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All Journal MEDIA MEDIKA INDONESIANA JURNAL WIDYA MEDIKA Jurnal Berkala Epidemiologi Folia Medica Indonesiana Majalah Obstetri dan Ginekologi Sari Pediatri Universa Medicina Paediatrica Indonesiana Health Notions Majalah Kedokteran Neurosains JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Neurologico Spinale Medico Chirurgico Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Cermin Dunia Kedokteran AKSONA MEDICINUS
Prastiya Indra Gunawan
Departemen Ilmu Kesehatan Masyarakat, Fakultas Kedokteran Unversitas Airlangga Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Topiramate sprinkle is effective in the treatment of childhood epilepsy Gunawan, Prastiya Indra; Suharso, Darto
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.34-42

Abstract

BackgroundEpilepsy remains one of the most frequently occurring pediatric problems. Approximately 10-15% patients do not respond to conventional therapy. Topiramate as a novel antiepileptic drug has a broad spectrum activity, presumably indicative of multiple anti-seizure mechanisms. Previous studies of topiramate as adjunctive and monotherapy in adults have shown beneficial effects. The objective of this research was to evaluate the efficacy and tolerability of topiramate sprinkle monotherapy in pediatric epilepsy.MethodsThis experimental research was conducted in the Pediatric Neurology outpatient clinic department, Soetomo hospital, Surabaya, involving 18 consecutive subjects. Subjects meeting the inclusion criteria were treated with topiramate sprinkle adjusted dose. Seizure frequency and side effects were observed in weeks 1, 4, 8, 12, 16, 20 and 24, respectively. Electro encephalogram (EEG) and laboratory examinations were performed prior to and after 6 months of treatment. The t-test for related samples and McNemar test were utilized for statistical analysis. ResultsA total of 15 subjects completed the study. Topiramate-treated patients showed a statistically significant difference of seizure frequency reduction from 2.7 ± 1.16 to 0.13 ± 0.51 (p=0.000) with 93.7% patients being seizure free in 20 weeks. EEG recordings did not differ statistically in decrement of epileptiform activity in 20% subjects. About 7% subjects developed drowsiness and 33.3% subjects suffered from appetite suppression in the initial treatment. Laboratory results showed no abnormalities. ConclusionsThere was reduction of seizure frequency and no EEG recording alterations after topiramate sprinkle monotherapy. Topiramate as a monotherapy is highly effcicacious in childhood epilepsy.
Seizure increases electroencephalographic abnormalities in children with tuberculous meningitis Gunawan, Prastiya Indra; Saharso, Darto
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.161-167

Abstract

BackgroundTuberculous meningitis (TBM) is a severe intracranial infection with fatal outcomes, permanent disabilities, and electroencephalographic (EEG) abnormalities. Seizures may occur in TBM. The EEG findings in TBM vary according to the site of the inflammatory process. There are few studies describing the EEG patterns and clinical manifestations of TBM. The objective of this study was to investigate the correlation between clinical findings and EEG patterns in children with TBM. MethodsA study of cross-sectional design using medical records was conducted on 12 children with TBM, with their EEG patterns classified as abnormal and normal. Clinical manifestations such as seizures, altered consciousness, headache or fever were collected. A positive cerebrospinal fluids Mycobacterium tuberculosis culture was considered to indicate definitive TBM. Abnormal EEG descriptions were classified into abnormal I, II or III. Correlation between EEG pattern and clinical manifestation were analyzed with Fisher’s exact test. ResultsThe study found cases of 12 children with TBM, the majority presenting with seizures, decreased consciousness and fever. Abnormal EEGs were found in 75% of children and 77% of them showed epileptogenic activities. The EEG results mostly described epileptogenic potentials in the frontotemporal region. There was a significant correlation between EEG abnormality and seizures in children with TBM (p<0.05).ConclusionsThe EEG pattern in children with TBM varies, and EEG abnormalities were more frequently localized in the frontotemporal region. Seizures were associated with EEG abnormalities in children with TBM. EEG abnormalities occurring simultaneously with seizures may predict the occurrence of seizures.
MODALITAS PEMBEDAHAN EPILEPSI INTRAKTABEL PADA ANAK Prastiya Indra Gunawan,* Wihasto Suryaningtyas,** Darto Saharso*
NEURONA Vol 32 No.4 September 2015
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION SURGERY IS CONSIDERED TO BE THE TREATMENTOF CHOICE FOR PEDIATRIC CASES OF INTRACTABLE EPILEPSY WHOSERESPONSE TO ORAL ANTIEPILEPSY AGENTS IS INADEQUATE SURGERY FOR INTRACTABLE EPILEPSY IN CHILDREN IS DIFFERENT COMPARED TO ADULTS
PENGGUNAAN MIDAZOLAM INTRAVENA SECARA INTRANASAL DALAM TATALAKSANA BANGKITAN PADA ANAK Prastiya Indra Gunawan,* Lasmauli Situmorang,* Desy Nurrosalia,* Dian Pratamastuti,* Darto Saharso*
NEURONA Vol. 33 No. 3 Juni 2016
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION PROLONGED SEIZURES IN CHILDREN IS A FRIGHTENING EXPERIENCE FOR FAMILIES CESSATION OF SEIZURE AS SOON AS POSSIBLE AND EASY TO DO ARE NEEDED BECAUSE SEIZURES IN CHILDREN MOSTLY OCCUR OUTSIDE OF THE HOSPITAL BENZODIAZEPINES ARE STILL THE PRIMARY CHOICE OF TREATMENT OF SEIZURES IN CHILDREN MIDAZOLAM IS A BENZODIAZEPINE THAT EASILY TO FIND IN FORM OF INTRAVENOUS OTHERWISE IT COULD BE INITIATED INTRANASALLY
EFEKTIVITAS MIDAZOLAM INTRAMUSKULAR UNTUK MENGHENTIKAN BANGKITAN EPILEPTIK PADA ANAK Prastiya Indra Gunawan,* Darto Saharso*
NEURONA Vol 34 No. 2 Maret 2017
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION SEIZURE IS THE TOP 2 AMONG 10 PEDIATRIC NEUROLOGIC COMPLAINTS IN PRIMARY CARE ACCORDING TO PEDIATRIC SURVEY DATA BENZODIAZEPINES ARE CONSIDERED AS THE DRUGS OF CHOICE FOR THE TREATMENT OF SEIZURES THE USE OF INTRAVENOUS ACCESS IS DIFFICULT AND REQUIRES MORE TIME THEREFORE OTHER ACCESS IS CONSIDERED TO BE MORE EFFICIENT IE INTRAMUSCULAR MIDAZOLAM HAS THE PHYSICALCHEMICAL CHARACTERISTICS THAT FACILITATE RAPID ABSORPTION FOLLOWING INTRAMUSCULAR INJECTION
Comparison of Clinical Characteristics and Neuroimaging of Cerebral Palsy with and without Epilepsy in Children Rizka Yulianti1 , Prastiya Indra Gunawan2, Darto Saharso3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13616

