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STUDI EFFEKTIVITAS KEFIR BENING DAN MENIRAN (Philanthus niruri) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA HEWAN TIKUS WISTAR HIPERGLIKEMIA DIINDUKSI STREPTOZOTOCIN ., Judiono; Hadisaputro, Soeharyo; Djokomoeljanto, RRJ; Laksono, Budi; W, Theophilus
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v33i2.89

EFFECTIVITY STUDY OF PLAIN KEFIR AND MENIRAN (PHILANTUS NIRURI) ON BLOOD GLUCOSE LEVELS ON HYPERGLYCEMIA WISTAR RATS INDUCED STREPTOZOTOCINTraditional medicines and functional foods used for diabetes therapy increased in Indonesia. Bioactive components play an important role in decreasing blood glucose. The study aims to prove the effectiveness of plain kefir and Meniran (Philanthus niruri) to decrease blood glucose levels in wistar rats with streptozotocin-induced hyperglycemia. The study design was randomized pre – post test control group. A number of 60 male rats aged 2.5-3 months, 150-250 g were made hyperglycemia by induced streptozotocin (STZ) 40 mg / kg berat badan. The hyperglycemic rats were grouped into: (1) treated with 0.76 UI insulin /day, (2) treated with 3.6 mL plain kefir /day, (3) treated 2.7 mL meniran / day, (4) positive control group of hyperglycemic rats, and (5) negative control group (standard diet ad libitum). The ratswere given feed refers to the AIN 93. Fasting glucose levels before and after treatment were measured by Super (Glucocard II) enzimatic method. The results showed that body weight increased in all treatments, except meniran, however the increaments were not differ significantly. Changes in body weight of insulin group were 13.800 + 16.104 g, kefir treatment amounted to 13.812 + 21.294, and meniran increased about 18.394 + 16.225. Changes in blood glucose in the insulin group about -118.571+55.815 mg/dL, kefir treatment at -102.875+60.454, while meniran group -66,625+37,784. In contrast, the positive control group tended to increase glucose levels. Conclusion In vitro, plain kefir and meniran potentially lowered blood glucose levels. However, kefir showed lowered glucose level better than meniran. Futher research needs to study bio- molecular mechanisms of the decline in the future.Key words: diabetes mellitus, meniran, plain kefir, streptozotocin (STZ), hyperglycemic rat

STUDI EFFEKTIVITAS KEFIR BENING DAN MENIRAN (Philanthus niruri) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA HEWAN TIKUS WISTAR HIPERGLIKEMIA DIINDUKSI STREPTOZOTOCIN ., Judiono; Hadisaputro, Soeharyo; Djokomoeljanto, RRJ; Laksono, Budi; W, Theophilus
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.919 KB)

EFFECTIVITY STUDY OF PLAIN KEFIR AND MENIRAN (PHILANTUS NIRURI) ON BLOOD GLUCOSE LEVELS ON HYPERGLYCEMIA WISTAR RATS INDUCED STREPTOZOTOCINTraditional medicines and functional foods used for diabetes therapy increased in Indonesia. Bioactive components play an important role in decreasing blood glucose. The study aims to prove the effectiveness of plain kefir and Meniran (Philanthus niruri) to decrease blood glucose levels in wistar rats with streptozotocin-induced hyperglycemia. The study design was randomized pre – post test control group. A number of 60 male rats aged 2.5-3 months, 150-250 g were made hyperglycemia by induced streptozotocin (STZ) 40 mg / kg berat badan. The hyperglycemic rats were grouped into: (1) treated with 0.76 UI insulin /day, (2) treated with 3.6 mL plain kefir /day, (3) treated 2.7 mL meniran / day, (4) positive control group of hyperglycemic rats, and (5) negative control group (standard diet ad libitum). The ratswere given feed refers to the AIN 93. Fasting glucose levels before and after treatment were measured by Super (Glucocard II) enzimatic method. The results showed that body weight increased in all treatments, except meniran, however the increaments were not differ significantly. Changes in body weight of insulin group were 13.800 + 16.104 g, kefir treatment amounted to 13.812 + 21.294, and meniran increased about 18.394 + 16.225. Changes in blood glucose in the insulin group about -118.571+55.815 mg/dL, kefir treatment at -102.875+60.454, while meniran group -66,625+37,784. In contrast, the positive control group tended to increase glucose levels. Conclusion In vitro, plain kefir and meniran potentially lowered blood glucose levels. However, kefir showed lowered glucose level better than meniran. Futher research needs to study bio- molecular mechanisms of the decline in the future.Key words: diabetes mellitus, meniran, plain kefir, streptozotocin (STZ), hyperglycemic rat

