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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Mandala of Health : A Scientific Journal

Muhamad Salman Fareza

Unknown Affiliation

Author-ID : 2687586

Dentistry Health Professions Medicine & Pharmacology Public Health

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Phytochemical Screening and Antibacterial Test of Leaf Extract of Canar Susu (Smilax macrocarpa Blume) Against Eschercihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis Lela Lailatul Khumaisah; Vina Juliana Anggraeni; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 7 No 1 (2019): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Smilax adalah salah satu genus Smilacaceae yang banyak dimanfaatkan sebagai tumbuhan obat karena mengandung berbagai metabolit sekunder dengan beberapa bioaktivitas, seperti anti-inflamasi, antirematik, analgentik, antioksidan, antikanker dan antibakteri. Spesies Smilax yang belum pernah dikaji dan hanya tumbuh di Indonesia adalah Smilax macrocarpa Blume (canar susu). Penelitian bertujuan untuk mengkaji karakteristik simplisia, kandungan fitokimia, beserta sifat toktsisitas dan antibakterinya dari ekstrak daun tumbuhan ini. Penelitian dilakukan dengan metode ekstraksi menggunakan teknik maserasi dengan pelarut metanol. Selanjutnya terhadap ekstrak S. macrocarpa Blume dilakukan karakteristik simplisia, uji toksisitas dengan metode BSLT, skrining fitokimia menurut metode Harborne, dan uji aktivitas antibakteri menggunakan metode mikrodilusi terhadap bakteri Escherihia coli, Pseudomonas aeruginosa, dan Staphylococcus epidermidis. Berdasarkan hasil yang diperoleh diketahui bahwa ekstrak metanol daun canar susu mengandung alkaloid, flavonoid, steroid, tanin, terpenoid, saponin dan glikosida. Kadar air, kadar abu, kadar abu tak larut asam, kadar sari air, dan kadar sari alkohol berturut-turut 8,74%; 3,60%; 0,11%; 19,01% dan 5,40%. Hasil toksisitas ekstrak diperoleh nilai LC50 sebesar 680,07 ppm. Pada uji aktivitas antibakteri terhadap E. coli memiliki nilai MIC 625 ppm, sedangkan pada P. aeruginosa dan S. epidermidis ATCC 12228 masing-masing 1.250 ppm. Adapun nilai MBC untuk E. coli, P. aeruginosa dan S. epidermidis ATCC 12228 masing-masing sebesar 5.000 ppm. Dari hasil ini canar susu tidak berpotensi sebagai antibakteri, tetapi bisa berpotensi sebagai biopestisida dilihat dari nilai toksisitasnya.

Aktivitas Antifungi Esktrak Etanol Daun Kamboja Merah (Plumeria rubra L.) Terhadap Pityrosporum ovale Rizki Akbar Ramadhan; Rehana Rehana; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 6 No 2 (2018): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Penelitian ini bertujuan untuk mengetahui metabolit sekunder dan konsentrasi hambat minimum (KHM) dari ekstrak etanol daun kamboja merah (Plumeria rubra L.) terhadap fungi Pityrosporum ovale penyebab ketombe. Ekstrak diperoleh dengan metode maserasi dalam pelarut etanol. Kandungan kimia pada ekstrak diidentifikasi dengan kromatografi lapis tipis. Aktivitas antifungi dilakukan dengan metode dilusi padat untuk memperoleh nilai KHM. Hasil penelitian menunjukkan ekstrak etanol daun kamboja merah mengandung flavonoid dan terpenoid. KHM yang didapat adalah 1750 ppm.

THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) TO THE NUMBER OF FIBROBLASTS IN IMIQUIMOD INDUCES PSORIASIS MICE MODEL Irse Priyaganda Bani Musa; Thianti Sylviningrum; Dody Novrial; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Imiquimod induces activation of Th17 cells and dendritic cells that play a role in psoriasis. Ciplukan extract ( Physalis angulata L.) contains steroid compounds, flavonoids, alkaloids, and saponins such as Physalin B, Physalin F, Physalin G which have anti-inflammatory activity in psoriasis pathophysiology. This research is an experimental research with post test only with control group design. Thirty five female mice were divided into 7 groups. Group A: negative control, group B: positive control, group C induced by imiquimod and given with ciplukan extract 400 mg/kg BW for 7 days, group D induced by imiquimod and given with ciplukan extract 800 mg/kg BW for 7 days, group E induced imiquimod and given with ciplukan extract 1,200 mg/kg BW for 7 days, group F induced by imiquimod and given with methotrexate 1 mg/kg BW for 7 days, and group G induced by imiquimod and given with a combination of ciplukan extract 1,200 mg/kgBW and methotrexate 1mg/kgBW for 7 days. 7 days. The number of fibroblast cells was counted on the fifteenth day by taken a sample of mouse skin and made histological preparations and then counted manually used a microscope. The mean number of fibroblast cells in groups A, B, C, D, E, F, and G were 21.6±2.3, respectively; 39.2±5.5; 30.6±1.3; 24.0±2.8; 24.8±2.9; 28,4±3,0;28,2±3,2 . The results of the test One Way ANOVA showed a value of p = 0.000 (p < 0.05), so that the results are significant. Keywords: ciplukan extract, fibroblast, methotrexate , Physalis angulata

THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL Putri Nur'afni Sa'adah; Thianti Sylviningrum; Dody Novrial; Fajar Wahyu Pribadi; Wahyu Dwi Kusdaryanto; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRACT Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L

Co-Authors Dody Novrial Fajar Wahyu Pribadi Irse Priyaganda Bani Musa Lela Lailatul Khumaisah Putri Nur'afni Sa'adah Rehana Rehana Rizki Akbar Ramadhan Thianti Sylviningrum Vina Juliana Anggraeni Wahyu Dwi Kusdaryanto

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