Abstract

Background: Cerebral palsy (CP) is one of the main causes of limited activity in children. The prevalenceof CP ranges from 2.6 to 2.9 per 1000 live births. Most of children with CP have at least one comorbid,including epilepsy. Epilepsy in CP is difficult to control, and can increase the severity of motor impairmentand cognitive function, therefore the prognosis is poor. The incidence of epilepsy in CP is associated witha specific clinical profile. This study aimed to analyze the comparison of clinical characteristics of cerebralpalsy in children with and without epilepsy.Methods: A cross-sectional study was conducted using medical record of children with cerebral palsy inpediatric neurology outpatient clinic in Dr. Soetomo Hospital Surabaya in March - May 2020. Childrenwith CP who met the inclusion criteria were included in this study. The variables studied included sex,perinatal history (preterm birth, low birth weight, and neonatal asphyxia), neonatal seizures, spastic type,level of GMFCS, head circumference, neuroimaging features, hearing loss, and eye abnormalities. Thestudy subjects were divided into two groups. Group 1 consisted of children with CP and epilepsy. Group 2consisted of children with CP without epilepsy. Data analysis was performed using the Chi-square test andfisher’s exact test using SPSS.Result: Significant comparison of the characteristics were found in the history of neonatal seizures andthe level of GMFCS. The percentage of neonatal seizures was higher in group 1 at 61.3% (p=0.049). Thedegree of GMFCS in group 1 was dominated by GMFCS III while in group 2 it was dominated by GMFCSIV (p=0.047). Subjects with GMFCS I and II levels were only found in group 2, while in group 1 withhigher level of GMFCS, they were GMFCS III, IV, and V. More abnormal neuroimaging was found ingroup 1, namely 64.3%, while in group 2 it was 57.1%. There was no statistically significant difference ofneuroimaging characteristics between the two groups (p= 0.911).Conclusion: There were differences in clinical characteristics associated with neonatal seizures and GMFCSbetween CP with and without epilepsy.
A case of juvenile dermatomyositis responding to methotrexate and steroid Gunawan, Prastiya Indra; Saharso, Darto
Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.401 KB) | DOI: 10.55175/cdk.v44i6.793

