Surgery is an invasive procedure to open up certain body parts and close it again. Plan surgery always gives discomfort, anxiety and erratic, anxious. If anxiety is not getting good treatment, then anxiety will worsen and impact the unpreparedness of patients undergoing surgery. Music therapy is one of non-pharmacological methods to reduce the level of anxiety, the music can provide comfort, serenity will make the patient more relax so that someone more calm in the face of something. Goal: The purpose of this research was to determine the effect of music therapy on anxiety levels in patients with preoperative surgical Santa Elisabeth’s Hospital Medan 2015. Methods: This research used experimental design, with methods one-group pre-post test design. Samples are 20 respondents, using purposive sampling technique. The instruments that used in this research was sheets of questionnaire of Anxiety Levels. The analysis data was performed by Wilcoxon Sign Rank Test p<0.05. Result: By the results of researched show that before the intervention to 65% experiencing severe anxiety, 35% had moderate anxiety. After the intervention found 90% experiencing moderate anxiety, 10% experienced mild anxiety. Wilcoxon Sign Rank Test results obtained value of p = 0.000 (p < 0.05). Conclusion: Results showed that there is influence of music therapy on anxiety levels in patients with preoperative surgical in Santa Elisabeth’s Hospital Medan. It is suggested to nurses, patients and families should be known and apply the music therapy because it is can reduce the anxiety level preoperative Surgical.