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All Journal Indonesian Journal of Cancer Chemoprevention Gadjah Mada Journal of Psychology
Maya Fitria
Program Studi Psikologi Universitas Islam Negeri Sunan Kalijaga Yogyakarta
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Leunca (Solanum nigrum L.) Herbs Ethanolic Extract Increase Cytotoxic Activity of Cisplatin on Hela Cervical Cancer Cells Istiaji, Raditya Prima; Fitria, Maya; Larasati, .; Tjondro, Fortunella; Maruti, Astrid Ayu; Setyowati, Erna Prawita; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Cervical cancer is one of leading causes of cancer death in women in the developing countries. The use of cisplatin as chemotherapy agent in cervical cancer is known to cause side effects and also resistance for long-term uses. One of the strategies to prevent cervical cancer based on combination agents is being developed. Leunca (Solanum nigrum L.) has been revealed to inhibit growth of human cancer cells. Therefore, it can be used in combination with cisplatin to reduce those side effects and prevent the occurrence of cell resistance. Ethanolic extract of Leunca Herb (ELH) and cisplatin were tested their cytotoxic effect on HeLa cervical cancer cell by using MTT assay to determine IC50 value. The combinationss of cisplatin-ELH were tested to determine the combination index (CI value).  The IC50 of ELH and cisplatin on HeLa cells were 227 µg/mL and 17 µM. rRespectively. Tthe study of combination resulted that almost all the index combinations were <0,9 showed  the effect of synergism combination. The Ooptimum concentration of combination was  1/8 IC50 cisplatin–1/8 IC50 ELH. The results indicated that ELH had a potency to be combination agent to enhance the activity of cisplatin on HeLa cervical cancer cells. Therefore, further study on its molecular mechanism needs to be explored.
Keadilan Gender dan Hak-hak Reproduksi di Pesantren Fitria, Maya; Helmi, Avin Fadilla
Jurnal Psikologi Vol 38, No 1 (2011)
Publisher : Faculty of Psychology, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.027 KB) | DOI: 10.22146/jpsi.7660

Abstract

This study was intended to understand how the phenomenon of gender equity and reproductive rights in pesantren using the theoretical framework of attitude. The research wasconducted in a qualitative approach through a case study method. Sources of data consisted of 10 interviewed subjects, 18 FGD subjects, and survey of 327 subjects. Subjects were varyingfrom pesantren’s supervisor, teacher, manager and doctor of pesantren’s Community Health Center, and santri itself. Data was also obtained from the observation of the supervisors’behaviors and the pesantren’s environment. Subjects tended to agree in distinguishing the male and female gender role based on what’s happening, different from the religious teachingsthey learned which tended to be gender fair. Regarding with women reproductive cases, subjects tended to be gender biased based on the interpretation of religious texts although theyadmitted that it was hard to be manifested in behavior, example: prefering monogamous marriage,never beating women, and not promoting early marriage. Subjects agreed andunderstood that women had different, and yet more complex anatomical processes and functions, however their health service were just considered the same as men.
Co-Authors . Larasati Astrid Ayu Maruti Avin Fadilla Helmi Edy Meiyanto Erna Prawita Setyowati Fortunella Tjondro Raditya Prima Istiaji