Ika Fikriah
Program Pendidikan Dokter Universitas Mulawarman Kalimantan Timur

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

PENGARUH CURCUMIN TERHADAP KADAR KOLESTEROL TOTAL, LDL-KOLESTEROL, JUMLAH F2 -ISOPROSTAN, DAN SEL BUSA (FOAM CELL) DINDING AORTA PADA TIKUS DENGAN DIET ATEROGENIK Fikriah, Ika; Kalim, Handono; Dradjat, Respati Suryanto
Jurnal Kedokteran Brawijaya Vol 21, No 2 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.016 KB) | DOI: 10.21776/ub.jkb.2005.021.02.1

Abstract

ABSTRACT Death  caused  by  cardiovascular  and  cerebrovascular diseases  are  still  the  highest.  Atherosclerosis  due  to hypercholesterolemia is a predispositioning factor of both diseases. Curcumin has an antioxidant character that can inhibit lipid peroxidase to atherogenesis process. The aim of this study was to observe the effect of curcumin in decreasing total cholesterol level, LDL-cholesterol, the number of  F2-isoprostan and foam cell of aorta’s wall of white rats strain wistar after giving atherogenic diet for 10 weeks. There were 6 groups in this study (n=24): atherogenic diet group (group I as positive control), atherogenic diet group + curcumin 50 mg/kg b.w. per day (group II), atherogenic diet group + curcumin 100 mg/kg b.w. per day (group III), atherogenic diet group + curcumin 200 mg/kg b.w. per day (group IV), atherogenic diet group + curcumin 400 mg/kg b.w. per day (group V), normal diet group (group VI as negative control). After 10th, the level of total cholesterol and LDL-cholesterol were measured by spectrofotometri. Staining F2-isoprostan was done with Avidin Biotin Complex imunohystochemistry method, and staining foam cell with HE-oil Red O. The number of  F2-isoprostan and foam cells were counting semi quantitatively using  light microscope. The highest total cholesterol level was found in group I (275,15 ± 10,01; Mean ± SD), the highest LDL-cholesterol level was found in group I (158,15 ± 12,19). Statistically total cholesterol level and LDL-cholesterol level in group I were significantly higher (p ≤ 0,05) than other
HUBUNGAN PREEKLAMPSIA BERAT DENGAN KOMPLIKASI PADA JANIN DI RSUD ABDUL 2 WAHAB SJAHRANIE SAMARINDA 3 TAHUN 2017-2018 Rifqiya Faiza, Mita Maulida; Fransiska Ngo, Novia; Fikriah, Ika
Jurnal Kebidanan Mutiara Mahakam Vol 7 No 2 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan Mutiara Mahakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.912 KB) | DOI: 10.36998/jkmm.v7i2.59

Abstract

Preeclampsia defined as new onset of hypertension and proteinuria after 20 weeks of gestation. Preeclampsia is one of the three main causes of maternal mortality with an incidence of 128,273 each year or around 5.3% in Indonesia. Preeclampsia is classified as preeclampsia without severe features and severe preeclampsia. Severe preeclampsia can be a problem, both in the mother and the fetus due to vascular vasospasm. If uteroplacental blood flow to the fetus is limited, the fetus can be born under low birth weight (LBW), preterm birth, intra uterine fetal death, and low Apgar score. The aim of this research is to determine the correlation of severe preeclampsia with fetal complication, that is intra uterine fetal death (IUFD), preterm labor, neonatal asphyxia, and low birth weight (LBW). The design of this research is case control study with 46 sample for both case and control groups. The data analysis used chi-square for 2x2 table and likelihood ratio for 2x3 table. The results of this this research is showed that there was correlation between severe preeclampsia with preterm labor (p=0,000)and severe preeclampsia with low birth weight (p=0,000), there was no correlation between severe preeclampsia with IUFD (p=0,822) and severe preeclampsia with neonatal asphyxia (p=0,060)