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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Respirologi Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Budi Yanti
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Health Professions Medicine & Pharmacology Public Health

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Profil Sitologi Efusi Pleura di RSUD Zainoel Abidin Banda Aceh Fitri Dewi Ismida; Budi Yanti; Cut Asmaul Husna; Istanul Badiri; Reno Keumalazia kamarlis
Jurnal Kedokteran Syiah Kuala Vol 21, No 3 (2021): Volume 21 Nomor 3 Desember 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i3.23805

Abstract

Efusi pleura merupakan problem diagnosticutama pada kelainanparukarena pleura merupakansuaturongga yang melapisiparutanpaadaaksesapapun. Analisissitologiefusi pleura seringkalidigunakansebagailinipertamapenapisandalampenegakan diagnosis dan tindakanpenatalaksananlebihlanjut. Pemeriksaansitologiefusi pleura sangatpentingkarenadapatmemberikaninformasiinflamasi, keganasan dan metastasis.Penelitianinimenggunakanmetodedeskriptif, mengamatiseluruhbahanefusi pleura yang dilakukananalisissitologiselamaperiodeduatahun dan diperoleh 697 kasusefusi pleura di laboratoriumPatologiAnatomiRumahSakitZainoelAbidin, Banda Aceh. Hasil pemeriksaansitologi 697 bahanefusi pleura ditemukan paling banyakmenunjukkan diagnosis klinistidakdapatdisimpulkan 344 efusi pleura dan diagnosis klinisbukansuatu proses keganasan 294 (total 91,52%), diantaranya paling banyakmenunjukkansuatuperadangankronisdengansebaransellimfosit yang dominanyaitu 124 (41.5%). Dan dari 59 bahanefusi pleura denganjeniskeganasanmenunjukkanbahwa paling banyakditemukan adenocarsinomayaitu 29 (49,1%) dan terdapat 22 (37,3%) bahanefusi pleura denganjeniskeganasan primer yaituSquamousCellCarsinoma. Sitologiefusi pleura merupakanmodalitasdiagnosticmudah dan sederhana yang  sangatmembantudalammenegakkan diagnosis efusi pleura dan berperandalammelakukaneksplorasietiologi dan prognosis penyakit. Oleh karenaitu, semuakelainanefusi pleura yang belumterdiagnosissebaiknyadilakukanpemeriksaansitologiuntuk diagnosis awal dan manajemenpasienselanjutnya.
Perbedaan diagnosis asma, penyakit paru obstruktif kronik dan asthma-COPD overlap syndrome Dianita Permatasari; Budi Yanti
Jurnal Kedokteran Syiah Kuala Vol 20, No 3 (2020): Volume 20 Nomor 3 Desember 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i3.18640

Abstract

Abstrak. Penyakit Asma dan PPOK terjadi karena dua mekanisme yang berbeda dan dipicu oleh etiologi dan patogen yang berbeda, keduanya memiliki ciri dan gejala inflamasi jalan nafas dan obstruksi jalan nafas, akan tetapi ada juga penyakit yang memiliki ciri dan gejala asma dan PPOK secara bersamaan. Penyakit ini umumnya dikenal sebagai Asthma-COPD Overlape Syndrome (ACOS). Penyakit ini sering ditemui di klinik dengan manifestasi klinis yang mirip  dengan asma dan PPOK. Meskipun ini belum definit, akan tetapi  di klinik penyakit ini sering ditemui dengan manifestasi fenotipe klinis yang berbeda sehingga perlu untuk memhami beberapa mekanisme mendasar yang berbeda dari penyakit tersebut.  Pada literatur review ini bertujuan untuk menjelaskan patogenesis ACOS untuk memahami mekanisme tumpang tindih asma dan PPOK. Kata kunci: asma, PPOK, ACOS. Abstract. Asthma and COPD occur due to two different mechanisms and triggered by different etiologies and pathogens, both asthma and COPD have features and symptoms of airway inflammation and airway obstruction, but some diseases have the characteristics and symptoms of asthma and COPD simultaneously. This disease is commonly known as Asthma-COPD Overlap Syndrome (ACOS) and is often encountered in clinics with the similarity of the clinical manifestations between asthma and COPD. Although this is not definite yet, ACOS  is often appeared by different clinical phenotypic manifestations, so it is necessary to understand some of the different underlying mechanisms of the disease. This literature review aims to explain the differences between Asthma, COPD, and ACOS to understand the overlapping mechanism of these diseases. Keywords: asthma, COPD, ACOS
Peran pemeriksaan radiologis pada diagnosis Coronavirus disease 2019 Budi Yanti; Ulfa Hayatun
Jurnal Kedokteran Syiah Kuala Vol 20, No 1 (2020): Volume 20 Nomor 1 April 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i1.18300

