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PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN Donastin, Adyan; Bakhtiar, Arief; Maranatha, Daniel
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.617

Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.

Correlation between Coenzyme Q10 Level Long-Term Steroid Inhalation in Patients with Bronchial Asthma Deny Perdana Putra1, Arief Bakhtiar2, Muhammad Amin2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3378

Background: The main therapy of asthma is inhaled steroids and is often used for long periods of time. Coenzyme Q10 is a potent antioxidant produced largely by mitochondria. Treatment of long-term oral steroids can cause mitochondrial damage which lowers the level of coenzyme Q10. Objective: To analyze the relationship between coenzyme Q10 levels and long-term steroid inhalation in asthma patients. Method: The study was conducted at Asthma Unit/COPD of Dr. Soetomo General Hospital Surabaya Indoensia, Pulmonology Unit of. Dr. M. Soewandhie General Hospital Surabaya Indonesia, and Pulmonology Unit of Universitas Airlangga Hospital Surabaya Indonesia. We measured coenzyme Q10 levels and the duration of inhaled steroid use in the subjects. The data were processed using computer statistics program. The correlation between coenzyme Q10 level and long-term steroid inhalation was analyzed using Pearson correlation test (p <0.05). Result: Coenzyme Q10 levels in all samples were normal and increasing. There was no low coenzyme Q10 level found in all samples. The result of Pearson’s correlation test between coenzyme Q10 level with longterm steroid inhalation showed r = -0.037; p = 0.848 (p> 0.05). Conclusion: There was no correlation between coenzyme Q10 level and long-term steroid inhalation found in this study.

Appropriate Antibiotic Use for Community-Acquired Pneumonia in Inpatient Settings and Its Impact on 30-days Readmission and Mortality Rate Rafida Sofi Kamila1, Maftuchah Rochmanti2*, Arief Bakhtiar3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13817

Background: Community-Acquired Pneumonia (CAP) is a lower respiratory tract infection with bacteriaas the most frequent causative agent. Therapy for pneumonia includes appropriate antibiotic usage.Inappropriate antibiotic use supposedly increase 30-days readmission and mortality rate.Objective: To evaluate the antibiotic use and the impact of appropriate antibiotic use on the 30-daysreadmission and mortality of CAP patients in inpatient non-ICU settings.Method: A cross-sectional, analytic study was conducted. We collected data from Universitas Airlanggahospital’s medical record to obtain the details of antibiotic usage. Result were evaluated using the Gyssensalgorithm. A chi-square test was used to identify the impact of appropriate antibiotic use on the 30-daysreadmission and mortality.Result: A total of 90 patients with CAP fulfilled the inclusion criteria. One gram of ceftriaxone IV wasthe most prescribed antibiotic for therapy of CAP. The amount of appropriate antibiotic use is 85.6%. Fivepatients (5.6%) went through the 30-days readmission. There was no death reported. The statistical testbetween antibiotic use and 30-days readmission obtained p value=0.894 (p>0.05).Conclusion: There was no significant impact of appropriate antibiotic use on the 30-days readmission rateand the mortality rate could not be assessed.

PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN Adyan Donastin; Arief Bakhtiar; Daniel Maranatha
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.617

Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020 Muhammad Raihan Habibi; Arief Bakhtiar; Danti Nur Indiastuti; Resti Yudhawati Meliana
Jurnal Ilmiah Universitas Batanghari Jambi Vol 22, No 1 (2022): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v22i1.1908

