an evaluation of the extraction method effect on leaves, young fruits and stems of R. fraxinifolius on the content of polyphenols and their antioxidant activity, have been done. Method: The leaves, fruits, and stems of R. fraxinifolius were extracted by maceration, reflux, and soxhlet using methanol as a solvent. Each extract was determined the total polyphenol content using Folin-Ciocalteu reagent and antioxidant activity test using DPPH reduction method. Result: The highest extract yield was R. fraxinifolius leaf reflux extract (30.20%). The highest total polyphenol content was given by the Soxhlet extract of leaf R. fraxinifolius (48.79 mg GAE / g extract). The highest antioxidant activity was leaf Soxhlet extract of R. fraxinifolius (98.29% at 100 ppm). Conclusion: From this study it was shown that the methanol extract of R. fraxinifolius leaves extracted by Soxhlet gave the highest polyphenol content and antioxidant activity.
Stabilitas Kimia Senyawa Etil P-Metoksi Sinamat (EPMS) dari Rimpang Kencur (Kaempferia galanga L.) dalam Krim Anti Jerawat dengan Metode Kromatografi Lapis Tipis Densitometer (TLC Scanner) Ika Maruya Kusuma; Berna Elya; Mahdi Jufri
SAINSTECH FARMA Vol 10 No 1 (2017): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v10i1.799

Abstract

Senyawa Etil P-Metoksi Sinamat (EPMS) merupakan senyawa yang tidak stabil dalam suhu panas dan mudah terhidrolisis menjadi asam p-metoksi sinamat (APMS). Senyawa EPMS dengan penyimpanan yang cukup lama dikhawatirkan dapat mempengaruhi pH sediaan krim dan dapat menyebabkan kulit menjadi iritasi yang berbahaya bagi pasien. Penelitian ini bertujuan untuk mengetahui stabilitas kimia senyawa EPMS pada sedian krim anti jerawat tipe O/W yang diukur tiap 2 minggu selama penyimpanan 3 bulan, dengan metode Kromatografi Lapis Tipis Densitometer (TLC Scanner). Dari penelitian ini diketahui stabilitas kimia krim EPMS selama penyimpanan 3 bulan mengalami sedikit perubahan dengan penurunan kadar EPMS dalam krim sebesar 4,89%.
Antibakteri Ekstrak Kulit Batang Manggis Hutan (Garcinia rigida miq.) Elya, Berna; Soemiati, Atiek; Farida, Farida
Majalah Ilmu Kefarmasian Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

A research on the antibacterial activity of n-hexane extract and the ethyl acetate Garcinia rigida Miq. Bark against Salmonella typhosa ATCC 14028, Staphylo-coccus aureus ATCC 29213 dan Bacillus subtilis ATCC 6633 has been carried out. The research was included the determination of the growth inhibition zona with the cylinder diffusion method and the minimum inhibitory concentration with the petri dish dilution method. The result of this study showed that the n-hexane extract of Garcinia rigida Miq.bark did not give the growth inhibition zona to Salmonella typhosa ATCC 14028, Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6633, but gave the minimum inhibitory concentration at 500 mg/ml for Sal-monella typhosa ATCC 14028, 250 mg/ml for Staphylococcus aureus ATCC 29213 and 125 mg/ml for Bacillus subtilis ATCC 6633. Whereas the ethyl acetate extract of Garcinia rigida Miq. bark gave the growth inhibition zona of concentra-tion 500, 250 and 125 mg/ml with average diameter to Salmonella typhosa ATCC 14028 were about 11.15, 9.05, 7.55 mm, to Staphylococcus aureus ATCC 29213 were about 14.25, 11.10, 8.95 mm and to Bacillus subtilis ATCC 6633 were about 20.97, 15.00, 10.07 mm. The minimum inhibitory concentration to ethyl acetate extract to Salmonella typhosa ATCC 14028, Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6633 were about 250, 62,5 and 31,25 mg/ml respec-tively. As a conclusion, the ethyl acetate extract of Garcinia rigida Miq. bark had more better antibacterial activity than the n-hexane extract of Garcinia rigida Miq. Bark.
Uji Aktivitas Penghambatan Enzim Alfaglukosidase Pada Beberapa Tanaman Suku Euphorbiaceae Elya, Berna; Katrin, Katrin; Bangun, Anastasia
Majalah Ilmu Kefarmasian Vol. 9, No. 3
Publisher : UI Scholars Hub

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Abstract

Diabetes mellitus (types 1 and 2) is recognized as a serious global health problem that characterized by hyperglycemia. Type 2 diabetes is more common in diabetic populations. In type 2 diabetes mellitus, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. Avoiding the adverse effects of current agents, it is still necessary to search alternative for better options. Plants have been a rich source of α-glucosidase inhibitors. In this research, screenings based on chemotaxonomic approach to determine the class of chemical constituents and to know α-glucosidase inhibiting activity of some plants from Euphorbiaceae. The simplisia powder was extracted using ethanol 80% by reflux. Measurement of inhibitory activity of α-glucosidase performed using a spectrophotometer UV-VIS. In vitro assays of α-glucosidase activity showed 14 extracts had IC50 values of between 2.34 µg/mL and 64.78 µg/mL, which were lower than that of acarbose (117.20 µg/mL). Leaves extract from Antidesma celebicum had the highest α-glucosidase inhibiting activity with an IC50 of 2.34 µg/mL. The results of phytochemical screening in 15 extracts generally contain glycosides, terpenoids/ sterols, tannins, saponins and alkaloids.
Uji Stabilitas Fisik Losio Yang Mengandung Fraksi Diklorometana Ekstrak Metanol Kulit Buah Manggis (Garcinia mangostana L.) Apriyanti, Elis; Jufri, Mahdi; Elya, Berna
Majalah Ilmu Kefarmasian
Publisher : UI Scholars Hub