Abstract

A 4-year-old patient presented with skin rash and weakness. She was diagnosed with juvenile dermatomyositis based on Bohan and Peter criteria and laboratory result. The treatment consist of steroid combined with methotrexate. The response is good.Pasien anak perempuan berusia 4 tahun dengan keluhan bercak kemerahan di kulit dengan kelumpuhan. Pasien didiagnosis juvenile dermatomyositis berdasarkan kriteria Bohar dan Peter dan hasil laboratorium. Pasien mendapat terapi steroid dikombinasi dengan methotrexate, menunjukkan hasil baik.
THE CORRELATION BETWEEN APGAR SCORE AND GESTATIONAL AGE WITH NEONATAL SEPSIS AND ASSOCIATED MORTALITY Nabila Annisa Harum; Martono Tri Utomo; Aditiawarman -; Prastiya Indra Gunawan
JURNAL WIDYA MEDIKA Vol 7, No 2 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i2.3388

Abstract

Background: Neonatal sepsis is increasingly recognized as an important global health problem that challenges neonatal survival. In 2018, sepsis caused approximately 15% of all neonatal deaths worldwide. Recent data regarding preterm birth and low Apgar score as risk factors for neonatal sepsis-related death have not been reported in Indonesia. Methods: This was a case-control study conducted in Dr.Soetomo General Hospital. A case group was obtained from medical records by a total sampling of all neonates diagnosed with neonatal sepsis in 2019, and a control group of non-neonatal sepsis cases was taken by random sampling. Chi-square test and logistic regression were used to analyze the data. Results: Statistical analysis showed a significant correlation between one and five-minute Apgar score
Pseudomonas Pseudoalcaligenes Caused Otogenic Cerebellar Brain Abscess In Indonesian Child Prastiya Indra Gunawan; Achmad Chusnu Romdhoni
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15901

Abstract

Otogenic brain abscess is a common intracranial complication from chronic supurative otitis media.Pseudomonas pseudoalcaligenes is a rare cause of brain abscess. Prompt diagnosis and decision making issignificant in order to decrease the mortality rate from this type of abscess. We described A 13-year-old boypresented with decreased consciousness, positive meningeal signs, and pathological reflexes. There was ahistory of chronic suppurative otitis media. A head CT scan revealed multiple left cerebellar abscesses andbrain edema. The abscess wall culture revealed P. pseudoalcaligenes. After being managed with surgicalabscess drainage, mastoidectomy, ear flushing, and antimicrobial therapy for six weeks, his consciousnesslevel improved. Cerebellar neurological impairment was still observed. Physical and neurologicalrehabilitation was performed in order to improve the patient’s condition.
Pattern of Electroencephalography in Recurrent Febrile Seizure Patient Adinda Chairunnisa; Prastiya Indra Gunawan; Isti Suharjanti
Health Notions Vol 3, No 12 (2019): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.438 KB) | DOI: 10.33846/hn31203

Abstract

Background: Febrile seizures are seizures that often occur in children, usually of a non-hazardous nature and do not have a prolonged effect. Febrile seizures most often occur in children under five years of age and are reported to occur in 2-5% of the pediatric population. Febrile seizures are categorized as simple, complex and plus febrile seizures. In some patients, EEG is needed to ascertain whether a true febrile seizure occurs. Objective: This study aims to determine the EEG pattern in recurrent febrile seizure patients at the Child Inpatient Installation of Dr. Soetomo Surabaya. Method: This study used a retrospective descriptive method with medical record instruments. Results: This study showed that of 46 recurrent febrile seizures, only 21 patients could see the EEG results. Of the 18 patients with complicated febrile seizures there were 27.78% abnormal and 72.22% normal. One simple febrile seizure patient obtained a normal EEG result. Of the two patients with febrile seizures plus 50% abnormal results and 50% normal results. Conclusions: The EEG pattern in patients with recurring complex febrile seizure obtains the most abnormal result. Keywords: recurrent febrile seizure; electroencephalography; prevalence
Co-Authors Abdurachman Abdurachman Adinda Chairunnisa Aditiawarman - Agus Sulistyono Alfira Nailatul Izzah Aminuddin Harahap Andriati Andriati Arinda Putri Auna Vanadia Avida Marisa Ilmi Budi Utomo Darto Saharso Darto Saharso Darto Saharso Darto Saharso Darto Saharso Darto Suharso Darto Suharso, Darto Denisa Dwi Rahmayani Faroek Hoesin Florentina Sustini Hanik Badriyah Hidayati, Hanik Badriyah Heru Setiawan Indri Wahyuni Irwanto Irwanto Irwanto Irwanto Kanti Ismayani, Isti Suharjanti, Paulus Sugianto Lady Sherly Nuramalia Lourin Nova Martono Tri Utomo Mohammad Aldika Akbar Mohammad Nata Ardiansyah Mohammad Sjaifullah Noer Muhammad Arifin Parenrengi Nabila Annisa Harum Nabila Fitri Ariyati Ni Wayan Tirthaningsih Ninik Asmaningsih Soemyarso Pravita Tri Andrianti Ratih Dwi Andini Risky Vitria Prasetyo Romdhoni, Achmad Chusnu Rozalina Loebis Sri Andreani Utomo Theresa Laura Limanto Viskasari P. Kalanjati