Multidrug-Resistant Tuberculosis (MDR TB) is a condition when Mycobacterium tuberculosis were resistant to Isoniazid and Rifampicin simultaneously, with or without being followed by other first-line Anti-Tuberculosis Drugs. Diabetic patients who also have TB are more susceptible to drug resistance. There is ample evidence noting that a history of previous TB treatment is one of the main factors contributing to the development of MDR TB. This study was a case-control study. The sample of this study was all patients from TB Polyclinic Dr. Soetomo Hospital who were diagnosed with pulmonary TB by pulmonologists on January 1, 2019 – December 31, 2020, who met the inclusion criteria. The data obtained were analyzed using the IBM SPSS Statistics 23 application with a binary logistic regression test.There were 178 samples of this study. MDR TB (65.8%) was the dominant resistance type in Drug-Resistant Tuberculosis (DR TB) patients. Patients with DM were 2.2 times more likely to develop MDR TB than patients without DM. Patients with histories of previous tuberculosis (TB) treatment tended to be three times more likely to develop MDR TB than new patients. Other factors such as age, sex, BMI, history of alcohol consumption, and history of smoking did not show a significant relationship with the incidence of MDR TB. Diabetes Mellitus comorbidity and history of previous Tuberculosis treatment were significant risk factors for developing MDR TB.

Kanker Paru dan Penatalaksanaannya Arief Bakhtiar; Bambang Soeprijanto
Jurnal Kedokteran Syiah Kuala Vol 6, No 1 (2006): Volume 6 Nomor 1 April 2006
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstr ak. Keluhan kanker paru terjadi akibat kelainan : intra pulmonal, intra torasik ekstra pulmonal, ekstra torasik metastatik, ekstra torasik non meiastatik. Prosedur diagnosa meliputi deteksi dini dan tindakan diagnostik lebih Ianjut yang secara garis besar dapat dibagi dua : Tindakan Non lnvasif ( CT Scan Toraks, Positron Emission Tomography (PET) Magnetic Resonance Imaging); dan tindakan invasif (Transthoracic Needle Aspiration, Fiber Optik Bronkoscopi, Endoscopic Ultrasound, Mediastinoskopi). Klasifikasi kanker paru jenis karsinorna bukan sel kecil berdasarkan TNM staging, sedangkan small cell lung carsinoma berdasarkan Veterans Administrasion Lung Cancer Study grup. Penatalaksanaan kanker paru bersifat multimodalitas terapi yang terdiri dari: pernbedahan, radiasi, kernoterapi, irnunoterapi, terapi hormonal dan tempi gen. (JKS 2006;1:23-38) Kata kunci : karsinorna bron.kogenik, diagnose, penatalaksanaan. Abstract. Lung cancer is caused by intrapulmonary, intrathoracic extrapulmonary, extrathoracic metastatic, and extra thoracic nonmetastatic abnormalities. The diagnosis procedure includes early detection and further diagnostic action which are divided into two: NonInvasive Action (Thoracic CT Scan, Positron Emission Tomography (PET), Magnetic Resonance Imaging) and invasive (Transthoracic Needle Aspiration, Fiber Optical Bronchoscopy, Endoscopic Ultrasound, Mediastinoscopy). The classification of carcinoma lung caricer of nonsmall cell carcinoma is based on TNM staging, whereas small cell lung Veterans Administrasion carcinoma is based on Lung Cancer Study Group. The treatment of lung cancer is identi lied as multi modality therapy consisting of surgery,radiation, chemotherapy, irnrnunotherapy, hormonal therapy and gene therapy. (JKS 2006;1:23-38) Keywords: carcinoma bronchogenic, diagnosis, treatment.

Case Report: Survival of A Coronavirus Disease-2019 (Covid-19) Patient with Acute Respiratory Distress Syndrome (ARDS) in Dr. Soetomo Hospital, Surabaya, Indonesia Soedarsono Soedarsono; Bambang Pudjo Semedi; Rosy Setiawati; Resti Yudhawati Meliana; Tutik Kusmiati; Ariani Permatasari; Arief Bakhtiar; Irmi Syafa’ah; Dwi Wahyu Indrawanto
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. Currently, there is no vaccine or specific antiviral for COVID-19. A study reported 7.3% of critical patients admitted to ICU, 71% of them required mechanical ventilation, and 38.5% of them were survived. Herein, we reported a 54 year old man with Acute Respiratory Distress Syndrome (ARDS) of COVID-19 who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharingeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory, chest radiograph, and chest CT scan. Alcaligenes faecalis and Candida albicans were also identified from sputum culture. Treatment for this patient was causal and supportive therapy, including antibiotic, antiviral, and antifungal therapy according to the culture results, fluid resuscitation, and oxygen supply from the mechanical ventilator. This patient was survived and discharged on hospital day-29. A fibrosis in parenchyma pulmonary and sensory peripheral neuropathy occurred after survived from ARDS. Monitoring of clinical, laboratory, and chest radiograph were continued after the patient discharged from the hospital. This case highlights the importance of early diagnosis and effective treatment to the care of COVID-19 patient.

