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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Journal of Biomedicine and Translational Research Berkala Ilmu Kesehatan Kulit dan Kelamin IJEMS (Indonesian Journal of Environmental Management and Sustainability) Biosaintifika: Journal of Biology & Biology Education Media Medika Muda Medica Hospitalia Jurnal Aisyah : Jurnal Ilmu Kesehatan
Renni Yuniati
Dept Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Diponegoro
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Effects of Spirulina platensis extract on serum Malondialdehyde (MDA) levels and differential leukocyte count on motor vehicle exhaust emissions exposure (in vivo study on Wistar rats) Dea May Fitry; Nani Maharani; Renni Yuniati
Indonesian Journal of Environmental Management and Sustainability Vol. 4 No. 3 (2020): September
Publisher : Research Centre of Inorganic Materials and Complexs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/ijems.2020.4.3.85-89

Abstract

The particulate matter in vehicle emission has been shown to cause an increase in free radical levels which can increase serum MDA levels and leukocyte count. Spirulina platensis is an algae that has antioxidant effects that can scavenge free radicals. In this research, twenty-four of wistar mice are divided into 4 groups. Groups X1 and X2 received vehicle emission smoke exposure treatment and were given oral Spirulina platensis extract at a dose of 500 and 750 mg / kgBW / day for 14 days, the negative control group (C2) was given 0.9% NaCl orally and the normal control group did not get vehicle emission smoke exposure and Spirulina platensis extract. Serum MDA levels were checked by ELISA method and leukocyte count by giemsa staining. Data analysis was performed by using the one-way ANOVA test followed by Post Hoc Bonferroni. The results showed the mean serum MDA levels there was a significant difference between group C2 and group X2. In the mean absolute value of neutrophils and lymphocytes, there were significant differences between the C2 group with the administration of X1 and X2. In the mean absolute value of eosinophils and monocytes, there were significant differences between groups C1 and C2 and group X2 and between groups X1 and C1. Furthermore, the given doses of Spirulina platensis extract at a dose of 750mg / kgBW had an effect on serum MDA levels as well as the number of neutrophils and lymphocytes and the administration of doses of 500 and 750mg / kgBW affected the number of eosinophils and monocytes.
PERBEDAANKADAR IL-8 PADA PENDERITA KUSTA TIPE MB DENGAN REAKSI REVERSAL Renni Yuniati
Media Medika Muda Vol 2, No 1 (2017)
Publisher : Faculty of Medicine Diponegoro University

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Abstract

Latar belakang :Kusta ,merupakan penyakit infeksi kronis dengan kesulitan utama penatalaksanaan reaksi kusta. Reaksi reversal merupakan reaksi kusta tipe 1. Beberapa penelitian menunjukkan peningkatan IL-6, IL-8 pada reaksi reversal. Interleukin-8 merupakan faktor kemotaktik spesifik neutrofil. Efek utama IL-8 adalah aktivasi dan rekrutmen netrofil ke lokasi infeksi. Studi ini bertujuan mengetahui perbedaan perbedaan kadar IL-8 pada pasien kusta multibasiler dengan dan tanpa reaksi reversal.Metode: Desain penelitian ini adalah analitik observasional dengan pendekatan cross-sectional. Berdasarkan perhitungan sampel , kelompok reaksi berjumlah 28 sampel, kelompok non reaksi berjumlah 28 sampel sehingga sampel keseluruhan adalah 56 orang. Dilakukan pemeriksaan kadar IL-8 serum dengan metode ELISA kemudian dihitung dengan uji beda kadar IL-8 antara 2 kelompok dengan Uji T2 sampel bebas.Hasil: Hasil penelitian ini terdapat perbedaan bermakna kadar IL-8 diantara dua kelompok , didapatkan p>0.05 .Simpulan :Terdapat perbedaan kadar IL-8 pada pasien kusta dengan reaksi  reversalKata kunci: kusta tipe multibasiler, reaksi reversal, IL-8
Effect of Clitoria Ternatea as Adjuvant Therapy on Serum Cortisol Levels in Leprosy Reaction Purnamasari, Rina; Muniroh, Muflihatul; Kusumaningrum, Novi; Mundhofir, Farmaditya EP; Yuniati, Renni
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 1: March 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (632.391 KB) | DOI: 10.30604/jika.v8i1.1502

Abstract

This study was to investigate the effect of using an extract from Clitoria ternatea as adjuvant therapy on the levels of blood cortisol in patient with leprosy reaction. The current investigation is an experimental study designed a single-blind randomized controlled trial comparison between two groups. The control group which received standard prednisolone therapy and the intervention group received standard prednisolone therapy and adjuvant therapy of Clitoria ternatea extract dose 2 g/day for one month. Serum levels of cortisol were measured by ELISA. The average serum level of cortisol decrease in control grup with statistically significant (p=0.008). The average serum level of cortisol increase in treatment grup with statistically significant (p=0.026) similar with average difference of both groups (p=0.02). According to the results of the study, the use of an extract from Clitoria ternatea extract 2 g / day for one month as adjuvant therapy significantly increase the serum cortisol levels in patients with leprosy reaction
Co-Authors Agnes Sri Siswati Anum, Qaira Arifin S Bambang Sulardiono Dea May Fitry Dhelya Widasmara Dimarti, Safira Chairani Djoko Handojo Djoko Handojo Enricco Hendra Mamuaja Farmaditya EP Mundhofir, Farmaditya EP Fifa Argentina Hardian Hardian Hendra Gunawan Herry Maha Putra Surbakti I Gusti Nyoman Darmaputra Intan Nurmawati Putri Kusumaningrum, Hermin Kusumaningrum, Novi Luh Made Mas Rusyati Muhammad Yulianto Listiawan Muhammad Zainuri Muniroh, Muflihatul Najatullah Najatullah Nani Maharani Nauval Marta Kusuma Neni Susilaningsih Nur Rachmat Mulianto Purnamasari, Rina Putri, Ajeng Kurniasari Ramona D. Lubis Regitta Indira Agusni Riawan W Riski Dwi Utami Rollin Hansen Sidauruk Sri Linuwih Susetyo Wardhani, Sri Linuwih Susetyo Tri Nur Kristina Vitayani Muchtar Widasmara D