FAKTOR YANG BERPENGARUH TERHADAP KEJADIAN DEMAM BERDARAH DENGUE PADA ANAK USIA 6-12 TAHUN Sandra, Tuti; Sofro, Muchlis AU; Suhartono, Suhartono; Martini, Martini; Hadisaputro, Soeharyo
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 9 No 1 (2019): Januari
Publisher : LPPM STIKES KENDAL

Demam Berdarah Dengue (DBD) adalah penyakit infeksi yang masih menjadi masalah kesehatan yang serius karena bersifat endemis. Penyebaran di daerah tropis dan subtropis terutama di Asia Selatan-Timur, Asia Tenggara. Penelitian ini bertujuan untuk menjelaskan beberapa faktor yang berpengaruh terhadap kejadian DBD pada anak usia 6-12 tahun. Penelitian menggunakan desain penelitian campuran atau mixed methode yang mengkobinasikan bentuk kuantitatif dan kualitatif. Spesifikasi penelitian kuantitatif :observasional analitik desain case control study. Dilakukan kajian kualitatif dengan wawancara mendalam. Populasi studi adalah semua anak usia 6-12 tahun yang tinggal di Kota Semarang. Jumlah subyek 70 kasus dan 70 kontrol yang diambil secara consecutive sampling. Data di analisis secara bivariat dan multivariat dengan metode regresi logistik. Faktor-faktor  yang terbukti berpengaruh terhadap kejadian DBD pada anak usia 6-12 tahun; pendidikan ibu rendah (p= 0.004; OR  3.031; 95%CI 1.4281-6.434), kebiasaan tidak memakai obat anti nyamuk ( p= 0.001; OR 4.293; 95%CI 1.935-9.526), kebiasaan tidak memakai pakaian panjang (p= 0.013; OR 2.759; 95%CI 1.240-6.138) Sedangkan faktor yang terbukti tidak berpengaruh; kebiasaan tidur siang, kebiasaan menggantung pakaian dalam rumah, forum penyampaian informasi, rutinitas pemeriksaan jentik dan praktik PSN. Faktor-faktor yang terbukti berpengaruh terhadap kejadian DBD pada anak usia 6-12 tahun adalah pendidikan ibu rendah, kebiasaan tidak memakai obat anti nyamuk dan kebiasaan tidak memakai pakaian panjang memiliki probabilitas 85,3% untuk mengalami DBD. Kata kunci  : DBD, nyamuk, dengue.   VARIOUS FACTORS INFLUENCING THE DENGUE FEVER OCCURRENCES IN THE CHILDREN AGE 6 TO 12 YEARS OLD   ABSTRACT The Dengue Fever is an infectious disease that still becomes a serious health issue since it is endemic. The disease spreads in the tropical and subtropical areas particularly in the Southeast Asia. This research aims to explain the various factors influencing the occurrences of the dengue fever in the children age 6 to 12 years old. This research uses mixed method research design combined with both quantitative and qualitative methods. The quantitative research specification is the observational analytic case control design while the indept interview technique is used as the qualitative research method. The population of the study is all children age 6 to 12 years old who live in the Semarang City. The number of the subjects is 70 cases and 70 controls which are taken by consecutive sampling method. The data are analyzed using the bivariate and multivariate with the regression logistic method. The factors that has been proven to influence the dengue fever occurrences in the children 6 to 12 years old are the lack of the mother?s education ((p= 0.004; OR  3.031; 95%CI 1.4281-6.434), the habit of not using the insect repellent use (p= 0.001; OR 4.293; 95%CI 1.935-9.526) and the habit of not wearing long clothes (p= 0.013; OR 2.759; 95%CI 1.240-6.138). Meanwhile, the habit of taking nap, the habit of hanging clothes, the information delivery forum, the routine examination of the mosquitos? larva and the mosquitos? eradication are not shown as the influential factors causing the dengue fever. The factors recognized as the significant factors against the occurrences of the dengue fever in the children age 6 to 12 years old are the lack of the mother?s education, the habit of not using the insect repellent and the habit of not wearing long clothes have the probability 85,3% to experience the dengue fever. Keywords : Dengue Fever, Mosquito, Dengue