Abstract

Abstrak. Coronavirus Disease 19 (COVID-19) telah menjadi pandemi di seluruh dunia dengan angka kejadian yang terus meningkat di beberapa negara. Kecepatan dan ketepatan diagnosis diperlukan untuk mencegah perburukan kondisi pasien. Real-Time Transcription Polymerase Chain Reaction (RT-PCR) sampai saat ini masih menjadi baku emas untuk menegakkan diagnosis COVID-19, namun uji diagnostik ini dilaporkan banyak menunjukkan hasil negatif palsu. Pemeriksaan radiologi berupa foto toraks dan CT-Scan dada banyak dilakukan untuk  menunjang diagnosis COVID-19. Gambaran foto toraks yang paling sering ditemukan adalah konsolidasi, ground-glass opacity (GGO), distribusi bilateral, perifer dan di lobus bawah paru-paru, namun pemeriksaan ini dianggap tidak sensitif untuk menemukan kelainan paru pada tahap awal penyakit. Meskipun demikian, foto toraks dapat digunakan untuk memantau perkembangan kelainan paru akibat COVID-19, salah satunya dengan metode Brixia Score. Pada sisi lain,CT-scan dada dinilai lebih sensitif daripada foto toraks serta mampu menunjukkan kelainan paru tahap awal pada pasien dengan hasil RT-PCR yang negatif. Gambaran pada CT-scan dada umumnya menunjukkan GGO, konsolidasi, crazy-paving stone, dan air bronchogram.  CT-scan dapat mengurangi angka negatif palsu pada RT-PCR dan sebagai alat skrining pada pasien yang dicurigai COVID-19 di lokasi epidemis saat hasil RT-PCR tidak tersedia. Penggunaan pemeriksaan radiologi dan RT-PCR dapat menghemat waktu serta membantu diagnosis dan manajemen COVID-19. Kata Kunci: Pencitraan COVID-19, Radiologi SARS-CoV-2Abstract. Coronavirus Disease 19 (COVID-19) has become a worldwide pandemic with an increasing incidence in several countries. Speed and accuracy of diagnosis are needed to prevent worsening of patient's condition. Real-Time Transcription Polymerase Chain Reaction (RT-PCR) is still a gold standard of COVID-19 diagnosis, however, this test shown false negative results in several case. Radiological examinations, chest X-Ray (CXR) and CT scan, are used to support the diagnosis. The most commonly found in CXR are consolidation, ground-glass opacity (GGO), bilateral distribution, peripheral and in the lower lobe, but this examination is insensitive to find lung abnormalities in early stages of disease. However, CXR can be used to monitor the development of lung abnormalities due to COVID-19, such as the Brixia Score method. On the other hand, CT-Scan is more sensitive than CXR and able to show early lung abnormalities in negative RT-PCR results. CT scan show the presence of GGO, consolidation, crazy-paving stone, and air bronchogram. CT-scanning can reduce the false-negative rate on RT-PCR and become a screening tool in suspected COVID-19 patients at epidemic area where RT-PCR is not available. The use of radiological examinations and RT-PCR can save the time and help in the diagnosis and management of COVID-19.Keywords: COVID-19’s Radiology, Imaging of SARS-CoV-2
Specific levels of calcidiol, calcitriol, cathelicidin and interferon gamma in diabetic patients with TB infection in Jakarta, Indonesia; Case control study Yunita Arliny; Dewi Behtri Yanifitri; Budi Yanti; Diennisa Mursalin
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.221

Abstract

Vitamin D plays a role in regulating the immune system via Vitamin D receptors, expressed by T-helper cells (Th). Cathelicidin LL-37 is an antimicrobial peptide that acts as the primary barrier against the Mycobacterium tuberculosis bacterial infection, which is induced by calcitriol, the active form of Vitamin D3. Interferon gamma (IFN-γ) is a cytokine released by Th-1 cells, and is essential for the elimination of M. tuberculosis. This study aims to determine the state of, and correlation between, calcidiol, calcitriol, cathelicidin and IFN-γ levels, as well as other clinical factors among patients with Type 2 Diabetes Mellitus (T2DM) with active TB coinfection. Further analysis is also performed to study the differences between T2DM patients with active tuberculosis, latent TB and without TB infection.
PHYLOGENY MAGNITUDE OF Mycobacterium tuberculosis BASED ON GENOMIC ANALYSIS Budi Yanti; Mulyadi Mulyadi; Soetjipto Soetjipto; Ni Made Mertaniasih; Muhammad Amin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art12

Abstract

Mycobacterium tuberculosis (MTB) is mostly found in humans, and it can cause more than two million deaths each year with increasing morbidity. Although lineages of MTB show identical nucleotide relationships, they have different characteristics such as evolution, transmission, drug resistance, host interaction, latency, and vaccine effectiveness. It is necessary to have better understanding of MTB relationships based on similarities in genome sizes and phylogenetic analysis. This paper observes the relationships of MTB based on nucleotide through phylogenetic frameworks. The MTB species consist of six lineages, and each lineage has various size of genomes . This difference contributes to virulence of MTB affecting levels of severity, morbidity, and mortality of diseases. Genetic diversity of MTB can contribute to global threats in the world such as outbreak of tuberculosis, Multi Drug Resistant (MDR) and Extensively Drug Resistant (XDR) tuberculosis.
Co-Authors Cut Asmaul Husna Dewi Behtri Yanifitri Dianita Permatasari Diennisa Mursalin Fitri Dewi Ismida Istanul Badiri Muhammad Amin Mulyadi Mulyadi Ni Made Mertaniasih Reno Keumalazia Kamarlis Soetjipto Soetjipto Ulfa Hayatun Yunita Arliny