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Abstract

Mangosteen pericarp (Garcinia mangostana L.) contains some of xanthones derivates which have antioxidant activity.Those compounds prevent formation of free radicals that cause premature aging. Dichloromethane fraction from methanol extract of mangosteen pericarp has very strong antioxidant activity. Dicholomethane fraction of mangosteen pericarp was formulated into lotion dosage form with different concentration 0.01; 0.05; and 0.25%.. Physical stability of lotion was evaluated by cycling test, centrifugal test, and stored the lotions at low temperature (4±2˚C), room temperature (27±2˚C), dan high temperature (40±2˚C). The result showed that the lotions stable at each strorage condition and cycling test. However, the result of centrifugal test showed separation phase of lotions.
Uji Penghambatan Aktivitas alfa-glukosidase Ekstrak dan Fraksi Daun Antidesma neurocarpum Miq. Widihasputri, Rieka; Elya, Berna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian
Publisher : UI Scholars Hub

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Abstract

Diabetes mellitus is a metabolic dysfunction disease showed by hyperglicemia and abnormality of carbohydrates, fats, and proteins metabolism. It is known can be cured with a-glucosidase inhibitor. Previous experiment reported that methanol extract from leaves of Antidesma neurocarpum Miq. has a strong inhibitory activity of a-glucosidase (IC50 = 2,18 mikrogram/mL). The aim of this experiment was to know about the most active extract and fraction of inhibitory activity of a-glycosidase and also the chemical compounds from those most active extract and fraction. Extraction is done by using multilevel maceration (n-hexane, ethyl acetate and methanol). Inhibitory activity of a-glucosidase tested with microplate reader at 405 nm wavelength. As standard, we used carbose (IC50=38.37 gg/mL). Methanol extract has the strongest inhibitory activity of a-glucosidase as shown the highest inhibitor percentage (89.53%). It is identified the chemical compounds and fracinationed by flash column chromatography. Fractination produced 15 combined fractions. Combined fractions which more than 200 mg tested to know their inhibitory activity of a-glucosidase. Result showed that the most active fraction is the 8th (IC50=40.77 gg/mL) with a competitive inhibitor mechanism to a-glycosidase. Chemical compounds that is found in the methanol extract and 8th fraction of Antidesma neurocarpum Miq. leaves are flavonoids, tannins, glycosides, fenol and alkaloids.
Co-Authors . Azizahwati . Azizahwati . Farida . Frengki . Katrin . Katrin . Nofiantini Ali Muhammad Shodiq Anastasia Bangun Anastasia Bangun, Anastasia Arifianti, Ayun Erwina Atiek Soemiati Atiek Soemiati Atiek Soemiati Atriyon Julzarika Azizahwati Azizahwati Azizahwati Azizahwati, Azizahwati Chairunissa, Ananda Hanny Daan Khambri Dadang Kusmana Deddi Prima Donna Maretta Ariestanti Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Emiyanah . Fadlina Chany Saputri Farida Farida Farida Ibrahim Fatma Sri Wahyuni Febriani, Amelia Febriani, Amelia Febrina Amelia Saputri Forestrania, Roshamur Cahyan Frengki Frengki Henny Vanda Herman Suryadi Hindun Wilda Risni Iis Irawatty Dewi Ika Mustika Irianti, Marina Ika Jamilah Abbas Jamilah Abbas Jantan, Ibrahim Juheini Amin Juheini Amin Juheini Amin Kartika Citra Dewi Permata Sari Katrin Basah Katrin Katrin Kusuma, Ika Maruya Liza Ariantina Maharani, Fasya Hadaina Mahdi Jufri Makau, Juliann Nzembi Marcha Putri, Nada Mia Permawati Muhamad Iqbal Julian Muhammad Hanafi Muhammad Hanafi Nevy Krinalawaty Nisa Maria Nofiantini Nofiantini Nofiantini Nofiantini, Nofiantini Noni Zakiah Novita, Hessy Nugraha, Media Fitri Isma Rahmasari, Ratika Rajamuddin, Muh Alias L REFLINUR REFLINUR Regita Putri, Jasmine Rieka Widihasputri Rieka Widihasputri, Rieka Robiatul Adawiyah Roshamur Cahyan Forestrania ROSSA YUNITA Santy Rahmawati Siti Khadijah Soleh Kosela Soleh Kosela Taufiq Indra Rukmana Wening Enggarini Yesi Desmiaty, Yesi