Hubungan status besi dan ioidum ibu hamil trimester III terhadap berat badan dan lingkar kepala bayi lahir didaerah endemik GAKI Novitasari, Sherly; Hadisaputro, Soeharyo; SS, Darmono; Rachmawati, Banundari; Pemayun, Tjokorda Gde Dalem
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 1 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Iodine and iron were micronutrient that highly related with formation of thyroid hormone. Iodine and iron deficiency during pregnancy, will affect fetal development. Weight and born babyâ€™s head circumference were early indicator of infant development, because it describe the result of interaction of several factors for fetus during pregnancy. Objectives: To determine correlation between iodine and iron status of pregnant women in third trimester with born babyâ€™s weight and head circumference. Methods: Cross sectional study with 49 pregnant women on third trimester and their baby born. Measurement of iron status used sTfR level by ELISA and iodine status used EIU. Meanwhile for the born baby, measurement was taken place on the babyâ€™s weight and head circumference. Results: The average of iron status is 22,15 nmol/L, meanwhile average of iodine status is 168,63 Î¼g/L with urine median value 165 Î¼g/L. Statistical analysis with multiple correlation test showed no significant relationship between iron and iodine status of third trimester pregnant women to birth weight (r = 0,286; p = 0,141) as well as the babies head circumference (r = 0,195; p = 0,412).Conclusion: Iron and iodine status of third trimester pregnant women have low correlation to the born babies weight or head circumference in endemic area.

Pengaruh pemberian rumput laut sargassum sp terhadap kadar hemoglobin dan feritin serum Yuniarti, Anita; Hadisaputro, Soeharyo; W, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 1 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : Anemia is a global phenomenon involving developing countries. Fifty percent of anemia cases is caused by iron deficiency. Indonesia is a tropical country that is rich in various kinds of marine plants and still not used optimally.Sargassum sp is one of high iron contains seaweed but still less utilized. Objectives: the aim of this study was to analyze the influence of Sargassum sp on hemoglobin and serum ferritin level. Methods : a simple randomized with pre and posttest control group design was used in this study. Sixteen Wistar male rats were divided into 2 groups (1) control (2) treatment and fed with Sargassum sp 0,49 g for 14 days. During the treatment pre and post hemoglobin and serum ferritin was measured. Results : : iron level in Sargassum sp was 122,37mg/g and Pb level was 0,00009%. In the treatment group hemoglobin level was significantly increased 5,24 mg/dl (p<0,05) and serum ferritin was increased 4,20 Âµg/ml (p>0,05). Conclusion : sargassum sp increased hemoglobin level on anemic wistar rat but not in serum ferritin significantly.Â

Iron Status of Newborns and Umbilical Cord Blood Hepcidin Levels in Gender Differences Santosa, Qodri; Soemantri, AG; Hadisaputro, Soeharyo; Soejoenoes, Ariawan
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Fetal gender might affect the iron status of newborns. Hepcidin has an important role in the process of maternofetal iron transport. This study aims to compare the newborn iron status and the umbilical cord hepcidin levels between male and female gender. A cross-sectional study was conducted with subjects of 84 clinically healthy newborns. Written informed consent and ethical approval were carried out. Newborn iron status observed included (i) hematologic markers (RBC count, Hb, hematocrit, mean corpuscular volume (MCV) and red cell distribution width), and (ii) biochemical markers (serum iron (SI), serum ferritin (SF), soluble transferrin receptor (sTfR) and cord blood hepcidin). Hematologic markers were checked using Sysmex, XN-1000, while Hepcidin and sTfR were using ELISA. Serum iron was checked using IRON FlexÂ®. Statistical analysis was tested with the independent t-test and the Mann-Whitney. All newborns and their mothers were in normal condition. The mean sTfR levels of newborns were significantly higher in the male group than females (38.3Â±9.06 vs. 34.3Â±8.16 nmol/L) with p=0.033. High sTfR levels reflect a low iron status. In conclusion, fetal gender differences influence the iron status of newborns, and male newborns have a potentially higher iron deficiency.

PENGARUH PRENATAL YOGA TERHADAP LAMANYA PERSALINAN KALA I KONTRAKSI UTERUS DAN PERUBAHAN KADAR HORMON ENDORPHIN PADA IBU PRIMIGRAVIDA STUDI KASUS DI PUSKESMAS KADUGEDE KUNINGAN JAWA BARAT Kartikasari, Anggit; Hadisaputro, Soeharyo; Sumarni, Sri
Jurnal Ilmu Kesehatan Bhakti Husada: Health Sciences Journal Vol 11 No 1 (2020): Jurnal Ilmu Kesehatan Bhakti Husada: Health Science Journal
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Kesehatan Kuningan

