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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi

Sitti Amirah

Fakultas farmasi Universitas Muslim Indonesia Makassar

Author-ID : 2645087

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI ANTIMITOSIS EKSTRAK ETANOL BUAH MERAH (Pandanus conoideus Lam) DENGAN METODE PENGHAMBATAN PEMBELAHAN SEL TELUR Tripneustes gratilla Linn TERFERTILISASI Sitti Amirah; Heriyanto Beddu
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

The research concerning antimitotic assay of ”Buah Merah” (Pandanus conoideus Lam) ethanol extract using sea urchin Tripneustes gratilla Linn eggs cleavage inhibition method had been conducted. The aim of this study was to determine the antimitotic effect of buahMerah ethanol extract in to inhibit cell cleavage of fertilized sea urchin eggs. Buah Merah ethanol extract was made in to 5 concentration there was 0,001 µg/ml, 0,01 µg/ml, 0,1 µg/ml, 1 µg/ml and 10 µg/ml with vincristine as the compared. Quantivication of cell cleavage was performed visually under the light microscopy by counting the number of cleaveaged and non cleaveaged embryos after an incubation time of ± 2 hours. If 80-100% inhibition of cleavage (IC80-100) occurs at ≤ 16 mg/ml, the compound is considered to be active as antimitotic. The result of this research showed that IC80 value of ”BuahMerah” ethanol extract was 0,026 mg/ml. According to the value ethanol extract was categorized active as antimitotic, although their potency lower than vincristin which can inhibit 80 % of fertilized sea urchin eggs at 2,789x10-4 mg/ml.Key words: Pandanus conoideus Lam, Antimitotic, Tripneustes gratilla Linn.

UJI AKTIVITAS ANTIRADIKAL BEBAS EKSTRAK DIETIL ETER DAUN SIRSAK (Annona muricata Linn.) ASAL KOTA MAKASSAR DENGAN METODE DPPH Sitti Amirah; Rahmawati Rahmawati; Andi Evi Wulandari Luspi
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i2.129

Has been on concerning test of activity radical scavenging of soursop leaves (Annonamuricata Linn.) extract of dietileter with DPPH method. This research aimed to know the level activity of free radical based on binding of DPPH free radicals of Soursop leaves (Annonamuricata Linn.).Extraction of soursop leaves (Annonamuricata Linn.) by macerate with methanol, methanol extract then is partition with dietileter.Than measured of quantitative by five concentration 50 ppm, 100 ppm, 200 ppm, 300 ppm and 400 ppm, the result of measured have done with statistical method of regretion simple linier with average value of IC50 are 4980,4 ppm. This potency explainextract activity is still very lowers than vitamin C and BHT with value of IC50 are 10,304 mg/ml dan 43,394 ppm. Key Words :DPPH, Radical scavenging, Annonamuricata Linn.

UJI EFEK ANTIINFLAMASI EKSTRAK n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb) PADA MENCIT JANTAN (Mus musculus) YANG DIINDUKSI DENGAN KARAGEN Sitti Amirah; Rahmawati Rahmawati; Safriani Rahman; Franita Achmad
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

This research about antiinflammation effect from n-hexane extract of Beruwas Laut leaves (Scaevola taccada (Gaertn.) Roxb.) in male mice (Mus musculus) was conducted, the aim was assay the antiinflammation effect of Beruwas Laut leaves done extract based on decrease in edema volume of foot palm male mice. This research using 15 male mice that evaluated and divided into 5 groups that each group has 3 mice. In group I, diclofenac sodium as the compare administrated. In groups II, III, dan IV, n-hexane Extract of Beruwas Laut leaves in concentration of 2,5%, 5% and 7,5% administrated. In group V, 1% Na-CMC as negative control administrated. Induction carried out by injection 1% w/v carrageen 0,1 ml subcutan on the feet palm of mice. One hour later each group administered the preparation test 1 ml/30 gBW orally. The measurement of edema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between induction and antiinflammation effect analysed. Result indicated variety with n-hexane extract of Beruwas Laut leaves have the antiinflammation effect at concentration 7,5%. Key Word : Antiinflammation, Scaevola taccada (Gaertn.) Roxb, Mice, n-Hexane.