The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Siti Khaerunnisa; Irmi Syafa'ah; Citrawati Dyah Kencono Wungu; Gwenny Ichsan Prabowo; Retno Handajani; Indri Safitri; Harianto Notopuro; Ema Qurnianingsih; Lina Lukitasari; Ira Humairah; Arief Bakhtiar; Suwandito Suwandito; Susi Wahyuning Asih; Zuhrotul Eka Yulis Anggraeni; Ginanjar Sasmito Adi; Ely Rahmatika Nugrahani; Ayesie Natasha Zulka; Soetjipto Soetjipto
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.

The Relationship between Physical Activity and FEV1/FVC in Asthmatics Andis Putri Nawangasri; Budiono Budiono; Arief Bakhtiar; Budi Sutikno; Esti Maulidya Suryaningrum; Dahlia Damayanti
Surabaya Physical Medicine and Rehabilitation Journal Vol. 4 No. 1 (2022): SPMRJ, FEBRUARY 2022
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v4i1.24726

Background: Physical activity is any body movement that requires energy expenditure. Minimum physical activities per day can bring good impact for asthmatic patients (e.g.,reduce asthma symptoms). Many asthmatic patients limit their physical activity, so they tend to be inactive.Aim: To analyze the relationship between physical activity level and FEV1/FVC in asthmatics.Material and methods: This was an analytic observational study with a cross-sectional design. The number of participants in this study was 16 respondents (13 females and 3 males) who were recruited based on inclusion and exclusion criteria. The independent variable in this study is levels of physical activity and the dependent variable is FEV1/FVC values. This study study used the International Physical Activity Questionnaire (IPAQ) short form and spirometry test. The data were analyzed with Spearman's rho test.Result: There was a strong association between levels of physical activity with FEV1/FVC values (p=0,012).Conclusions: Increasing level of physical activity in asthmatics can improve their lung function showed by increased FEV1/FVC values.

PREVALENCE OF DIABETES MELLITUS WITH PULMONARY TUBERCULOSIS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA 2016 Heronimus Hansen Kaware; Deby Kusumaningrum; Arief Bakhtiar
Majalah Biomorfologi Vol. 32 No. 1 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i1.2022.18-21

Highlight:1. The signs and symptoms of patients with pulmonary tuberculosis and those of diabetes mellitus were similar.2. Male, aged 51-75 years old, and working in private sector are characteristics of most of the diabetic patients with pulmonary tuberculosis.Abstract:Background: Diabetes Mellitus is a type of disorder where the patients’ blood sugar is above average. Diabetes Mellitus can cause an abundance of comorbidities, from viral infection until metabolic abnormalities. The increased risk of infections is mostly because diabetes mellitus changes how the body works. The changes range from changes in mechanical barriers (humoral immunity) and cellular changes (cellular immunity), the changes of the humoral immunity that can increase the chance of protracting pulmonary tuberculosis. Objective: The purpose of this study was to describe the characteristics of diabetes mellitus in pulmonary tuberculosis in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from January to December 2016. Materials and Methods: The research method used was an observational study using a cross-sectional design conducted in Central Medical Record for hospitalized patients, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The diabetes mellitus patients’ data collected from the medical records of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2016 were 1,410 and 11 of them were also diagnosed with pulmonary tuberculosis. The final data taken were from 67 out of 115 patients due to the incomplete medical record. Results: According to the data, the most of the diabetic patients with pulmonary tuberculosis were male, age of 51-75 years old, and worked in private sector. Conclusion: There was a significantly higher number of diabetes mellitus with pulmonary tuberculosis patients in older age, males, and private-sector workers. Diabetic patients with pulmonary t

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