Prenatal yoga merupakan suatu program latihan bagi ibu hamil sehat untuk mempersiapkan kondisi fisik ibu dengan menjaga kondisi otot-otot dan persendian yang berperan dalam proses persalinan, serta mempersiapkan kondisi psikis ibu terutama menumbuhkan kepercayaan diri dalam menghadapi persalinan. Menjelaskan pengaruh prenatal yoga terhadap kualitas persalinan Ibu Primigravida. Metode penelitian quasy-experimental(experiment semu) rancangan Non-Equivalen Control Group Desain. Sampel adalah ibu primigravida trimester III, teknik sampling menggunakan purposive sampling. Analisis bivariat menggunakan independent t-test dan paired t-test. Hasil penelitian ini menunjukkan ada pengaruh prenatal yoga terhadap lama persalinan kala I fase aktif (p=0,000), ada pengaruh prenatal yoga terhadap kontraksi uterus (p=0,000), ada pengaruh prenatal yoga terhadap perubahan kadar hormon endorphin pada kelompok perlakuan(p=0,002), tidak ada pengaruh perubahan kadar hormon endorphin pada kelompok kontrol(p=0,074). prenatal yoga dapat mempengaruhi lama persalinan ibu menjadi lebih cepat, kontraksi uterus menjadi kuat dan ada peningkatan kadar hormon endorphi. Perlunya mengajarkan prenatal yoga pada ibu-ibu hamil dan membuat kelas-kelas antenatal pada setiap Bidan Praktik Swasta atau Puskesmas.

Berbagai Faktor Yang Berhubungan Dengan Kejadian Gangguan Fungsi Paru Dalam Ruang Kerja (Studi Kasus Pekerja Industri Rumahan Electroplating di Kecamatan Talang Kabupaten Tegal) Wulandari, Diah Rahayu; Hadisaputro, Soeharyo; Suhartono, Suhartono
Jurnal Kesehatan Lingkungan Indonesia Vol 12, No 1 (2013): April 2013
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.12.1.94 - 98

Background: electroplating home industryÂ use chromium as the base material. Chromium is used in the form of hexavalent chromium, which has toxic effects on health.Â Electroplating workers exposed chromium through the air into the lungs through inhalation. Objective: Describe the various factors assosiatedÂ to the pulmonary dysfunctionÂ in a workplace atÂ workers of electroplating home industry . Methods: This study was an observational study with cross sectional approachÂ on 31 electroplating workers with total sampling of each industry. Vital Lung Capacity Measurements with a spirometer with SpyroAnalyzer type ST-75. Dust levels of Chromium with High Volume Sampler. Results: Results minimal amount of dust in the air of 0.0731 Î¼g/m3, the maximum value of dust concentration in the air is 1.8433 Î¼g/m3 Î¼g/m3 with a mean of 0.774357. Multivariate analysis showed a variable duration of exposure to chromium is the most influential variable on the incidence of pulmonary dysfunction, (p = 0.010) with 95% CI (2.11 to 228.56), odds ratio (Exp B) = 21.97. Conclusion: The factor shown to be associated with pulmonary dysfunction in workers chromium electroplating is a duration of exposure to chromium more than 4 hours a day. Keywords: Electroplating, pulmonary dysfunction, chromium.

Pengaruh Ekstrak Ketumbar (Coriandum Sativum) terhadap Perubahan Tekanan Darah Tikus Pasca Melahirkan Utami, Vina Nurul; Hadisaputro, Soeharyo; Rahayu, Sri
Jurnal Keperawatan Soedirman Vol 11, No 3 (2016)
Publisher : Jurusan Keperawatan FIKES UNSOED

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jks.2016.11.3.653

Hypertension is the most commont complication during pregnancy and delivery. It causes 5-10% maternal morbidity and mortality incorporate with bleeding and infection. The Maternal mortality rate caused by hypertension is about 23,95%. Coriander seeds contain flavonoid which work as antihipypertension and diuretic. This study was to examine coriander extract several dosage on decreasing systolic on post partum rats. An experimental study with randomized pre test and post test controlled group design obvserved 30 white rat Wistar Sp which divided into 5 groups randommly. Sphyngonanometer was applied to measure the blood pressure. Paired t-test, One Way ANOVA, and Repeated Measures ANOVA were administered for data analyses. Results showed that coriander extract on 10 mg/kg BB, 20 mg/kg weight and 30 mg/kgweights dosage affected to blood pressure changes on the rat (p 0.000 ), while 20 mg/kgweights and 30 mg/kgweight had no significant effects (p 0.900). It concluded that coriander estract on dosage 30 mg/kg weight and 20 mg/kg weight did not effect significantly to decreasing ratâ€™s blood pressure. Measuring not only systole pressure was recommended for further studies.

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