UJI TOKSISITAS FRAKSI n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) DENGAN METODE BRINE SHRIMP LETHALITY TEST Rahmawati Rahmawati; Sitti Amirah; Andi Sulfika
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Research of effect toksisitas of n-heksan faction of the beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf at prawn larva of Artemia salina Leach have been done as a mean to determine potency of toksisitas and value of LC50 beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf. As control used n-heksan. Before treatment, prawn egg of Artemia salina Leach incubated at some stage and after 48 hours prawn larva of Artemia salina Leach are ready to given treatment. Hereinafter n-heksan faction of beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf with concentration 0,1 ; 1 ; 10 ; 100 µg/ml in sea water enhanced 10 prawn larvas. For control, done same treatment. Perception done after 24 hours treatment by counting dead prawn larva. Result of perception indicate that value of LC50 n-heksan faction of beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf 4,17 ± 2,59 µg/ml. So that can be expressed that n-heksan faction of beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf have potency as anticancer, this matter is based by standard of Meyer (1982) expressing that a natural materials compound have potency of anticancer if value of LC50 <1000 µg/ml. Key word : Toksisitas Test, Scaevola taccada (Gaertn.)Roxb, Brine Shrimp Lethality Test

Aktivitas Ekstrak Daun Salam (Syzygium polyanthum) sebagai Antirheumatoid Artritis pada Tikus yang Diinduksi Complete Freund’s Adjuvants (CFA): Antirheumatoid Arthritis Activity of Salam (Syzygium polyanthum) Leaf Extract to Mice Induced by Complete Freund’s Adjuvants (CFA) Sitti Amirah; Aulia Wati; Bayu Putra; Fitri Wasto Alani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Rheumatoid arthritis is an chronic autoimmune disease, which is characterized by inflammation and degradation of the joints and cartilages. Rheumatoid therapy is currently using immunosuppressant drugs, nonsteroidal anti-inflammatory drugs and corticosteroids. Treatment of chronic rheumatoid can trigger side effects. Syzygium polyanthum leaves contain alkaloid compounds, flavonoids, saponins, tannins and essential oils consist of citral and eugenol which are thought to be potential as antirheumatoid. This study aims to determine the effect antirheumatoid arthritis and effective dose of ethanol extracts of Syzygium polyanthum leaf. This study used 15 male rats. Treatment started by measuring foot volume using a pletismometer and then inducting CFA intraplantary as much as 0,1 mL on day 1 and left until day 16th. On the day 17th a foot volume and arthritis index was measured and then treated until the day 30th. The animals were divided into 5 groups: negative control (Na. CMC 1%), positive control (methylprednisolone dose 1.646 mg / kg BW), ethanol extractof Syzygium polyanthum leaf at a dose of 75 mg / kg, 150 mg / kg and 300 mg / kg. On the day 31st, foot volume and arthritis index measurements were taken again. The results showed a decrease in foot volume and arthritis index after given of the extract. Foot volume difference data were analyzed using the One Way Anova test followed by the Post Hoc LSD test. The difference between the arthritis index data was analyzed using Kruskal-Wallis followed by the Mann-Whitney test. Statistical results show that positive control has the same effect as extract (P> 0.05). Based on the results of statistical analysis of inflammation of the foot volume and the arthritis index shows that the ethanol extract of Syzygium polyanthum leaf had an effect as an antirheumatoid arthritis

AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE TERHADAP MIKROBA PATOGEN MENGGUNAKAN DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Sukmawati Sukmawati
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.967

Infectious diseases can be caused by the entry of microorganisms such as bacteria, fungi, parasites, and viruses that can cause diseases in humans. One of the plants used empirically by the Weda community in Central Halmahera is the stem part of the wole woe plant. The aim of this study was to determine the antimicrobial activity of the ethanol extract of wole woe stems against pathogenic microbes such as Propionibacterium acnes, Escherichia coli, Salmonella thypi, Shigella dysentriae, Vibrio cholerae, and Candida albicans. This study used the agar diffusion method with various concentrations of 2.5%, 5%, and 10%, and positive controls for bacteria with chloramphenicol, positive controls for fungi with nystatin, and DMSO as a negative control. Based on the average diameter of the inhibition zone obtained, the test microbes were classified into the medium-strong category because they had an inhibition zone diameter ranging from 9 mm to 13 mm. The positive control for chloramphenicol for bacteria was classified into the very strong category because it had an inhibition zone diameter of >20 mm, while the positive control for nystatin for fungi was classified into the strong category because it had an inhibition zone diameter of >10 mm. Based on these tests, it can be concluded that the ethanol extract of wole woe stems has antimicrobial activity

Co-Authors Anak Agung Istri Sri Wiadnyani Andi Evi Wulandari Luspi Andi Sulfika Aulia Wati Bayu Putra Fitri Wasto Alani Fitriana Fitriana Franita Achmad Heriyanto Beddu Safriani Rahman

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