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All Journal Berkala Kedokteran Jurnal Surya Medika Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat JURNAL PENDIDIKAN MIPA Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Riset Kefarmasian Indonesia Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Reswara: Jurnal Pengabdian Kepada Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indonesia Berdaya Hydrogen: Jurnal Kependidikan Kimia Jurnal Sains dan Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Journal of Pharmaceutical Care and Sciences Jurnal Matematika Dan Ilmu Pengetahuan Alam LLDikti Wilayah 1 (JUMPA) Jurnal Rumpun Ilmu Kesehatan Innovative: Journal Of Social Science Research Sains Medisina Journal of Advances in Medicine and Pharmaceutical Sciences Juragan (Jurnal Agroteknologi) JFARM (Jurnal Farmasi)
Kunti Nastiti
Universitas Sari Mulia
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Journal : Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

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SKRINING SENYAWA INHIBITOR H2 DARI KAYU MANIS (Cinnamomum verum J.Presl) Samsul Hadi; Diah Aulia Rosanti; Desiya Ramayanti Azhara; Kunti Nastiti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.519 KB) | DOI: 10.36387/jiis.v6i2.663

Abstract

Digestive tract disorders, especially gastric disorders, are often experienced by people. One drug to treat this disorder has a mechanism of blocking the H2 receptor. This research was conducted to find compounds from C.verum which have the stability of bind to H2 receptors. The method used is protein modeling with swiss-model, docking with PLANTS (CHEMPLP) and activity prediction. The test results obtained that the docking score was ?- amorphene (-65,79), ?-bergamotene (-65,48), ?-copaene (-66,62), ?-cubebene (-66,46), Cadinene (-64 , 79), Camphor (-52.15), Caryophyllene (-62.61), Cinnamaldehyde (-68.17), Epicatechin (-80.43), Ergosterol (-85.24), Eugenol (-67.35), Hydrocinnamaldehyde (-65,53), Quercetin (-74,38), Protocatechuic acid (-71,49), Stigmasterol (-88,88), 4- (2,3-dihydro-3- (hydroxymethyl) - 5- (3-hydroxypropyl) -7- (methoxy) benzofuranyl] -2-methoxyphenyl (-85,29). Combined with the probability activity of compounds that have the potential to be further developed are Epicatechin and urolignoside.
Co-Authors Adi Rahmadi Ana Maulana Ana Muliana Arif Subekti Citra Agustiani Kusuma Dahlia Syahrina Darini Kurniawati Darini Kurniawati Darini Kurniawati Dede Mahdiyah Deni Setiawan Desiya Ramayanti Azhara Diah Aulia Rosanti Dian Ekowati Dyan Fitri Nugraha Dyan Fitri Nugraha Dyan Fitri Nugraha Dyan Fitri Nugraha Faisal Rahman Feliya Carolina Firda Nirmalasari Fitri Yuliana Ghina Zhahera Ihda Syifa El Rahma Juliance Yolanda Putri Mambang Maria Dwi Ayu Listiawati Melviani Melviani Melviani Melviani Melviani Melviani Melviani Melviani Melviani Mia Audina Mia Audina Muhammad Noor N Noval N Novia Ni Ketut Linda Puspa Yani Noval Noval Nur Syifa Nurul Hidayah Putri Vidiasari Darsono Rahmadani Rahmadani Rahmayani Rahmayani Rizali, Muhammad Samsul Hadi Setia Budi Setia Budi Siti Malahayati Siti Malahayati Sukmana, M. Laily Qadry Tuti Alawiyah Umi Kalsum Vita Mayasari Witri Alya Yanti Saubari Yanti Saubari