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PF-18 Photomicrograph of Nanogel Andrographolide-Beta Cyclodextrine Inclusion Complex As Anti-Burns Bayu Febram Prasetyo; Ietje Wientarsih; Dondin Sajuthi; Vetnizah Juniantito
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Inclusion complex is a complex formed between drug molecules which act as guest or located inside the cavity of host molecule. Host molecules are commonly originated from the derivative group of cyclodextrin. Among cyclodextrin groups, beta cyclodextrin (BCD) is mostly used in formula development and drug delivery system [1].Andrographolide (AG) is a pure isolate chemically syntesized from sambiloto herbs (Andrographis paniculata Nees), in the form of needle cystal-like which is colorless and extremely bitter. AG has variety of medical properties, particularly as anti-inflamation to treat skin burns [2]. However AG has poor solubility in water. This will result in low abillity to solute, penetrate membrane, and distribute the drug when applied transdermally in burn skin. In burn skin, there is tendency to skin damage, especially in stratum corneum which acts as semipermeable barrier. The ability of drugs that applied transdermally tends to be high.Formation of inclusion complex using AG and BCD to increase the ability of AG in penetrating membrane should be done. Transmission Electron Microscope (TEM) is a fast technique to confirm the formation of drug or inclusion complex by  comparing the shape and particle size [3]. Study on percutaneous penetration of AG-BCD inclusion complex is produced through solvent evaporation method at mole ration 1:2 in viscolam gel preparation.
Aktivitas Sediaan Gel dari Ekstrak Lidah Buaya (Aloe barbadensis Mill.) pada Proses Persembuhan Luka Mencit (Mus musculus albinus) Vetnizah Juniantito; Bayu Febram Prasetyo
Jurnal Ilmu Pertanian Indonesia Vol. 11 No. 1 (2006): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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The purpose of this study was to examined the effectivity of Aloe vera gel formulation on the skin wound healing process based on the macroscopic and microscopic observation. Fourty five DDY strain, 6-8 weeks old mice were used for experimental animals. Mice were incised 1-1.5 cm in the dorsum using sterile scalpels. Mice were divided into three groups. Group I (control) were not treated by anything, Group II were treated by commercial drugs (Bioplacenton), and Group III were treated by Aloe vera gel. Bioplacenton and Aloe vera gel were given topically twice a day to the skin using sterile cotton buds. Each groups consisted of 15 mice and distributed into 5 observation days with 3 replication. Three mice from each groups were euthanized periodically at day 3rd, 5th, 7th, 14th, and 21st post incision for gross pathology examination and to sampling the skin. Gross examination revealed that Bioplacenton and Aloe vera gel showed better result on wound healing process, i.e. the scab formation, scab peeler and unite of the wounded skin edge compared to the control groups. Microscopically, the Bioplacenton and Aloe vera gel groups showed the fastest epidermal re-epithelization compared with the control group. Qualitatively Bioplacenton and Aloe vera gel groups showed more fibrosis and collagen fibres formation than the control groups especially at day 7th and 14th. Scoring Average of neocapillaries formation from all groups showed no difference. Scoring average of inflammatory cells number revealed that control groups showed more cells than the other groups that indicated an high inflammatory activity. Based on macroscopic and microscopic examination we suggest that the Aloe vera gel formulation has a benefit to promote wound healing, and could be used for the treatment of skin wound. Thus, the Aloe vera gel formulation is potential to developed as commercial drugs.
Aktivitas Sediaan Gel Ekstrak Batang Pohon Pisang Ambon dalam Proses Penyembuhan Luka pada Mencit Bayu Febram Prasetyo; Ietje Wientarsih; Bambang Pontjo Priosoeryanto
Jurnal Veteriner Vol 11 No 2 (2010)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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The purpose of this study is to examine the activity of Ambon banana extract in gel formulation on thewound healing process of mice skin (Mus musculus albinus) based on gross and microscopic observations.The wound healing process were observe grossly everyday while the microscopic lesion was observed on the3rd, 5th, 7th, 14th and 21st days after skin incisition. The wounded skin were sampled after the mice wereeuthanized for further microscopic observation. The gross parameters were the existence of blood coagulation,scab formation, wound covering and wound size. The microscopic parameters observed the percentation ofwound reepitelization and the the tickness of wound connective tissues (fibroblast). Gross lesion and thefibroblast thickness were presented descriptively as a qualitative data. Grossly, it was observed that thescab formation was faster in mice treated with the extract of ambon banana than that of negative control.Based on the research the ambon banana extrack in gel can be used in the acceleratiof wound healing.